Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02065:Dnajc16'

185616

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dnajc16

Ensembl Gene

ENSMUSG00000040697

Gene Name

DnaJ heat shock protein family (Hsp40) member C16

Synonyms

4732437J24Rik, 2900037O03Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.763) question?

Stock #

IGL02065

Quality Score

Status

Chromosome

Chromosomal Location

141760189-141790931 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 141776933 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 239 (F239I)

Ref Sequence

ENSEMBL: ENSMUSP00000048714 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038014]

AlphaFold

Q80TN4

PDB Structure

Solution structure of the J domain of the pseudo DnaJ protein, mouse hypothetical mKIAA0962 [SOLUTION NMR]

Predicted Effect

probably damaging
Transcript: ENSMUST00000038014
AA Change: F239I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000048714
Gene: ENSMUSG00000040697
AA Change: F239I

Domain	Start	End	E-Value	Type
DnaJ	28	85	4.5e-30	SMART
Pfam:Thioredoxin	142	243	4.4e-8	PFAM
low complexity region	537	549	N/A	INTRINSIC
low complexity region	730	750	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138654

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	C	T	17: 46,312,901 (GRCm38)	E770K	possibly damaging	Het
Abhd17a	C	A	10: 80,586,561 (GRCm38)	A22S	probably benign	Het
Actbl2	A	G	13: 111,255,691 (GRCm38)	T187A	probably benign	Het
Adgrl3	G	A	5: 81,512,217 (GRCm38)	G278R	probably damaging	Het
Apoh	C	A	11: 108,414,305 (GRCm38)		probably benign	Het
Atp2b2	A	G	6: 113,813,867 (GRCm38)	F192S	probably damaging	Het
Bdh1	T	C	16: 31,449,936 (GRCm38)	I163T	possibly damaging	Het
Bmp1	T	A	14: 70,490,107 (GRCm38)	I679F	probably damaging	Het
Bmp1	G	T	14: 70,486,220 (GRCm38)	N725K	probably damaging	Het
Bmp2	T	A	2: 133,560,924 (GRCm38)	F132I	probably benign	Het
Bpifb5	T	C	2: 154,227,183 (GRCm38)	L140P	probably damaging	Het
Brd8	C	T	18: 34,602,727 (GRCm38)	S899N	probably damaging	Het
Carmil3	T	C	14: 55,493,822 (GRCm38)		probably benign	Het
Ccdc57	T	C	11: 120,873,760 (GRCm38)	T730A	possibly damaging	Het
Cdh10	G	T	15: 19,013,256 (GRCm38)	K647N	probably damaging	Het
Cdh17	A	C	4: 11,771,373 (GRCm38)		probably benign	Het
Cep126	A	G	9: 8,099,924 (GRCm38)	S870P	probably benign	Het
Col6a4	T	C	9: 106,077,103 (GRCm38)	T346A	probably damaging	Het
Csmd3	A	C	15: 47,666,628 (GRCm38)	V2592G	probably damaging	Het
Entrep3	C	T	3: 89,188,596 (GRCm38)	R545*	probably null	Het
F5	G	A	1: 164,190,126 (GRCm38)	V591M	probably damaging	Het
Fchsd2	T	G	7: 101,177,222 (GRCm38)		probably null	Het
Flad1	A	T	3: 89,408,987 (GRCm38)	D89E	probably damaging	Het
Fsd1	C	A	17: 55,996,499 (GRCm38)	P457Q	probably damaging	Het
Gm21985	A	G	2: 112,357,584 (GRCm38)	D1012G	possibly damaging	Het
Gon4l	A	G	3: 88,857,210 (GRCm38)	D366G	probably null	Het
Hadha	A	G	5: 30,142,845 (GRCm38)		probably benign	Het
Kdr	A	G	5: 75,961,853 (GRCm38)		probably benign	Het
Kyat3	A	G	3: 142,720,375 (GRCm38)	K24R	probably benign	Het
Map3k21	A	G	8: 125,941,658 (GRCm38)	D661G	probably benign	Het
Mical1	A	T	10: 41,484,411 (GRCm38)	K615N	possibly damaging	Het
Ncor1	T	C	11: 62,419,609 (GRCm38)	K204E	possibly damaging	Het
Nmral1	T	A	16: 4,716,482 (GRCm38)	I32F	probably benign	Het
Nrros	T	C	16: 32,144,674 (GRCm38)	D175G	possibly damaging	Het
Or10ak8	G	A	4: 118,916,771 (GRCm38)	T232I	probably benign	Het
Or12j5	T	C	7: 140,504,164 (GRCm38)	I98M	probably benign	Het
Ryr2	A	G	13: 11,572,257 (GRCm38)	F4713L	possibly damaging	Het
Serpinb1b	G	A	13: 33,091,318 (GRCm38)	G142D	possibly damaging	Het
Slc10a1	A	G	12: 80,960,474 (GRCm38)	S178P	possibly damaging	Het
Spint1	G	A	2: 119,238,217 (GRCm38)	R144H	probably benign	Het
Sult6b1	C	T	17: 78,889,075 (GRCm38)	G213R	probably damaging	Het
Themis3	G	T	17: 66,555,905 (GRCm38)	H353N	probably benign	Het
Tpr	T	C	1: 150,413,774 (GRCm38)	S619P	probably benign	Het
Ttn	A	T	2: 76,814,790 (GRCm38)	V11161E	probably damaging	Het
Usp13	G	A	3: 32,933,165 (GRCm38)	V837I	probably damaging	Het
Usp25	T	C	16: 77,083,782 (GRCm38)	V677A	probably benign	Het
Wdr62	A	G	7: 30,243,469 (GRCm38)	V1001A	possibly damaging	Het
Whrn	A	T	4: 63,418,585 (GRCm38)	I580N	possibly damaging	Het
Wls	T	A	3: 159,911,356 (GRCm38)	V344D	probably damaging	Het
Zan	A	T	5: 137,386,960 (GRCm38)	Y5070*	probably null	Het

