Incidental Mutation 'IGL02078:Sult2a4'
ID 186027
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a4
Ensembl Gene ENSMUSG00000074377
Gene Name sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4
Synonyms Gm5584
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL02078
Quality Score
Status
Chromosome 7
Chromosomal Location 13643602-13723516 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13723469 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 15 (I15M)
Ref Sequence ENSEMBL: ENSMUSP00000130490 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108520] [ENSMUST00000165167]
AlphaFold L7N245
Predicted Effect probably benign
Transcript: ENSMUST00000108520
AA Change: I16M

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000104160
Gene: ENSMUSG00000074377
AA Change: I16M

DomainStartEndE-ValueType
Pfam:Sulfotransfer_3 5 205 1.5e-10 PFAM
Pfam:Sulfotransfer_1 34 278 1.2e-82 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165167
AA Change: I15M

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000130490
Gene: ENSMUSG00000074377
AA Change: I15M

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 33 277 1.3e-82 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933412E24Rik T C 15: 59,888,179 (GRCm39) D87G probably benign Het
Acap1 C T 11: 69,786,112 (GRCm39) R18Q probably damaging Het
Atp1a1 A C 3: 101,499,179 (GRCm39) V140G probably damaging Het
Bmpr1b G A 3: 141,576,498 (GRCm39) P112S possibly damaging Het
Chst8 T A 7: 34,374,759 (GRCm39) N360I possibly damaging Het
Cldn23 A T 8: 36,293,359 (GRCm39) V43E possibly damaging Het
Clta T C 4: 44,030,232 (GRCm39) F168S probably damaging Het
Cyp2c40 T C 19: 39,755,926 (GRCm39) I463V probably benign Het
E2f2 A G 4: 135,920,323 (GRCm39) D436G probably damaging Het
Fbxo24 T G 5: 137,622,611 (GRCm39) T52P probably damaging Het
Gria4 G A 9: 4,793,878 (GRCm39) A60V probably damaging Het
Grm1 C T 10: 10,565,354 (GRCm39) V985M probably benign Het
Hexa A G 9: 59,464,586 (GRCm39) T159A probably benign Het
Inf2 T A 12: 112,568,048 (GRCm39) V200E probably damaging Het
Kif20b T A 19: 34,913,044 (GRCm39) V319E probably damaging Het
Klhl10 A G 11: 100,336,577 (GRCm39) D188G probably benign Het
Mobp G A 9: 119,996,980 (GRCm39) R37H probably damaging Het
Mybpc2 T A 7: 44,153,204 (GRCm39) D1086V probably damaging Het
Nadk A C 4: 155,663,860 (GRCm39) probably benign Het
Or7g33 T A 9: 19,448,749 (GRCm39) H159L probably benign Het
Per1 A G 11: 68,995,125 (GRCm39) E619G probably damaging Het
Rab3gap1 G A 1: 127,796,652 (GRCm39) probably benign Het
Rimkla A G 4: 119,325,344 (GRCm39) L355P probably damaging Het
Rnf139 A G 15: 58,771,880 (GRCm39) D635G possibly damaging Het
Sall1 T A 8: 89,757,003 (GRCm39) N1034Y probably damaging Het
Serpinb13 A T 1: 106,926,688 (GRCm39) Q228L probably damaging Het
Sin3b G T 8: 73,480,208 (GRCm39) M903I possibly damaging Het
Slco1a5 A T 6: 142,200,172 (GRCm39) M204K probably benign Het
Smo A G 6: 29,754,707 (GRCm39) D259G possibly damaging Het
Spata31g1 A C 4: 42,972,685 (GRCm39) K673Q possibly damaging Het
Ttn T A 2: 76,772,785 (GRCm39) probably null Het
Wdtc1 C A 4: 133,033,271 (GRCm39) D176Y probably damaging Het
Other mutations in Sult2a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Sult2a4 APN 7 13,718,870 (GRCm39) missense probably damaging 1.00
IGL00835:Sult2a4 APN 7 13,643,714 (GRCm39) missense probably benign 0.01
IGL02409:Sult2a4 APN 7 13,718,844 (GRCm39) nonsense probably null
IGL02970:Sult2a4 APN 7 13,643,831 (GRCm39) splice site probably benign
IGL03201:Sult2a4 APN 7 13,665,692 (GRCm39) missense probably damaging 0.97
R0827:Sult2a4 UTSW 7 13,718,886 (GRCm39) missense probably benign 0.03
R1484:Sult2a4 UTSW 7 13,643,726 (GRCm39) missense probably benign
R1523:Sult2a4 UTSW 7 13,643,785 (GRCm39) nonsense probably null
R1613:Sult2a4 UTSW 7 13,723,420 (GRCm39) missense probably damaging 0.98
R2127:Sult2a4 UTSW 7 13,649,185 (GRCm39) missense probably damaging 0.99
R2372:Sult2a4 UTSW 7 13,649,225 (GRCm39) missense probably benign 0.15
R3161:Sult2a4 UTSW 7 13,723,396 (GRCm39) missense probably benign 0.17
R5181:Sult2a4 UTSW 7 13,722,316 (GRCm39) missense probably benign 0.04
R7124:Sult2a4 UTSW 7 13,722,320 (GRCm39) nonsense probably null
R7983:Sult2a4 UTSW 7 13,649,152 (GRCm39) missense probably damaging 1.00
R8214:Sult2a4 UTSW 7 13,723,401 (GRCm39) missense probably benign 0.10
R9508:Sult2a4 UTSW 7 13,723,437 (GRCm39) missense probably benign 0.01
X0028:Sult2a4 UTSW 7 13,722,166 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07