Incidental Mutation 'R1662:Vmn2r2'
| ID |
186823 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r2
|
| Ensembl Gene |
ENSMUSG00000043897 |
| Gene Name |
vomeronasal 2, receptor 2 |
| Synonyms |
|
| MMRRC Submission |
039698-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.093)
|
| Stock # |
R1662 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
64022699-64049349 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 64024551 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 677
(C677S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135110
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077958]
[ENSMUST00000177151]
|
| AlphaFold |
L7N2E9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077958
AA Change: C593S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000077109
Gene: ENSMUSG00000043897
AA Change: C593S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
416 |
4.5e-80 |
PFAM |
|
Pfam:NCD3G
|
458 |
511 |
8.3e-18 |
PFAM |
|
Pfam:7tm_3
|
542 |
779 |
1.3e-75 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177151
AA Change: C677S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000135110
Gene: ENSMUSG00000043897
AA Change: C677S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
500 |
1.6e-84 |
PFAM |
|
Pfam:NCD3G
|
542 |
595 |
2.6e-17 |
PFAM |
|
Pfam:7tm_3
|
628 |
862 |
1.9e-47 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 92.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5730409E04Rik |
T |
A |
4: 126,505,475 (GRCm39) |
M1K |
probably null |
Het |
| 5730507C01Rik |
A |
C |
12: 18,581,967 (GRCm39) |
R119S |
possibly damaging |
Het |
| Abca1 |
T |
A |
4: 53,090,251 (GRCm39) |
|
probably null |
Het |
| Aff1 |
G |
A |
5: 103,988,923 (GRCm39) |
G830D |
probably damaging |
Het |
| AI987944 |
T |
C |
7: 41,023,873 (GRCm39) |
T369A |
possibly damaging |
Het |
| Aoah |
A |
G |
13: 21,184,283 (GRCm39) |
|
probably null |
Het |
| Arhgap40 |
C |
G |
2: 158,381,190 (GRCm39) |
C349W |
probably damaging |
Het |
| Atic |
T |
A |
1: 71,615,286 (GRCm39) |
D438E |
probably benign |
Het |
| Barhl2 |
A |
T |
5: 106,601,365 (GRCm39) |
M338K |
probably benign |
Het |
| Btd |
T |
C |
14: 31,388,747 (GRCm39) |
V156A |
probably damaging |
Het |
| Catspere2 |
A |
G |
1: 177,874,552 (GRCm39) |
K140E |
unknown |
Het |
| Ccdc82 |
T |
C |
9: 13,262,397 (GRCm39) |
V319A |
probably damaging |
Het |
| Celsr1 |
G |
T |
15: 85,915,263 (GRCm39) |
N903K |
probably damaging |
Het |
| Cenpf |
T |
A |
1: 189,389,968 (GRCm39) |
N1288I |
probably damaging |
Het |
| Ciao1 |
G |
A |
2: 127,086,857 (GRCm39) |
T252I |
probably benign |
Het |
| Cma2 |
T |
C |
14: 56,210,573 (GRCm39) |
C87R |
probably damaging |
Het |
| Cops7a |
T |
A |
6: 124,939,401 (GRCm39) |
R83W |
probably damaging |
Het |
| Cxcr6 |
A |
T |
9: 123,639,613 (GRCm39) |
M205L |
possibly damaging |
Het |
| Dcc |
A |
G |
18: 71,553,409 (GRCm39) |
L749P |
probably benign |
Het |
| Dync1i2 |
C |
T |
2: 71,081,323 (GRCm39) |
T484I |
possibly damaging |
Het |
| Epas1 |
A |
T |
17: 87,136,455 (GRCm39) |
K742N |
probably damaging |
Het |
| Evc2 |
A |
G |
5: 37,506,094 (GRCm39) |
T138A |
probably benign |
Het |
| F5 |
T |
C |
1: 164,035,457 (GRCm39) |
I1877T |
probably damaging |
Het |
| Fat1 |
T |
G |
8: 45,406,201 (GRCm39) |
V984G |
probably benign |
Het |
| Fat4 |
T |
A |
3: 39,034,928 (GRCm39) |
V2860D |
