Incidental Mutation 'R1376:Taok3'
ID 186251
Institutional Source Beutler Lab
Gene Symbol Taok3
Ensembl Gene ENSMUSG00000061288
Gene Name TAO kinase 3
Synonyms 2900006A08Rik, A430105I05Rik
MMRRC Submission 039440-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1376 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 117258194-117413284 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 117404026 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 734 (Y734H)
Ref Sequence ENSEMBL: ENSMUSP00000136750 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092889] [ENSMUST00000111975] [ENSMUST00000111978] [ENSMUST00000179276]
AlphaFold Q8BYC6
Predicted Effect probably damaging
Transcript: ENSMUST00000092889
AA Change: Y734H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000090565
Gene: ENSMUSG00000061288
AA Change: Y734H

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000111975
AA Change: Y274H

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107606
Gene: ENSMUSG00000061288
AA Change: Y274H

DomainStartEndE-ValueType
coiled coil region 1 35 N/A INTRINSIC
low complexity region 60 72 N/A INTRINSIC
low complexity region 92 106 N/A INTRINSIC
coiled coil region 158 189 N/A INTRINSIC
coiled coil region 329 409 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000111978
AA Change: Y734H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000107609
Gene: ENSMUSG00000061288
AA Change: Y734H

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000179276
AA Change: Y734H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000136750
Gene: ENSMUSG00000061288
AA Change: Y734H

