Incidental Mutation 'IGL02064:Or5p58'
ID 185537
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5p58
Ensembl Gene ENSMUSG00000059031
Gene Name olfactory receptor family 5 subfamily P member 58
Synonyms Olfr482, MOR204-14, GA_x6K02T2PBJ9-10424354-10423383
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # IGL02064
Quality Score
Status
Chromosome 7
Chromosomal Location 107693804-107694775 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 107694454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 108 (T108P)
Ref Sequence ENSEMBL: ENSMUSP00000150755 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081184] [ENSMUST00000217304]
AlphaFold Q8VG03
Predicted Effect probably benign
Transcript: ENSMUST00000081184
AA Change: T108P

PolyPhen 2 Score 0.205 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000079948
Gene: ENSMUSG00000059031
AA Change: T108P

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-52 PFAM
Pfam:7tm_1 44 293 8.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207291
Predicted Effect probably benign
Transcript: ENSMUST00000217304
AA Change: T108P

PolyPhen 2 Score 0.205 (Sensitivity: 0.92; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm3 T C 3: 59,784,463 (GRCm39) L312P probably damaging Het
Acap2 A C 16: 30,946,146 (GRCm39) W284G probably damaging Het
Acsf3 T C 8: 123,506,986 (GRCm39) L93P possibly damaging Het
Agbl2 G T 2: 90,614,368 (GRCm39) probably benign Het
Arap3 C T 18: 38,124,754 (GRCm39) G242D probably damaging Het
Asxl3 G A 18: 22,657,401 (GRCm39) V1804I possibly damaging Het
Bnc1 C A 7: 81,623,251 (GRCm39) V659L probably benign Het
Brd8 C T 18: 34,735,780 (GRCm39) S899N probably damaging Het
Car9 A G 4: 43,507,363 (GRCm39) E103G probably benign Het
Chrm4 A G 2: 91,758,176 (GRCm39) T195A probably damaging Het
Cldn10 T C 14: 119,092,424 (GRCm39) I8T probably damaging Het
Col12a1 G A 9: 79,599,654 (GRCm39) S833F probably benign Het
Cryba2 T A 1: 74,929,720 (GRCm39) D139V possibly damaging Het
Emp1 T A 6: 135,354,210 (GRCm39) M1K probably null Het
Entrep3 C T 3: 89,095,903 (GRCm39) R545* probably null Het
Exosc4 C A 15: 76,213,836 (GRCm39) A220E probably damaging Het
Fryl A G 5: 73,282,112 (GRCm39) probably benign Het
Grid2 C T 6: 64,040,919 (GRCm39) T287I probably benign Het
Grifin C T 5: 140,550,494 (GRCm39) A7T probably damaging Het
Gzmg T C 14: 56,394,798 (GRCm39) K157E probably benign Het
Kcnq2 A T 2: 180,750,819 (GRCm39) I340N probably damaging Het
Klrb1 T A 6: 128,687,600 (GRCm39) H98L probably benign Het
Krt90 T C 15: 101,471,088 (GRCm39) H58R possibly damaging Het
Krtap5-2 C A 7: 141,729,468 (GRCm39) G71C unknown Het
Krtap7-1 A T 16: 89,305,011 (GRCm39) M47K probably benign Het
Lmntd1 T A 6: 145,373,002 (GRCm39) probably null Het
Ly6g2 A G 15: 75,093,505 (GRCm39) probably benign Het
Musk A G 4: 58,286,128 (GRCm39) N6S possibly damaging Het
Or2aj4 A G 16: 19,385,298 (GRCm39) C112R probably damaging Het
Or51a39 A G 7: 102,362,808 (GRCm39) F271L probably damaging Het
Or56a42-ps1 A T 7: 104,776,241 (GRCm39) F89Y possibly damaging Het
Or8c15 T A 9: 38,120,874 (GRCm39) I122N probably damaging Het
Pcdh19 A G X: 132,586,719 (GRCm39) M432T probably benign Het
