Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02061:Ppp1r26'

185408

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ppp1r26

Ensembl Gene

ENSMUSG00000035829

Gene Name

protein phosphatase 1, regulatory subunit 26

Synonyms

LOC241289

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02061

Quality Score

Status

Chromosome

Chromosomal Location

28446800-28455508 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 28450627 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 90 (C90S)

Ref Sequence

ENSEMBL: ENSMUSP00000139546 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040324] [ENSMUST00000189694]

AlphaFold

Q6A025

Predicted Effect

possibly damaging
Transcript: ENSMUST00000040324
AA Change: C90S

PolyPhen 2 Score 0.676 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000042173
Gene: ENSMUSG00000035829
AA Change: C90S

Domain	Start	End	E-Value	Type
Pfam:PPP1R26_N	1	812	N/A	PFAM
low complexity region	901	913	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128199

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150362

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154081

Predicted Effect

possibly damaging
Transcript: ENSMUST00000189694
AA Change: C90S

PolyPhen 2 Score 0.676 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000139546
Gene: ENSMUSG00000035829
AA Change: C90S

Domain	Start	End	E-Value	Type
low complexity region	122	132	N/A	INTRINSIC
low complexity region	487	504	N/A	INTRINSIC
low complexity region	515	536	N/A	INTRINSIC
low complexity region	551	559	N/A	INTRINSIC
low complexity region	636	654	N/A	INTRINSIC
low complexity region	766	780	N/A	INTRINSIC
low complexity region	901	913	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arl15	T	A	13: 113,794,657	D3E	probably benign	Het
Atp4a	A	G	7: 30,715,029	Y159C	probably damaging	Het
Card10	A	G	15: 78,778,215	F861S	probably damaging	Het
Ccdc85c	A	G	12: 108,221,743	V279A	probably damaging	Het
Cndp1	G	A	18: 84,634,626	R136W	probably damaging	Het
Eif2b3	A	G	4: 117,028,411	E50G	possibly damaging	Het
Eva1c	C	T	16: 90,866,275	Q67*	probably null	Het
Exoc1	A	G	5: 76,542,120	E169G	probably damaging	Het
Fam189b	C	T	3: 89,188,596	R545*	probably null	Het
Fsd2	T	A	7: 81,540,424	K537*	probably null	Het
Gbf1	T	G	19: 46,279,258	S1236A	possibly damaging	Het
Gpt	C	A	15: 76,699,417		probably benign	Het
Gsap	A	G	5: 21,281,611		probably benign	Het
Hdac6	A	C	X: 7,943,639		probably null	Het
Ivns1abp	T	A	1: 151,351,573	L44Q	probably damaging	Het
Kcnt1	T	A	2: 25,900,482		probably null	Het
Kdm2b	A	G	5: 122,883,341	I58T	probably damaging	Het
Mrpl23	C	T	7: 142,540,582	P76S	probably benign	Het
Nbea	A	G	3: 55,717,887	I2261T	possibly damaging	Het
Oasl1	G	A	5: 114,923,592	V61M	probably damaging	Het
Olfr1288	T	A	2: 111,479,269	F162I	possibly damaging	Het
Pabpc2	A	G	18: 39,774,993	Q437R	probably benign	Het
Ppp3ca	A	G	3: 136,797,863	T66A	probably benign	Het
Prss55	A	G	14: 64,075,743	Y231H	possibly damaging	Het
Psmb10	T	C	8: 105,937,711	T38A	probably damaging	Het
Rfx5	A	G	3: 94,958,481	T364A	probably benign	Het
Scgb2b26	T	C	7: 33,943,185	N107S	probably benign	Het
Seh1l	A	G	18: 67,787,258		probably benign	Het
Sod1	T	A	16: 90,225,238	H111Q	probably benign	Het
Thbs2	A	T	17: 14,679,914	D592E	probably benign	Het
Tmem67	G	A	4: 12,053,526	A740V	probably damaging	Het
Tra2a	A	G	6: 49,249,098	V136A	possibly damaging	Het
Ttc37	T	A	13: 76,129,541		probably null	Het
Utp18	T	C	11: 93,882,141	D158G	probably benign	Het
Zfp524	A	G	7: 5,017,872	E133G	probably damaging	Het

Other mutations in Ppp1r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00975:Ppp1r26	APN	2	28453718	missense	probably damaging	1.00
IGL01092:Ppp1r26	APN	2	28453860	utr 3 prime	probably benign
IGL02399:Ppp1r26	APN	2	28453280	missense	probably benign
R0518:Ppp1r26	UTSW	2	28452302	missense	probably damaging	1.00
R0763:Ppp1r26	UTSW	2	28450367	missense	probably damaging	1.00
R1082:Ppp1r26	UTSW	2	28452134	missense	probably damaging	1.00
R1477:Ppp1r26	UTSW	2	28452788	missense	probably benign	0.00
R1512:Ppp1r26	UTSW	2	28451516	missense	probably benign	0.01
R2157:Ppp1r26	UTSW	2	28452358	missense	probably benign	0.00
R2228:Ppp1r26	UTSW	2	28453786	missense	possibly damaging	0.91
R2275:Ppp1r26	UTSW	2	28452701	missense	possibly damaging	0.86
R3015:Ppp1r26	UTSW	2	28452302	missense	probably damaging	1.00
R4402:Ppp1r26	UTSW	2	28451606	missense	probably benign	0.00
R4614:Ppp1r26	UTSW	2	28450848	missense	probably benign	0.04
R5521:Ppp1r26	UTSW	2	28451426	missense	probably benign	0.27
R5873:Ppp1r26	UTSW	2	28451605	missense	probably benign	0.10
R5988:Ppp1r26	UTSW	2	28452554	missense	probably benign	0.01
R6060:Ppp1r26	UTSW	2	28451030	missense	probably benign	0.00
R7007:Ppp1r26	UTSW	2	28451159	missense	probably damaging	0.99
R7501:Ppp1r26	UTSW	2	28450737	missense	probably damaging	1.00
R8812:Ppp1r26	UTSW	2	28451180	missense	probably benign	0.00
R8986:Ppp1r26	UTSW	2	28452790	nonsense	probably null
R9213:Ppp1r26	UTSW	2	28453637	missense	probably benign	0.04
Z1176:Ppp1r26	UTSW	2	28452847	missense	probably damaging	1.00
Z1177:Ppp1r26	UTSW	2	28450892	missense	probably benign	0.17
Z1177:Ppp1r26	UTSW	2	28452868	missense	probably benign	0.45
Z1177:Ppp1r26	UTSW	2	28453480	missense	probably damaging	0.98

Posted On

2014-05-07