Incidental Mutation 'IGL02079:Lcor'
ID 186055
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lcor
Ensembl Gene ENSMUSG00000025019
Gene Name ligand dependent nuclear receptor corepressor
Synonyms LOC381224, A630025C20Rik, Gm340, 3110023F06Rik, Mlr2
Accession Numbers
Essential gene? Possibly essential (E-score: 0.560) question?
Stock # IGL02079
Quality Score
Status
Chromosome 19
Chromosomal Location 41471076-41574975 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 41544126 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 106 (S106R)
Ref Sequence ENSEMBL: ENSMUSP00000126441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067795] [ENSMUST00000163929]
AlphaFold Q6ZPI3
Predicted Effect probably benign
Transcript: ENSMUST00000067795
AA Change: S106R

PolyPhen 2 Score 0.399 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000067603
Gene: ENSMUSG00000025019
AA Change: S106R

DomainStartEndE-ValueType
low complexity region 36 48 N/A INTRINSIC
Pfam:HTH_psq 350 395 1.2e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163929
AA Change: S106R

PolyPhen 2 Score 0.399 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000126441
Gene: ENSMUSG00000025019
AA Change: S106R

DomainStartEndE-ValueType
low complexity region 36 48 N/A INTRINSIC
Pfam:HTH_psq 350 395 5.1e-18 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 T C 2: 31,579,960 (GRCm39) probably benign Het
Ago4 A T 4: 126,410,877 (GRCm39) M204K probably damaging Het
Alms1 T C 6: 85,605,616 (GRCm39) V2422A probably damaging Het
Ap5z1 T C 5: 142,462,868 (GRCm39) probably null Het
Arsa T C 15: 89,357,554 (GRCm39) T470A probably benign Het
Bri3bp T C 5: 125,531,753 (GRCm39) V233A probably damaging Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Elapor1 T A 3: 108,388,675 (GRCm39) N236I possibly damaging Het
Ephb6 T A 6: 41,592,948 (GRCm39) D395E possibly damaging Het
Flt1 T A 5: 147,505,641 (GRCm39) probably benign Het
Fry A T 5: 150,323,089 (GRCm39) N1080I probably damaging Het
Gdpgp1 T A 7: 79,888,768 (GRCm39) D266E probably benign Het
Gspt1 A G 16: 11,058,693 (GRCm39) S123P probably benign Het
Kctd17 T C 15: 78,314,356 (GRCm39) probably benign Het
Lamb2 T A 9: 108,359,312 (GRCm39) C313S probably damaging Het
Lgr5 A C 10: 115,288,099 (GRCm39) S776R probably damaging Het
Mettl16 T G 11: 74,708,450 (GRCm39) C510G probably damaging Het
Mlip T C 9: 77,146,811 (GRCm39) T101A possibly damaging Het
Myh6 A T 14: 55,187,998 (GRCm39) L1152Q probably damaging Het
Mylk G A 16: 34,681,001 (GRCm39) R87H possibly damaging Het
Npepl1 C T 2: 173,961,183 (GRCm39) probably benign Het
Nrxn1 A T 17: 90,950,511 (GRCm39) M548K probably damaging Het
Or10a48 T A 7: 108,425,143 (GRCm39) E21V probably damaging Het
Or4c11c T A 2: 88,661,991 (GRCm39) C177S probably damaging Het
Pate3 T A 9: 35,557,449 (GRCm39) Q69L probably damaging Het
Piwil1 T C 5: 128,819,067 (GRCm39) V192A possibly damaging Het
Plcxd2 A T 16: 45,792,706 (GRCm39) I211N probably benign Het
Plekhg3 T A 12: 76,607,203 (GRCm39) Y88N probably benign Het
Rabgap1l C T 1: 160,566,540 (GRCm39) C58Y probably benign Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Rusc2 A G 4: 43,425,668 (GRCm39) S1258G probably benign Het
Scn1a T C 2: 66,153,704 (GRCm39) R710G probably benign Het
Wwc1 A G 11: 35,766,885 (GRCm39) S457P probably damaging Het
Xdh C T 17: 74,198,272 (GRCm39) G1205D probably damaging Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Zfp592 T C 7: 80,688,978 (GRCm39) S1080P probably benign Het
Other mutations in Lcor
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00737:Lcor APN 19 41,541,139 (GRCm39) missense probably damaging 0.97
IGL02100:Lcor APN 19 41,547,193 (GRCm39) missense possibly damaging 0.93
IGL02444:Lcor APN 19 41,547,450 (GRCm39) missense probably damaging 0.99
IGL02578:Lcor APN 19 41,547,589 (GRCm39) missense probably damaging 1.00
IGL03072:Lcor APN 19 41,547,253 (GRCm39) missense possibly damaging 0.85
IGL03118:Lcor APN 19 41,546,808 (GRCm39) missense probably damaging 0.99
IGL03153:Lcor APN 19 41,546,795 (GRCm39) missense probably damaging 0.98
BB003:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
BB013:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
R0006:Lcor UTSW 19 41,573,338 (GRCm39) missense probably benign 0.00