Prdm1 A G 10: 44,317,338 (GRCm39) F495S probably damaging Het
Prkar2a T C 9: 108,610,403 (GRCm39) Y211H possibly damaging Het
Ralgapa1 C A 12: 55,754,862 (GRCm39) G1143V probably damaging Het
Rbbp7 A G X: 161,552,783 (GRCm39) probably null Het
Scel C A 14: 103,770,762 (GRCm39) H65Q probably damaging Het
Sec24d T C 3: 123,137,463 (GRCm39) probably benign Het
Sfswap C A 5: 129,637,860 (GRCm39) T839N probably benign Het
Slc15a1 T C 14: 121,699,911 (GRCm39) I636V possibly damaging Het
Slc15a1 G T 14: 121,699,886 (GRCm39) P644H probably benign Het
Slc6a21 T A 7: 44,935,883 (GRCm39) I38N possibly damaging Het
Sucla2 C T 14: 73,816,913 (GRCm39) Q218* probably null Het
Tbc1d14 A T 5: 36,665,019 (GRCm39) L237* probably null Het
Trpm7 C T 2: 126,639,863 (GRCm39) E1578K probably damaging Het
Ttc17 G A 2: 94,161,012 (GRCm39) T896I probably damaging Het
Virma A G 4: 11,513,163 (GRCm39) D339G possibly damaging Het
Vmn2r54 T A 7: 12,349,533 (GRCm39) Y683F probably benign Het
Xrra1 T A 7: 99,563,411 (GRCm39) L466Q probably damaging Het
Other mutations in Or5p58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01400:Or5p58 APN 7 107,694,046 (GRCm39) missense probably damaging 1.00
IGL01482:Or5p58 APN 7 107,694,693 (GRCm39) missense probably benign 0.01
IGL01710:Or5p58 APN 7 107,694,449 (GRCm39) missense probably benign 0.00
IGL02930:Or5p58 APN 7 107,694,621 (GRCm39) missense probably damaging 1.00
IGL03206:Or5p58 APN 7 107,694,261 (GRCm39) missense probably damaging 1.00
IGL03255:Or5p58 APN 7 107,694,024 (GRCm39) missense probably damaging 1.00
R0378:Or5p58 UTSW 7 107,694,429 (GRCm39) missense probably benign 0.10
R0552:Or5p58 UTSW 7 107,693,985 (GRCm39) missense probably benign 0.01
R1538:Or5p58 UTSW 7 107,694,493 (GRCm39) missense probably damaging 1.00
R1771:Or5p58 UTSW 7 107,694,816 (GRCm39) splice site probably null
R1939:Or5p58 UTSW 7 107,694,348 (GRCm39) missense probably benign 0.06
R2258:Or5p58 UTSW 7 107,694,402 (GRCm39) missense possibly damaging 0.95
R4169:Or5p58 UTSW 7 107,694,591 (GRCm39) missense probably damaging 1.00
R4170:Or5p58 UTSW 7 107,694,280 (GRCm39) missense probably benign 0.00
R4485:Or5p58 UTSW 7 107,694,222 (GRCm39) missense probably benign
R4803:Or5p58 UTSW 7 107,694,666 (GRCm39) missense probably damaging 0.99
R4887:Or5p58 UTSW 7 107,694,303 (GRCm39) missense probably benign 0.18
R5059:Or5p58 UTSW 7 107,694,522 (GRCm39) missense probably damaging 1.00
R5445:Or5p58 UTSW 7 107,693,949 (GRCm39) missense possibly damaging 0.69
R5539:Or5p58 UTSW 7 107,694,433 (GRCm39) missense probably benign 0.23
R5644:Or5p58 UTSW 7 107,694,011 (GRCm39) nonsense probably null
R6200:Or5p58 UTSW 7 107,694,732 (GRCm39) frame shift probably null
R7171:Or5p58 UTSW 7 107,694,342 (GRCm39) missense probably benign 0.00
R8024:Or5p58 UTSW 7 107,694,496 (GRCm39) missense probably benign 0.19
R8316:Or5p58 UTSW 7 107,694,450 (GRCm39) missense probably benign 0.09
R9013:Or5p58 UTSW 7 107,694,471 (GRCm39) missense probably benign 0.02
R9376:Or5p58 UTSW 7 107,694,471 (GRCm39) missense possibly damaging 0.93
X0021:Or5p58 UTSW 7 107,694,166 (GRCm39) missense probably benign 0.20
Z1176:Or5p58 UTSW 7 107,694,201 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07