Incidental Mutation 'R0047:Or5ac19'
ID 18522
Institutional Source Beutler Lab
Gene Symbol Or5ac19
Ensembl Gene ENSMUSG00000074995
Gene Name olfactory receptor family 5 subfamily AC member 19
Synonyms Olfr201, MOR182-2, GA_x54KRFPKG5P-55483936-55483010
MMRRC Submission 038341-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R0047 (G1)
Quality Score
Status Validated
Chromosome 16
Chromosomal Location 59089102-59090028 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 59089574 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 152 (G152D)
Ref Sequence ENSEMBL: ENSMUSP00000150660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099656] [ENSMUST00000216834]
AlphaFold Q7TS38
Predicted Effect probably damaging
Transcript: ENSMUST00000099656
AA Change: G152D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097248
Gene: ENSMUSG00000074995
AA Change: G152D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-46 PFAM
Pfam:7tm_1 41 290 8e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216834
AA Change: G152D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 89.2%
  • 3x: 86.3%
  • 10x: 78.8%
  • 20x: 65.9%
Validation Efficiency 95% (110/116)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,772,025 (GRCm39) T405A probably damaging Het
Acer1 A T 17: 57,262,624 (GRCm39) D175E possibly damaging Het
Adamts9 G A 6: 92,882,287 (GRCm39) probably benign Het
Amigo3 T C 9: 107,931,857 (GRCm39) S427P probably benign Het
Arid4a T G 12: 71,122,193 (GRCm39) L858W probably damaging Het
Bbox1 A G 2: 110,098,647 (GRCm39) F310S probably damaging Het
Bltp1 T A 3: 36,962,341 (GRCm39) L481M possibly damaging Het
Bmper T A 9: 23,317,982 (GRCm39) C534S probably damaging Het
Cacna1d T G 14: 30,068,747 (GRCm39) probably benign Het
Capn12 G A 7: 28,589,812 (GRCm39) probably null Het
Chchd1 T C 14: 20,754,231 (GRCm39) S48P possibly damaging Het
Cnot7 A G 8: 40,948,962 (GRCm39) probably benign Het
Cux1 T C 5: 136,392,107 (GRCm39) probably benign Het
Cyp2b19 T A 7: 26,466,251 (GRCm39) D351E probably benign Het
Dctn1 G T 6: 83,159,614 (GRCm39) G31* probably null Het
Duox1 T A 2: 122,177,122 (GRCm39) probably benign Het
Egflam T G 15: 7,282,911 (GRCm39) E382A possibly damaging Het
Ext1 T C 15: 53,208,542 (GRCm39) N73S probably benign Het
Glg1 A T 8: 111,892,214 (GRCm39) M866K probably damaging Het
Gm3333 A G 13: 62,422,285 (GRCm39) noncoding transcript Het
Golm1 T A 13: 59,792,914 (GRCm39) H197L probably benign Het
Gtse1 A G 15: 85,746,579 (GRCm39) K132E probably damaging Het
Gxylt2 A T 6: 100,710,339 (GRCm39) probably benign Het
Hrc T A 7: 44,986,113 (GRCm39) S421R probably benign Het
Ighg2c T A 12: 113,251,788 (GRCm39) probably benign Het
Ihh A G 1: 74,985,750 (GRCm39) I245T probably benign Het
Ilf3 T A 9: 21,300,010 (GRCm39) M65K possibly damaging Het
Kif9 A G 9: 110,314,106 (GRCm39) I33V probably benign Het
Lama1 A T 17: 68,102,181 (GRCm39) probably benign Het
Lamb1 T C 12: 31,328,600 (GRCm39) I188T possibly damaging Het
Lpp T A 16: 24,480,550 (GRCm39) probably benign Het
Mark2 A C 19: 7,260,942 (GRCm39) probably benign Het
Mmp3 T C 9: 7,451,910 (GRCm39) probably benign Het
Mthfd1l T A 10: 3,928,727 (GRCm39) probably benign Het
Mtr A T 13: 12,237,112 (GRCm39) S569T probably damaging Het
Myh13 T A 11: 67,258,063 (GRCm39) S1752T probably benign Het
Myo5a T A 9: 75,063,489 (GRCm39) L565H probably damaging Het
Numa1 A G 7: 101,658,660 (GRCm39) K296E probably damaging Het
Obi1 T A 14: 104,740,780 (GRCm39) probably null Het
Or51ab3 A T 7: 103,201,529 (GRCm39) Y179F probably damaging Het
Or5b120 A G 19: 13,479,953 (GRCm39) E82G probably benign Het
