Incidental Mutation 'IGL02077:Il27'
ID 186017
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il27
Ensembl Gene ENSMUSG00000044701
Gene Name interleukin 27
Synonyms IL-27, IL-27p28, Il30, p28
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02077
Quality Score
Status
Chromosome 7
Chromosomal Location 126188182-126194113 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 126194051 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000054637 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058429] [ENSMUST00000058429]
AlphaFold Q8K3I6
Predicted Effect probably null
Transcript: ENSMUST00000058429
SMART Domains Protein: ENSMUSP00000054637
Gene: ENSMUSG00000044701

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
low complexity region 137 148 N/A INTRINSIC
low complexity region 160 177 N/A INTRINSIC
low complexity region 210 228 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000058429
SMART Domains Protein: ENSMUSP00000054637
Gene: ENSMUSG00000044701

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
low complexity region 137 148 N/A INTRINSIC
low complexity region 160 177 N/A INTRINSIC
low complexity region 210 228 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele develop an exaggerated delayed-type hypersensitivity response and are more susceptible to experimental autoimmune encephalomyelitis due to the presence of an increased number of Th17 cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap11a G T 2: 113,667,816 (GRCm39) T395K possibly damaging Het
Dop1b T C 16: 93,577,648 (GRCm39) S58P probably damaging Het
F5 T A 1: 164,026,435 (GRCm39) V1669E probably damaging Het
Fndc7 T A 3: 108,790,784 (GRCm39) T81S probably benign Het
Hnf4a G T 2: 163,404,527 (GRCm39) probably null Het
Lhcgr G A 17: 89,057,558 (GRCm39) T311I probably benign Het
Mafb A G 2: 160,207,687 (GRCm39) S304P probably benign Het
Mfrp C T 9: 44,016,517 (GRCm39) T404M probably damaging Het
Ntpcr T A 8: 126,464,107 (GRCm39) Y77* probably null Het
Otof A G 5: 30,556,579 (GRCm39) S301P probably damaging Het
Prpf6 G A 2: 181,282,457 (GRCm39) G533R probably damaging Het
Prpf8 T A 11: 75,386,635 (GRCm39) H1041Q probably damaging Het
Pyurf T C 6: 57,666,820 (GRCm39) I81V probably benign Het
Rsl1d1 A G 16: 11,012,320 (GRCm39) probably benign Het
Sema6a A T 18: 47,416,465 (GRCm39) D387E possibly damaging Het
Serpinb3a T G 1: 106,974,111 (GRCm39) T267P probably damaging Het
Tgm7 A T 2: 120,934,316 (GRCm39) M192K probably damaging Het
Thbs1 G T 2: 117,943,591 (GRCm39) V70L probably benign Het
Thsd7b T A 1: 129,744,419 (GRCm39) I769N probably damaging Het
Tlr9 A G 9: 106,102,704 (GRCm39) Y665C possibly damaging Het
Ttn T C 2: 76,600,506 (GRCm39) D18928G probably damaging Het
Uggt1 A G 1: 36,215,875 (GRCm39) S131P probably damaging Het
Unc80 A G 1: 66,564,875 (GRCm39) N854S possibly damaging Het
Vps13b A G 15: 35,910,759 (GRCm39) T3508A possibly damaging Het
Wdr43 G A 17: 71,947,286 (GRCm39) A381T probably benign Het
Zfyve26 A T 12: 79,323,169 (GRCm39) M859K possibly damaging Het
Other mutations in Il27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00895:Il27 APN 7 126,188,555 (GRCm39) missense probably benign 0.25
IGL02861:Il27 APN 7 126,191,821 (GRCm39) missense probably damaging 1.00
R1670:Il27 UTSW 7 126,188,647 (GRCm39) missense probably benign 0.02
R4673:Il27 UTSW 7 126,190,251 (GRCm39) missense possibly damaging 0.73
R5494:Il27 UTSW 7 126,192,100 (GRCm39) missense probably damaging 1.00
R5852:Il27 UTSW 7 126,191,786 (GRCm39) missense possibly damaging 0.84
R5955:Il27 UTSW 7 126,194,070 (GRCm39) missense probably benign 0.00
R5995:Il27 UTSW 7 126,188,535 (GRCm39) unclassified probably benign
R8529:Il27 UTSW 7 126,191,977 (GRCm39) missense probably damaging 1.00
R8872:Il27 UTSW 7 126,190,194 (GRCm39) missense probably damaging 1.00
X0064:Il27 UTSW 7 126,191,798 (GRCm39) missense probably benign 0.04
Posted On 2014-05-07