Incidental Mutation 'R1657:Zfp985'
ID 186452
Institutional Source Beutler Lab
Gene Symbol Zfp985
Ensembl Gene ENSMUSG00000065999
Gene Name zinc finger protein 985
Synonyms Gm13154
MMRRC Submission 039693-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.476) question?
Stock # R1657 (G1)
Quality Score 142
Status Not validated
Chromosome 4
Chromosomal Location 147553277-147585198 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 147584110 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 478 (N478K)
Ref Sequence ENSEMBL: ENSMUSP00000080438 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081742] [ENSMUST00000139784] [ENSMUST00000143885]
AlphaFold A2A7A5
Predicted Effect probably benign
Transcript: ENSMUST00000081742
AA Change: N478K

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000080438
Gene: ENSMUSG00000065999
AA Change: N478K

DomainStartEndE-ValueType
KRAB 13 72 4.36e-15 SMART
ZnF_C2H2 238 260 8.34e-3 SMART
ZnF_C2H2 266 288 1.47e-3 SMART
ZnF_C2H2 294 316 2.36e-2 SMART
ZnF_C2H2 322 344 8.34e-3 SMART
ZnF_C2H2 350 372 7.67e-2 SMART
ZnF_C2H2 378 400 8.6e-5 SMART
ZnF_C2H2 406 428 8.6e-5 SMART
ZnF_C2H2 434 456 7.9e-4 SMART
ZnF_C2H2 462 484 1.95e-3 SMART
ZnF_C2H2 490 512 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000139784
SMART Domains Protein: ENSMUSP00000123296
Gene: ENSMUSG00000065999

DomainStartEndE-ValueType
KRAB 13 72 4.36e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000143885
SMART Domains Protein: ENSMUSP00000121177
Gene: ENSMUSG00000065999

DomainStartEndE-ValueType
KRAB 13 72 4.36e-15 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610009B22Rik T C 11: 51,685,678 (GRCm38) Q131R probably benign Het
3632451O06Rik G C 14: 49,773,560 (GRCm38) T230S probably damaging Het
Acaca T G 11: 84,264,084 (GRCm38) D988E probably benign Het
Als2 A G 1: 59,180,601 (GRCm38) V1185A probably damaging Het
Amdhd2 A G 17: 24,156,055 (GRCm38) V391A probably damaging Het
Caprin1 A T 2: 103,769,506 (GRCm38) V608E probably damaging Het
Celsr3 T A 9: 108,842,952 (GRCm38) C2512* probably null Het
Cfl1 A T 19: 5,493,555 (GRCm38) R187W probably damaging Het
Cgnl1 C T 9: 71,725,944 (GRCm38) V42I probably damaging Het
Chd2 A G 7: 73,480,430 (GRCm38) Y826H probably damaging Het
Col9a2 C A 4: 121,040,974 (GRCm38) P28T unknown Het
Cyp3a44 G A 5: 145,779,743 (GRCm38) P346S probably damaging Het
Dact2 A G 17: 14,197,990 (GRCm38) V151A probably benign Het
Dhx29 T C 13: 112,952,843 (GRCm38) I716T probably damaging Het
Esam T C 9: 37,537,621 (GRCm38) S342P probably damaging Het
Fam189a2 C A 19: 23,975,635 (GRCm38) C437F probably damaging Het
Fer1l4 A G 2: 156,035,598 (GRCm38) V1053A possibly damaging Het
Grk3 A G 5: 112,966,982 (GRCm38) F124S probably damaging Het
H2-DMa G A 17: 34,137,399 (GRCm38) probably null Het
