Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02067:Tecrl'

185698

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tecrl

Ensembl Gene

ENSMUSG00000049537

Gene Name

trans-2,3-enoyl-CoA reductase-like

Synonyms

Srd5a2l2, D330017N19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL02067

Quality Score

Status

Chromosome

Chromosomal Location

83425992-83503042 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 83432122 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 258 (C258S)

Ref Sequence

ENSEMBL: ENSMUSP00000062122 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053543]

AlphaFold

Q8BFZ1

Predicted Effect

probably benign
Transcript: ENSMUST00000053543
AA Change: C258S

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000062122
Gene: ENSMUSG00000049537
AA Change: C258S

Domain	Start	End	E-Value	Type
PDB:2DZJ\|A	53	135	1e-17	PDB
Blast:UBQ	59	135	2e-7	BLAST
transmembrane domain	139	161	N/A	INTRINSIC
Pfam:Steroid_dh	208	361	3.8e-22	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700028K03Rik	C	T	5: 107,691,816 (GRCm39)	R36*	probably null	Het
Aplp2	T	A	9: 31,062,191 (GRCm39)	K688N	probably damaging	Het
Arhgef28	G	T	13: 98,213,825 (GRCm39)	Q13K	probably damaging	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Chrna6	A	G	8: 27,894,424 (GRCm39)	S494P	probably damaging	Het
Clcc1	T	A	3: 108,576,037 (GRCm39)	L195H	probably damaging	Het
Coq3	A	G	4: 21,900,397 (GRCm39)	E208G	probably benign	Het
Dock4	T	G	12: 40,884,384 (GRCm39)	S1684A	probably damaging	Het
Duoxa2	G	A	2: 122,131,072 (GRCm39)	V78M	possibly damaging	Het
Entrep3	C	T	3: 89,095,903 (GRCm39)	R545*	probably null	Het
Fam8a1	G	T	13: 46,823,324 (GRCm39)	R88L	possibly damaging	Het
Ganc	A	G	2: 120,236,785 (GRCm39)	D23G	probably benign	Het
Gm14305	A	T	2: 176,411,110 (GRCm39)	E53D	probably damaging	Het
Ing5	T	A	1: 93,739,648 (GRCm39)	L58Q	probably damaging	Het
Klrb1-ps1	A	G	6: 129,106,351 (GRCm39)	D164G	probably damaging	Het
Lama2	G	A	10: 27,052,792 (GRCm39)	T1389M	probably benign	Het
Lrp6	A	T	6: 134,457,359 (GRCm39)	I815K	probably damaging	Het
Nek10	A	G	14: 14,861,639 (GRCm38)	D565G	probably benign	Het
Opa1	A	G	16: 29,435,473 (GRCm39)	E641G	probably damaging	Het
Rbm44	T	C	1: 91,080,567 (GRCm39)	S252P	probably damaging	Het
Sbf1	A	G	15: 89,173,247 (GRCm39)	V1810A	probably damaging	Het
Sh3pxd2b	T	C	11: 32,373,095 (GRCm39)	V754A	probably benign	Het
Slc27a6	A	G	18: 58,745,263 (GRCm39)	T566A	probably benign	Het
Stxbp6	C	T	12: 44,908,081 (GRCm39)	R179Q	probably damaging	Het
Supt6	T	A	11: 78,121,983 (GRCm39)	Y223F	probably benign	Het
Tdrd6	T	C	17: 43,939,100 (GRCm39)	I649M	probably damaging	Het
Zfp128	T	C	7: 12,618,977 (GRCm39)	I74T	possibly damaging	Het

