Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02066:Anp32a'

185665

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Anp32a

Ensembl Gene

ENSMUSG00000032249

Gene Name

acidic nuclear phosphoprotein 32 family member A

Synonyms

pp32, Anp32

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02066

Quality Score

Status

Chromosome

Chromosomal Location

62248637-62286084 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 62284615 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085519] [ENSMUST00000128636] [ENSMUST00000135395]

AlphaFold

O35381

Predicted Effect

unknown
Transcript: ENSMUST00000085519
AA Change: D218N

SMART Domains

Protein: ENSMUSP00000082652
Gene: ENSMUSG00000032249
AA Change: D218N

Domain	Start	End	E-Value	Type
Pfam:LRR_4	64	107	5.2e-9	PFAM
Pfam:LRR_8	64	125	1.9e-9	PFAM
LRRcap	128	146	3.19e-2	SMART
coiled coil region	167	199	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126451

Predicted Effect

probably benign
Transcript: ENSMUST00000128636

SMART Domains

Protein: ENSMUSP00000123574
Gene: ENSMUSG00000032249

Domain	Start	End	E-Value	Type
Pfam:LRR_8	67	128	3.1e-10	PFAM
Pfam:LRR_4	77	111	3e-8	PFAM
Pfam:LRR_6	90	110	7.2e-6	PFAM
Pfam:LRR_7	91	107	9.5e-4	PFAM
Pfam:LRR_1	92	115	1.7e-4	PFAM
LRRcap	131	149	3.19e-2	SMART
coiled coil region	170	198	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129026

Predicted Effect

unknown
Transcript: ENSMUST00000135395
AA Change: D204N

SMART Domains

Protein: ENSMUSP00000122165
Gene: ENSMUSG00000032249
AA Change: D204N

Domain	Start	End	E-Value	Type
Pfam:LRR_8	50	111	4.9e-10	PFAM
Pfam:LRR_6	73	93	9e-6	PFAM
Pfam:LRR_7	74	90	1.2e-3	PFAM
Pfam:LRR_1	75	98	2.2e-4	PFAM
LRRcap	114	132	3.19e-2	SMART
coiled coil region	153	185	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136603