probably damaging |
Het |
| Foxn4 |
C |
T |
5: 114,394,955 (GRCm39) |
R324Q |
probably benign |
Het |
| Gapdhs |
C |
T |
7: 30,436,427 (GRCm39) |
R120H |
probably damaging |
Het |
| Gcnt3 |
T |
C |
9: 69,941,659 (GRCm39) |
D303G |
probably benign |
Het |
| Gng11 |
A |
T |
6: 4,008,066 (GRCm39) |
Y43F |
probably benign |
Het |
| Hectd4 |
A |
C |
5: 121,455,308 (GRCm39) |
M651L |
probably benign |
Het |
| Ifngr2 |
T |
A |
16: 91,357,484 (GRCm39) |
Y200N |
probably benign |
Het |
| Iqgap3 |
T |
C |
3: 88,005,708 (GRCm39) |
V512A |
probably benign |
Het |
| Kdm2a |
A |
C |
19: 4,378,240 (GRCm39) |
D187E |
probably damaging |
Het |
| Klhl8 |
A |
G |
5: 104,019,911 (GRCm39) |
V370A |
probably damaging |
Het |
| Kmt2a |
G |
A |
9: 44,747,967 (GRCm39) |
|
probably benign |
Het |
| Krt12 |
C |
A |
11: 99,311,650 (GRCm39) |
V184F |
probably benign |
Het |
| Lrrc8c |
A |
T |
5: 105,754,623 (GRCm39) |
I133F |
probably benign |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Map1a |
C |
G |
2: 121,136,889 (GRCm39) |
S2568R |
possibly damaging |
Het |
| Mbnl1 |
C |
A |
3: 60,532,593 (GRCm39) |
Q301K |
probably damaging |
Het |
| Med12l |
A |
T |
3: 59,001,038 (GRCm39) |
K724N |
probably damaging |
Het |
| Mroh2a |
A |
C |
1: 88,169,340 (GRCm39) |
I672L |
probably benign |
Het |
| Mybph |
C |
T |
1: 134,121,374 (GRCm39) |
P45S |
probably benign |
Het |
| Myo15a |
T |
A |
11: 60,392,527 (GRCm39) |
S2157T |
probably damaging |
Het |
| Or14j2 |
G |
T |
17: 37,886,164 (GRCm39) |
T50K |
probably damaging |
Het |
| Or1ab2 |
T |
C |
8: 72,863,623 (GRCm39) |
V71A |
probably benign |
Het |
| Or2t35 |
T |
A |
14: 14,407,880 (GRCm38) |
Y217* |
probably null |
Het |
| Or5h25 |
T |
C |
16: 58,930,967 (GRCm39) |
E2G |
probably benign |
Het |
| Otogl |
A |
G |
10: 107,634,218 (GRCm39) |
I1419T |
possibly damaging |
Het |
| Ovol1 |
A |
T |
19: 5,601,667 (GRCm39) |
F118L |
probably damaging |
Het |
| Pak5 |
T |
C |
2: 135,958,680 (GRCm39) |
D136G |
probably damaging |
Het |
| Pik3r2 |
T |
C |
8: 71,223,250 (GRCm39) |
Y417C |
probably damaging |
Het |
| Ppp2r2a |
T |
C |
14: 67,254,052 (GRCm39) |
N372S |
probably benign |
Het |
| Prss30 |
G |
T |
17: 24,191,806 (GRCm39) |
N238K |
possibly damaging |
Het |
| Prss33 |
C |
A |
17: 24,053,785 (GRCm39) |
|
probably null |
Het |
| Ptpn4 |
T |
C |
1: 119,692,788 (GRCm39) |
E187G |
probably damaging |
Het |
| Ptprg |
A |
T |
14: 12,207,357 (GRCm38) |
N100I |
probably damaging |
Het |
| Rbpms2 |
T |
C |
9: 65,558,324 (GRCm39) |
V130A |
probably benign |
Het |
| Rdh7 |
A |
T |
10: 127,724,481 (GRCm39) |
M1K |
probably null |
Het |
| Rtp3 |
A |
C |
9: 110,815,751 (GRCm39) |
S205A |
probably benign |
Het |
| Ryr3 |
G |
T |
2: 112,539,618 (GRCm39) |
D3207E |
probably damaging |
Het |
| Scn9a |
T |
A |
2: 66,313,803 (GRCm39) |
T1972S |
probably benign |
Het |
| Scnn1b |
T |
C |
7: 121,501,551 (GRCm39) |
V122A |
probably benign |
Het |
| Slc15a4 |
A |
G |
5: 127,686,043 (GRCm39) |
L213S |
probably damaging |
Het |
| Slc27a5 |
T |
A |
7: 12,725,173 (GRCm39) |
I425F |
probably damaging |
Het |
| Spata31d1b |
A |
G |
13: 59,864,442 (GRCm39) |
D530G |
probably benign |
Het |
| Tcf25 |
T |
A |
8: 124,108,289 (GRCm39) |
S115T |
probably benign |
Het |
| Tet2 |
A |
G |
3: 133,172,613 (GRCm39) |
L1883P |
possibly damaging |
Het |
| Trim21 |
T |
A |
7: 102,211,105 (GRCm39) |