Other mutations in Dnajc16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00495:Dnajc16	APN	4	141,763,563 (GRCm38)	splice site	probably null
IGL00840:Dnajc16	APN	4	141,768,003 (GRCm38)	missense	probably damaging	1.00
IGL01503:Dnajc16	APN	4	141,763,697 (GRCm38)	missense	possibly damaging	0.65
IGL01919:Dnajc16	APN	4	141,774,629 (GRCm38)	missense	probably benign	0.06
IGL02544:Dnajc16	APN	4	141,764,647 (GRCm38)	missense	probably damaging	1.00
IGL03028:Dnajc16	APN	4	141,767,732 (GRCm38)	nonsense	probably null
PIT4418001:Dnajc16	UTSW	4	141,770,949 (GRCm38)	missense	probably damaging	0.99
PIT4585001:Dnajc16	UTSW	4	141,764,685 (GRCm38)	missense	probably damaging	1.00
R0071:Dnajc16	UTSW	4	141,768,007 (GRCm38)	missense	probably benign
R0415:Dnajc16	UTSW	4	141,789,048 (GRCm38)	nonsense	probably null
R0532:Dnajc16	UTSW	4	141,789,009 (GRCm38)	missense	probably damaging	1.00
R1418:Dnajc16	UTSW	4	141,767,741 (GRCm38)	nonsense	probably null
R2959:Dnajc16	UTSW	4	141,766,545 (GRCm38)	nonsense	probably null
R3025:Dnajc16	UTSW	4	141,774,611 (GRCm38)	missense	probably benign
R3796:Dnajc16	UTSW	4	141,767,737 (GRCm38)	missense	probably benign
R3854:Dnajc16	UTSW	4	141,763,653 (GRCm38)	nonsense	probably null
R3856:Dnajc16	UTSW	4	141,763,653 (GRCm38)	nonsense	probably null
R4661:Dnajc16	UTSW	4	141,763,548 (GRCm38)	missense	probably damaging	1.00
R4841:Dnajc16	UTSW	4	141,774,625 (GRCm38)	missense	probably damaging	1.00
R4842:Dnajc16	UTSW	4	141,774,625 (GRCm38)	missense	probably damaging	1.00
R5116:Dnajc16	UTSW	4	141,767,969 (GRCm38)	nonsense	probably null
R5126:Dnajc16	UTSW	4	141,774,509 (GRCm38)	missense	probably benign	0.01
R5140:Dnajc16	UTSW	4	141,764,683 (GRCm38)	missense	possibly damaging	0.85
R5275:Dnajc16	UTSW	4	141,767,928 (GRCm38)	missense	possibly damaging	0.82
R5295:Dnajc16	UTSW	4	141,767,928 (GRCm38)	missense	possibly damaging	0.82
R5891:Dnajc16	UTSW	4	141,775,392 (GRCm38)	missense	probably benign
R6888:Dnajc16	UTSW	4	141,776,992 (GRCm38)	missense	probably benign	0.24
R7062:Dnajc16	UTSW	4	141,766,690 (GRCm38)	missense	probably damaging	1.00
R7441:Dnajc16	UTSW	4	141,763,813 (GRCm38)	missense	probably damaging	1.00
R7684:Dnajc16	UTSW	4	141,774,568 (GRCm38)	missense	probably benign	0.02
R8843:Dnajc16	UTSW	4	141,764,691 (GRCm38)	missense	possibly damaging	0.87
R8924:Dnajc16	UTSW	4	141,766,707 (GRCm38)	nonsense	probably null
R9005:Dnajc16	UTSW	4	141,764,634 (GRCm38)	missense	possibly damaging	0.95
R9053:Dnajc16	UTSW	4	141,783,060 (GRCm38)	missense	probably benign	0.28
R9550:Dnajc16	UTSW	4	141,767,747 (GRCm38)	missense	possibly damaging	0.95

Posted On

2014-05-07