Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02064:Agbl2'

185576

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Agbl2

Ensembl Gene

ENSMUSG00000040812

Gene Name

ATP/GTP binding protein-like 2

Synonyms

A430081C19Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02064

Quality Score

Status

Chromosome

Chromosomal Location

90782727-90834437 bp(+) (GRCm38)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

G to T at 90784024 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000129216 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000013759] [ENSMUST00000037206] [ENSMUST00000037219] [ENSMUST00000051831] [ENSMUST00000111481] [ENSMUST00000136058] [ENSMUST00000170320]

AlphaFold

Q8CDK2

Predicted Effect

probably benign
Transcript: ENSMUST00000013759

SMART Domains

Protein: ENSMUSP00000013759
Gene: ENSMUSG00000008200

Domain	Start	End	E-Value	Type
low complexity region	65	140	N/A	INTRINSIC
low complexity region	165	175	N/A	INTRINSIC
low complexity region	204	235	N/A	INTRINSIC
WW	265	298	3.58e-5	SMART
low complexity region	372	381	N/A	INTRINSIC
low complexity region	386	393	N/A	INTRINSIC
low complexity region	404	416	N/A	INTRINSIC
coiled coil region	442	478	N/A	INTRINSIC
low complexity region	515	533	N/A	INTRINSIC
WW	650	683	1.77e-9	SMART
low complexity region	757	788	N/A	INTRINSIC
low complexity region	891	909	N/A	INTRINSIC
low complexity region	955	1002	N/A	INTRINSIC
low complexity region	1018	1032	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000037206

SMART Domains

Protein: ENSMUSP00000047936
Gene: ENSMUSG00000040812

Domain	Start	End	E-Value	Type
low complexity region	98	106	N/A	INTRINSIC
Pfam:Peptidase_M14	375	541	1.8e-18	PFAM
low complexity region	640	655	N/A	INTRINSIC
low complexity region	674	689	N/A	INTRINSIC
low complexity region	761	776	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000037219

SMART Domains

Protein: ENSMUSP00000048647
Gene: ENSMUSG00000040812

Domain	Start	End	E-Value	Type
low complexity region	98	106	N/A	INTRINSIC
Pfam:Peptidase_M14	374	618	5e-32	PFAM
low complexity region	640	655	N/A	INTRINSIC
low complexity region	674	689	N/A	INTRINSIC
low complexity region	761	776	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000051831

SMART Domains

Protein: ENSMUSP00000051620
Gene: ENSMUSG00000040812

Domain	Start	End	E-Value	Type
low complexity region	98	106	N/A	INTRINSIC
Pfam:Peptidase_M14	376	565	1.6e-18	PFAM
low complexity region	640	655	N/A	INTRINSIC
low complexity region	674	689	N/A	INTRINSIC
low complexity region	761	776	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111481

SMART Domains

Protein: ENSMUSP00000107106
Gene: ENSMUSG00000040812

Domain	Start	End	E-Value	Type
low complexity region	98	106	N/A	INTRINSIC
Pfam:Peptidase_M14	374	618	5e-32	PFAM
low complexity region	640	655	N/A	INTRINSIC
low complexity region	674	689	N/A	INTRINSIC
low complexity region	761	776	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000136058

SMART Domains

Protein: ENSMUSP00000115632
Gene: ENSMUSG00000040812

Domain	Start	End	E-Value	Type
low complexity region	98	106	N/A	INTRINSIC
Pfam:Peptidase_M14	374	618	2.8e-32	PFAM
low complexity region	640	655	N/A	INTRINSIC
low complexity region	674	689	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149037

