Incidental Mutation 'R1663:Zfp605'
ID 186921
Institutional Source Beutler Lab
Gene Symbol Zfp605
Ensembl Gene ENSMUSG00000023284
Gene Name zinc finger protein 605
Synonyms A830023I12Rik
MMRRC Submission 039699-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R1663 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 110257958-110277660 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 110275451 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 190 (V190I)
Ref Sequence ENSEMBL: ENSMUSP00000108147 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086686] [ENSMUST00000112528] [ENSMUST00000147631]
AlphaFold E9QAH2
Predicted Effect probably benign
Transcript: ENSMUST00000086686
AA Change: V190I

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000083891
Gene: ENSMUSG00000023284
AA Change: V190I

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
low complexity region 147 159 N/A INTRINSIC
ZnF_C2H2 200 222 1.36e-2 SMART
ZnF_C2H2 228 250 4.38e1 SMART
ZnF_C2H2 305 327 1.18e-2 SMART
ZnF_C2H2 333 355 5.14e-3 SMART
ZnF_C2H2 361 383 9.73e-4 SMART
ZnF_C2H2 389 411 4.99e1 SMART
ZnF_C2H2 443 465 5.4e1 SMART
ZnF_C2H2 471 493 1.3e-4 SMART
ZnF_C2H2 499 521 4.24e-4 SMART
ZnF_C2H2 527 549 1.95e-3 SMART
ZnF_C2H2 555 577 2.09e-3 SMART
ZnF_C2H2 583 605 1.2e-3 SMART
ZnF_C2H2 611 633 1.79e-2 SMART
ZnF_C2H2 639 661 2.53e-2 SMART
ZnF_C2H2 667 689 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112528
AA Change: V190I

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000108147
Gene: ENSMUSG00000023284
AA Change: V190I

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
low complexity region 147 159 N/A INTRINSIC
ZnF_C2H2 200 222 1.36e-2 SMART
ZnF_C2H2 228 250 4.38e1 SMART
ZnF_C2H2 305 327 1.18e-2 SMART
ZnF_C2H2 333 355 5.14e-3 SMART
ZnF_C2H2 361 383 9.73e-4 SMART
ZnF_C2H2 389 411 4.99e1 SMART
ZnF_C2H2 443 465 5.4e1 SMART
ZnF_C2H2 471 493 1.3e-4 SMART
ZnF_C2H2 499 521 4.24e-4 SMART
ZnF_C2H2 527 549 1.95e-3 SMART
ZnF_C2H2 555 577 2.09e-3 SMART
ZnF_C2H2 583 605 1.2e-3 SMART
ZnF_C2H2 611 633 1.79e-2 SMART
ZnF_C2H2 639 661 2.53e-2 SMART
ZnF_C2H2 667 689 2.09e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144089
Predicted Effect probably benign
Transcript: ENSMUST00000147631
SMART Domains Protein: ENSMUSP00000122236
Gene: ENSMUSG00000023284

