Incidental Mutation 'IGL02070:Ccl25'
ID 185775
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccl25
Ensembl Gene ENSMUSG00000023235
Gene Name C-C motif chemokine ligand 25
Synonyms Scya25, CKb15, TECK
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL02070
Quality Score
Status
Chromosome 8
Chromosomal Location 4375210-4410020 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 4398700 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140747 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024004] [ENSMUST00000069762] [ENSMUST00000098949] [ENSMUST00000110982] [ENSMUST00000127460] [ENSMUST00000136191] [ENSMUST00000155797]
AlphaFold O35903
Predicted Effect probably benign
Transcript: ENSMUST00000024004
SMART Domains Protein: ENSMUSP00000024004
Gene: ENSMUSG00000023235

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
SCY 27 88 1.34e-5 SMART
Predicted Effect unknown
Transcript: ENSMUST00000069762
AA Change: I117T
Predicted Effect probably benign
Transcript: ENSMUST00000098949
Predicted Effect probably benign
Transcript: ENSMUST00000110982
SMART Domains Protein: ENSMUSP00000106610
Gene: ENSMUSG00000023235

DomainStartEndE-ValueType
SCY 27 88 1.34e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000127460
SMART Domains Protein: ENSMUSP00000120719
Gene: ENSMUSG00000023235

DomainStartEndE-ValueType
transmembrane domain 87 109 N/A INTRINSIC
SCY 111 172 1.34e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136191
SMART Domains Protein: ENSMUSP00000117515
Gene: ENSMUSG00000023235

DomainStartEndE-ValueType
Pfam:IL8 23 66 2.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155797
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired accumulation of antigen-specific CD8+ T lymphocytes within both lamina propria and epithelium of the small intestine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg6 A G 10: 14,343,336 (GRCm39) Y204H probably damaging Het
Akap13 C A 7: 75,316,293 (GRCm39) T583K probably benign Het
Alms1 C A 6: 85,628,385 (GRCm39) Q2948K possibly damaging Het
Auts2 C T 5: 131,499,259 (GRCm39) R327Q probably damaging Het
Card14 A C 11: 119,235,530 (GRCm39) E988A probably damaging Het
Cttnbp2nl A C 3: 104,918,582 (GRCm39) V86G probably damaging Het
Cyb5r2 G A 7: 107,350,394 (GRCm39) T213I probably damaging Het
Ear6 A G 14: 52,091,903 (GRCm39) H150R probably damaging Het
Ecm2 T C 13: 49,671,846 (GRCm39) C116R probably damaging Het
Gabrr2 G T 4: 33,095,340 (GRCm39) E385* probably null Het
Hyal5 T A 6: 24,876,961 (GRCm39) V278D probably damaging Het
Mboat1 T C 13: 30,408,380 (GRCm39) L181P probably benign Het
Mdm1 A G 10: 117,982,523 (GRCm39) I53V probably damaging Het
Mfrp T C 9: 44,015,986 (GRCm39) Y368H probably benign Het
Myo1b A G 1: 51,833,496 (GRCm39) V365A probably damaging Het
Nexmif G T X: 103,126,817 (GRCm39) H1509Q probably benign Het
Nlrp4a G T 7: 26,148,703 (GRCm39) K103N possibly damaging Het
Obox6 G A 7: 15,568,804 (GRCm39) S24L probably damaging Het
Optc T A 1: 133,828,914 (GRCm39) I178F probably damaging Het
Or4p22 T A 2: 88,317,346 (GRCm39) I90N probably damaging Het
Or56a42-ps1 G T 7: 104,776,254 (GRCm39) L85I probably benign Het
Pcdh15 T A 10: 74,466,700 (GRCm39) N1535K probably benign Het
Pcdhb19 A T 18: 37,631,597 (GRCm39) N464I probably damaging Het
Pcsk5 C T 19: 17,416,406 (GRCm39) V1681I probably benign Het
Phf8-ps T C 17: 33,285,104 (GRCm39) E566G probably damaging Het
Pknox1 T A 17: 31,822,339 (GRCm39) probably benign Het
Ppa2 T C 3: 133,083,623 (GRCm39) F327S probably damaging Het
Rab39b G T X: 74,618,309 (GRCm39) L174M probably damaging Het
Reep5 A T 18: 34,505,526 (GRCm39) Y48* probably null Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Sar1a T A 10: 61,520,673 (GRCm39) probably benign Het
Satb1 T A 17: 52,047,095 (GRCm39) D740V probably damaging Het
Sema3f G A 9: 107,569,440 (GRCm39) T128I probably damaging Het
Snx1 A T 9: 66,005,731 (GRCm39) S129R probably damaging Het
Sptb T A 12: 76,652,313 (GRCm39) K1641N possibly damaging Het
Sptbn1 T C 11: 30,095,979 (GRCm39) E305G probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Taar7d A T 10: 23,904,152 (GRCm39) I345F probably benign Het
Tes T C 6: 17,099,779 (GRCm39) L258P probably damaging Het
Trav9-4 A T 14: 53,913,817 (GRCm39) T24S possibly damaging Het
Utp20 A G 10: 88,657,739 (GRCm39) probably benign Het
Vcam1 T A 3: 115,919,646 (GRCm39) T207S probably benign Het
Xkrx T C X: 133,051,311 (GRCm39) S447G probably benign Het
Zfp318 T C 17: 46,707,644 (GRCm39) L234P probably damaging Het
Other mutations in Ccl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02188:Ccl25 APN 8 4,398,552 (GRCm39) intron probably benign
IGL03338:Ccl25 APN 8 4,399,898 (GRCm39) intron probably benign
R0584:Ccl25 UTSW 8 4,404,085 (GRCm39) splice site probably benign
R0613:Ccl25 UTSW 8 4,399,850 (GRCm39) missense probably benign 0.42
R1208:Ccl25 UTSW 8 4,407,631 (GRCm39) missense possibly damaging 0.92
R1208:Ccl25 UTSW 8 4,407,631 (GRCm39) missense possibly damaging 0.92
R1413:Ccl25 UTSW 8 4,403,892 (GRCm39) makesense probably null
R3844:Ccl25 UTSW 8 4,404,183 (GRCm39) missense possibly damaging 0.86
R4279:Ccl25 UTSW 8 4,399,829 (GRCm39) missense probably damaging 1.00
R4921:Ccl25 UTSW 8 4,403,913 (GRCm39) missense possibly damaging 0.92
R7021:Ccl25 UTSW 8 4,399,641 (GRCm39) intron probably benign
R7033:Ccl25 UTSW 8 4,399,641 (GRCm39) intron probably benign
R7630:Ccl25 UTSW 8 4,403,955 (GRCm39) missense probably damaging 1.00
R8317:Ccl25 UTSW 8 4,404,138 (GRCm39) missense probably benign 0.00
R8550:Ccl25 UTSW 8 4,377,890 (GRCm39) missense possibly damaging 0.72
R9799:Ccl25 UTSW 8 4,377,799 (GRCm39) missense unknown
Posted On 2014-05-07