Incidental Mutation 'IGL02079:Olfr1205'
ID186050
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1205
Ensembl Gene ENSMUSG00000057447
Gene Nameolfactory receptor 1205
SynonymsMOR230-1, MOR230-3, Olfr1203, GA_x6K02T2Q125-50304328-50305251, GA_x6K02T2Q125-50336588-50337313
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL02079
Quality Score
Status
Chromosome2
Chromosomal Location88829737-88837104 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 88831647 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 177 (C177S)
Ref Sequence ENSEMBL: ENSMUSP00000150206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
Predicted Effect probably damaging
Transcript: ENSMUST00000076438
AA Change: C177S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: C177S

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215929
AA Change: C177S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5330417C22Rik T A 3: 108,481,359 N236I possibly damaging Het
Abl1 T C 2: 31,689,948 probably benign Het
Ago4 A T 4: 126,517,084 M204K probably damaging Het
Alms1 T C 6: 85,628,634 V2422A probably damaging Het
Ap5z1 T C 5: 142,477,113 probably null Het
Arsa T C 15: 89,473,351 T470A probably benign Het
Bri3bp T C 5: 125,454,689 V233A probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Ephb6 T A 6: 41,616,014 D395E possibly damaging Het
Flt1 T A 5: 147,568,831 probably benign Het
Fry A T 5: 150,399,624 N1080I probably damaging Het
Gdpgp1 T A 7: 80,239,020 D266E probably benign Het
Gspt1 A G 16: 11,240,829 S123P probably benign Het
Kctd17 T C 15: 78,430,156 probably benign Het
Lamb2 T A 9: 108,482,113 C313S probably damaging Het
Lcor T A 19: 41,555,687 S106R probably benign Het
Lgr5 A C 10: 115,452,194 S776R probably damaging Het
Mettl16 T G 11: 74,817,624 C510G probably damaging Het
Mlip T C 9: 77,239,529 T101A possibly damaging Het
Myh6 A T 14: 54,950,541 L1152Q probably damaging Het
Mylk G A 16: 34,860,631 R87H possibly damaging Het
Npepl1 C T 2: 174,119,390 probably benign Het
Nrxn1 A T 17: 90,643,083 M548K probably damaging Het
Olfr514 T A 7: 108,825,936 E21V probably damaging Het
Pate3 T A 9: 35,646,153 Q69L probably damaging Het
Piwil1 T C 5: 128,742,003 V192A possibly damaging Het
Plcxd2 A T 16: 45,972,343 I211N probably benign Het
Plekhg3 T A 12: 76,560,429 Y88N probably benign Het
Rabgap1l C T 1: 160,738,970 C58Y probably benign Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Rusc2 A G 4: 43,425,668 S1258G probably benign Het
Scn1a T C 2: 66,323,360 R710G probably benign Het
Wwc1 A G 11: 35,876,058 S457P probably damaging Het
Xdh C T 17: 73,891,277 G1205D probably damaging Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Zfp592 T C 7: 81,039,230 S1080P probably benign Het
Other mutations in Olfr1205
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Olfr1205 APN 2 88831112 splice site probably null
IGL02183:Olfr1205 APN 2 88832028 missense probably benign
IGL02813:Olfr1205 APN 2 88831151 missense probably benign 0.34
IGL02839:Olfr1205 APN 2 88831648 missense probably damaging 1.00
IGL02895:Olfr1205 APN 2 88831642 missense probably damaging 1.00
R0680:Olfr1205 UTSW 2 88831780 missense probably benign
R2029:Olfr1205 UTSW 2 88831405 missense possibly damaging 0.88
R2095:Olfr1205 UTSW 2 88831290 missense probably damaging 1.00
R6158:Olfr1205 UTSW 2 88831146 missense probably damaging 1.00
R6216:Olfr1205 UTSW 2 88831311 missense probably damaging 1.00
R6240:Olfr1205 UTSW 2 88831363 missense probably benign 0.22
R6377:Olfr1205 UTSW 2 88831269 nonsense probably null
R6429:Olfr1205 UTSW 2 88831525 missense probably benign 0.01
R6521:Olfr1205 UTSW 2 88831356 missense probably benign 0.03
R7065:Olfr1205 UTSW 2 88831386 missense probably damaging 1.00
R7343:Olfr1205 UTSW 2 88831846 missense probably damaging 1.00
R7476:Olfr1205 UTSW 2 88831588 missense probably benign 0.07
R7570:Olfr1205 UTSW 2 88831128 missense possibly damaging 0.82
R8303:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8306:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8307:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8308:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8344:Olfr1205 UTSW 2 88831383 missense probably benign 0.00
R8386:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8387:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
Z1176:Olfr1205 UTSW 2 88831578 missense probably damaging 0.99
Posted On2014-05-07