Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00155:Mettl15'

1863

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mettl15

Ensembl Gene

ENSMUSG00000057234

Gene Name

methyltransferase like 15

Synonyms

0610027B03Rik, Mett5d1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.121) question?

Stock #

IGL00155

Quality Score

Status

Chromosome

Chromosomal Location

108922642-109111093 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 108923521 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 300 (Y300*)

Ref Sequence

ENSEMBL: ENSMUSP00000080337 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081631]

AlphaFold

Q9DCL4

Predicted Effect

probably null
Transcript: ENSMUST00000081631
AA Change: Y300*

SMART Domains

Protein: ENSMUSP00000080337
Gene: ENSMUSG00000057234
AA Change: Y300*

Domain	Start	End	E-Value	Type
Pfam:Methyltransf_5	69	406	1.5e-90	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147376

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	T	C	5: 125,590,235 (GRCm39)	F498S	probably damaging	Het
Arhgap11a	A	G	2: 113,664,601 (GRCm39)	S561P	probably benign	Het
Best3	T	C	10: 116,824,632 (GRCm39)	Y33H	probably damaging	Het
Cd209b	T	A	8: 3,969,945 (GRCm39)		probably benign	Het
Cep152	A	G	2: 125,405,808 (GRCm39)	S1575P	probably benign	Het
Crabp2	A	G	3: 87,859,506 (GRCm39)	Y52C	probably damaging	Het
Crybg1	T	C	10: 43,868,505 (GRCm39)	D1017G	probably damaging	Het
Ctnna2	A	T	6: 76,957,744 (GRCm39)	W137R	probably damaging	Het
Cxcl9	T	A	5: 92,471,728 (GRCm39)	H104L	possibly damaging	Het
Ddr2	A	G	1: 169,811,996 (GRCm39)	I742T	possibly damaging	Het
Frem1	A	G	4: 82,877,626 (GRCm39)	V223A	possibly damaging	Het
Fzd10	T	A	5: 128,678,592 (GRCm39)	I104N	probably damaging	Het
Greb1	A	G	12: 16,761,962 (GRCm39)	S473P	probably damaging	Het
Gtf2i	T	C	5: 134,271,602 (GRCm39)	Y873C	probably damaging	Het
Igsf6	T	A	7: 120,669,876 (GRCm39)	K89*	probably null	Het
Ints3	A	G	3: 90,313,636 (GRCm39)	F331L	probably damaging	Het
Kcnh3	A	T	15: 99,140,354 (GRCm39)	H1080L	possibly damaging	Het
Mms19	A	G	19: 41,936,672 (GRCm39)	F654L	probably benign	Het
Myc	A	G	15: 61,861,669 (GRCm39)	H425R	probably benign	Het
Ntn1	G	T	11: 68,117,445 (GRCm39)		probably benign	Het
Ormdl2	C	A	10: 128,655,944 (GRCm39)	G69W	probably damaging	Het
Pdpr	T	C	8: 111,828,704 (GRCm39)	V69A	possibly damaging	Het
Rbbp6	T	C	7: 122,587,908 (GRCm39)	I254T	probably damaging	Het
Sema6d	A	G	2: 124,501,785 (GRCm39)	R543G	possibly damaging	Het
Slc18a1	C	T	8: 69,503,998 (GRCm39)	A314T	probably damaging	Het
Slc22a26	A	G	19: 7,760,201 (GRCm39)	L514P	probably damaging	Het
Slc22a28	A	C	19: 8,107,567 (GRCm39)	S167A	possibly damaging	Het
Speer1m	A	G	5: 11,971,377 (GRCm39)	S110G	possibly damaging	Het
Tchh	A	G	3: 93,352,606 (GRCm39)	E682G	unknown	Het
Thbs2	A	T	17: 14,889,097 (GRCm39)	M1134K	probably damaging	Het
Tmem26	A	G	10: 68,611,184 (GRCm39)	S218G	probably damaging	Het
Tmprss11c	A	T	5: 86,387,254 (GRCm39)	S208R	probably benign	Het
Tnfrsf8	T	C	4: 145,019,161 (GRCm39)		probably null	Het
Ush2a	T	C	1: 188,596,875 (GRCm39)	S3872P	probably benign	Het
Vmn1r69	T	C	7: 10,313,879 (GRCm39)	N205S	probably benign	Het
Vmn2r54	T	A	7: 12,365,840 (GRCm39)		probably benign	Het
Wwtr1	A	T	3: 57,370,942 (GRCm39)	M328K	possibly damaging	Het
Zfp64	G	A	2: 168,768,601 (GRCm39)	S337L	probably benign	Het

Other mutations in Mettl15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00657:Mettl15	APN	2	108,923,552 (GRCm39)	missense	probably damaging	1.00
IGL02684:Mettl15	APN	2	108,961,925 (GRCm39)	missense	probably damaging	0.97
IGL03367:Mettl15	APN	2	108,961,916 (GRCm39)	missense	probably benign	0.10
R1433:Mettl15	UTSW	2	108,923,266 (GRCm39)	missense	probably benign	0.00
R1538:Mettl15	UTSW	2	108,962,010 (GRCm39)	critical splice acceptor site	probably null
R3890:Mettl15	UTSW	2	109,021,924 (GRCm39)	missense	probably benign	0.03
R5464:Mettl15	UTSW	2	109,021,967 (GRCm39)	missense	probably benign	0.00
R6609:Mettl15	UTSW	2	108,967,687 (GRCm39)	missense	probably null	1.00
R7619:Mettl15	UTSW	2	108,923,220 (GRCm39)	nonsense	probably null
R7737:Mettl15	UTSW	2	108,967,723 (GRCm39)	missense	probably damaging	0.99
R8914:Mettl15	UTSW	2	108,967,625 (GRCm39)	intron	probably benign
R9121:Mettl15	UTSW	2	109,104,948 (GRCm39)	missense
R9159:Mettl15	UTSW	2	108,923,444 (GRCm39)	missense	probably damaging	1.00
R9192:Mettl15	UTSW	2	109,104,810 (GRCm39)	nonsense	probably null
R9364:Mettl15	UTSW	2	108,961,960 (GRCm39)	missense	probably benign	0.06
R9566:Mettl15	UTSW	2	108,923,592 (GRCm39)	missense	possibly damaging	0.61

Posted On

2011-07-12