Incidental Mutation 'IGL02054:Iws1'
ID185184
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iws1
Ensembl Gene ENSMUSG00000024384
Gene NameIWS1, SUPT6 interacting protein
Synonyms1700069O15Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.962) question?
Stock #IGL02054
Quality Score
Status
Chromosome18
Chromosomal Location32067741-32104328 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 32090542 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025243] [ENSMUST00000212675]
Predicted Effect probably null
Transcript: ENSMUST00000025243
SMART Domains Protein: ENSMUSP00000025243
Gene: ENSMUSG00000024384

DomainStartEndE-ValueType
low complexity region 21 32 N/A INTRINSIC
low complexity region 73 86 N/A INTRINSIC
low complexity region 92 109 N/A INTRINSIC
internal_repeat_2 112 179 9.21e-13 PROSPERO
internal_repeat_1 118 184 9.82e-20 PROSPERO
internal_repeat_1 183 296 9.82e-20 PROSPERO
internal_repeat_2 229 316 9.21e-13 PROSPERO
low complexity region 320 332 N/A INTRINSIC
low complexity region 357 373 N/A INTRINSIC
low complexity region 384 404 N/A INTRINSIC
low complexity region 407 418 N/A INTRINSIC
low complexity region 422 442 N/A INTRINSIC
low complexity region 528 540 N/A INTRINSIC
Pfam:Med26 584 636 4.8e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212115
Predicted Effect probably null
Transcript: ENSMUST00000212458
Predicted Effect probably null
Transcript: ENSMUST00000212675
Predicted Effect probably benign
Transcript: ENSMUST00000213074
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 G T 11: 110,292,123 P1036Q probably damaging Het
Bag4 T C 8: 25,771,225 S163G probably benign Het
Camkk1 G A 11: 73,025,882 R102Q probably damaging Het
Caprin1 A C 2: 103,771,798 probably null Het
Cct8 A T 16: 87,490,476 probably benign Het
Dlgap2 A G 8: 14,843,552 M941V probably damaging Het
Dock7 C T 4: 98,973,409 R1327Q probably damaging Het
Fam160a2 A G 7: 105,384,423 S529P probably damaging Het
Gbp9 T C 5: 105,082,807 D417G probably benign Het
Gemin2 G A 12: 59,021,737 probably null Het
Grk6 G T 13: 55,454,397 A346S probably benign Het
Gtf2h1 A G 7: 46,815,425 probably benign Het
Irak3 T A 10: 120,176,259 Q200L probably benign Het
Irx4 A G 13: 73,268,828 T448A probably damaging Het
Kcnk18 G A 19: 59,235,613 probably benign Het
Klk1b11 C A 7: 43,998,827 S86Y possibly damaging Het
Lgals7 T C 7: 28,866,189 F136S probably damaging Het
Luc7l T A 17: 26,279,340 probably benign Het
Mta2 T A 19: 8,950,912 V525E probably benign Het
Mtnr1b G T 9: 15,874,240 A74E possibly damaging Het
Myo1c A G 11: 75,661,136 T354A probably benign Het
Nat1 T C 8: 67,491,422 F153S probably damaging Het
Oasl2 T C 5: 114,897,806 C48R probably damaging Het
Olfr1313 T G 2: 112,071,924 I220L probably benign Het
Pkm C A 9: 59,678,201 R489S probably damaging Het
Pth2r T A 1: 65,336,781 I66N probably damaging Het
Slc25a18 T C 6: 120,792,397 probably null Het
Tnip3 T C 6: 65,590,611 S2P possibly damaging Het
Vmn2r61 T C 7: 42,276,734 probably null Het
Other mutations in Iws1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Iws1 APN 18 32084688 missense probably benign 0.07
IGL01432:Iws1 APN 18 32083466 splice site probably benign
IGL01647:Iws1 APN 18 32097222 nonsense probably null
IGL02189:Iws1 APN 18 32093125 missense probably damaging 1.00
IGL02664:Iws1 APN 18 32070164 missense possibly damaging 0.81
IGL03384:Iws1 APN 18 32093150 missense probably damaging 1.00
IGL03394:Iws1 APN 18 32088248 splice site probably benign
R0352:Iws1 UTSW 18 32084205 missense probably damaging 1.00
R1385:Iws1 UTSW 18 32090430 missense probably benign 0.03
R1486:Iws1 UTSW 18 32097256 missense probably damaging 1.00
R1526:Iws1 UTSW 18 32080125 missense probably benign 0.00
R1529:Iws1 UTSW 18 32080281 missense probably benign
R2094:Iws1 UTSW 18 32084666 missense probably damaging 1.00
R3774:Iws1 UTSW 18 32079995 missense probably damaging 1.00
R3907:Iws1 UTSW 18 32079920 missense possibly damaging 0.93
R4018:Iws1 UTSW 18 32070152 nonsense probably null
R4423:Iws1 UTSW 18 32083450 missense probably damaging 1.00
R4703:Iws1 UTSW 18 32080013 missense probably benign 0.19
R4979:Iws1 UTSW 18 32093267 unclassified probably benign
R5228:Iws1 UTSW 18 32088261 missense probably damaging 1.00
R5352:Iws1 UTSW 18 32083404 missense probably damaging 1.00
R6428:Iws1 UTSW 18 32086290 missense probably damaging 1.00
R6846:Iws1 UTSW 18 32086273 unclassified probably benign
R6892:Iws1 UTSW 18 32086274 missense probably damaging 0.99
R7163:Iws1 UTSW 18 32093224 missense possibly damaging 0.80
R7540:Iws1 UTSW 18 32080483 missense possibly damaging 0.94
R7605:Iws1 UTSW 18 32089487 missense probably benign 0.01
R7714:Iws1 UTSW 18 32090515 missense probably benign 0.00
Posted On2014-05-07