Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02064:Gm8298'

185570

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm8298

Ensembl Gene

ENSMUSG00000095522

Gene Name

predicted gene 8298

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL02064

Quality Score

Status

Chromosome

Chromosomal Location

59861051-59877313 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 59877042 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 312 (L312P)

Ref Sequence

ENSEMBL: ENSMUSP00000137307 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179799]

AlphaFold

J3QPI0

Predicted Effect

probably damaging
Transcript: ENSMUST00000179799
AA Change: L312P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000137307
Gene: ENSMUSG00000095522
AA Change: L312P

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:COesterase	91	217	9.6e-7	PFAM
Pfam:Abhydrolase_3	107	279	1.1e-36	PFAM
Pfam:Abhydrolase_3	284	375	1.2e-11	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194941

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4732456N10Rik	T	C	15: 101,562,653	H58R	possibly damaging	Het
Acap2	A	C	16: 31,127,328	W284G	probably damaging	Het
Acsf3	T	C	8: 122,780,247	L93P	possibly damaging	Het
Agbl2	G	T	2: 90,784,024		probably benign	Het
Arap3	C	T	18: 37,991,701	G242D	probably damaging	Het
Asxl3	G	A	18: 22,524,344	V1804I	possibly damaging	Het
BC025446	A	G	15: 75,221,656		probably benign	Het
Bnc1	C	A	7: 81,973,503	V659L	probably benign	Het
Brd8	C	T	18: 34,602,727	S899N	probably damaging	Het
Car9	A	G	4: 43,507,363	E103G	probably benign	Het
Chrm4	A	G	2: 91,927,831	T195A	probably damaging	Het
Cldn10	T	C	14: 118,855,012	I8T	probably damaging	Het
Col12a1	G	A	9: 79,692,372	S833F	probably benign	Het
Cryba2	T	A	1: 74,890,561	D139V	possibly damaging	Het
Emp1	T	A	6: 135,377,212	M1K	probably null	Het
Exosc4	C	A	15: 76,329,636	A220E	probably damaging	Het
Fam189b	C	T	3: 89,188,596	R545*	probably null	Het
Fryl	A	G	5: 73,124,769		probably benign	Het
Grid2	C	T	6: 64,063,935	T287I	probably benign	Het
Grifin	C	T	5: 140,564,739	A7T	probably damaging	Het
Gzmg	T	C	14: 56,157,341	K157E	probably benign	Het
Kcnq2	A	T	2: 181,109,026	I340N	probably damaging	Het
Klrb1	T	A	6: 128,710,637	H98L	probably benign	Het
Krtap5-2	C	A	7: 142,175,731	G71C	unknown	Het
Krtap7-1	A	T	16: 89,508,123	M47K	probably benign	Het
Lmntd1	T	A	6: 145,427,276		probably null	Het
Musk	A	G	4: 58,286,128	N6S	possibly damaging	Het
Olfr169	A	G	16: 19,566,548	C112R	probably damaging	Het
Olfr33	A	G	7: 102,713,601	F271L	probably damaging	Het
Olfr482	T	G	7: 108,095,247	T108P	probably benign	Het
Olfr682-ps1	A	T	7: 105,127,034	F89Y	possibly damaging	Het
Olfr893	T	A	9: 38,209,578	I122N	probably damaging	Het
Pcdh19	A	G	X: 133,685,970	M432T	probably benign	Het
Prdm1	A	G	10: 44,441,342	F495S	probably damaging	Het
Prkar2a	T	C	9: 108,733,204	Y211H	possibly damaging	Het
Ralgapa1	C	A	12: 55,708,077	G1143V	probably damaging	Het
Rbbp7	A	G	X: 162,769,787		probably null	Het
Scel	C	A	14: 103,533,326	H65Q	probably damaging	Het
Sec24d	T	C	3: 123,343,814		probably benign	Het
Sfswap	C	A	5: 129,560,796	T839N	probably benign	Het
Slc15a1	T	C	14: 121,462,499	I636V	possibly damaging	Het
Slc15a1	G	T	14: 121,462,474	P644H	probably benign	Het
Slc6a21	T	A	7: 45,286,459	I38N	possibly damaging	Het
Sucla2	C	T	14: 73,579,473	Q218*	probably null	Het
Tbc1d14	A	T	5: 36,507,675	L237*	probably null	Het
Trpm7	C	T	2: 126,797,943	E1578K	probably damaging	Het
Ttc17	G	A	2: 94,330,667	T896I	probably damaging	Het
Virma	A	G	4: 11,513,163	D339G	possibly damaging	Het
Vmn2r54	T	A	7: 12,615,606	Y683F	probably benign	Het
Xrra1	T	A	7: 99,914,204	L466Q	probably damaging	Het

Other mutations in Gm8298

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01712:Gm8298	APN	3	59868900	missense	possibly damaging	0.80
IGL02317:Gm8298	APN	3	59876987	missense	probably benign	0.00
R0270:Gm8298	UTSW	3	59877019	missense	probably benign
R0580:Gm8298	UTSW	3	59877049	missense	probably damaging	1.00
R1124:Gm8298	UTSW	3	59865218	missense	probably benign	0.39
R1208:Gm8298	UTSW	3	59865294	missense	probably benign	0.27
R1222:Gm8298	UTSW	3	59877261	nonsense	probably null
R1436:Gm8298	UTSW	3	59865339	missense	probably damaging	0.98
R1529:Gm8298	UTSW	3	59861112	missense	probably benign
R1806:Gm8298	UTSW	3	59877150	missense	probably damaging	1.00
R2130:Gm8298	UTSW	3	59865348	missense	probably damaging	1.00
R4209:Gm8298	UTSW	3	59877156	missense	probably damaging	1.00
R4597:Gm8298	UTSW	3	59876793	missense	possibly damaging	0.47
R4910:Gm8298	UTSW	3	59869014	critical splice donor site	probably null
R5571:Gm8298	UTSW	3	59877219	missense	probably damaging	1.00
R6131:Gm8298	UTSW	3	59868903	missense	possibly damaging	0.76
R6447:Gm8298	UTSW	3	59865398	missense	probably damaging	0.99
R6481:Gm8298	UTSW	3	59861057	missense	probably benign	0.00
R6795:Gm8298	UTSW	3	59868936	missense	probably damaging	1.00
R7092:Gm8298	UTSW	3	59861079	missense	probably benign	0.41
R7334:Gm8298	UTSW	3	59868959	missense	probably damaging	1.00
R7602:Gm8298	UTSW	3	59877276	missense	probably benign	0.17
R7660:Gm8298	UTSW	3	59865268	missense	probably benign	0.05
R7705:Gm8298	UTSW	3	59876747	missense	probably benign	0.25
R7708:Gm8298	UTSW	3	59865335	missense	probably benign	0.00
R7981:Gm8298	UTSW	3	59876939	missense	probably damaging	1.00
R8167:Gm8298	UTSW	3	59877211	missense	probably benign	0.03
R8941:Gm8298	UTSW	3	59876979	missense	probably damaging	1.00
R9547:Gm8298	UTSW	3	59865235	missense	probably benign	0.00
R9557:Gm8298	UTSW	3	59877233	missense	possibly damaging	0.81
R9675:Gm8298	UTSW	3	59877117	missense	probably damaging	1.00
X0011:Gm8298	UTSW	3	59861177	missense	probably benign
X0022:Gm8298	UTSW	3	59877024	missense	probably benign	0.01

Posted On

2014-05-07