Incidental Mutation 'R1662:Ptprg'
ID 186873
Institutional Source Beutler Lab
Gene Symbol Ptprg
Ensembl Gene ENSMUSG00000021745
Gene Name protein tyrosine phosphatase receptor type G
Synonyms RPTPgamma, 5430405N12Rik
MMRRC Submission 039698-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1662 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 10227722-10916220 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 12207357 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 100 (N100I)
Ref Sequence ENSEMBL: ENSMUSP00000113679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022264] [ENSMUST00000119888] [ENSMUST00000142917]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000022264
AA Change: N875I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000022264
Gene: ENSMUSG00000021745
AA Change: N875I

DomainStartEndE-ValueType
Carb_anhydrase 60 321 6.38e-109 SMART
FN3 347 433 5.4e-7 SMART
low complexity region 474 484 N/A INTRINSIC
low complexity region 515 525 N/A INTRINSIC
coiled coil region 581 617 N/A INTRINSIC
transmembrane domain 734 756 N/A INTRINSIC
PTPc 844 1118 1.76e-136 SMART
PTPc 1146 1409 1.32e-85 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000119888
AA Change: N100I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113679
Gene: ENSMUSG00000021745
AA Change: N100I

DomainStartEndE-ValueType
PTPc 69 343 1.76e-136 SMART
PTPc 371 634 1.32e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000142917
SMART Domains Protein: ENSMUSP00000121268
Gene: ENSMUSG00000021745

DomainStartEndE-ValueType
Carb_anhydrase 60 260 1.6e-50 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223890
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730409E04Rik T A 4: 126,505,475 (GRCm39) M1K probably null Het
5730507C01Rik A C 12: 18,581,967 (GRCm39) R119S possibly damaging Het
Abca1 T A 4: 53,090,251 (GRCm39) probably null Het
Aff1 G A 5: 103,988,923 (GRCm39) G830D probably damaging Het
AI987944 T C 7: 41,023,873 (GRCm39) T369A possibly damaging Het
Aoah A G 13: 21,184,283 (GRCm39) probably null Het
Arhgap40 C G 2: 158,381,190 (GRCm39) C349W probably damaging Het
Atic T A 1: 71,615,286 (GRCm39) D438E probably benign Het
Barhl2 A T 5: 106,601,365 (GRCm39) M338K probably benign Het
Btd T C 14: 31,388,747 (GRCm39) V156A probably damaging Het
Catspere2 A G 1: 177,874,552 (GRCm39) K140E unknown Het
Ccdc82 T C 9: 13,262,397 (GRCm39) V319A probably damaging Het
Celsr1 G T 15: 85,915,263 (GRCm39) N903K probably damaging Het
Cenpf T A 1: 189,389,968 (GRCm39) N1288I probably damaging Het
Ciao1 G A 2: 127,086,857 (GRCm39) T252I probably benign Het
Cma2 T C 14: 56,210,573 (GRCm39) C87R probably damaging Het
Cops7a T A 6: 124,939,401 (GRCm39) R83W probably damaging Het
Cxcr6 A T 9: 123,639,613 (GRCm39) M205L possibly damaging Het
Dcc A G 18: 71,553,409 (GRCm39) L749P probably benign Het
Dync1i2 C T 2: 71,081,323 (GRCm39) T484I possibly damaging Het
Epas1 A T 17: 87,136,455 (GRCm39) K742N probably damaging Het
Evc2 A G 5: 37,506,094 (GRCm39) T138A probably benign Het
F5 T C 1: 164,035,457 (GRCm39) I1877T probably damaging Het
Fat1 T G 8: 45,406,201 (GRCm39) V984G probably benign Het
Fat4 T A 3: 39,034,928 (GRCm39) V2860D probably damaging Het
Foxn4 C T 5: 114,394,955 (GRCm39) R324Q probably benign Het
