Incidental Mutation 'IGL02073:Vmn1r17'
ID185881
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r17
Ensembl Gene ENSMUSG00000115644
Gene Namevomeronasal 1 receptor 17
SynonymsV1rc16
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.287) question?
Stock #IGL02073
Quality Score
Status
Chromosome6
Chromosomal Location57359239-57363727 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 57360802 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 193 (I193V)
Ref Sequence ENSEMBL: ENSMUSP00000154129 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176395] [ENSMUST00000227186] [ENSMUST00000227966] [ENSMUST00000228156] [ENSMUST00000228294] [ENSMUST00000228342]
Predicted Effect probably benign
Transcript: ENSMUST00000176395
AA Change: I193V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000135746
Gene: ENSMUSG00000093411
AA Change: I193V

DomainStartEndE-ValueType
Pfam:V1R 28 293 1.4e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227186
AA Change: I193V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000227966
AA Change: I193V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000228156
AA Change: I144V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000228294
AA Change: I144V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000228342
AA Change: I193V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930566N20Rik C A 3: 157,208,402 probably benign Het
6330409D20Rik T G 2: 32,740,686 probably benign Het
Als2cl A G 9: 110,894,339 K659E probably benign Het
Bbx G A 16: 50,202,491 T702I probably damaging Het
Bcas3 A G 11: 85,557,437 D405G probably damaging Het
Brpf3 A G 17: 28,807,396 Y481C probably benign Het
Csnk1g1 T A 9: 66,002,251 Y217N probably damaging Het
Cyp4f37 G T 17: 32,627,851 V171L possibly damaging Het
Dock8 G A 19: 25,200,986 probably null Het
Extl3 C A 14: 65,076,339 G465W probably damaging Het
Fam208b T C 13: 3,574,721 D1743G probably benign Het
Fbxo10 A G 4: 45,046,349 I587T possibly damaging Het
Fstl5 A C 3: 76,659,652 probably benign Het
Gabbr2 T C 4: 46,667,547 N866S probably benign Het
Gm4871 T A 5: 145,032,578 K44* probably null Het
Hnrnpul1 T C 7: 25,722,341 probably benign Het
Jup A G 11: 100,383,389 probably benign Het
Mccc2 A T 13: 100,000,275 H57Q probably benign Het
Myo1a A T 10: 127,710,225 D239V probably damaging Het
Ncapd3 T A 9: 27,063,316 S695T probably benign Het
Ncor1 A T 11: 62,358,917 S1052T probably damaging Het
Olfr175-ps1 A G 16: 58,823,806 I301T probably benign Het
Olfr250 C T 9: 38,368,307 H244Y probably damaging Het
Olfr834 T A 9: 18,988,325 N112K possibly damaging Het
Pcnx3 A T 19: 5,679,386 I526K probably damaging Het
Pcnx4 A G 12: 72,574,328 D974G possibly damaging Het
Peg3 T C 7: 6,711,002 E407G probably damaging Het
Polk A G 13: 96,504,551 V166A probably damaging Het
Prkar2a A G 9: 108,733,123 I184V probably damaging Het
Ptpa T C 2: 30,443,350 S64P probably damaging Het
Rbsn A G 6: 92,189,359 L768P probably damaging Het
Ripk3 C T 14: 55,786,025 probably null Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Sar1b T C 11: 51,789,193 probably benign Het
Slx A T X: 26,534,455 W89R probably benign Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Svep1 T C 4: 58,070,104 I2561V probably benign Het
Tm7sf3 A G 6: 146,623,710 L79P possibly damaging Het
Trub1 A T 19: 57,452,947 M1L probably benign Het
Unc80 A G 1: 66,612,227 D1577G possibly damaging Het
Vat1 A T 11: 101,460,579 M312K possibly damaging Het
Vps13b A G 15: 35,875,586 I2706V possibly damaging Het
Wls T C 3: 159,907,253 probably null Het
Zfp955b A G 17: 33,300,590 T11A possibly damaging Het
Other mutations in Vmn1r17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Vmn1r17 APN 6 57361200 missense possibly damaging 0.48
IGL03117:Vmn1r17 APN 6 57360516 missense probably benign 0.08
IGL03168:Vmn1r17 APN 6 57360598 missense probably benign 0.01
R0472:Vmn1r17 UTSW 6 57361319 missense probably benign
R0590:Vmn1r17 UTSW 6 57361014 missense probably benign 0.01
R0648:Vmn1r17 UTSW 6 57360475 missense probably damaging 0.98
R1025:Vmn1r17 UTSW 6 57361255 missense probably benign 0.05
R1545:Vmn1r17 UTSW 6 57361332 missense probably benign 0.01
R2035:Vmn1r17 UTSW 6 57360588 missense probably benign 0.13
R2507:Vmn1r17 UTSW 6 57361259 missense probably damaging 0.99
R2508:Vmn1r17 UTSW 6 57360870 missense possibly damaging 0.76
R3084:Vmn1r17 UTSW 6 57360783 missense probably damaging 0.99
R3688:Vmn1r17 UTSW 6 57360559 missense probably damaging 0.99
R3696:Vmn1r17 UTSW 6 57360538 missense possibly damaging 0.74
R4436:Vmn1r17 UTSW 6 57360734 missense possibly damaging 0.91
R4741:Vmn1r17 UTSW 6 57361352 nonsense probably null
R4989:Vmn1r17 UTSW 6 57360475 missense possibly damaging 0.47
R5013:Vmn1r17 UTSW 6 57360843 missense probably benign 0.05
R5133:Vmn1r17 UTSW 6 57360843 missense probably benign 0.05
R5134:Vmn1r17 UTSW 6 57360843 missense probably benign 0.05
R5162:Vmn1r17 UTSW 6 57360843 missense probably benign 0.05
R5184:Vmn1r17 UTSW 6 57360843 missense probably benign 0.05
R5185:Vmn1r17 UTSW 6 57360843 missense probably benign 0.05
R5831:Vmn1r17 UTSW 6 57361014 missense probably benign 0.01
R6487:Vmn1r17 UTSW 6 57361224 missense possibly damaging 0.94
R7436:Vmn1r17 UTSW 6 57360877 missense probably benign 0.03
R7600:Vmn1r17 UTSW 6 57360921 missense probably benign 0.01
Posted On2014-05-07