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149361

Predicted Effect

probably benign
Transcript: ENSMUST00000170320

SMART Domains

Protein: ENSMUSP00000129216
Gene: ENSMUSG00000040812

Domain	Start	End	E-Value	Type
low complexity region	98	106	N/A	INTRINSIC
Pfam:Peptidase_M14	376	558	1.8e-18	PFAM
low complexity region	640	655	N/A	INTRINSIC
low complexity region	674	689	N/A	INTRINSIC
low complexity region	761	776	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mice for a targeted allele are viable and fertile. Mice exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4732456N10Rik	T	C	15: 101,562,653	H58R	possibly damaging	Het
Acap2	A	C	16: 31,127,328	W284G	probably damaging	Het
Acsf3	T	C	8: 122,780,247	L93P	possibly damaging	Het
Arap3	C	T	18: 37,991,701	G242D	probably damaging	Het
Asxl3	G	A	18: 22,524,344	V1804I	possibly damaging	Het
BC025446	A	G	15: 75,221,656		probably benign	Het
Bnc1	C	A	7: 81,973,503	V659L	probably benign	Het
Brd8	C	T	18: 34,602,727	S899N	probably damaging	Het
Car9	A	G	4: 43,507,363	E103G	probably benign	Het
Chrm4	A	G	2: 91,927,831	T195A	probably damaging	Het
Cldn10	T	C	14: 118,855,012	I8T	probably damaging	Het
Col12a1	G	A	9: 79,692,372	S833F	probably benign	Het
Cryba2	T	A	1: 74,890,561	D139V	possibly damaging	Het
Emp1	T	A	6: 135,377,212	M1K	probably null	Het
Exosc4	C	A	15: 76,329,636	A220E	probably damaging	Het
Fam189b	C	T	3: 89,188,596	R545*	probably null	Het
Fryl	A	G	5: 73,124,769		probably benign	Het
Gm8298	T	C	3: 59,877,042	L312P	probably damaging	Het
Grid2	C	T	6: 64,063,935	T287I	probably benign	Het
Grifin	C	T	5: 140,564,739	A7T	probably damaging	Het
Gzmg	T	C	14: 56,157,341	K157E	probably benign	Het
Kcnq2	A	T	2: 181,109,026	I340N	probably damaging	Het
Klrb1	T	A	6: 128,710,637	H98L	probably benign	Het
Krtap5-2	C	A	7: 142,175,731	G71C	unknown	Het
Krtap7-1	A	T	16: 89,508,123	M47K	probably benign	Het
Lmntd1	T	A	6: 145,427,276		probably null	Het
Musk	A	G	4: 58,286,128	N6S	possibly damaging	Het
Olfr169	A	G	16: 19,566,548	C112R	probably damaging	Het
Olfr33	A	G	7: 102,713,601	F271L	probably damaging	Het
Olfr482	T	G	7: 108,095,247	T108P	probably benign	Het
Olfr682-ps1	A	T	7: 105,127,034	F89Y	possibly damaging	Het
Olfr893	T	A	9: 38,209,578	I122N	probably damaging	Het
Pcdh19	A	G	X: 133,685,970	M432T	probably benign	Het
Prdm1	A	G	10: 44,441,342	F495S	probably damaging	Het
Prkar2a	T	C	9: 108,733,204	Y211H	possibly damaging	Het
Ralgapa1	C	A	12: 55,708,077	G1143V	probably damaging	Het
Rbbp7	A	G	X: 162,769,787		probably null	Het
Scel	C	A	14: 103,533,326	H65Q	probably damaging	Het
Sec24d	T	C	3: 123,343,814		probably benign	Het
Sfswap	C	A	5: 129,560,796	T839N	probably benign	Het
Slc15a1	T	C	14: 121,462,499	I636V	possibly damaging	Het
Slc15a1	G	T	14: 121,462,474	P644H	probably benign	Het
Slc6a21	T	A	7: 45,286,459	I38N	possibly damaging	Het
Sucla2	C	T	14: 73,579,473	Q218*	probably null	Het
Tbc1d14	A	T	5: 36,507,675	L237*	probably null	Het
Trpm7	C	T	2: 126,797,943	E1578K	probably damaging	Het
Ttc17	G	A	2: 94,330,667	T896I	probably damaging	Het
Virma	A	G	4: 11,513,163	D339G	possibly damaging	Het
Vmn2r54	T	A	7: 12,615,606	Y683F	probably benign	Het
Xrra1	T	A	7: 99,914,204	L466Q	probably damaging	Het

