Incidental Mutation 'R1658:Trabd'
ID186550
Institutional Source Beutler Lab
Gene Symbol Trabd
Ensembl Gene ENSMUSG00000015363
Gene NameTraB domain containing
Synonyms
MMRRC Submission 039694-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R1658 (G1)
Quality Score225
Status Not validated
Chromosome15
Chromosomal Location89075124-89087077 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to A at 89085866 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000081020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081702] [ENSMUST00000082439] [ENSMUST00000130700] [ENSMUST00000165690] [ENSMUST00000168863] [ENSMUST00000169870] [ENSMUST00000169891]
Predicted Effect possibly damaging
Transcript: ENSMUST00000081702
AA Change: L355Q

PolyPhen 2 Score 0.783 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000080403
Gene: ENSMUSG00000015363
AA Change: L355Q

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
Pfam:TraB 63 367 8e-49 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000082439
SMART Domains Protein: ENSMUSP00000081020
Gene: ENSMUSG00000035757

DomainStartEndE-ValueType
low complexity region 24 38 N/A INTRINSIC
Pfam:UPF0061 79 625 8.3e-131 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000130700
SMART Domains Protein: ENSMUSP00000138382
Gene: ENSMUSG00000035757

DomainStartEndE-ValueType
low complexity region 24 38 N/A INTRINSIC
Pfam:UPF0061 80 241 1.5e-39 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163696
Predicted Effect possibly damaging
Transcript: ENSMUST00000165690
AA Change: L355Q

PolyPhen 2 Score 0.783 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000131228
Gene: ENSMUSG00000015363
AA Change: L355Q

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
Pfam:TraB 63 310 9.9e-31 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168863
SMART Domains Protein: ENSMUSP00000130292
Gene: ENSMUSG00000015363

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
Pfam:TraB 63 235 1e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169870
Predicted Effect probably benign
Transcript: ENSMUST00000169891
SMART Domains Protein: ENSMUSP00000128721
Gene: ENSMUSG00000015363

