Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02059:Vmn2r39'

185319

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r39

Ensembl Gene

ENSMUSG00000096658

Gene Name

vomeronasal 2, receptor 39

Synonyms

EG545909

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.107) question?

Stock #

IGL02059

Quality Score

Status

Chromosome

Chromosomal Location

9017749-9033681 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 9026643 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 453 (I453V)

Ref Sequence

ENSEMBL: ENSMUSP00000134010 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000174388]

AlphaFold

L7N2E5

Predicted Effect

probably benign
Transcript: ENSMUST00000174388
AA Change: I453V

PolyPhen 2 Score 0.192 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000134010
Gene: ENSMUSG00000096658
AA Change: I453V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	9.1e-32	PFAM
Pfam:NCD3G	512	565	7.9e-21	PFAM
Pfam:7tm_3	598	833	2.6e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	C	11: 110,051,220 (GRCm39)		probably benign	Het
Anks1	A	G	17: 28,227,020 (GRCm39)	M558V	possibly damaging	Het
Arhgef1	T	A	7: 24,611,977 (GRCm39)		probably benign	Het
Atad3a	G	A	4: 155,839,207 (GRCm39)		probably benign	Het
Bhmt2	A	G	13: 93,803,171 (GRCm39)	Y121H	probably benign	Het
Cbx5	A	G	15: 103,108,192 (GRCm39)	V151A	probably damaging	Het
Copa	T	A	1: 171,927,320 (GRCm39)	I231N	probably damaging	Het
Csf3r	T	A	4: 125,925,920 (GRCm39)	C168*	probably null	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Dnah9	A	T	11: 65,963,784 (GRCm39)	I1723N	probably damaging	Het
Epb42	G	A	2: 120,855,188 (GRCm39)	P466S	probably damaging	Het
Fem1b	C	T	9: 62,703,446 (GRCm39)	V605I	possibly damaging	Het
Gclc	T	G	9: 77,695,098 (GRCm39)	S403A	probably damaging	Het
Gpr135	A	T	12: 72,116,858 (GRCm39)	V303D	possibly damaging	Het
Gprin3	C	A	6: 59,332,310 (GRCm39)		probably benign	Het
Grik1	T	A	16: 87,852,937 (GRCm39)	Q82L	possibly damaging	Het
Hacl1	T	C	14: 31,354,891 (GRCm39)	N118D	probably benign	Het
Hdac9	A	G	12: 34,481,967 (GRCm39)	V146A	probably damaging	Het
Hltf	T	C	3: 20,160,621 (GRCm39)	F763L	probably benign	Het
Impg2	C	T	16: 56,080,335 (GRCm39)	S713L	probably damaging	Het
Ints7	T	A	1: 191,347,872 (GRCm39)	M748K	probably benign	Het
Kalrn	A	G	16: 34,072,711 (GRCm39)	S724P	possibly damaging	Het
Kyat1	T	C	2: 30,075,565 (GRCm39)	Q359R	probably benign	Het
Mtmr4	A	G	11: 87,491,950 (GRCm39)	N206S	possibly damaging	Het
Nos3	T	C	5: 24,573,996 (GRCm39)	I227T	probably damaging	Het
Or52e2	T	C	7: 102,804,310 (GRCm39)	I215V	probably benign	Het
Pde1a	A	T	2: 79,727,421 (GRCm39)	H169Q	possibly damaging	Het
Ppp1r13b	A	T	12: 111,799,781 (GRCm39)	D665E	probably damaging	Het
Prickle4	G	T	17: 48,001,174 (GRCm39)	L131M	probably damaging	Het
Prl6a1	T	A	13: 27,499,348 (GRCm39)	Y39N	probably benign	Het
Slco6d1	T	C	1: 98,374,531 (GRCm39)	V350A	possibly damaging	Het
Srsf7	T	A	17: 80,510,121 (GRCm39)	S209C	probably null	Het
Syde2	C	T	3: 145,707,927 (GRCm39)	A622V	possibly damaging	Het
Ugt1a6a	T	A	1: 88,066,403 (GRCm39)	S70T	possibly damaging	Het
Zc3h7a	A	G	16: 10,978,862 (GRCm39)		probably benign	Het
Zeb1	G	T	18: 5,766,892 (GRCm39)	V468F	probably damaging	Het
Zfp148	T	A	16: 33,316,933 (GRCm39)	V493D	probably damaging	Het

Other mutations in Vmn2r39

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03017:Vmn2r39	APN	7	9,017,940 (GRCm39)	missense	probably damaging	1.00
R1314:Vmn2r39	UTSW	7	9,017,981 (GRCm39)	missense	probably damaging	1.00
R1358:Vmn2r39	UTSW	7	9,026,687 (GRCm39)	missense	possibly damaging	0.63
R1480:Vmn2r39	UTSW	7	9,017,955 (GRCm39)	missense	probably damaging	1.00
R4119:Vmn2r39	UTSW	7	9,026,673 (GRCm39)	missense	probably benign	0.01
R4120:Vmn2r39	UTSW	7	9,026,673 (GRCm39)	missense	probably benign	0.01
R4720:Vmn2r39	UTSW	7	9,026,469 (GRCm39)	critical splice donor site	probably null
R4990:Vmn2r39	UTSW	7	9,026,675 (GRCm39)	missense	probably benign
R5079:Vmn2r39	UTSW	7	9,026,489 (GRCm39)	missense	probably benign	0.05
R5695:Vmn2r39	UTSW	7	9,028,150 (GRCm39)	missense	possibly damaging	0.87
R6131:Vmn2r39	UTSW	7	9,017,963 (GRCm39)	missense	probably damaging	1.00
R6561:Vmn2r39	UTSW	7	9,018,092 (GRCm39)	missense	probably damaging	1.00
R7108:Vmn2r39	UTSW	7	9,026,667 (GRCm39)	missense	probably damaging	0.96
R7122:Vmn2r39	UTSW	7	9,017,761 (GRCm39)	missense	possibly damaging	0.72
R8793:Vmn2r39	UTSW	7	9,028,149 (GRCm39)	missense	probably damaging	1.00
R9324:Vmn2r39	UTSW	7	9,030,684 (GRCm39)	missense	probably damaging	0.96
Z1176:Vmn2r39	UTSW	7	9,018,032 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07