Incidental Mutation 'IGL02059:Prl6a1'
ID 185337
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl6a1
Ensembl Gene ENSMUSG00000069259
Gene Name prolactin family 6, subfamily a, member 1
Synonyms PLP-B, Prlpb
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL02059
Quality Score
Status
Chromosome 13
Chromosomal Location 27496610-27503235 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 27499348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 39 (Y39N)
Ref Sequence ENSEMBL: ENSMUSP00000089269 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091679] [ENSMUST00000091680]
AlphaFold O35257
Predicted Effect probably benign
Transcript: ENSMUST00000091679
AA Change: Y44N

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000089268
Gene: ENSMUSG00000069259
AA Change: Y44N

DomainStartEndE-ValueType
low complexity region 4 15 N/A INTRINSIC
Pfam:Hormone_1 21 235 8e-65 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091680
AA Change: Y39N

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000089269
Gene: ENSMUSG00000069259
AA Change: Y39N

DomainStartEndE-ValueType
Pfam:Hormone_1 16 230 1.1e-61 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119758
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A C 11: 110,051,220 (GRCm39) probably benign Het
Anks1 A G 17: 28,227,020 (GRCm39) M558V possibly damaging Het
Arhgef1 T A 7: 24,611,977 (GRCm39) probably benign Het
Atad3a G A 4: 155,839,207 (GRCm39) probably benign Het
Bhmt2 A G 13: 93,803,171 (GRCm39) Y121H probably benign Het
Cbx5 A G 15: 103,108,192 (GRCm39) V151A probably damaging Het
Copa T A 1: 171,927,320 (GRCm39) I231N probably damaging Het
Csf3r T A 4: 125,925,920 (GRCm39) C168* probably null Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Dnah9 A T 11: 65,963,784 (GRCm39) I1723N probably damaging Het
Epb42 G A 2: 120,855,188 (GRCm39) P466S probably damaging Het
Fem1b C T 9: 62,703,446 (GRCm39) V605I possibly damaging Het
Gclc T G 9: 77,695,098 (GRCm39) S403A probably damaging Het
Gpr135 A T 12: 72,116,858 (GRCm39) V303D possibly damaging Het
Gprin3 C A 6: 59,332,310 (GRCm39) probably benign Het
Grik1 T A 16: 87,852,937 (GRCm39) Q82L possibly damaging Het
Hacl1 T C 14: 31,354,891 (GRCm39) N118D probably benign Het
Hdac9 A G 12: 34,481,967 (GRCm39) V146A probably damaging Het
Hltf T C 3: 20,160,621 (GRCm39) F763L probably benign Het
Impg2 C T 16: 56,080,335 (GRCm39) S713L probably damaging Het
Ints7 T A 1: 191,347,872 (GRCm39) M748K probably benign Het
Kalrn A G 16: 34,072,711 (GRCm39) S724P possibly damaging Het
Kyat1 T C 2: 30,075,565 (GRCm39) Q359R probably benign Het
Mtmr4 A G 11: 87,491,950 (GRCm39) N206S possibly damaging Het
Nos3 T C 5: 24,573,996 (GRCm39) I227T probably damaging Het
Or52e2 T C 7: 102,804,310 (GRCm39) I215V probably benign Het
Pde1a A T 2: 79,727,421 (GRCm39) H169Q possibly damaging Het
Ppp1r13b A T 12: 111,799,781 (GRCm39) D665E probably damaging Het
Prickle4 G T 17: 48,001,174 (GRCm39) L131M probably damaging Het
Slco6d1 T C 1: 98,374,531 (GRCm39) V350A possibly damaging Het
Srsf7 T A 17: 80,510,121 (GRCm39) S209C probably null Het
Syde2 C T 3: 145,707,927 (GRCm39) A622V possibly damaging Het
Ugt1a6a T A 1: 88,066,403 (GRCm39) S70T possibly damaging Het
Vmn2r39 T C 7: 9,026,643 (GRCm39) I453V probably benign Het
Zc3h7a A G 16: 10,978,862 (GRCm39) probably benign Het
Zeb1 G T 18: 5,766,892 (GRCm39) V468F probably damaging Het
Zfp148 T A 16: 33,316,933 (GRCm39) V493D probably damaging Het
Other mutations in Prl6a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01124:Prl6a1 APN 13 27,500,347 (GRCm39) missense possibly damaging 0.72
IGL01688:Prl6a1 APN 13 27,501,969 (GRCm39) missense probably damaging 1.00
IGL01922:Prl6a1 APN 13 27,499,343 (GRCm39) missense possibly damaging 0.57
IGL03170:Prl6a1 APN 13 27,499,406 (GRCm39) missense possibly damaging 0.95
R0027:Prl6a1 UTSW 13 27,502,011 (GRCm39) missense probably damaging 1.00
R0027:Prl6a1 UTSW 13 27,502,011 (GRCm39) missense probably damaging 1.00
R0049:Prl6a1 UTSW 13 27,501,980 (GRCm39) missense probably damaging 0.99
R0606:Prl6a1 UTSW 13 27,498,177 (GRCm39) intron probably benign
R0944:Prl6a1 UTSW 13 27,502,149 (GRCm39) splice site probably benign
R1518:Prl6a1 UTSW 13 27,502,911 (GRCm39) missense probably null 0.19
R1518:Prl6a1 UTSW 13 27,502,910 (GRCm39) missense possibly damaging 0.72
R1566:Prl6a1 UTSW 13 27,499,410 (GRCm39) missense possibly damaging 0.84
R1621:Prl6a1 UTSW 13 27,501,993 (GRCm39) missense probably benign 0.01
R2011:Prl6a1 UTSW 13 27,499,352 (GRCm39) missense probably benign 0.00
R2058:Prl6a1 UTSW 13 27,503,081 (GRCm39) missense probably benign 0.05
R2937:Prl6a1 UTSW 13 27,499,303 (GRCm39) missense probably damaging 0.98
R3079:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense possibly damaging 0.71
R4685:Prl6a1 UTSW 13 27,500,307 (GRCm39) missense probably benign 0.00
R4856:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense probably damaging 0.98
R4886:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense probably damaging 0.98
R5495:Prl6a1 UTSW 13 27,496,654 (GRCm39) missense possibly damaging 0.95
R5923:Prl6a1 UTSW 13 27,500,346 (GRCm39) missense probably benign 0.08
R6772:Prl6a1 UTSW 13 27,503,031 (GRCm39) missense probably damaging 1.00
R7411:Prl6a1 UTSW 13 27,502,125 (GRCm39) missense probably damaging 1.00
R7501:Prl6a1 UTSW 13 27,500,282 (GRCm39) missense possibly damaging 0.69
R7549:Prl6a1 UTSW 13 27,502,954 (GRCm39) missense probably damaging 0.96
R7563:Prl6a1 UTSW 13 27,498,221 (GRCm39) critical splice donor site probably null
R7773:Prl6a1 UTSW 13 27,502,125 (GRCm39) missense probably damaging 1.00
R8024:Prl6a1 UTSW 13 27,502,678 (GRCm39) intron probably benign
R8994:Prl6a1 UTSW 13 27,499,417 (GRCm39) missense probably benign 0.01
R9129:Prl6a1 UTSW 13 27,502,064 (GRCm39) missense
R9395:Prl6a1 UTSW 13 27,499,400 (GRCm39) missense possibly damaging 0.71
Z1177:Prl6a1 UTSW 13 27,499,304 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07