Incidental Mutation 'IGL02070:Sar1a'
ID185801
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sar1a
Ensembl Gene ENSMUSG00000020088
Gene Namesecretion associated Ras related GTPase 1A
Synonyms1600019H17Rik, Sara1
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.433) question?
Stock #IGL02070
Quality Score
Status
Chromosome10
Chromosomal Location61680299-61693297 bp(+) (GRCm38)
Type of Mutationutr 5 prime
DNA Base Change (assembly) T to A at 61684894 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151339 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020285] [ENSMUST00000218474] [ENSMUST00000219055] [ENSMUST00000219506] [ENSMUST00000220372]
Predicted Effect probably benign
Transcript: ENSMUST00000020285
SMART Domains Protein: ENSMUSP00000020285
Gene: ENSMUSG00000020088

DomainStartEndE-ValueType
SAR 9 197 7.79e-99 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218172
Predicted Effect probably benign
Transcript: ENSMUST00000218474
Predicted Effect probably benign
Transcript: ENSMUST00000218741
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218968
Predicted Effect probably benign
Transcript: ENSMUST00000219055
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219142
Predicted Effect probably benign
Transcript: ENSMUST00000219506
Predicted Effect probably benign
Transcript: ENSMUST00000220372
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921501E09Rik T C 17: 33,066,130 E566G probably damaging Het
Adgrg6 A G 10: 14,467,592 Y204H probably damaging Het
Akap13 C A 7: 75,666,545 T583K probably benign Het
Alms1 C A 6: 85,651,403 Q2948K possibly damaging Het
Auts2 C T 5: 131,470,421 R327Q probably damaging Het
Card14 A C 11: 119,344,704 E988A probably damaging Het
Ccl25 T C 8: 4,348,700 probably benign Het
Cttnbp2nl A C 3: 105,011,266 V86G probably damaging Het
Cyb5r2 G A 7: 107,751,187 T213I probably damaging Het
Ear6 A G 14: 51,854,446 H150R probably damaging Het
Ecm2 T C 13: 49,518,370 C116R probably damaging Het
Gabrr2 G T 4: 33,095,340 E385* probably null Het
Hyal5 T A 6: 24,876,962 V278D probably damaging Het
Mboat1 T C 13: 30,224,397 L181P probably benign Het
Mdm1 A G 10: 118,146,618 I53V probably damaging Het
Mfrp T C 9: 44,104,689 Y368H probably benign Het
Myo1b A G 1: 51,794,337 V365A probably damaging Het
Nexmif G T X: 104,083,211 H1509Q probably benign Het
Nlrp4a G T 7: 26,449,278 K103N possibly damaging Het
Obox6 G A 7: 15,834,879 S24L probably damaging Het
Olfr1184 T A 2: 88,487,002 I90N probably damaging Het
Olfr682-ps1 G T 7: 105,127,047 L85I probably benign Het
Optc T A 1: 133,901,176 I178F probably damaging Het
Pcdh15 T A 10: 74,630,868 N1535K probably benign Het
Pcdhb19 A T 18: 37,498,544 N464I probably damaging Het
Pcsk5 C T 19: 17,439,042 V1681I probably benign Het
Pknox1 T A 17: 31,603,365 probably benign Het
Ppa2 T C 3: 133,377,862 F327S probably damaging Het
Rab39b G T X: 75,574,703 L174M probably damaging Het
Reep5 A T 18: 34,372,473 Y48* probably null Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Satb1 T A 17: 51,740,067 D740V probably damaging Het
Sema3f G A 9: 107,692,241 T128I probably damaging Het
Snx1 A T 9: 66,098,449 S129R probably damaging Het
Sptb T A 12: 76,605,539 K1641N possibly damaging Het
Sptbn1 T C 11: 30,145,979 E305G probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Taar7d A T 10: 24,028,254 I345F probably benign Het
Tes T C 6: 17,099,780 L258P probably damaging Het
Trav9-4 A T 14: 53,676,360 T24S possibly damaging Het
Utp20 A G 10: 88,821,877 probably benign Het
Vcam1 T A 3: 116,125,997 T207S probably benign Het
Xkrx T C X: 134,150,562 S447G probably benign Het
Zfp318 T C 17: 46,396,718 L234P probably damaging Het
Other mutations in Sar1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01715:Sar1a APN 10 61685627 splice site probably benign
IGL01756:Sar1a APN 10 61686456 missense probably benign
IGL03355:Sar1a APN 10 61684939 missense possibly damaging 0.76
R1033:Sar1a UTSW 10 61685616 missense probably damaging 1.00
R1964:Sar1a UTSW 10 61685168 missense probably benign 0.01
R3956:Sar1a UTSW 10 61686393 missense possibly damaging 0.80
R5086:Sar1a UTSW 10 61691346 missense probably damaging 1.00
R5758:Sar1a UTSW 10 61685072 missense probably benign 0.27
R7505:Sar1a UTSW 10 61691294 missense probably benign
R8004:Sar1a UTSW 10 61685166 missense probably benign 0.06
Posted On2014-05-07