Incidental Mutation 'R0038:Rnf32'
ID18593
Institutional Source Beutler Lab
Gene Symbol Rnf32
Ensembl Gene ENSMUSG00000029130
Gene Namering finger protein 32
Synonyms2700025B22Rik, 1700009J01Rik, Lmbr2, 4930542N22Rik
MMRRC Submission 038332-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.159) question?
Stock #R0038 (G1)
Quality Score
Status Validated
Chromosome5
Chromosomal Location29195992-29228457 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 29205654 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144394 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001247] [ENSMUST00000160246] [ENSMUST00000160383] [ENSMUST00000160888] [ENSMUST00000161398] [ENSMUST00000168460] [ENSMUST00000198669]
Predicted Effect probably benign
Transcript: ENSMUST00000001247
SMART Domains Protein: ENSMUSP00000001247
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 97 107 N/A INTRINSIC
RING 129 170 4.8e-7 SMART
IQ 187 209 1.23e-1 SMART
RING 295 357 3.84e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160246
SMART Domains Protein: ENSMUSP00000124657
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 97 107 N/A INTRINSIC
RING 129 170 4.8e-7 SMART
IQ 187 209 1.23e-1 SMART
RING 295 357 3.84e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160383
SMART Domains Protein: ENSMUSP00000125515
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160887
Predicted Effect probably benign
Transcript: ENSMUST00000160888
SMART Domains Protein: ENSMUSP00000124499
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 97 107 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161398
SMART Domains Protein: ENSMUSP00000125741
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 6 17 N/A INTRINSIC
low complexity region 24 38 N/A INTRINSIC
low complexity region 80 90 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162975
SMART Domains Protein: ENSMUSP00000123952
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
low complexity region 60 70 N/A INTRINSIC
RING 92 133 4.8e-7 SMART
IQ 150 172 1.23e-1 SMART
RING 202 264 3.84e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168460
SMART Domains Protein: ENSMUSP00000132213
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 97 107 N/A INTRINSIC
RING 129 170 4.8e-7 SMART
IQ 187 209 1.23e-1 SMART
RING 295 357 3.84e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000198669
Coding Region Coverage
  • 1x: 83.6%
  • 3x: 76.1%
  • 10x: 58.6%
  • 20x: 40.4%
Validation Efficiency 91% (67/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agfg1 T C 1: 82,886,102 probably benign Het
Ahnak2 T C 12: 112,774,462 T253A probably benign Het
Ankrd28 A T 14: 31,708,035 M892K probably damaging Het
Arhgef25 T C 10: 127,186,865 probably benign Het
Cldn8 A G 16: 88,563,034 M1T probably null Het
Clec11a A G 7: 44,306,482 probably benign Het
Ddx39 T C 8: 83,722,498 L305P probably damaging Het
Depdc5 A G 5: 32,868,853 E60G probably benign Het
Etl4 A T 2: 20,743,574 H39L probably damaging Het
Gramd1b G A 9: 40,317,526 T252M probably damaging Het
Hcrtr2 A T 9: 76,259,681 S125T probably benign Het
Htr2a T G 14: 74,706,247 S422R probably benign Het
Kirrel3 T A 9: 34,911,770 probably null Het
Krtap9-5 G A 11: 99,948,602 C43Y possibly damaging Het
Lama2 T C 10: 26,986,797 D2990G probably benign Het
Ncor1 A G 11: 62,392,551 F437L probably damaging Het
Nlrp1b A G 11: 71,172,171 S685P possibly damaging Het
Oog4 T C 4: 143,438,944 D211G probably benign Het
Pcdh15 A T 10: 74,643,440 E723V possibly damaging Het
Pgm3 A T 9: 86,564,673 probably benign Het
Pnpla5 A G 15: 84,122,513 Y90H probably damaging Het
Polr1b C T 2: 129,115,668 R548* probably null Het
Rnf168 T C 16: 32,298,995 V458A probably benign Het
Sclt1 T C 3: 41,629,508 probably benign Het
Serpina12 A G 12: 104,037,957 F139L probably damaging Het
Stag3 T A 5: 138,301,036 probably null Het
Stard5 T C 7: 83,636,743 probably benign Het
Suclg1 A G 6: 73,260,503 E77G probably benign Het
Ush2a G T 1: 188,626,612 G2112C probably benign Het
Zfp644 T G 5: 106,635,043 E1155A probably benign Het
Other mutations in Rnf32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01591:Rnf32 APN 5 29224274 missense probably damaging 1.00
IGL01786:Rnf32 APN 5 29206814 unclassified probably benign
IGL02832:Rnf32 APN 5 29205703 critical splice donor site probably null
IGL02976:Rnf32 APN 5 29206712 unclassified probably null
R0038:Rnf32 UTSW 5 29205654 unclassified probably benign
R0070:Rnf32 UTSW 5 29225127 missense probably benign 0.00
R1812:Rnf32 UTSW 5 29206260 missense possibly damaging 0.88
R2279:Rnf32 UTSW 5 29225280 missense probably benign 0.36
R4903:Rnf32 UTSW 5 29198578 missense probably benign 0.00
R4964:Rnf32 UTSW 5 29198578 missense probably benign 0.00
R4966:Rnf32 UTSW 5 29198578 missense probably benign 0.00
R5155:Rnf32 UTSW 5 29203147 missense probably damaging 1.00
R5987:Rnf32 UTSW 5 29203147 missense probably damaging 1.00
R6060:Rnf32 UTSW 5 29206754 missense probably benign 0.01
R6374:Rnf32 UTSW 5 29225268 nonsense probably null
R7627:Rnf32 UTSW 5 29197950 start gained probably benign
Z1176:Rnf32 UTSW 5 29225250 missense probably damaging 0.99
Posted On2013-03-25