Incidental Mutation 'IGL02070:Olfr682-ps1'
ID185795
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr682-ps1
Ensembl Gene ENSMUSG00000059768
Gene Nameolfactory receptor 682, pseudogene 1
SynonymsGA_x6K02T2PBJ9-7755919-7755070, GA_x6K02SYW8DF-188-1037, MOR40-19_p, Olfr217-ps1, MOR40-6P
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL02070
Quality Score
Status
Chromosome7
Chromosomal Location105126366-105127062 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 105127047 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Isoleucine at position 85 (L85I)
Ref Sequence ENSEMBL: ENSMUSP00000154164 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071242] [ENSMUST00000098157] [ENSMUST00000214399] [ENSMUST00000215517] [ENSMUST00000215564] [ENSMUST00000216247]
Predicted Effect probably benign
Transcript: ENSMUST00000071242
AA Change: L85I

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000071223
Gene: ENSMUSG00000059768
AA Change: L85I

DomainStartEndE-ValueType
Pfam:7tm_4 23 299 1.2e-71 PFAM
Pfam:7TM_GPCR_Srsx 27 297 3.9e-10 PFAM
Pfam:7tm_1 33 283 3.4e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000071242
AA Change: L85I

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000098157
SMART Domains Protein: ENSMUSP00000095760
Gene: ENSMUSG00000095248

DomainStartEndE-ValueType
Pfam:7tm_4 35 313 2e-72 PFAM
Pfam:7TM_GPCR_Srsx 39 311 6.1e-10 PFAM
Pfam:7tm_1 45 296 7.6e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214399
AA Change: L75I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215180
Predicted Effect probably benign
Transcript: ENSMUST00000215517
Predicted Effect probably benign
Transcript: ENSMUST00000215564
Predicted Effect probably benign
Transcript: ENSMUST00000216247
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921501E09Rik T C 17: 33,066,130 E566G probably damaging Het
Adgrg6 A G 10: 14,467,592 Y204H probably damaging Het
Akap13 C A 7: 75,666,545 T583K probably benign Het
Alms1 C A 6: 85,651,403 Q2948K possibly damaging Het
Auts2 C T 5: 131,470,421 R327Q probably damaging Het
Card14 A C 11: 119,344,704 E988A probably damaging Het
Ccl25 T C 8: 4,348,700 probably benign Het
Cttnbp2nl A C 3: 105,011,266 V86G probably damaging Het
Cyb5r2 G A 7: 107,751,187 T213I probably damaging Het
Ear6 A G 14: 51,854,446 H150R probably damaging Het
Ecm2 T C 13: 49,518,370 C116R probably damaging Het
Gabrr2 G T 4: 33,095,340 E385* probably null Het
Hyal5 T A 6: 24,876,962 V278D probably damaging Het
Mboat1 T C 13: 30,224,397 L181P probably benign Het
Mdm1 A G 10: 118,146,618 I53V probably damaging Het
Mfrp T C 9: 44,104,689 Y368H probably benign Het
Myo1b A G 1: 51,794,337 V365A probably damaging Het
Nexmif G T X: 104,083,211 H1509Q probably benign Het
Nlrp4a G T 7: 26,449,278 K103N possibly damaging Het
Obox6 G A 7: 15,834,879 S24L probably damaging Het
Olfr1184 T A 2: 88,487,002 I90N probably damaging Het
Optc T A 1: 133,901,176 I178F probably damaging Het
Pcdh15 T A 10: 74,630,868 N1535K probably benign Het
Pcdhb19 A T 18: 37,498,544 N464I probably damaging Het
Pcsk5 C T 19: 17,439,042 V1681I probably benign Het
Pknox1 T A 17: 31,603,365 probably benign Het
Ppa2 T C 3: 133,377,862 F327S probably damaging Het
Rab39b G T X: 75,574,703 L174M probably damaging Het
Reep5 A T 18: 34,372,473 Y48* probably null Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Sar1a T A 10: 61,684,894 probably benign Het
Satb1 T A 17: 51,740,067 D740V probably damaging Het
Sema3f G A 9: 107,692,241 T128I probably damaging Het
Snx1 A T 9: 66,098,449 S129R probably damaging Het
Sptb T A 12: 76,605,539 K1641N possibly damaging Het
Sptbn1 T C 11: 30,145,979 E305G probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Taar7d A T 10: 24,028,254 I345F probably benign Het
Tes T C 6: 17,099,780 L258P probably damaging Het
Trav9-4 A T 14: 53,676,360 T24S possibly damaging Het
Utp20 A G 10: 88,821,877 probably benign Het
Vcam1 T A 3: 116,125,997 T207S probably benign Het
Xkrx T C X: 134,150,562 S447G probably benign Het
Zfp318 T C 17: 46,396,718 L234P probably damaging Het
Other mutations in Olfr682-ps1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02064:Olfr682-ps1 APN 7 105127034 missense possibly damaging 0.91
R0597:Olfr682-ps1 UTSW 7 105128218 missense possibly damaging 0.55
R4909:Olfr682-ps1 UTSW 7 105128228 missense probably benign 0.00
R6800:Olfr682-ps1 UTSW 7 105127010 missense probably benign 0.01
R6866:Olfr682-ps1 UTSW 7 105126618 missense probably benign 0.00
R7365:Olfr682-ps1 UTSW 7 105128345 missense probably benign 0.03
R7724:Olfr682-ps1 UTSW 7 105128252 missense probably damaging 1.00
R7761:Olfr682-ps1 UTSW 7 105126719 missense probably benign 0.31
Z1177:Olfr682-ps1 UTSW 7 105128353 missense probably damaging 1.00
Posted On2014-05-07