Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02049:Klk10'

185051

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Klk10

Ensembl Gene

ENSMUSG00000030693

Gene Name

kallikrein related-peptidase 10

Synonyms

2300002A13Rik, PRSSL1, NES1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL02049

Quality Score

Status

Chromosome

Chromosomal Location

43430478-43434834 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 43433882 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000014058 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000014058]

AlphaFold

Q99M20

Predicted Effect

probably benign
Transcript: ENSMUST00000014058

SMART Domains

Protein: ENSMUSP00000014058
Gene: ENSMUSG00000030693

Domain	Start	End	E-Value	Type
signal peptide	1	32	N/A	INTRINSIC
Tryp_SPc	46	271	1.35e-71	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181454

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930568D16Rik	T	A	2: 35,254,801 (GRCm39)	R27S	probably benign	Het
4930596D02Rik	C	A	14: 35,533,535 (GRCm39)	V78L	probably benign	Het
Abca3	T	A	17: 24,595,704 (GRCm39)	C352*	probably null	Het
Acat3	T	A	17: 13,144,207 (GRCm39)	Y324F	probably benign	Het
Adamts8	T	C	9: 30,862,650 (GRCm39)	V285A	probably damaging	Het
Anpep	A	G	7: 79,484,929 (GRCm39)	I652T	probably damaging	Het
Arhgef6	T	A	X: 56,321,271 (GRCm39)	Q320L	probably damaging	Het
Armh1	A	T	4: 117,094,860 (GRCm39)	I60K	probably benign	Het
Atp11b	T	C	3: 35,854,642 (GRCm39)	V145A	probably damaging	Het
Cacna1c	T	C	6: 118,580,880 (GRCm39)	T1674A	probably benign	Het
Capn2	A	T	1: 182,301,519 (GRCm39)		probably benign	Het
Cfd	A	G	10: 79,726,776 (GRCm39)	Y6C	probably benign	Het
Cps1	A	G	1: 67,183,113 (GRCm39)	K157R	possibly damaging	Het
Csmd3	T	A	15: 47,864,870 (GRCm39)	R786S	possibly damaging	Het
Dna2	A	T	10: 62,792,815 (GRCm39)	I277L	probably damaging	Het
Gm5168	A	T	X: 25,999,005 (GRCm39)	D50E	probably damaging	Het
Grik4	T	A	9: 42,455,049 (GRCm39)		probably benign	Het
Ift56	A	G	6: 38,402,067 (GRCm39)	T520A	probably benign	Het
Iqgap2	A	G	13: 95,811,913 (GRCm39)		probably benign	Het
Kng1	A	G	16: 22,892,187 (GRCm39)	Y250C	probably damaging	Het
Las1l	A	T	X: 94,981,059 (GRCm39)	M690K	probably benign	Het
Mug1	T	A	6: 121,848,295 (GRCm39)	M673K	probably benign	Het
Myh9	T	C	15: 77,654,070 (GRCm39)	H1245R	probably benign	Het
Oprk1	C	T	1: 5,669,067 (GRCm39)	T171I	probably damaging	Het
Pgm5	A	T	19: 24,801,782 (GRCm39)	S149T	probably benign	Het
Pla2g4a	T	C	1: 149,736,847 (GRCm39)	N424S	probably benign	Het
Plec	A	T	15: 76,063,149 (GRCm39)	L2334Q	probably damaging	Het
Pus7l	G	A	15: 94,438,059 (GRCm39)	S262F	probably damaging	Het
Rps24	C	A	14: 24,541,823 (GRCm39)	D3E	probably benign	Het
Rxfp1	T	C	3: 79,557,799 (GRCm39)	N560D	probably damaging	Het
Sema3c	C	T	5: 17,926,923 (GRCm39)		probably benign	Het
Slc47a2	A	G	11: 61,233,365 (GRCm39)	F55S	probably damaging	Het
Slco1a6	A	G	6: 142,047,309 (GRCm39)		probably benign	Het
Taf4b	A	T	18: 14,963,196 (GRCm39)	E645D	probably benign	Het
Tmem161a	T	A	8: 70,631,624 (GRCm39)	V158E	probably damaging	Het
Trav13-2	A	G	14: 53,872,604 (GRCm39)	S27G	possibly damaging	Het
Trav13-2	G	T	14: 53,872,603 (GRCm39)	Q26H	probably damaging	Het
Trav13-2	A	T	14: 53,872,602 (GRCm39)	Q26L	possibly damaging	Het
Vmn2r108	T	A	17: 20,691,608 (GRCm39)	H305L	probably benign	Het
Zfp263	A	G	16: 3,562,482 (GRCm39)	I82V	probably damaging	Het

Other mutations in Klk10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01488:Klk10	APN	7	43,434,400 (GRCm39)	missense	probably damaging	1.00
IGL01657:Klk10	APN	7	43,431,013 (GRCm39)	missense	possibly damaging	0.49
IGL02725:Klk10	APN	7	43,431,044 (GRCm39)	missense	probably damaging	1.00
IGL03382:Klk10	APN	7	43,433,883 (GRCm39)	splice site	probably benign
R0433:Klk10	UTSW	7	43,430,989 (GRCm39)	missense	possibly damaging	0.51
R1521:Klk10	UTSW	7	43,432,304 (GRCm39)	missense	probably benign	0.00
R1580:Klk10	UTSW	7	43,432,286 (GRCm39)	missense	probably damaging	1.00
R4825:Klk10	UTSW	7	43,433,022 (GRCm39)	missense	probably damaging	1.00
R5969:Klk10	UTSW	7	43,434,409 (GRCm39)	missense	probably damaging	1.00
R6437:Klk10	UTSW	7	43,432,241 (GRCm39)	missense	probably benign	0.04
R6641:Klk10	UTSW	7	43,434,324 (GRCm39)	missense	possibly damaging	0.94
R7589:Klk10	UTSW	7	43,433,051 (GRCm39)	missense	probably benign	0.00
R7599:Klk10	UTSW	7	43,433,851 (GRCm39)	missense	probably benign	0.03
R7902:Klk10	UTSW	7	43,432,942 (GRCm39)	missense	probably benign	0.34
R8519:Klk10	UTSW	7	43,432,239 (GRCm39)	nonsense	probably null
R9560:Klk10	UTSW	7	43,433,746 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07