Incidental Mutation 'IGL02056:Fgl2'
ID185222
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fgl2
Ensembl Gene ENSMUSG00000039899
Gene Namefibrinogen-like protein 2
Synonyms
Accession Numbers

Genbank: NM_008013; MGI: 103266

Is this an essential gene? Probably non essential (E-score: 0.182) question?
Stock #IGL02056
Quality Score
Status
Chromosome5
Chromosomal Location21372642-21378374 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 21375545 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Lysine at position 295 (I295K)
Ref Sequence ENSEMBL: ENSMUSP00000046131 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030552] [ENSMUST00000035799] [ENSMUST00000115245]
Predicted Effect probably benign
Transcript: ENSMUST00000030552
SMART Domains Protein: ENSMUSP00000030552
Gene: ENSMUSG00000064280

DomainStartEndE-ValueType
coiled coil region 1 33 N/A INTRINSIC
low complexity region 120 130 N/A INTRINSIC
coiled coil region 194 320 N/A INTRINSIC
low complexity region 333 342 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000035799
AA Change: I295K

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000046131
Gene: ENSMUSG00000039899
AA Change: I295K

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 54 70 N/A INTRINSIC
coiled coil region 71 158 N/A INTRINSIC
FBG 201 428 1.6e-131 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115245
SMART Domains Protein: ENSMUSP00000110900
Gene: ENSMUSG00000064280

DomainStartEndE-ValueType
coiled coil region 1 33 N/A INTRINSIC
low complexity region 120 130 N/A INTRINSIC
coiled coil region 194 320 N/A INTRINSIC
low complexity region 333 342 N/A INTRINSIC
coiled coil region 438 477 N/A INTRINSIC
coiled coil region 549 595 N/A INTRINSIC
coiled coil region 617 663 N/A INTRINSIC
coiled coil region 690 720 N/A INTRINSIC
coiled coil region 770 793 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice for one allele have unaltered type 1 immunity responses. Homozygous null mice for another allele show partial embryonic lethality, hemorrhage at implantation sites, decreased susceptibility to hepatitis virus infection and prolongedsurvival of heart grafts. [provided by MGI curators]
Allele List at MGI

All alleles(2) : Targeted, knock-out(1) Targeted, other(1)

Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310050C09Rik T A 3: 92,868,893 Q161L probably benign Het
Atg101 T C 15: 101,290,337 S108P probably damaging Het
BB014433 A T 8: 15,042,435 C139* probably null Het
Cacna1s A G 1: 136,119,000 N1808S probably benign Het
Ccdc148 A G 2: 59,004,069 probably benign Het
Dnah7a T G 1: 53,504,342 N2223T probably benign Het
Foxj3 T C 4: 119,585,757 I126T probably damaging Het
Gm4540 T A 3: 106,034,740 probably benign Het
Hps5 T G 7: 46,788,182 K156N probably damaging Het
Hsp90aa1 T C 12: 110,694,015 probably benign Het
Il12rb1 C T 8: 70,811,187 R131* probably null Het
Itgb2l T C 16: 96,427,689 E438G probably damaging Het
Nbeal2 A T 9: 110,627,324 L2379Q probably benign Het
Neurl4 T C 11: 69,905,790 V481A probably damaging Het
Nos1ap A G 1: 170,318,623 F454S possibly damaging Het
Pik3r5 G T 11: 68,490,855 G242C possibly damaging Het
Pkd1l3 A G 8: 109,631,378 N834S probably benign Het
Prkar2b A G 12: 31,975,910 probably benign Het
Pusl1 T C 4: 155,890,572 T191A probably benign Het
Rasal2 A G 1: 157,299,261 V51A probably damaging Het
Rsc1a1 T A 4: 141,685,485 I39F probably benign Het
Slc2a3 G A 6: 122,735,478 P269L probably damaging Het
Sntb1 C T 15: 55,648,039 G383D possibly damaging Het
Washc5 T C 15: 59,350,336 T547A possibly damaging Het
Zfr T C 15: 12,154,447 V572A probably damaging Het
Zmym6 T A 4: 127,103,414 N275K probably damaging Het
Other mutations in Fgl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01622:Fgl2 APN 5 21373177 missense possibly damaging 0.57
IGL01623:Fgl2 APN 5 21373177 missense possibly damaging 0.57
IGL03128:Fgl2 APN 5 21373293 missense probably benign
A4554:Fgl2 UTSW 5 21372778 missense probably benign 0.01
R0049:Fgl2 UTSW 5 21375663 missense possibly damaging 0.95
R0049:Fgl2 UTSW 5 21375663 missense possibly damaging 0.95
R0052:Fgl2 UTSW 5 21375349 missense probably damaging 1.00
R0052:Fgl2 UTSW 5 21375349 missense probably damaging 1.00
R0149:Fgl2 UTSW 5 21375785 missense probably damaging 1.00
R0316:Fgl2 UTSW 5 21375523 missense possibly damaging 0.82
R1336:Fgl2 UTSW 5 21373183 missense possibly damaging 0.52
R1703:Fgl2 UTSW 5 21372732 missense possibly damaging 0.89
R1893:Fgl2 UTSW 5 21375671 missense probably benign 0.01
R2371:Fgl2 UTSW 5 21375818 missense probably damaging 1.00
R4803:Fgl2 UTSW 5 21375920 missense probably benign 0.00
R5250:Fgl2 UTSW 5 21375523 missense possibly damaging 0.82
R5422:Fgl2 UTSW 5 21375810 missense probably damaging 1.00
R6759:Fgl2 UTSW 5 21373258 missense probably benign 0.00
R7808:Fgl2 UTSW 5 21373231 missense possibly damaging 0.53
R7812:Fgl2 UTSW 5 21372898 missense probably benign 0.01
R7838:Fgl2 UTSW 5 21372754 missense probably benign 0.01
R8177:Fgl2 UTSW 5 21373309 critical splice donor site probably null
R8725:Fgl2 UTSW 5 21375679 nonsense probably null
R8727:Fgl2 UTSW 5 21375679 nonsense probably null
X0017:Fgl2 UTSW 5 21375652 missense probably damaging 0.98
X0026:Fgl2 UTSW 5 21375713 missense probably damaging 1.00
Posted On2014-05-07