Gapdhs C T 7: 30,436,427 (GRCm39) R120H probably damaging Het
Gcnt3 T C 9: 69,941,659 (GRCm39) D303G probably benign Het
Gng11 A T 6: 4,008,066 (GRCm39) Y43F probably benign Het
Hectd4 A C 5: 121,455,308 (GRCm39) M651L probably benign Het
Ifngr2 T A 16: 91,357,484 (GRCm39) Y200N probably benign Het
Iqgap3 T C 3: 88,005,708 (GRCm39) V512A probably benign Het
Kdm2a A C 19: 4,378,240 (GRCm39) D187E probably damaging Het
Klhl8 A G 5: 104,019,911 (GRCm39) V370A probably damaging Het
Kmt2a G A 9: 44,747,967 (GRCm39) probably benign Het
Krt12 C A 11: 99,311,650 (GRCm39) V184F probably benign Het
Lrrc8c A T 5: 105,754,623 (GRCm39) I133F probably benign Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Map1a C G 2: 121,136,889 (GRCm39) S2568R possibly damaging Het
Mbnl1 C A 3: 60,532,593 (GRCm39) Q301K probably damaging Het
Med12l A T 3: 59,001,038 (GRCm39) K724N probably damaging Het
Mroh2a A C 1: 88,169,340 (GRCm39) I672L probably benign Het
Mybph C T 1: 134,121,374 (GRCm39) P45S probably benign Het
Myo15a T A 11: 60,392,527 (GRCm39) S2157T probably damaging Het
Or14j2 G T 17: 37,886,164 (GRCm39) T50K probably damaging Het
Or1ab2 T C 8: 72,863,623 (GRCm39) V71A probably benign Het
Or2t35 T A 14: 14,407,880 (GRCm38) Y217* probably null Het
Or5h25 T C 16: 58,930,967 (GRCm39) E2G probably benign Het
Otogl A G 10: 107,634,218 (GRCm39) I1419T possibly damaging Het
Ovol1 A T 19: 5,601,667 (GRCm39) F118L probably damaging Het
Pak5 T C 2: 135,958,680 (GRCm39) D136G probably damaging Het
Pik3r2 T C 8: 71,223,250 (GRCm39) Y417C probably damaging Het
Ppp2r2a T C 14: 67,254,052 (GRCm39) N372S probably benign Het
Prss30 G T 17: 24,191,806 (GRCm39) N238K possibly damaging Het
Prss33 C A 17: 24,053,785 (GRCm39) probably null Het
Ptpn4 T C 1: 119,692,788 (GRCm39) E187G probably damaging Het
Rbpms2 T C 9: 65,558,324 (GRCm39) V130A probably benign Het
Rdh7 A T 10: 127,724,481 (GRCm39) M1K probably null Het
Rtp3 A C 9: 110,815,751 (GRCm39) S205A probably benign Het
Ryr3 G T 2: 112,539,618 (GRCm39) D3207E probably damaging Het
Scn9a T A 2: 66,313,803 (GRCm39) T1972S probably benign Het
Scnn1b T C 7: 121,501,551 (GRCm39) V122A probably benign Het
Slc15a4 A G 5: 127,686,043 (GRCm39) L213S probably damaging Het
Slc27a5 T A 7: 12,725,173 (GRCm39) I425F probably damaging Het
Spata31d1b A G 13: 59,864,442 (GRCm39) D530G probably benign Het
Tcf25 T A 8: 124,108,289 (GRCm39) S115T probably benign Het
Tet2 A G 3: 133,172,613 (GRCm39) L1883P possibly damaging Het
Trim21 T A 7: 102,211,105 (GRCm39) R205* probably null Het
Ttc23 G T 7: 67,375,069 (GRCm39) probably null Het
Tut7 T C 13: 59,947,717 (GRCm39) E466G possibly damaging Het
Unc13d T C 11: 115,959,499 (GRCm39) K658R probably null Het
Vmn1r43 A G 6: 89,846,572 (GRCm39) F305L possibly damaging Het
Vmn2r2 A T 3: 64,024,551 (GRCm39) C677S probably benign Het
Wnt5a T C 14: 28,240,300 (GRCm39) M150T probably benign Het
Ythdc1 G A 5: 86,975,981 (GRCm39) probably null Het
Zdbf2 A T 1: 63,343,408 (GRCm39) R596* probably null Het
Other mutations in Ptprg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Ptprg APN 14 12,215,992 (GRCm38) missense probably damaging 1.00
IGL00484:Ptprg APN 14 12,215,220 (GRCm38) missense probably damaging 0.99
