Incidental Mutation 'IGL02059:Olfr589'
ID185328
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr589
Ensembl Gene ENSMUSG00000051362
Gene Nameolfactory receptor 589
SynonymsMOR32-3, GA_x6K02T2PBJ9-5871256-5870303
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.155) question?
Stock #IGL02059
Quality Score
Status
Chromosome7
Chromosomal Location103154792-103156356 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 103155103 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 215 (I215V)
Ref Sequence ENSEMBL: ENSMUSP00000151739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061055] [ENSMUST00000218483]
Predicted Effect probably benign
Transcript: ENSMUST00000061055
AA Change: I215V

PolyPhen 2 Score 0.144 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000060166
Gene: ENSMUSG00000051362
AA Change: I215V

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 3.1e-132 PFAM
Pfam:7TM_GPCR_Srsx 37 171 1.5e-7 PFAM
Pfam:7tm_1 43 293 1.1e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218483
AA Change: I215V

PolyPhen 2 Score 0.144 (Sensitivity: 0.92; Specificity: 0.86)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A C 11: 110,160,394 probably benign Het
Anks1 A G 17: 28,008,046 M558V possibly damaging Het
Arhgef1 T A 7: 24,912,552 probably benign Het
Atad3a G A 4: 155,754,750 probably benign Het
Bhmt2 A G 13: 93,666,663 Y121H probably benign Het
Cbx5 A G 15: 103,199,765 V151A probably damaging Het
Copa T A 1: 172,099,753 I231N probably damaging Het
Csf3r T A 4: 126,032,127 C168* probably null Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dnah9 A T 11: 66,072,958 I1723N probably damaging Het
Epb42 G A 2: 121,024,707 P466S probably damaging Het
Fem1b C T 9: 62,796,164 V605I possibly damaging Het
Gclc T G 9: 77,787,816 S403A probably damaging Het
Gpr135 A T 12: 72,070,084 V303D possibly damaging Het
Gprin3 C A 6: 59,355,325 probably benign Het
Grik1 T A 16: 88,056,049 Q82L possibly damaging Het
Hacl1 T C 14: 31,632,934 N118D probably benign Het
Hdac9 A G 12: 34,431,968 V146A probably damaging Het
Hltf T C 3: 20,106,457 F763L probably benign Het
Impg2 C T 16: 56,259,972 S713L probably damaging Het
Ints7 T A 1: 191,615,760 M748K probably benign Het
Kalrn A G 16: 34,252,341 S724P possibly damaging Het
Kyat1 T C 2: 30,185,553 Q359R probably benign Het
Mtmr4 A G 11: 87,601,124 N206S possibly damaging Het
Nos3 T C 5: 24,368,998 I227T probably damaging Het
Pde1a A T 2: 79,897,077 H169Q possibly damaging Het
Ppp1r13b A T 12: 111,833,347 D665E probably damaging Het
Prickle4 G T 17: 47,690,249 L131M probably damaging Het
Prl6a1 T A 13: 27,315,365 Y39N probably benign Het
Slco6d1 T C 1: 98,446,806 V350A possibly damaging Het
Srsf7 T A 17: 80,202,692 S209C probably null Het
Syde2 C T 3: 146,002,172 A622V possibly damaging Het
Ugt1a6a T A 1: 88,138,681 S70T possibly damaging Het
Vmn2r39 T C 7: 9,023,644 I453V probably benign Het
Zc3h7a A G 16: 11,160,998 probably benign Het
Zeb1 G T 18: 5,766,892 V468F probably damaging Het
Zfp148 T A 16: 33,496,563 V493D probably damaging Het
Other mutations in Olfr589
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01955:Olfr589 APN 7 103154854 nonsense probably null
IGL02336:Olfr589 APN 7 103155565 missense probably benign 0.09
IGL03355:Olfr589 APN 7 103155201 missense probably damaging 1.00
PIT4508001:Olfr589 UTSW 7 103155313 missense probably benign
R0900:Olfr589 UTSW 7 103155313 missense probably benign
R2250:Olfr589 UTSW 7 103154950 missense probably damaging 1.00
R3500:Olfr589 UTSW 7 103155090 missense probably damaging 1.00
R4756:Olfr589 UTSW 7 103155125 missense probably benign 0.24
R4776:Olfr589 UTSW 7 103155414 missense probably benign 0.40
R5022:Olfr589 UTSW 7 103155735 missense probably benign
R5151:Olfr589 UTSW 7 103155386 missense probably damaging 0.99
R5231:Olfr589 UTSW 7 103154968 missense probably damaging 1.00
R5870:Olfr589 UTSW 7 103155741 missense probably benign 0.00
R5973:Olfr589 UTSW 7 103154874 missense possibly damaging 0.93
R6567:Olfr589 UTSW 7 103154928 missense possibly damaging 0.94
R7095:Olfr589 UTSW 7 103155330 missense probably damaging 1.00
Posted On2014-05-07