Incidental Mutation 'IGL02059:Gpr135'
ID 185329
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr135
Ensembl Gene ENSMUSG00000043398
Gene Name G protein-coupled receptor 135
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.181) question?
Stock # IGL02059
Quality Score
Status
Chromosome 12
Chromosomal Location 72114748-72117875 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 72116858 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 303 (V303D)
Ref Sequence ENSEMBL: ENSMUSP00000058762 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019862] [ENSMUST00000050649]
AlphaFold Q7TQP2
Predicted Effect probably benign
Transcript: ENSMUST00000019862
SMART Domains Protein: ENSMUSP00000019862
Gene: ENSMUSG00000019718

DomainStartEndE-ValueType
Pfam:Pro_racemase 22 352 8.7e-122 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000050649
AA Change: V303D

PolyPhen 2 Score 0.873 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000058762
Gene: ENSMUSG00000043398
AA Change: V303D

DomainStartEndE-ValueType
low complexity region 26 44 N/A INTRINSIC
low complexity region 65 88 N/A INTRINSIC
Pfam:7tm_1 89 350 7.5e-43 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A C 11: 110,051,220 (GRCm39) probably benign Het
Anks1 A G 17: 28,227,020 (GRCm39) M558V possibly damaging Het
Arhgef1 T A 7: 24,611,977 (GRCm39) probably benign Het
Atad3a G A 4: 155,839,207 (GRCm39) probably benign Het
Bhmt2 A G 13: 93,803,171 (GRCm39) Y121H probably benign Het
Cbx5 A G 15: 103,108,192 (GRCm39) V151A probably damaging Het
Copa T A 1: 171,927,320 (GRCm39) I231N probably damaging Het
Csf3r T A 4: 125,925,920 (GRCm39) C168* probably null Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Dnah9 A T 11: 65,963,784 (GRCm39) I1723N probably damaging Het
Epb42 G A 2: 120,855,188 (GRCm39) P466S probably damaging Het
Fem1b C T 9: 62,703,446 (GRCm39) V605I possibly damaging Het
Gclc T G 9: 77,695,098 (GRCm39) S403A probably damaging Het
Gprin3 C A 6: 59,332,310 (GRCm39) probably benign Het
Grik1 T A 16: 87,852,937 (GRCm39) Q82L possibly damaging Het
Hacl1 T C 14: 31,354,891 (GRCm39) N118D probably benign Het
Hdac9 A G 12: 34,481,967 (GRCm39) V146A probably damaging Het
Hltf T C 3: 20,160,621 (GRCm39) F763L probably benign Het
Impg2 C T 16: 56,080,335 (GRCm39) S713L probably damaging Het
Ints7 T A 1: 191,347,872 (GRCm39) M748K probably benign Het
Kalrn A G 16: 34,072,711 (GRCm39) S724P possibly damaging Het
Kyat1 T C 2: 30,075,565 (GRCm39) Q359R probably benign Het
Mtmr4 A G 11: 87,491,950 (GRCm39) N206S possibly damaging Het
Nos3 T C 5: 24,573,996 (GRCm39) I227T probably damaging Het
Or52e2 T C 7: 102,804,310 (GRCm39) I215V probably benign Het
Pde1a A T 2: 79,727,421 (GRCm39) H169Q possibly damaging Het
Ppp1r13b A T 12: 111,799,781 (GRCm39) D665E probably damaging Het
Prickle4 G T 17: 48,001,174 (GRCm39) L131M probably damaging Het
Prl6a1 T A 13: 27,499,348 (GRCm39) Y39N probably benign Het
Slco6d1 T C 1: 98,374,531 (GRCm39) V350A possibly damaging Het
Srsf7 T A 17: 80,510,121 (GRCm39) S209C probably null Het
Syde2 C T 3: 145,707,927 (GRCm39) A622V possibly damaging Het
Ugt1a6a T A 1: 88,066,403 (GRCm39) S70T possibly damaging Het
Vmn2r39 T C 7: 9,026,643 (GRCm39) I453V probably benign Het
Zc3h7a A G 16: 10,978,862 (GRCm39) probably benign Het
Zeb1 G T 18: 5,766,892 (GRCm39) V468F probably damaging Het
Zfp148 T A 16: 33,316,933 (GRCm39) V493D probably damaging Het
Other mutations in Gpr135
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Gpr135 APN 12 72,116,442 (GRCm39) missense probably benign
IGL02219:Gpr135 APN 12 72,117,047 (GRCm39) missense probably damaging 1.00
IGL02273:Gpr135 APN 12 72,116,732 (GRCm39) missense probably damaging 0.96
R4688:Gpr135 UTSW 12 72,117,720 (GRCm39) missense probably benign
R4791:Gpr135 UTSW 12 72,116,642 (GRCm39) missense probably benign 0.12
R5001:Gpr135 UTSW 12 72,117,282 (GRCm39) missense probably benign 0.10
R5811:Gpr135 UTSW 12 72,116,641 (GRCm39) missense possibly damaging 0.87
R5857:Gpr135 UTSW 12 72,117,614 (GRCm39) missense probably benign 0.25
R7604:Gpr135 UTSW 12 72,116,641 (GRCm39) missense possibly damaging 0.87
R7708:Gpr135 UTSW 12 72,116,733 (GRCm39) missense probably benign 0.06
R9367:Gpr135 UTSW 12 72,117,473 (GRCm39) missense possibly damaging 0.95
Posted On 2014-05-07