R0686:Lcor UTSW 19 41,570,811 (GRCm39) missense possibly damaging 0.73
R1104:Lcor UTSW 19 41,574,502 (GRCm39) missense probably damaging 0.99
R1278:Lcor UTSW 19 41,573,122 (GRCm39) missense probably benign 0.07
R1606:Lcor UTSW 19 41,573,513 (GRCm39) missense probably benign 0.35
R1756:Lcor UTSW 19 41,547,705 (GRCm39) missense probably benign
R1833:Lcor UTSW 19 41,573,387 (GRCm39) missense probably benign 0.00
R1889:Lcor UTSW 19 41,547,567 (GRCm39) missense probably damaging 0.99
R1905:Lcor UTSW 19 41,572,013 (GRCm39) missense possibly damaging 0.73
R1913:Lcor UTSW 19 41,546,913 (GRCm39) missense probably benign 0.40
R1983:Lcor UTSW 19 41,546,806 (GRCm39) missense probably damaging 0.98
R2697:Lcor UTSW 19 41,572,466 (GRCm39) missense probably benign 0.43
R2881:Lcor UTSW 19 41,571,488 (GRCm39) missense probably damaging 1.00
R3885:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3886:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3888:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3889:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R4720:Lcor UTSW 19 41,574,334 (GRCm39) missense probably benign 0.04
R4864:Lcor UTSW 19 41,573,803 (GRCm39) missense probably benign
R4908:Lcor UTSW 19 41,572,601 (GRCm39) missense probably benign 0.00
R5160:Lcor UTSW 19 41,544,053 (GRCm39) missense probably damaging 0.99
R5193:Lcor UTSW 19 41,570,969 (GRCm39) missense probably damaging 1.00
R5215:Lcor UTSW 19 41,574,371 (GRCm39) missense probably damaging 1.00
R5276:Lcor UTSW 19 41,573,478 (GRCm39) missense probably damaging 0.98
R5319:Lcor UTSW 19 41,574,791 (GRCm39) missense probably damaging 0.99
R5321:Lcor UTSW 19 41,573,643 (GRCm39) missense probably damaging 1.00
R5432:Lcor UTSW 19 41,573,042 (GRCm39) missense probably damaging 1.00
R5605:Lcor UTSW 19 41,571,302 (GRCm39) missense probably damaging 1.00
R5941:Lcor UTSW 19 41,574,839 (GRCm39) missense probably damaging 1.00
R6020:Lcor UTSW 19 41,571,986 (GRCm39) missense possibly damaging 0.88
R6024:Lcor UTSW 19 41,572,396 (GRCm39) missense possibly damaging 0.84
R6112:Lcor UTSW 19 41,547,520 (GRCm39) missense possibly damaging 0.92
R6149:Lcor UTSW 19 41,573,641 (GRCm39) missense probably damaging 1.00
R6260:Lcor UTSW 19 41,570,810 (GRCm39) missense possibly damaging 0.73
R6260:Lcor UTSW 19 41,570,809 (GRCm39) missense probably null 0.91
R6476:Lcor UTSW 19 41,571,518 (GRCm39) missense probably benign 0.04
R7051:Lcor UTSW 19 41,574,191 (GRCm39) missense probably benign 0.05
R7285:Lcor UTSW 19 41,572,754 (GRCm39) missense possibly damaging 0.91
R7372:Lcor UTSW 19 41,573,945 (GRCm39) missense probably damaging 1.00
R7762:Lcor UTSW 19 41,572,106 (GRCm39) missense probably benign 0.02
R7777:Lcor UTSW 19 41,547,234 (GRCm39) missense probably benign 0.33
R7833:Lcor UTSW 19 41,573,024 (GRCm39) missense probably benign 0.02
R7926:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
R8164:Lcor UTSW 19 41,573,849 (GRCm39) missense probably damaging 1.00
R8319:Lcor UTSW 19 41,571,343 (GRCm39) missense probably damaging 1.00
R8323:Lcor UTSW 19 41,572,036 (GRCm39) missense probably benign 0.01
R8327:Lcor UTSW 19 41,570,996 (GRCm39) missense probably damaging 1.00
R8423:Lcor UTSW 19 41,573,888 (GRCm39) missense possibly damaging 0.95
R8556:Lcor UTSW 19 41,546,863 (GRCm39) frame shift probably null
R8780:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8781:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8788:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8798:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9013:Lcor UTSW 19 41,573,189 (GRCm39) missense probably damaging 1.00
R9035:Lcor UTSW 19 41,573,399 (GRCm39) missense probably benign 0.00
R9065:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9067:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9083:Lcor UTSW 19 41,574,839 (GRCm39) missense probably damaging 0.99
R9105:Lcor UTSW 19 41,573,311 (GRCm39) missense possibly damaging 0.88
R9487:Lcor UTSW 19 41,573,685 (GRCm39) missense probably damaging 1.00
R9573:Lcor UTSW 19 41,573,471 (GRCm39) missense probably damaging 1.00
R9704:Lcor UTSW 19 41,572,498 (GRCm39) missense possibly damaging 0.61
X0013:Lcor UTSW 19 41,572,971 (GRCm39) missense probably damaging 0.99
Posted On 2014-05-07