R205* |
probably null |
Het |
| Ttc23 |
G |
T |
7: 67,375,069 (GRCm39) |
|
probably null |
Het |
| Tut7 |
T |
C |
13: 59,947,717 (GRCm39) |
E466G |
possibly damaging |
Het |
| Unc13d |
T |
C |
11: 115,959,499 (GRCm39) |
K658R |
probably null |
Het |
| Vmn1r43 |
A |
G |
6: 89,846,572 (GRCm39) |
F305L |
possibly damaging |
Het |
| Wnt5a |
T |
C |
14: 28,240,300 (GRCm39) |
M150T |
probably benign |
Het |
| Ythdc1 |
G |
A |
5: 86,975,981 (GRCm39) |
|
probably null |
Het |
| Zdbf2 |
A |
T |
1: 63,343,408 (GRCm39) |
R596* |
probably null |
Het |
|
| Other mutations in Vmn2r2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00326:Vmn2r2
|
APN |
3 |
64,041,319 (GRCm39) |
splice site |
probably benign |
|
|
IGL00980:Vmn2r2
|
APN |
3 |
64,024,601 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01389:Vmn2r2
|
APN |
3 |
64,024,430 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01804:Vmn2r2
|
APN |
3 |
64,041,677 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02750:Vmn2r2
|
APN |
3 |
64,024,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02829:Vmn2r2
|
APN |
3 |
64,026,172 (GRCm39) |
splice site |
probably benign |
|
|
IGL03036:Vmn2r2
|
APN |
3 |
64,024,321 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03174:Vmn2r2
|
APN |
3 |
64,024,544 (GRCm39) |
nonsense |
probably null |
|
|
PIT4151001:Vmn2r2
|
UTSW |
3 |
64,024,334 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0029:Vmn2r2
|
UTSW |
3 |
64,024,365 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0310:Vmn2r2
|
UTSW |
3 |
64,042,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Vmn2r2
|
UTSW |
3 |
64,041,320 (GRCm39) |
splice site |
probably null |
|
|
R0637:Vmn2r2
|
UTSW |
3 |
64,033,999 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1626:Vmn2r2
|
UTSW |
3 |
64,041,921 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1710:Vmn2r2
|
UTSW |
3 |
64,024,820 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1797:Vmn2r2
|
UTSW |
3 |
64,042,128 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1862:Vmn2r2
|
UTSW |
3 |
64,041,942 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1971:Vmn2r2
|
UTSW |
3 |
64,034,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2051:Vmn2r2
|
UTSW |
3 |
64,024,766 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R2099:Vmn2r2
|
UTSW |
3 |
64,024,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Vmn2r2
|
UTSW |
3 |
64,023,930 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3078:Vmn2r2
|
UTSW |
3 |
64,042,053 (GRCm39) |
missense |
probably benign |
0.22 |
|
R3418:Vmn2r2
|
UTSW |
3 |
64,024,320 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3419:Vmn2r2
|
UTSW |
3 |
64,024,320 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3959:Vmn2r2
|
UTSW |
3 |
64,047,947 (GRCm39) |
missense |
probably benign |
|
|
R4230:Vmn2r2
|
UTSW |
3 |
64,041,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4258:Vmn2r2
|
UTSW |
3 |
64,042,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4810:Vmn2r2
|
UTSW |
3 |
64,044,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4822:Vmn2r2
|
UTSW |
3 |
64,041,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4919:Vmn2r2
|
UTSW |
3 |
64,024,578 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4925:Vmn2r2
|
UTSW |
3 |
64,044,892 (GRCm39) |
start codon destroyed |
probably null |
0.03 |
|
R4954:Vmn2r2
