Incidental Mutation 'IGL02052:Mogat2'
ID 185112
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mogat2
Ensembl Gene ENSMUSG00000052396
Gene Name monoacylglycerol O-acyltransferase 2
Synonyms DGAT2L5, Mgat2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.104) question?
Stock # IGL02052
Quality Score
Status
Chromosome 7
Chromosomal Location 98868291-98887818 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to T at 98887771 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000064041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064231]
AlphaFold Q80W94
Predicted Effect probably null
Transcript: ENSMUST00000064231
AA Change: M1K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000064041
Gene: ENSMUSG00000052396
AA Change: M1K

DomainStartEndE-ValueType
Pfam:DAGAT 39 334 9.1e-120 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132343
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit resistance to diet induced obesity, hyperinsulinemia, hyperlipidemia, and steatosis with decreased lipid absorption and increased oxygen consumption when fed a high fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef37 C T 18: 61,632,839 (GRCm39) V533M probably damaging Het
Bicd2 A G 13: 49,532,665 (GRCm39) D343G possibly damaging Het
Ccl26 C T 5: 135,592,193 (GRCm39) S48N possibly damaging Het
Cdkn1b A T 6: 134,897,970 (GRCm39) R30* probably null Het
Cds1 G T 5: 101,962,338 (GRCm39) V318L probably benign Het
Ceacam11 A G 7: 17,707,548 (GRCm39) S111G probably benign Het
Cntn1 A C 15: 92,189,584 (GRCm39) I636L possibly damaging Het
Cog2 G A 8: 125,269,627 (GRCm39) probably null Het
Cyp2g1 G A 7: 26,513,719 (GRCm39) probably benign Het
Ddx54 T C 5: 120,763,783 (GRCm39) V644A possibly damaging Het
Dnah1 T C 14: 30,990,743 (GRCm39) Q3192R probably damaging Het
Dyrk2 T G 10: 118,696,448 (GRCm39) H270P probably damaging Het
Ephb6 A G 6: 41,590,256 (GRCm39) T3A probably benign Het
Fam120a G A 13: 49,087,421 (GRCm39) probably benign Het
Fam184a A G 10: 53,573,216 (GRCm39) probably benign Het
Fmo1 A G 1: 162,677,629 (GRCm39) probably null Het
Gaa A G 11: 119,175,021 (GRCm39) Y874C possibly damaging Het
Gabrr1 T A 4: 33,152,567 (GRCm39) I169N probably damaging Het
Gm13734 T C 2: 86,966,665 (GRCm39) probably null Het
Gnb1 T C 4: 155,618,148 (GRCm39) probably benign Het
Hecw2 G T 1: 53,965,670 (GRCm39) F385L probably benign Het
Kif5a C T 10: 127,079,368 (GRCm39) V277M probably damaging Het
Mrgprx2 A T 7: 48,132,042 (GRCm39) W259R possibly damaging Het
Nf1 T C 11: 79,303,553 (GRCm39) L410S probably damaging Het
Ntn4 T G 10: 93,543,211 (GRCm39) N312K probably damaging Het
Papss2 T C 19: 32,637,983 (GRCm39) V365A possibly damaging Het
Pde4c A G 8: 71,201,062 (GRCm39) N420S probably damaging Het
Plec C T 15: 76,064,541 (GRCm39) R1911H probably damaging Het
Pramel21 A C 4: 143,341,643 (GRCm39) D24A probably benign Het
Rnf19b A G 4: 128,965,613 (GRCm39) H237R probably damaging Het
Slfn4 T C 11: 83,077,800 (GRCm39) L196P possibly damaging Het
Steap2 G T 5: 5,723,586 (GRCm39) F431L probably damaging Het
Tex15 A G 8: 34,072,493 (GRCm39) E2680G probably benign Het
Tmprss15 A T 16: 78,884,394 (GRCm39) I96N probably damaging Het
Trim34a T G 7: 103,897,038 (GRCm39) V34G probably benign Het
Ttyh1 A G 7: 4,133,573 (GRCm39) probably benign Het
Usp29 A C 7: 6,965,525 (GRCm39) H456P probably benign Het
Wdfy1 A G 1: 79,692,661 (GRCm39) S219P probably damaging Het
Zfp738 A T 13: 67,819,600 (GRCm39) S117R possibly damaging Het
Other mutations in Mogat2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01343:Mogat2 APN 7 98,881,775 (GRCm39) missense possibly damaging 0.60
IGL02153:Mogat2 APN 7 98,872,761 (GRCm39) missense possibly damaging 0.94
R0227:Mogat2 UTSW 7 98,872,339 (GRCm39) missense probably benign 0.02
R0490:Mogat2 UTSW 7 98,872,351 (GRCm39) missense probably benign 0.11
R1331:Mogat2 UTSW 7 98,872,722 (GRCm39) missense possibly damaging 0.66
R1546:Mogat2 UTSW 7 98,881,766 (GRCm39) missense probably damaging 1.00
R2879:Mogat2 UTSW 7 98,871,573 (GRCm39) missense possibly damaging 0.46
R4954:Mogat2 UTSW 7 98,887,724 (GRCm39) missense possibly damaging 0.95
R5040:Mogat2 UTSW 7 98,887,724 (GRCm39) missense possibly damaging 0.95
R5184:Mogat2 UTSW 7 98,872,842 (GRCm39) missense possibly damaging 0.90
R5822:Mogat2 UTSW 7 98,869,112 (GRCm39) missense possibly damaging 0.82
R6056:Mogat2 UTSW 7 98,872,720 (GRCm39) missense possibly damaging 0.95
R6256:Mogat2 UTSW 7 98,869,102 (GRCm39) missense probably damaging 1.00
R6500:Mogat2 UTSW 7 98,871,553 (GRCm39) missense probably benign 0.04
R7358:Mogat2 UTSW 7 98,881,673 (GRCm39) missense possibly damaging 0.93
R7375:Mogat2 UTSW 7 98,872,905 (GRCm39) missense probably damaging 1.00
Y5408:Mogat2 UTSW 7 98,872,837 (GRCm39) missense probably damaging 1.00
Z1177:Mogat2 UTSW 7 98,872,836 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07