IGL00847:Ptprg APN 14 12,215,265 (GRCm38) missense probably damaging 1.00
IGL01089:Ptprg APN 14 12,215,286 (GRCm38) missense probably damaging 0.97
IGL01382:Ptprg APN 14 12,237,797 (GRCm38) missense probably benign 0.16
IGL01470:Ptprg APN 14 12,213,702 (GRCm38) nonsense probably null
IGL01762:Ptprg APN 14 12,037,386 (GRCm38) missense probably benign 0.00
IGL01886:Ptprg APN 14 12,179,280 (GRCm38) missense probably benign 0.22
IGL01963:Ptprg APN 14 12,220,661 (GRCm38) missense probably damaging 1.00
IGL02015:Ptprg APN 14 12,237,782 (GRCm38) missense possibly damaging 0.46
IGL02086:Ptprg APN 14 12,110,080 (GRCm38) nonsense probably null
IGL02197:Ptprg APN 14 12,220,613 (GRCm38) missense probably damaging 0.98
IGL02341:Ptprg APN 14 12,154,360 (GRCm38) missense probably benign 0.00
IGL02732:Ptprg APN 14 12,225,617 (GRCm38) critical splice donor site probably null
IGL03011:Ptprg APN 14 12,219,029 (GRCm38) missense probably damaging 1.00
IGL03261:Ptprg APN 14 12,225,552 (GRCm38) missense probably damaging 0.99
R0038:Ptprg UTSW 14 12,213,710 (GRCm38) missense probably damaging 1.00
R0383:Ptprg UTSW 14 12,219,024 (GRCm38) missense possibly damaging 0.93
R0433:Ptprg UTSW 14 12,220,620 (GRCm38) missense probably damaging 1.00
R0488:Ptprg UTSW 14 12,220,653 (GRCm38) missense probably damaging 1.00
R0503:Ptprg UTSW 14 12,237,138 (GRCm38) missense possibly damaging 0.89
R0520:Ptprg UTSW 14 12,199,783 (GRCm38) missense possibly damaging 0.92
R0570:Ptprg UTSW 14 12,215,896 (GRCm38) missense probably damaging 1.00
R0606:Ptprg UTSW 14 12,154,131 (GRCm38) missense probably benign
R1086:Ptprg UTSW 14 11,952,706 (GRCm38) splice site probably benign
R1468:Ptprg UTSW 14 12,190,767 (GRCm38) missense probably benign 0.02
R1468:Ptprg UTSW 14 12,190,767 (GRCm38) missense probably benign 0.02
R1519:Ptprg UTSW 14 12,220,596 (GRCm38) missense probably damaging 1.00
R1714:Ptprg UTSW 14 12,213,697 (GRCm38) missense probably damaging 1.00
R1716:Ptprg UTSW 14 12,154,360 (GRCm38) missense probably benign 0.00
R1797:Ptprg UTSW 14 12,199,743 (GRCm38) missense probably damaging 1.00
R1803:Ptprg UTSW 14 12,091,410 (GRCm38) splice site probably null
R2104:Ptprg UTSW 14 11,952,897 (GRCm38) critical splice donor site probably null
R2125:Ptprg UTSW 14 12,179,283 (GRCm38) missense possibly damaging 0.74
R2126:Ptprg UTSW 14 12,154,355 (GRCm38) missense probably benign
R2133:Ptprg UTSW 14 12,211,637 (GRCm38) missense probably damaging 1.00
R2471:Ptprg UTSW 14 12,210,327 (GRCm38) missense probably damaging 1.00
R2571:Ptprg UTSW 14 12,122,135 (GRCm38) missense probably benign
R3821:Ptprg UTSW 14 12,226,375 (GRCm38) missense probably benign 0.00
R4196:Ptprg UTSW 14 12,122,002 (GRCm38) missense possibly damaging 0.51
R4392:Ptprg UTSW 14 12,142,467 (GRCm38) missense possibly damaging 0.80
R4665:Ptprg UTSW 14 12,215,288 (GRCm38) missense possibly damaging 0.90
R4730:Ptprg UTSW 14 12,213,713 (GRCm38) missense probably damaging 1.00
R4737:Ptprg UTSW 14 12,226,314 (GRCm38) missense probably damaging 1.00
R4764:Ptprg UTSW 14 12,122,068 (GRCm38) missense probably benign 0.01
R4801:Ptprg UTSW 14 11,554,233 (GRCm38) utr 5 prime probably benign
R4825:Ptprg UTSW 14 12,220,654 (GRCm38) missense probably damaging 1.00
R4960:Ptprg UTSW 14 12,237,837 (GRCm38) missense probably benign 0.07