Pla2g2c T C 4: 138,470,901 (GRCm39) probably benign Het
Pnpla7 A T 2: 24,901,618 (GRCm39) E548V probably damaging Het
Ppm1m C A 9: 106,073,895 (GRCm39) E273* probably null Het
Ppp2r1b C T 9: 50,772,873 (GRCm39) R117* probably null Het
Psg-ps1 A G 7: 17,411,806 (GRCm39) noncoding transcript Het
Rabgap1l G A 1: 160,059,359 (GRCm39) probably benign Het
Rapgef6 T A 11: 54,437,204 (GRCm39) M49K possibly damaging Het
Rtel1 T G 2: 180,965,198 (GRCm39) I146M probably damaging Het
Sdr9c7 A T 10: 127,739,541 (GRCm39) M219L probably benign Het
Serpinb1a A T 13: 33,034,259 (GRCm39) L44Q probably damaging Het
Slc13a4 A G 6: 35,264,297 (GRCm39) I190T possibly damaging Het
Slc46a2 A G 4: 59,914,392 (GRCm39) L177P probably damaging Het
Slc47a2 C T 11: 61,227,068 (GRCm39) V167M possibly damaging Het
Snrnp200 C T 2: 127,076,874 (GRCm39) probably benign Het
Snx13 C A 12: 35,151,123 (GRCm39) probably benign Het
Snx25 C T 8: 46,494,402 (GRCm39) A828T probably damaging Het
Spic A G 10: 88,511,803 (GRCm39) L151P probably damaging Het
Sptb G T 12: 76,669,724 (GRCm39) Q535K probably damaging Het
Ssu2 G A 6: 112,351,781 (GRCm39) H315Y probably damaging Het
Stk32a T C 18: 43,446,443 (GRCm39) probably benign Het
Tcaf2 A G 6: 42,606,547 (GRCm39) I469T probably benign Het
Tln2 A G 9: 67,147,954 (GRCm39) probably benign Het
Top2a T A 11: 98,888,682 (GRCm39) I1260L probably benign Het
Treml1 C A 17: 48,672,008 (GRCm39) S91* probably null Het
Trmt11 T C 10: 30,411,239 (GRCm39) N418S probably benign Het
Ttf1 A G 2: 28,974,667 (GRCm39) Y801C probably damaging Het
Usp34 C T 11: 23,414,403 (GRCm39) A2782V probably benign Het
Vps4a T C 8: 107,763,333 (GRCm39) L29P probably damaging Het
Wdfy3 A G 5: 102,091,899 (GRCm39) I480T probably damaging Het
Ywhag A T 5: 135,940,153 (GRCm39) V147E probably damaging Het
Other mutations in Or5ac19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01734:Or5ac19 APN 16 59,089,213 (GRCm39) missense probably benign 0.07
IGL01985:Or5ac19 APN 16 59,089,442 (GRCm39) missense probably benign
IGL02618:Or5ac19 APN 16 59,089,290 (GRCm39) missense probably damaging 1.00
IGL02830:Or5ac19 APN 16 59,089,416 (GRCm39) missense possibly damaging 0.94
PIT4449001:Or5ac19 UTSW 16 59,089,493 (GRCm39) missense probably damaging 1.00
R0047:Or5ac19 UTSW 16 59,089,574 (GRCm39) missense probably damaging 1.00
R1035:Or5ac19 UTSW 16 59,089,307 (GRCm39) missense probably damaging 1.00
R1037:Or5ac19 UTSW 16 59,089,307 (GRCm39) missense probably damaging 1.00
R1163:Or5ac19 UTSW 16 59,089,518 (GRCm39) missense probably benign 0.23
R1225:Or5ac19 UTSW 16 59,089,587 (GRCm39) missense probably benign
R1519:Or5ac19 UTSW 16 59,089,307 (GRCm39) missense probably damaging 1.00
R1583:Or5ac19 UTSW 16 59,089,394 (GRCm39) missense probably benign 0.00
R2075:Or5ac19 UTSW 16 59,089,274 (GRCm39) missense possibly damaging 0.60
R4591:Or5ac19 UTSW 16 59,089,776 (GRCm39) missense possibly damaging 0.94
R5547:Or5ac19 UTSW 16 59,089,479 (GRCm39) missense probably benign 0.35
R6132:Or5ac19 UTSW 16 59,089,367 (GRCm39) missense probably damaging 0.97
R6737:Or5ac19 UTSW 16 59,089,175 (GRCm39) missense possibly damaging 0.60
R6872:Or5ac19 UTSW 16 59,089,961 (GRCm39) missense probably benign 0.20
R8001:Or5ac19 UTSW 16 59,089,472 (GRCm39) missense probably benign 0.01
R8525:Or5ac19 UTSW 16 59,089,571 (GRCm39) missense probably benign 0.07
R9003:Or5ac19 UTSW 16 59,089,263 (GRCm39) missense probably benign 0.05
R9260:Or5ac19 UTSW 16 59,089,677 (GRCm39) missense probably damaging 0.98
R9584:Or5ac19 UTSW 16 59,089,580 (GRCm39) missense probably benign 0.05
Posted On 2013-03-25