Other mutations in Tecrl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01981:Tecrl	APN	5	83,442,453 (GRCm39)	missense	probably benign
IGL02111:Tecrl	APN	5	83,502,639 (GRCm39)	missense	probably damaging	1.00
IGL02391:Tecrl	APN	5	83,502,674 (GRCm39)	missense	probably benign	0.00
IGL02860:Tecrl	APN	5	83,502,844 (GRCm39)	missense	probably benign	0.01
IGL03079:Tecrl	APN	5	83,442,447 (GRCm39)	missense	probably damaging	0.96
IGL03109:Tecrl	APN	5	83,457,156 (GRCm39)	intron	probably benign
gaudenz	UTSW	5	83,457,049 (GRCm39)	critical splice donor site	probably null
Whoopie	UTSW	5	83,442,453 (GRCm39)	missense	probably damaging	1.00
BB004:Tecrl	UTSW	5	83,502,666 (GRCm39)	missense	probably damaging	1.00
BB014:Tecrl	UTSW	5	83,502,666 (GRCm39)	missense	probably damaging	1.00
R0095:Tecrl	UTSW	5	83,442,417 (GRCm39)	splice site	probably benign
R0347:Tecrl	UTSW	5	83,442,479 (GRCm39)	missense	probably damaging	1.00
R0372:Tecrl	UTSW	5	83,442,506 (GRCm39)	missense	probably damaging	1.00
R0403:Tecrl	UTSW	5	83,502,605 (GRCm39)	splice site	probably benign
R0426:Tecrl	UTSW	5	83,502,610 (GRCm39)	splice site	probably benign
R0597:Tecrl	UTSW	5	83,502,775 (GRCm39)	nonsense	probably null
R1607:Tecrl	UTSW	5	83,428,355 (GRCm39)	splice site	probably null
R1771:Tecrl	UTSW	5	83,439,134 (GRCm39)	missense	probably damaging	1.00
R1800:Tecrl	UTSW	5	83,427,077 (GRCm39)	missense	probably damaging	1.00
R1815:Tecrl	UTSW	5	83,427,081 (GRCm39)	missense	probably benign	0.01
R1869:Tecrl	UTSW	5	83,502,706 (GRCm39)	missense	probably benign	0.00
R1870:Tecrl	UTSW	5	83,502,706 (GRCm39)	missense	probably benign	0.00
R4296:Tecrl	UTSW	5	83,461,174 (GRCm39)	nonsense	probably null
R4471:Tecrl	UTSW	5	83,461,134 (GRCm39)	missense	probably benign
R6281:Tecrl	UTSW	5	83,442,453 (GRCm39)	missense	probably damaging	1.00
R6343:Tecrl	UTSW	5	83,442,447 (GRCm39)	missense	probably damaging	0.96
R6866:Tecrl	UTSW	5	83,461,161 (GRCm39)	missense	probably damaging	1.00
R6948:Tecrl	UTSW	5	83,457,097 (GRCm39)	missense	probably benign
R6971:Tecrl	UTSW	5	83,502,649 (GRCm39)	missense	possibly damaging	0.58
R6981:Tecrl	UTSW	5	83,502,768 (GRCm39)	missense	possibly damaging	0.83
R7246:Tecrl	UTSW	5	83,427,182 (GRCm39)	missense	probably damaging	0.99
R7282:Tecrl	UTSW	5	83,502,754 (GRCm39)	missense	probably benign	0.26
R7444:Tecrl	UTSW	5	83,502,915 (GRCm39)	unclassified	probably benign
R7900:Tecrl	UTSW	5	83,427,188 (GRCm39)	missense	probably benign	0.04
R7927:Tecrl	UTSW	5	83,502,666 (GRCm39)	missense	probably damaging	1.00
R8246:Tecrl	UTSW	5	83,427,156 (GRCm39)	missense	probably damaging	0.99
R8360:Tecrl	UTSW	5	83,448,764 (GRCm39)	missense	probably damaging	1.00
R8466:Tecrl	UTSW	5	83,428,367 (GRCm39)	nonsense	probably null
R8947:Tecrl	UTSW	5	83,461,154 (GRCm39)	missense	probably benign	0.10
R8949:Tecrl	UTSW	5	83,461,154 (GRCm39)	missense	probably benign	0.10
R9009:Tecrl	UTSW	5	83,432,121 (GRCm39)	missense	probably damaging	0.96
R9115:Tecrl	UTSW	5	83,427,906 (GRCm39)	missense	possibly damaging	0.93
R9182:Tecrl	UTSW	5	83,457,049 (GRCm39)	critical splice donor site	probably null
R9320:Tecrl	UTSW	5	83,428,422 (GRCm39)	missense	possibly damaging	0.67
X0019:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0024:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0034:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0035:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0036:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0037:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0038:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0039:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0040:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0052:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0053:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0054:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0058:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0060:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0061:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0062:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0063:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32

Posted On

2014-05-07