R4972:Ptprg UTSW 14 12,226,427 (GRCm38) missense possibly damaging 0.94
R4980:Ptprg UTSW 14 12,154,421 (GRCm38) missense probably benign 0.16
R5004:Ptprg UTSW 14 12,220,667 (GRCm38) missense probably damaging 1.00
R5058:Ptprg UTSW 14 12,037,387 (GRCm38) missense possibly damaging 0.82
R5182:Ptprg UTSW 14 12,154,174 (GRCm38) missense probably benign
R5258:Ptprg UTSW 14 12,142,431 (GRCm38) missense probably benign 0.11
R5338:Ptprg UTSW 14 12,154,111 (GRCm38) missense probably benign
R5353:Ptprg UTSW 14 11,554,235 (GRCm38) utr 5 prime probably benign
R5373:Ptprg UTSW 14 12,213,665 (GRCm38) missense probably benign 0.00
R5387:Ptprg UTSW 14 12,153,873 (GRCm38) missense probably damaging 1.00
R5616:Ptprg UTSW 14 12,122,120 (GRCm38) missense probably benign
R5623:Ptprg UTSW 14 12,153,857 (GRCm38) missense probably damaging 1.00
R5976:Ptprg UTSW 14 12,211,625 (GRCm38) missense probably damaging 0.96
R6027:Ptprg UTSW 14 12,220,613 (GRCm38) missense possibly damaging 0.87
R6091:Ptprg UTSW 14 12,215,979 (GRCm38) missense probably damaging 1.00
R6184:Ptprg UTSW 14 12,153,943 (GRCm38) missense probably benign 0.00
R6234:Ptprg UTSW 14 12,213,747 (GRCm38) missense probably damaging 1.00
R6318:Ptprg UTSW 14 12,237,118 (GRCm38) missense probably damaging 1.00
R6324:Ptprg UTSW 14 12,226,314 (GRCm38) missense probably damaging 1.00
R6334:Ptprg UTSW 14 12,166,832 (GRCm38) missense probably damaging 1.00
R6646:Ptprg UTSW 14 11,962,714 (GRCm38) missense probably damaging 1.00
R6647:Ptprg UTSW 14 11,962,714 (GRCm38) missense probably damaging 1.00
R6992:Ptprg UTSW 14 11,962,602 (GRCm38) missense probably damaging 1.00
R7088:Ptprg UTSW 14 12,207,365 (GRCm38) missense probably damaging 1.00
R7250:Ptprg UTSW 14 12,166,767 (GRCm38) missense probably benign 0.18
R7342:Ptprg UTSW 14 12,237,151 (GRCm38) missense possibly damaging 0.90
R7358:Ptprg UTSW 14 12,154,198 (GRCm38) missense possibly damaging 0.59
R7410:Ptprg UTSW 14 11,962,657 (GRCm38) missense probably damaging 1.00
R7448:Ptprg UTSW 14 12,142,461 (GRCm38) missense probably benign 0.12
R7514:Ptprg UTSW 14 12,179,342 (GRCm38) missense possibly damaging 0.86
R7523:Ptprg UTSW 14 12,237,130 (GRCm38) missense probably damaging 0.97
R7672:Ptprg UTSW 14 12,211,668 (GRCm38) missense probably benign 0.04
R7709:Ptprg UTSW 14 12,226,452 (GRCm38) missense probably damaging 1.00
R7720:Ptprg UTSW 14 12,211,703 (GRCm38) missense probably benign 0.31
R8860:Ptprg UTSW 14 12,213,685 (GRCm38) missense probably damaging 1.00
R8992:Ptprg UTSW 14 12,154,170 (GRCm38) missense probably benign 0.00
R9054:Ptprg UTSW 14 12,213,638 (GRCm38) missense possibly damaging 0.58
R9587:Ptprg UTSW 14 12,215,992 (GRCm38) missense probably damaging 1.00
R9621:Ptprg UTSW 14 12,237,809 (GRCm38) missense probably benign
R9625:Ptprg UTSW 14 12,152,027 (GRCm38) missense probably damaging 1.00
R9773:Ptprg UTSW 14 12,199,806 (GRCm38) missense probably damaging 0.97
X0020:Ptprg UTSW 14 12,110,070 (GRCm38) frame shift probably null
X0027:Ptprg UTSW 14 12,110,070 (GRCm38) frame shift probably null
Predicted Primers PCR Primer
(F):5'- CAGCCACAGTGTGGTCTTAGAGAAC -3'
(R):5'- CAGGCAGTCGCTAGGAACATACATC -3'

Sequencing Primer
(F):5'- CAGTGTGGTCTTAGAGAACTACTATC -3'
(R):5'- GTCGCTAGGAACATACATCCTCTG -3'
Posted On 2014-05-09