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
Pfam:TraB 63 276 8.8e-44 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170754
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrd1 T G 5: 129,178,100 S604A probably benign Het
Apbb1 G A 7: 105,574,084 P107S probably damaging Het
Baz2a T A 10: 128,124,383 M1489K probably benign Het
Cd84 A G 1: 171,872,750 T145A possibly damaging Het
Cdca2 A G 14: 67,677,699 S704P possibly damaging Het
Chfr T C 5: 110,153,169 I312T probably damaging Het
Csmd1 A G 8: 16,081,725 V1662A possibly damaging Het
Dgkd T A 1: 87,926,268 L611Q probably damaging Het
Dicer1 A G 12: 104,700,414 V1376A probably benign Het
Elp2 C T 18: 24,617,413 T269M probably benign Het
Ephb6 T A 6: 41,614,245 V112E probably damaging Het
Fbxo11 A T 17: 88,012,658 Y209N probably benign Het
Frem1 C T 4: 83,001,808 R437Q probably damaging Het
G6pc2 A T 2: 69,227,069 K353M probably damaging Het
Gabbr1 A G 17: 37,047,507 T46A probably damaging Het
Gbp9 T A 5: 105,094,468 Q135L probably damaging Het
Gstp1 A T 19: 4,037,375 M20K probably damaging Het
Heatr6 A G 11: 83,758,367 R183G probably damaging Het
Ints11 A G 4: 155,887,728 K397E probably damaging Het
Intu A G 3: 40,692,781 T695A probably benign Het
Kif21b T C 1: 136,171,285 V1437A probably damaging Het
Klhl24 T A 16: 20,107,092 Y123* probably null Het
Lipm C T 19: 34,116,447 L255F probably benign Het
Max A T 12: 76,938,581 M121K probably benign Het
Mga A T 2: 119,941,689 I1677L possibly damaging Het
Msantd1 C A 5: 34,921,561 L147M probably damaging Het
Msantd1 T A 5: 34,921,562 L147Q probably benign Het
Mylk4 T C 13: 32,712,789 D363G possibly damaging Het
Naaa T C 5: 92,272,441 probably null Het
Ninl A G 2: 150,964,159 Y381H probably damaging Het
Nwd2 A G 5: 63,807,246 N1391S probably damaging Het
Olfr1537 C T 9: 39,237,959 C155Y probably benign Het
Olfr421-ps1 G A 1: 174,152,223 A236T probably damaging Het
Phip A G 9: 82,871,498 V1731A probably benign Het
Plxnb1 T A 9: 109,102,871 C488* probably null Het
Rgs7 T C 1: 175,079,554 I374V probably benign Het
Rin2 A T 2: 145,876,456 M574L probably benign Het
Rps18 A T 17: 33,952,418 D92E probably benign Het
Scrn1 T A 6: 54,520,806 I267L probably benign Het
Stard9 T C 2: 120,701,542 V67A probably benign Het
Syne1 T G 10: 5,367,616 M493L probably benign Het
Tbc1d2 G A 4: 46,614,207 R625C probably damaging Het
Tcerg1l A G 7: 138,394,180 S200P probably damaging Het
Tet3 A T 6: 83,369,057 V1331E probably benign Het
Ticrr A T 7: 79,695,549 I1721F possibly damaging Het
Tjp2 T C 19: 24,112,947 D577G probably damaging Het
Tmem2 T C 19: 21,801,879 V351A probably damaging Het
Tmem38b A G 4: 53,840,713 M43V probably benign Het
Trpv5 C A 6: 41,674,282 D277Y probably damaging Het
Tubb1 A C 2: 174,456,623 D67A probably damaging Het
Ubxn7 A G 16: 32,381,236 probably null Het
Ugp2 G A 11: 21,333,774 P98S probably benign Het
Vmn2r66 G T 7: 85,007,747 P150Q probably benign Het
Zbtb11 A T 16: 55,974,225 H55L possibly damaging Het
Other mutations in Trabd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01540:Trabd APN 15 89084795 missense probably benign 0.01
R0355:Trabd UTSW 15 89085613 missense possibly damaging 0.53
R0603:Trabd UTSW 15 89082726 missense probably damaging 1.00
R1806:Trabd UTSW 15 89085621 missense possibly damaging 0.96
R1883:Trabd UTSW 15 89081981 missense probably damaging 0.98
R2015:Trabd UTSW 15 89084726 missense possibly damaging 0.55
R4507:Trabd UTSW 15 89085630 missense probably damaging 0.97
R4653:Trabd UTSW 15 89085839 missense probably damaging 1.00
R4842:Trabd UTSW 15 89082712 missense probably benign 0.33
R5364:Trabd UTSW 15 89082804 splice site probably benign
R5561:Trabd UTSW 15 89081984 missense probably benign 0.28
R7378:Trabd UTSW 15 89085290 missense possibly damaging 0.56
R7843:Trabd UTSW 15 89081954 missense possibly damaging 0.94
R8157:Trabd UTSW 15 89085821 missense probably damaging 1.00
R8331:Trabd UTSW 15 89084928 missense probably damaging 0.99
R8353:Trabd UTSW 15 89085413 missense possibly damaging 0.69
R8443:Trabd UTSW 15 89085904 missense probably benign 0.41
R8453:Trabd UTSW 15 89085413 missense possibly damaging 0.69
R8739:Trabd UTSW 15 89084949 missense probably damaging 1.00
Z1177:Trabd UTSW 15 89076595 intron probably benign
Z1177:Trabd UTSW 15 89084936 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATCCAGGAGATCATGACGTGAGTG -3'
(R):5'- AGGTAGAGCAACAGCTTGCCAAAC -3'

Sequencing Primer
(F):5'- ATCATGACGTGAGTGCCTCC -3'
(R):5'- CAAACCCACCTGGGGTTAAGG -3'
Posted On2014-05-09