Incidental Mutation 'IGL02073:Cyp4f37'
ID185899
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4f37
Ensembl Gene ENSMUSG00000062464
Gene Namecytochrome P450, family 4, subfamily f, polypeptide 37
SynonymsGm9705
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.096) question?
Stock #IGL02073
Quality Score
Status
Chromosome17
Chromosomal Location32621319-32636184 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 32627851 bp
ZygosityHeterozygous
Amino Acid Change Valine to Leucine at position 171 (V171L)
Ref Sequence ENSEMBL: ENSMUSP00000076827 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077639]
Predicted Effect possibly damaging
Transcript: ENSMUST00000077639
AA Change: V171L

PolyPhen 2 Score 0.591 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000076827
Gene: ENSMUSG00000062464
AA Change: V171L

DomainStartEndE-ValueType
Pfam:p450 52 515 1.1e-136 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930566N20Rik C A 3: 157,208,402 probably benign Het
6330409D20Rik T G 2: 32,740,686 probably benign Het
Als2cl A G 9: 110,894,339 K659E probably benign Het
Bbx G A 16: 50,202,491 T702I probably damaging Het
Bcas3 A G 11: 85,557,437 D405G probably damaging Het
Brpf3 A G 17: 28,807,396 Y481C probably benign Het
Csnk1g1 T A 9: 66,002,251 Y217N probably damaging Het
Dock8 G A 19: 25,200,986 probably null Het
Extl3 C A 14: 65,076,339 G465W probably damaging Het
Fam208b T C 13: 3,574,721 D1743G probably benign Het
Fbxo10 A G 4: 45,046,349 I587T possibly damaging Het
Fstl5 A C 3: 76,659,652 probably benign Het
Gabbr2 T C 4: 46,667,547 N866S probably benign Het
Gm4871 T A 5: 145,032,578 K44* probably null Het
Hnrnpul1 T C 7: 25,722,341 probably benign Het
Jup A G 11: 100,383,389 probably benign Het
Mccc2 A T 13: 100,000,275 H57Q probably benign Het
Myo1a A T 10: 127,710,225 D239V probably damaging Het
Ncapd3 T A 9: 27,063,316 S695T probably benign Het
Ncor1 A T 11: 62,358,917 S1052T probably damaging Het
Olfr175-ps1 A G 16: 58,823,806 I301T probably benign Het
Olfr250 C T 9: 38,368,307 H244Y probably damaging Het
Olfr834 T A 9: 18,988,325 N112K possibly damaging Het
Pcnx3 A T 19: 5,679,386 I526K probably damaging Het
Pcnx4 A G 12: 72,574,328 D974G possibly damaging Het
Peg3 T C 7: 6,711,002 E407G probably damaging Het
Polk A G 13: 96,504,551 V166A probably damaging Het
Prkar2a A G 9: 108,733,123 I184V probably damaging Het
Ptpa T C 2: 30,443,350 S64P probably damaging Het
Rbsn A G 6: 92,189,359 L768P probably damaging Het
Ripk3 C T 14: 55,786,025 probably null Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Sar1b T C 11: 51,789,193 probably benign Het
Slx A T X: 26,534,455 W89R probably benign Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Svep1 T C 4: 58,070,104 I2561V probably benign Het
Tm7sf3 A G 6: 146,623,710 L79P possibly damaging Het
Trub1 A T 19: 57,452,947 M1L probably benign Het
Unc80 A G 1: 66,612,227 D1577G possibly damaging Het
Vat1 A T 11: 101,460,579 M312K possibly damaging Het
Vmn1r17 T C 6: 57,360,802 I193V probably benign Het
Vps13b A G 15: 35,875,586 I2706V possibly damaging Het
Wls T C 3: 159,907,253 probably null Het
Zfp955b A G 17: 33,300,590 T11A possibly damaging Het
Other mutations in Cyp4f37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Cyp4f37 APN 17 32629053 missense probably benign 0.20
IGL01994:Cyp4f37 APN 17 32625176 nonsense probably null
IGL02145:Cyp4f37 APN 17 32630035 missense probably benign 0.43
IGL02814:Cyp4f37 APN 17 32634671 missense probably benign 0.01
IGL02873:Cyp4f37 APN 17 32625168 missense probably benign 0.00
IGL02937:Cyp4f37 APN 17 32625189 missense probably benign 0.00
IGL03170:Cyp4f37 APN 17 32625119 splice site probably benign
R0625:Cyp4f37 UTSW 17 32634678 missense probably damaging 1.00
R1774:Cyp4f37 UTSW 17 32629890 missense possibly damaging 0.59
R1871:Cyp4f37 UTSW 17 32634665 missense probably damaging 1.00
R2232:Cyp4f37 UTSW 17 32634270 missense probably benign 0.23
R2847:Cyp4f37 UTSW 17 32629125 missense probably damaging 1.00
R2848:Cyp4f37 UTSW 17 32629125 missense probably damaging 1.00
R4027:Cyp4f37 UTSW 17 32631672 missense probably benign 0.00
R4463:Cyp4f37 UTSW 17 32627736 critical splice acceptor site probably null
R4517:Cyp4f37 UTSW 17 32631592 missense probably benign 0.00
R4573:Cyp4f37 UTSW 17 32629087 missense probably benign 0.23
R4670:Cyp4f37 UTSW 17 32625152 missense probably benign
R5752:Cyp4f37 UTSW 17 32631332 missense probably damaging 1.00
R5930:Cyp4f37 UTSW 17 32629983 missense possibly damaging 0.79
R6248:Cyp4f37 UTSW 17 32629890 missense possibly damaging 0.59
R7412:Cyp4f37 UTSW 17 32629844 missense possibly damaging 0.87
R8066:Cyp4f37 UTSW 17 32635073 missense probably benign 0.21
X0057:Cyp4f37 UTSW 17 32625224 missense probably benign 0.01
Posted On2014-05-07