Hsd3b5 T A 3: 98,619,720 (GRCm38) I137F possibly damaging Het
Itgav A T 2: 83,801,779 (GRCm38) I902F probably benign Het
Itsn1 G T 16: 91,909,223 (GRCm38) C179F probably damaging Het
Kcnh8 G A 17: 52,839,125 (GRCm38) R347H probably damaging Het
Kif9 T C 9: 110,489,966 (GRCm38) M166T possibly damaging Het
Kmt5c C T 7: 4,746,454 (GRCm38) Q324* probably null Het
Lcn9 G A 2: 25,824,710 (GRCm38) E154K probably benign Het
Mfge8 A T 7: 79,141,773 (GRCm38) L227Q probably benign Het
Mroh2b A T 15: 4,931,043 (GRCm38) R753* probably null Het
Mtif2 G A 11: 29,540,721 (GRCm38) R475Q probably benign Het
Nln C T 13: 104,036,947 (GRCm38) V584I possibly damaging Het
Nr2e3 T C 9: 59,948,767 (GRCm38) E129G probably benign Het
Ocstamp T C 2: 165,397,516 (GRCm38) D250G probably damaging Het
Olfr1065 A C 2: 86,445,218 (GRCm38) L255V probably damaging Het
Olfr403 A T 11: 74,195,896 (GRCm38) H131L probably damaging Het
Olfr503 T C 7: 108,545,377 (GRCm38) I284T possibly damaging Het
Pld1 A T 3: 28,071,187 (GRCm38) I417L probably benign Het
Polr1a A T 6: 71,941,535 (GRCm38) K692N probably damaging Het
Qsox2 A T 2: 26,220,747 (GRCm38) Y152* probably null Het
Rpap1 T C 2: 119,783,778 (GRCm38) D46G possibly damaging Het
Rpe65 A G 3: 159,614,448 (GRCm38) T246A probably damaging Het
Scn5a T C 9: 119,562,380 (GRCm38) D82G probably damaging Het
Sema3d A G 5: 12,584,974 (GRCm38) E669G possibly damaging Het
Serpinb6c T C 13: 33,880,226 (GRCm38) N282S probably benign Het
Snap47 A T 11: 59,428,770 (GRCm38) S181T probably benign Het
Snx9 A C 17: 5,918,436 (GRCm38) T336P possibly damaging Het
Sphkap G A 1: 83,277,515 (GRCm38) R838* probably null Het
Terb1 A T 8: 104,488,491 (GRCm38) D284E possibly damaging Het
Tmem266 C T 9: 55,418,008 (GRCm38) A153V probably damaging Het
Ttn T C 2: 76,742,804 (GRCm38) E25915G possibly damaging Het
Tubal3 A G 13: 3,933,011 (GRCm38) T264A possibly damaging Het
Vldlr G A 19: 27,245,670 (GRCm38) R747Q probably benign Het
Zc3h8 G T 2: 128,929,957 (GRCm38) probably benign Het
Zfp184 C T 13: 21,959,273 (GRCm38) T383M probably damaging Het
Zfp455 T C 13: 67,198,639 (GRCm38) F38S possibly damaging Het
Zfp746 A G 6: 48,082,174 (GRCm38) V167A possibly damaging Het
Other mutations in Zfp985
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0098:Zfp985 UTSW 4 147,577,109 (GRCm38) missense probably damaging 0.97
R0324:Zfp985 UTSW 4 147,582,857 (GRCm38) missense probably benign 0.00
R1307:Zfp985 UTSW 4 147,583,247 (GRCm38) missense probably benign
R1594:Zfp985 UTSW 4 147,583,080 (GRCm38) missense probably benign 0.05
R1667:Zfp985 UTSW 4 147,583,950 (GRCm38) missense possibly damaging 0.84
R1761:Zfp985 UTSW 4 147,584,045 (GRCm38) missense probably benign 0.00
R1858:Zfp985 UTSW 4 147,582,858 (GRCm38) missense probably benign 0.29
R2509:Zfp985 UTSW 4 147,582,986 (GRCm38) missense possibly damaging 0.75