Other mutations in Agbl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00471:Agbl2	APN	2	90801045	missense	probably damaging	1.00
IGL00515:Agbl2	APN	2	90793960	missense	possibly damaging	0.93
IGL01694:Agbl2	APN	2	90801074	missense	probably damaging	1.00
IGL02708:Agbl2	APN	2	90801342	missense	probably benign	0.23
IGL02715:Agbl2	APN	2	90805868	missense	probably damaging	0.99
IGL02717:Agbl2	APN	2	90805868	missense	probably damaging	0.99
IGL02982:Agbl2	APN	2	90805815	missense	probably damaging	1.00
IGL03039:Agbl2	APN	2	90801222	missense	possibly damaging	0.93
IGL03339:Agbl2	APN	2	90797563	missense	probably damaging	1.00
R0243:Agbl2	UTSW	2	90791481	missense	possibly damaging	0.80
R0381:Agbl2	UTSW	2	90784098	missense	probably damaging	1.00
R0441:Agbl2	UTSW	2	90797483	nonsense	probably null
R0549:Agbl2	UTSW	2	90789843	splice site	probably benign
R0665:Agbl2	UTSW	2	90801210	missense	probably damaging	1.00
R1412:Agbl2	UTSW	2	90788954	missense	probably benign
R1682:Agbl2	UTSW	2	90784090	missense	probably benign	0.06
R1694:Agbl2	UTSW	2	90801320	missense	probably damaging	1.00
R1733:Agbl2	UTSW	2	90810745	missense	probably damaging	1.00
R1750:Agbl2	UTSW	2	90816376	utr 3 prime	probably benign
R1916:Agbl2	UTSW	2	90815441	missense	possibly damaging	0.73
R1940:Agbl2	UTSW	2	90811282	missense	probably damaging	0.99
R3115:Agbl2	UTSW	2	90805901	missense	possibly damaging	0.85
R3407:Agbl2	UTSW	2	90791618	missense	probably damaging	1.00
R3710:Agbl2	UTSW	2	90805808	missense	probably benign	0.00
R4227:Agbl2	UTSW	2	90801453	missense	probably damaging	0.96
R4719:Agbl2	UTSW	2	90815389	missense	probably benign	0.01
R4903:Agbl2	UTSW	2	90797473	missense	possibly damaging	0.50
R5170:Agbl2	UTSW	2	90803197	missense	probably benign	0.10
R5535:Agbl2	UTSW	2	90810006	missense	probably benign	0.26
R5677:Agbl2	UTSW	2	90807978	missense	possibly damaging	0.66
R6041:Agbl2	UTSW	2	90808027	missense	probably benign	0.00
R6195:Agbl2	UTSW	2	90813313	missense	probably benign	0.02
R6233:Agbl2	UTSW	2	90813313	missense	probably benign	0.02
R6607:Agbl2	UTSW	2	90801326	missense	probably damaging	0.99
R6752:Agbl2	UTSW	2	90803074	missense	probably damaging	1.00
R7104:Agbl2	UTSW	2	90797547	missense	probably damaging	1.00
R7261:Agbl2	UTSW	2	90788944	missense	possibly damaging	0.94
R7555:Agbl2	UTSW	2	90791555	missense	probably damaging	1.00
R7704:Agbl2	UTSW	2	90789005	missense	probably benign	0.05
R7833:Agbl2	UTSW	2	90815433	missense	probably benign	0.00
R7960:Agbl2	UTSW	2	90791631	missense	probably benign	0.01
R8070:Agbl2	UTSW	2	90791565	missense	probably benign	0.00
R8248:Agbl2	UTSW	2	90797564	missense	probably damaging	1.00
R8249:Agbl2	UTSW	2	90797564	missense	probably damaging	1.00
R8250:Agbl2	UTSW	2	90797564	missense	probably damaging	1.00
R8486:Agbl2	UTSW	2	90801155	missense	possibly damaging	0.61
R8501:Agbl2	UTSW	2	90797564	missense	probably damaging	1.00
R8856:Agbl2	UTSW	2	90801744	missense	probably damaging	1.00
R9039:Agbl2	UTSW	2	90815386	missense	probably benign	0.00
R9475:Agbl2	UTSW	2	90784093	missense	probably benign	0.00
R9513:Agbl2	UTSW	2	90801114	missense	possibly damaging	0.60
R9580:Agbl2	UTSW	2	90805904	missense	probably benign	0.10

Posted On

2014-05-07