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Meta Mutation Damage Score 0.2966 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.9%
  • 20x: 89.2%
Validation Efficiency 100% (29/29)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730455P16Rik A T 11: 80,254,735 (GRCm39) I362N possibly damaging Het
9130023H24Rik A G 7: 127,836,182 (GRCm39) V137A probably benign Het
Adal A G 2: 120,983,011 (GRCm39) D177G probably damaging Het
Cdcp2 G T 4: 106,959,956 (GRCm39) V124F possibly damaging Het
Ceacam3 T C 7: 16,897,088 (GRCm39) C685R probably damaging Het
Cep295 T C 9: 15,252,164 (GRCm39) probably benign Het
Cfd T C 10: 79,727,986 (GRCm39) I174T possibly damaging Het
Dapk2 C G 9: 66,127,925 (GRCm39) R68G probably damaging Het
Ehd1 C T 19: 6,344,418 (GRCm39) T226M probably damaging Het
Elp5 A G 11: 69,865,916 (GRCm39) V120A probably benign Het
Fzd1 G A 5: 4,807,174 (GRCm39) T136M possibly damaging Het
Galntl5 G T 5: 25,391,286 (GRCm39) V62F probably benign Het
Gm11787 A G 4: 3,516,373 (GRCm39) noncoding transcript Het
Josd2 C A 7: 44,120,539 (GRCm39) P50H probably damaging Het
Lect2 T A 13: 56,690,577 (GRCm39) I133F probably damaging Het
Lifr A G 15: 7,214,245 (GRCm39) T700A probably benign Het
Lpl T C 8: 69,340,250 (GRCm39) W82R probably damaging Het
Man2a1 C T 17: 64,979,038 (GRCm39) R523C possibly damaging Het
Mast4 T C 13: 102,872,916 (GRCm39) K1959E possibly damaging Het
Minar1 T C 9: 89,473,299 (GRCm39) T871A probably damaging Het
Or10ag57 A G 2: 87,218,162 (GRCm39) M38V probably benign Het
Or10ag58 C T 2: 87,264,903 (GRCm39) S24L possibly damaging Het
Pde4dip A G 3: 97,650,533 (GRCm39) V963A probably damaging Het
Pdgfd A G 9: 6,376,994 (GRCm39) I357V probably benign Het
Pold1 T C 7: 44,189,986 (GRCm39) D400G probably damaging Het
Ppp1r12a T C 10: 108,034,779 (GRCm39) I108T probably damaging Het
Rimbp2 G C 5: 128,847,355 (GRCm39) P931A possibly damaging Het
Rsf1 GCG GCGACG 7: 97,229,114 (GRCm39) probably benign Homo
Sec24a A C 11: 51,591,740 (GRCm39) probably benign Het
Sf3b1 A T 1: 55,058,424 (GRCm39) V55E probably damaging Het
Sult2a2 T C 7: 13,468,696 (GRCm39) V54A probably damaging Het
Tasor A G 14: 27,151,338 (GRCm39) K105E probably benign Het
Tuba3b A G 6: 145,564,500 (GRCm39) E90G possibly damaging Het
Vmn2r115 ATCTTCT ATCT 17: 23,578,962 (GRCm39) probably benign Het
Other mutations in Taok3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Taok3 APN 5 117,410,262 (GRCm39) missense probably benign 0.20
IGL01632:Taok3 APN 5 117,403,993 (GRCm39) missense possibly damaging 0.95
IGL02894:Taok3 APN 5 117,401,678 (GRCm39) missense probably benign 0.19
bonze UTSW 5 117,410,294 (GRCm39) nonsense probably null
daoist UTSW 5 117,347,636 (GRCm39) missense probably damaging 0.99
haller UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
Perseveration UTSW 5 117,393,928 (GRCm39) missense probably benign 0.25
taoist UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
Three_treasures UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
PIT4366001:Taok3 UTSW 5 117,366,050 (GRCm39) missense probably benign 0.21
R0046:Taok3 UTSW 5 117,410,294 (GRCm39) nonsense probably null
R0046:Taok3 UTSW 5 117,410,294 (GRCm39) nonsense probably null
R0158:Taok3 UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
R0245:Taok3 UTSW 5 117,390,744 (GRCm39) splice site probably benign
R0371:Taok3 UTSW 5 117,344,752 (GRCm39) nonsense probably null
R1140:Taok3 UTSW 5 117,366,118 (GRCm39) missense possibly damaging 0.94
R1302:Taok3 UTSW 5 117,337,108 (GRCm39) missense possibly damaging 0.46
R1376:Taok3 UTSW 5 117,404,026 (GRCm39) missense probably damaging 1.00
R1387:Taok3 UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
R1711:Taok3 UTSW 5 117,393,991 (GRCm39) missense possibly damaging 0.68
R1977:Taok3 UTSW 5 117,403,989 (GRCm39) missense probably damaging 0.98
R2898:Taok3 UTSW 5 117,338,134 (GRCm39) critical splice acceptor site probably null
R3824:Taok3 UTSW 5 117,394,002 (GRCm39) missense probably benign 0.01
R4378:Taok3 UTSW 5 117,347,636 (GRCm39) missense probably damaging 0.99
R4695:Taok3 UTSW 5 117,366,131 (GRCm39) missense probably benign 0.11
R4882:Taok3 UTSW 5 117,390,695 (GRCm39) missense probably damaging 0.99
R5286:Taok3 UTSW 5 117,404,140 (GRCm39) missense probably damaging 1.00
R5522:Taok3 UTSW 5 117,411,822 (GRCm39) missense probably benign 0.00
R5562:Taok3 UTSW 5 117,389,029 (GRCm39) missense probably damaging 1.00
R5643:Taok3 UTSW 5 117,344,785 (GRCm39) missense probably benign
R6241:Taok3 UTSW 5 117,410,262 (GRCm39) missense probably benign 0.33
R6290:Taok3 UTSW 5 117,342,433 (GRCm39) missense probably damaging 1.00
R6310:Taok3 UTSW 5 117,394,003 (GRCm39) missense possibly damaging 0.48
R6339:Taok3 UTSW 5 117,366,095 (GRCm39) missense probably benign
R6717:Taok3 UTSW 5 117,379,015 (GRCm39) intron probably benign
R6721:Taok3 UTSW 5 117,393,928 (GRCm39) missense probably benign 0.25
R6755:Taok3 UTSW 5 117,344,732 (GRCm39) missense probably damaging 1.00
R7046:Taok3 UTSW 5 117,411,771 (GRCm39) missense probably damaging 1.00
R7053:Taok3 UTSW 5 117,390,627 (GRCm39) missense probably benign 0.00
R7259:Taok3 UTSW 5 117,390,608 (GRCm39) missense probably benign 0.00
R7308:Taok3 UTSW 5 117,338,216 (GRCm39) nonsense probably null
R7439:Taok3 UTSW 5 117,388,974 (GRCm39) missense probably damaging 0.99
R7732:Taok3 UTSW 5 117,331,813 (GRCm39) missense possibly damaging 0.53
R7758:Taok3 UTSW 5 117,388,972 (GRCm39) missense probably damaging 1.00
R7939:Taok3 UTSW 5 117,331,902 (GRCm39) missense probably benign 0.01
R8412:Taok3 UTSW 5 117,404,102 (GRCm39) missense possibly damaging 0.59
R8485:Taok3 UTSW 5 117,389,142 (GRCm39) missense possibly damaging 0.54
R8989:Taok3 UTSW 5 117,379,227 (GRCm39) missense probably benign
R9135:Taok3 UTSW 5 117,379,245 (GRCm39) missense possibly damaging 0.70
R9135:Taok3 UTSW 5 117,379,168 (GRCm39) missense probably benign
R9135:Taok3 UTSW 5 117,344,744 (GRCm39) missense probably damaging 1.00
R9182:Taok3 UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AAGCAGTTCACCCATTTGCAATCAC -3'
(R):5'- CTTACCGCTTGAGAGGCCATCATC -3'

Sequencing Primer
(F):5'- CATGAAATCCAGAGCCCTGGTAG -3'
(R):5'- GAGAGGCCATCATCTCGTTTATAC -3'
Posted On 2014-05-09