Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02061:Arl15'

185413

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Arl15

Ensembl Gene

ENSMUSG00000042348

Gene Name

ADP-ribosylation factor-like 15

Synonyms

C230032K13Rik, Arfrp2

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02061

Quality Score

Status

Chromosome

Chromosomal Location

113931041-114293997 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 113931193 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 3 (D3E)

Ref Sequence

ENSEMBL: ENSMUSP00000153127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091201] [ENSMUST00000224068] [ENSMUST00000224858]

AlphaFold

Q8BGR6

Predicted Effect

probably benign
Transcript: ENSMUST00000091201
AA Change: D3E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000088740
Gene: ENSMUSG00000042348
AA Change: D3E

Domain	Start	End	E-Value	Type
Pfam:Arf	27	194	7.7e-37	PFAM
Pfam:SRPRB	31	192	7.7e-10	PFAM
Pfam:Roc	34	146	6.5e-10	PFAM
Pfam:Ras	34	196	5.4e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000224068
AA Change: D3E

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

Predicted Effect

unknown
Transcript: ENSMUST00000224858
AA Change: D3E

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224943

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp4a	A	G	7: 30,414,454 (GRCm39)	Y159C	probably damaging	Het
Card10	A	G	15: 78,662,415 (GRCm39)	F861S	probably damaging	Het
Ccdc85c	A	G	12: 108,188,002 (GRCm39)	V279A	probably damaging	Het
Cndp1	G	A	18: 84,652,751 (GRCm39)	R136W	probably damaging	Het
Eif2b3	A	G	4: 116,885,608 (GRCm39)	E50G	possibly damaging	Het
Entrep3	C	T	3: 89,095,903 (GRCm39)	R545*	probably null	Het
Eva1c	C	T	16: 90,663,163 (GRCm39)	Q67*	probably null	Het
Exoc1	A	G	5: 76,689,967 (GRCm39)	E169G	probably damaging	Het
Fsd2	T	A	7: 81,190,172 (GRCm39)	K537*	probably null	Het
Gbf1	T	G	19: 46,267,697 (GRCm39)	S1236A	possibly damaging	Het
Gpt	C	A	15: 76,583,617 (GRCm39)		probably benign	Het
Gsap	A	G	5: 21,486,609 (GRCm39)		probably benign	Het
Hdac6	A	C	X: 7,809,878 (GRCm39)		probably null	Het
Ivns1abp	T	A	1: 151,227,324 (GRCm39)	L44Q	probably damaging	Het
Kcnt1	T	A	2: 25,790,494 (GRCm39)		probably null	Het
Kdm2b	A	G	5: 123,021,404 (GRCm39)	I58T	probably damaging	Het
Mrpl23	C	T	7: 142,094,319 (GRCm39)	P76S	probably benign	Het
Nbea	A	G	3: 55,625,308 (GRCm39)	I2261T	possibly damaging	Het
Oasl1	G	A	5: 115,061,651 (GRCm39)	V61M	probably damaging	Het
Or4g7	T	A	2: 111,309,614 (GRCm39)	F162I	possibly damaging	Het
Pabpc2	A	G	18: 39,908,046 (GRCm39)	Q437R	probably benign	Het
Ppp1r26	T	A	2: 28,340,639 (GRCm39)	C90S	possibly damaging	Het
Ppp3ca	A	G	3: 136,503,624 (GRCm39)	T66A	probably benign	Het
Prss55	A	G	14: 64,313,192 (GRCm39)	Y231H	possibly damaging	Het
Psmb10	T	C	8: 106,664,343 (GRCm39)	T38A	probably damaging	Het
Rfx5	A	G	3: 94,865,792 (GRCm39)	T364A	probably benign	Het
Scgb2b26	T	C	7: 33,642,610 (GRCm39)	N107S	probably benign	Het
Seh1l	A	G	18: 67,920,328 (GRCm39)		probably benign	Het
Skic3	T	A	13: 76,277,660 (GRCm39)		probably null	Het
Sod1	T	A	16: 90,022,126 (GRCm39)	H111Q	probably benign	Het
Thbs2	A	T	17: 14,900,176 (GRCm39)	D592E	probably benign	Het
Tmem67	G	A	4: 12,053,526 (GRCm39)	A740V	probably damaging	Het
Tra2a	A	G	6: 49,226,032 (GRCm39)	V136A	possibly damaging	Het
Utp18	T	C	11: 93,772,967 (GRCm39)	D158G	probably benign	Het
Zfp524	A	G	7: 5,020,871 (GRCm39)	E133G	probably damaging	Het

Other mutations in Arl15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Arl15	APN	13	114,291,288 (GRCm39)	missense	probably benign	0.00
IGL01986:Arl15	APN	13	114,058,902 (GRCm39)	missense	possibly damaging	0.90
IGL02871:Arl15	APN	13	114,291,374 (GRCm39)	missense	probably benign	0.00
R1452:Arl15	UTSW	13	114,104,319 (GRCm39)	missense	probably benign	0.01
R2114:Arl15	UTSW	13	114,104,196 (GRCm39)	missense	probably damaging	1.00
R2115:Arl15	UTSW	13	114,104,196 (GRCm39)	missense	probably damaging	1.00
R2117:Arl15	UTSW	13	114,104,196 (GRCm39)	missense	probably damaging	1.00
R3500:Arl15	UTSW	13	114,104,228 (GRCm39)	missense	probably damaging	1.00
R4701:Arl15	UTSW	13	114,104,261 (GRCm39)	missense	probably benign	0.26
R5977:Arl15	UTSW	13	114,070,645 (GRCm39)	missense	probably damaging	0.99
R6057:Arl15	UTSW	13	114,104,151 (GRCm39)	missense	probably damaging	1.00
R7649:Arl15	UTSW	13	114,104,208 (GRCm39)	missense	possibly damaging	0.72
R8471:Arl15	UTSW	13	114,037,632 (GRCm39)	intron	probably benign

Posted On

2014-05-07