|
UTSW |
3 |
64,047,905 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5071:Vmn2r2
|
UTSW |
3 |
64,024,321 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5315:Vmn2r2
|
UTSW |
3 |
64,024,377 (GRCm39) |
missense |
probably benign |
0.37 |
|
R5450:Vmn2r2
|
UTSW |
3 |
64,034,011 (GRCm39) |
missense |
probably benign |
|
|
R5577:Vmn2r2
|
UTSW |
3 |
64,024,416 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5595:Vmn2r2
|
UTSW |
3 |
64,034,036 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5727:Vmn2r2
|
UTSW |
3 |
64,024,608 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5810:Vmn2r2
|
UTSW |
3 |
64,024,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5919:Vmn2r2
|
UTSW |
3 |
64,044,723 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6052:Vmn2r2
|
UTSW |
3 |
64,024,782 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6084:Vmn2r2
|
UTSW |
3 |
64,024,467 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6299:Vmn2r2
|
UTSW |
3 |
64,024,074 (GRCm39) |
nonsense |
probably null |
|
|
R6762:Vmn2r2
|
UTSW |
3 |
64,041,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6858:Vmn2r2
|
UTSW |
3 |
64,044,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6889:Vmn2r2
|
UTSW |
3 |
64,024,688 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6990:Vmn2r2
|
UTSW |
3 |
64,024,608 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7195:Vmn2r2
|
UTSW |
3 |
64,023,900 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7269:Vmn2r2
|
UTSW |
3 |
64,033,998 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7699:Vmn2r2
|
UTSW |
3 |
64,024,536 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7717:Vmn2r2
|
UTSW |
3 |
64,042,019 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7798:Vmn2r2
|
UTSW |
3 |
64,041,518 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7914:Vmn2r2
|
UTSW |
3 |
64,041,526 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7974:Vmn2r2
|
UTSW |
3 |
64,024,808 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8394:Vmn2r2
|
UTSW |
3 |
64,044,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8478:Vmn2r2
|
UTSW |
3 |
64,024,257 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8731:Vmn2r2
|
UTSW |
3 |
64,024,404 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9035:Vmn2r2
|
UTSW |
3 |
64,024,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9182:Vmn2r2
|
UTSW |
3 |
64,044,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Vmn2r2
|
UTSW |
3 |
64,034,021 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9266:Vmn2r2
|
UTSW |
3 |
64,024,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9427:Vmn2r2
|
UTSW |
3 |
64,041,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9659:Vmn2r2
|
UTSW |
3 |
64,041,942 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9666:Vmn2r2
|
UTSW |
3 |
64,023,870 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9771:Vmn2r2
|
UTSW |
3 |
64,042,079 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9788:Vmn2r2
|
UTSW |
3 |
64,041,942 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
X0024:Vmn2r2
|
UTSW |
3 |
64,044,707 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGCGAGCCACAAAAGTTGTAAG -3'
(R):5'- TTATGGAGAGGCACTGGGGTTCAC -3'
Sequencing Primer
(F):5'- CTTGAACATTCTTGGAGGCTC -3'
(R):5'- GCACTGGGGTTCACTCTTG -3'
|
| Posted On |
2014-05-09 |
Incidental Mutation