R2510:Zfp985 UTSW 4 147,582,986 (GRCm38) missense possibly damaging 0.75
R2847:Zfp985 UTSW 4 147,583,011 (GRCm38) nonsense probably null
R2848:Zfp985 UTSW 4 147,583,011 (GRCm38) nonsense probably null
R4245:Zfp985 UTSW 4 147,582,939 (GRCm38) missense probably damaging 0.96
R4260:Zfp985 UTSW 4 147,583,572 (GRCm38) missense probably damaging 1.00
R4434:Zfp985 UTSW 4 147,583,911 (GRCm38) missense probably benign 0.37
R4480:Zfp985 UTSW 4 147,584,079 (GRCm38) missense probably benign 0.07
R4512:Zfp985 UTSW 4 147,583,563 (GRCm38) missense probably damaging 1.00
R4514:Zfp985 UTSW 4 147,583,563 (GRCm38) missense probably damaging 1.00
R4528:Zfp985 UTSW 4 147,582,890 (GRCm38) missense possibly damaging 0.49
R4836:Zfp985 UTSW 4 147,584,155 (GRCm38) missense probably damaging 0.97
R4884:Zfp985 UTSW 4 147,583,344 (GRCm38) missense probably benign 0.04
R5054:Zfp985 UTSW 4 147,582,981 (GRCm38) missense probably damaging 0.98
R5106:Zfp985 UTSW 4 147,584,155 (GRCm38) missense probably damaging 0.97
R5205:Zfp985 UTSW 4 147,582,911 (GRCm38) missense probably damaging 1.00
R5266:Zfp985 UTSW 4 147,582,832 (GRCm38) critical splice acceptor site probably null
R5468:Zfp985 UTSW 4 147,583,245 (GRCm38) missense probably benign
R5533:Zfp985 UTSW 4 147,582,983 (GRCm38) nonsense probably null
R6282:Zfp985 UTSW 4 147,583,348 (GRCm38) missense probably benign 0.00
R6303:Zfp985 UTSW 4 147,583,775 (GRCm38) missense probably benign 0.01
R6609:Zfp985 UTSW 4 147,583,667 (GRCm38) missense probably damaging 1.00
R6609:Zfp985 UTSW 4 147,583,121 (GRCm38) missense probably benign
R6722:Zfp985 UTSW 4 147,583,071 (GRCm38) missense probably benign 0.26
R6858:Zfp985 UTSW 4 147,583,307 (GRCm38) nonsense probably null
R7064:Zfp985 UTSW 4 147,583,116 (GRCm38) missense probably benign 0.20
R7216:Zfp985 UTSW 4 147,583,456 (GRCm38) missense probably damaging 1.00
R7471:Zfp985 UTSW 4 147,582,931 (GRCm38) missense possibly damaging 0.75
R7583:Zfp985 UTSW 4 147,583,489 (GRCm38) nonsense probably null
R7685:Zfp985 UTSW 4 147,582,874 (GRCm38) missense probably benign 0.00
R8242:Zfp985 UTSW 4 147,584,182 (GRCm38) missense possibly damaging 0.52
R8504:Zfp985 UTSW 4 147,583,426 (GRCm38) missense possibly damaging 0.70
R8780:Zfp985 UTSW 4 147,583,955 (GRCm38) missense possibly damaging 0.79
R8785:Zfp985 UTSW 4 147,583,623 (GRCm38) missense probably damaging 1.00
R9485:Zfp985 UTSW 4 147,583,823 (GRCm38) missense probably damaging 1.00
R9513:Zfp985 UTSW 4 147,583,542 (GRCm38) missense probably damaging 1.00
R9631:Zfp985 UTSW 4 147,581,285 (GRCm38) missense probably damaging 1.00
R9722:Zfp985 UTSW 4 147,583,161 (GRCm38) missense possibly damaging 0.63
R9786:Zfp985 UTSW 4 147,583,590 (GRCm38) missense probably benign
X0050:Zfp985 UTSW 4 147,583,271 (GRCm38) frame shift probably null
Predicted Primers
Posted On 2014-05-09