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138226

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145679

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141277

Predicted Effect

probably benign
Transcript: ENSMUST00000156461

SMART Domains

Protein: ENSMUSP00000115293
Gene: ENSMUSG00000032249

Domain	Start	End	E-Value	Type
Pfam:LRR_9	5	138	8e-13	PFAM
Pfam:LRR_4	60	104	9.7e-10	PFAM
Pfam:LRR_8	60	121	8.6e-10	PFAM
Pfam:LRR_4	84	129	2.8e-9	PFAM
Pfam:LRR_1	85	106	1.4e-3	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutant mice are viable, fertile, behaviorally normal, and show no defects of the central nervous system. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	A	6: 121,626,854 (GRCm39)	C569S	probably damaging	Het
Adck5	T	C	15: 76,479,406 (GRCm39)	V487A	probably damaging	Het
Agfg1	A	G	1: 82,871,279 (GRCm39)	T483A	probably damaging	Het
Akr1c12	T	C	13: 4,326,236 (GRCm39)	T82A	probably damaging	Het
Ano2	T	A	6: 125,667,702 (GRCm39)	L6Q	probably benign	Het
Bltp2	G	A	11: 78,164,058 (GRCm39)	R1133H	probably damaging	Het
Cep250	C	A	2: 155,818,441 (GRCm39)	A871D	probably damaging	Het
Chl1	T	C	6: 103,675,185 (GRCm39)	V624A	probably benign	Het
Clasp1	G	A	1: 118,492,990 (GRCm39)		probably null	Het
Clca3a2	T	G	3: 144,519,216 (GRCm39)	D320A	probably benign	Het
Cnot9	A	G	1: 74,566,212 (GRCm39)	Q201R	possibly damaging	Het
Cox4i2	C	T	2: 152,602,602 (GRCm39)	R99C	probably damaging	Het
Csmd1	A	T	8: 15,976,594 (GRCm39)	F2875I	probably damaging	Het
Dpagt1	A	G	9: 44,243,203 (GRCm39)	Y246C	probably damaging	Het
Dsc1	A	G	18: 20,241,860 (GRCm39)		probably benign	Het
Eef1d	G	A	15: 75,768,704 (GRCm39)	T464I	probably benign	Het
Efna2	C	T	10: 80,024,500 (GRCm39)		probably benign	Het
Entrep3	C	T	3: 89,095,903 (GRCm39)	R545*	probably null	Het
Etaa1	C	A	11: 17,896,687 (GRCm39)	V477L	probably benign	Het
Fam83d	C	T	2: 158,627,793 (GRCm39)	T494M	probably benign	Het
Fbxo24	C	T	5: 137,611,132 (GRCm39)	V553M	probably damaging	Het
Gal3st2	A	G	1: 93,801,379 (GRCm39)	T12A	probably damaging	Het
Gba2	G	A	4: 43,570,175 (GRCm39)	T373I	probably benign	Het
Kitl	T	A	10: 99,912,744 (GRCm39)	C154S	probably damaging	Het
Lrp1b	A	T	2: 41,001,091 (GRCm39)	C2044*	probably null	Het
Lrp6	G	T	6: 134,427,900 (GRCm39)	S1564*	probably null	Het
Manea	A	T	4: 26,340,965 (GRCm39)		probably benign	Het
Myt1	T	C	2: 181,438,982 (GRCm39)	L168P	probably damaging	Het
Notch1	T	C	2: 26,350,408 (GRCm39)	E2244G	possibly damaging	Het
Nsd3	T	G	8: 26,203,515 (GRCm39)	V1343G	probably damaging	Het
Nup155	T	C	15: 8,187,250 (GRCm39)		probably benign	Het
Obox6	T	C	7: 15,568,628 (GRCm39)	I83V	probably benign	Het
Or12k5	A	T	2: 36,895,321 (GRCm39)	F102I	probably damaging	Het
Or13a24	A	T	7: 140,154,413 (GRCm39)	T116S	possibly damaging	Het
Pdgfra	T	C	5: 75,331,241 (GRCm39)	V282A	possibly damaging	Het
Pkd1l2	A	G	8: 117,736,303 (GRCm39)		probably benign	Het
Pmfbp1	A	T	8: 110,268,365 (GRCm39)	I971F	possibly damaging	Het
Ppp6c	T	C	2: 39,089,683 (GRCm39)	T199A	probably benign	Het
Ptpra	A	G	2: 30,333,308 (GRCm39)	T3A	possibly damaging	Het
Rb1	A	T	14: 73,435,974 (GRCm39)	M897K	probably benign	Het
Rptn	A	C	3: 93,304,436 (GRCm39)	S590R	probably benign	Het
Rreb1	A	G	13: 38,115,482 (GRCm39)	D947G	probably benign	Het
Samd9l	T	C	6: 3,376,575 (GRCm39)	T229A	probably damaging	Het
Slc5a9	A	T	4: 111,744,719 (GRCm39)	M423K	probably damaging	Het
Slc6a12	T	A	6: 121,329,015 (GRCm39)	I111N	probably damaging	Het
Slc6a15	T	A	10: 103,252,519 (GRCm39)	L561I	probably damaging	Het
Spag5	A	G	11: 78,195,358 (GRCm39)	N222D	probably benign	Het
Spp2	G	A	1: 88,344,965 (GRCm39)	M54I	probably benign	Het
Sptbn4	T	C	7: 27,063,940 (GRCm39)	E847G	possibly damaging	Het
Timd2	T	A	11: 46,569,050 (GRCm39)	N203Y	probably damaging	Het
Togaram1	G	T	12: 65,030,195 (GRCm39)	D1000Y	probably damaging	Het
Usp47	C	T	7: 111,663,604 (GRCm39)	R258C	probably damaging	Het
Uts2r	A	C	11: 121,051,523 (GRCm39)	D129A	probably damaging	Het
Vmn2r102	G	A	17: 19,914,191 (GRCm39)	M585I	probably benign	Het
Vmn2r77	A	T	7: 86,452,836 (GRCm39)	R518*	probably null	Het
Wdfy4	C	T	14: 32,871,523 (GRCm39)	R296K	probably benign	Het
Xirp2	A	T	2: 67,356,415 (GRCm39)	K3725N	probably benign	Het
Xntrpc	T	C	7: 101,727,036 (GRCm39)	S142P	probably benign	Het
Zfat	T	C	15: 68,052,678 (GRCm39)	H372R	probably damaging	Het

Other mutations in Anp32a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00655:Anp32a	APN	9	62,278,994 (GRCm39)	splice site	probably benign
IGL01799:Anp32a	APN	9	62,279,092 (GRCm39)	missense	probably benign	0.06
IGL02536:Anp32a	APN	9	62,279,110 (GRCm39)	missense	probably damaging	0.98
R1608:Anp32a	UTSW	9	62,279,375 (GRCm39)	missense	probably damaging	0.99
R2149:Anp32a	UTSW	9	62,279,084 (GRCm39)	missense	probably benign	0.19
R5287:Anp32a	UTSW	9	62,249,275 (GRCm39)	missense	possibly damaging	0.50
R5381:Anp32a	UTSW	9	62,279,459 (GRCm39)	missense	probably damaging	0.97
R5403:Anp32a	UTSW	9	62,249,275 (GRCm39)	missense	possibly damaging	0.50
R5427:Anp32a	UTSW	9	62,284,598 (GRCm39)	unclassified	probably benign
R6856:Anp32a	UTSW	9	62,279,397 (GRCm39)	missense	possibly damaging	0.95
R6906:Anp32a	UTSW	9	62,284,851 (GRCm39)	unclassified	probably benign
R7949:Anp32a	UTSW	9	62,280,948 (GRCm39)	missense	unknown
R8134:Anp32a	UTSW	9	62,284,863 (GRCm39)	missense	unknown
R9501:Anp32a	UTSW	9	62,282,019 (GRCm39)	missense	unknown

Posted On

2014-05-07