DomainStartEndE-ValueType
KRAB 6 66 3.75e-28 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 T A 8: 25,177,949 (GRCm39) T11S probably benign Het
Adgb T C 10: 10,215,419 (GRCm39) M1529V possibly damaging Het
Ankrd36 T A 11: 5,570,126 (GRCm39) D531E possibly damaging Het
Ankzf1 C T 1: 75,172,914 (GRCm39) P337S probably damaging Het
Apc A G 18: 34,401,378 (GRCm39) I55V probably damaging Het
Aplnr A G 2: 84,967,038 (GRCm39) D21G possibly damaging Het
Apol10b A T 15: 77,472,914 (GRCm39) F47I probably damaging Het
Arhgef5 G A 6: 43,253,899 (GRCm39) A1131T probably damaging Het
Arrb2 A T 11: 70,328,429 (GRCm39) Q83L probably damaging Het
Atf7ip A G 6: 136,580,322 (GRCm39) Q1082R possibly damaging Het
Atl2 A G 17: 80,172,140 (GRCm39) S28P probably damaging Het
Brd7 T C 8: 89,084,651 (GRCm39) K89E possibly damaging Het
Cc2d1b A G 4: 108,480,744 (GRCm39) T55A probably damaging Het
Ccdc18 A G 5: 108,363,956 (GRCm39) E1217G probably damaging Het
Cdc42ep4 A T 11: 113,620,277 (GRCm39) M38K probably damaging Het
Cldn14 A G 16: 93,716,166 (GRCm39) S227P probably damaging Het
Clspn T A 4: 126,459,768 (GRCm39) C332S probably benign Het
Col5a1 T C 2: 27,841,488 (GRCm39) S370P unknown Het
Comp T C 8: 70,826,250 (GRCm39) L10P possibly damaging Het
Dcc A T 18: 71,959,123 (GRCm39) N216K probably damaging Het
Dcstamp C T 15: 39,618,340 (GRCm39) Q250* probably null Het
Drd5 T C 5: 38,478,198 (GRCm39) F397S probably benign Het
Dst T C 1: 34,202,466 (GRCm39) S265P probably damaging Het
Dync2i1 T C 12: 116,193,230 (GRCm39) Q574R probably benign Het
Enam A T 5: 88,651,853 (GRCm39) S1046C probably damaging Het
Eno3 T C 11: 70,553,100 (GRCm39) probably null Het
Fam13a G A 6: 58,931,357 (GRCm39) R408* probably null Het
Gipc2 T A 3: 151,799,801 (GRCm39) M310L probably benign Het
Gm14496 T C 2: 181,639,230 (GRCm39) V440A probably benign Het
Gzmg A T 14: 56,394,265 (GRCm39) C210S probably damaging Het
Helb G T 10: 119,941,338 (GRCm39) A450E probably damaging Het
Hepacam2 A T 6: 3,483,439 (GRCm39) I190N possibly damaging Het
Hk3 A T 13: 55,154,388 (GRCm39) S773T probably benign Het
Hnrnpc A G 14: 52,312,852 (GRCm39) S221P probably damaging Het
Ifna9 T C 4: 88,510,220 (GRCm39) T135A probably benign Het
Igfn1 C T 1: 135,896,046 (GRCm39) G1507R probably benign Het
Kank3 A G 17: 34,037,349 (GRCm39) T218A probably benign Het
Kcp G T 6: 29,498,964 (GRCm39) R337S possibly damaging Het
Krt74 A T 15: 101,665,109 (GRCm39) noncoding transcript Het
Lrp1 A T 10: 127,392,790 (GRCm39) D2758E probably damaging Het
Ly75 T C 2: 60,144,578 (GRCm39) E1295G probably damaging Het
Mccc1 C A 3: 36,033,082 (GRCm39) W354L probably damaging Het
Mmp1a C T 9: 7,465,657 (GRCm39) T198M probably benign Het
Mtmr2 C T 9: 13,714,797 (GRCm39) T519I probably damaging Het
Nbea A G 3: 55,553,407 (GRCm39) S2632P possibly damaging Het
Nbn T A 4: 15,970,903 (GRCm39) D295E probably benign Het
Ndufb8 T C 19: 44,538,820 (GRCm39) Y167C probably damaging Het
Nisch A G 14: 30,913,478 (GRCm39) probably benign Het
Notch3 C T 17: 32,375,093 (GRCm39) G407D probably damaging Het
Nucb1 A G 7: 45,148,288 (GRCm39) F175S probably damaging Het
Or1l8 T G 2: 36,817,346 (GRCm39) Y260S probably damaging Het
Or6c6c G A 10: 129,541,160 (GRCm39) V138M probably benign Het
Or7g12 T A 9: 18,900,006 (GRCm39) C241S probably damaging Het
Or8b44 T G 9: 38,410,868 (GRCm39) I301R unknown Het
Pip5k1c T C 10: 81,148,349 (GRCm39) V425A probably damaging Het
Pnisr T A 4: 21,873,857 (GRCm39) probably benign Het
Prkag1 A G 15: 98,713,776 (GRCm39) V18A probably damaging Het
Rad50 T C 11: 53,559,050 (GRCm39) N1063S probably benign Het
Rnf170 C T 8: 26,619,171 (GRCm39) H132Y probably damaging Het
Rnf213 A G 11: 119,328,498 (GRCm39) D1977G probably benign Het
Sema3a G A 5: 13,607,092 (GRCm39) probably null Het
Setx T A 2: 29,016,917 (GRCm39) C7S probably damaging Het
Slc23a2 A G 2: 131,907,384 (GRCm39) I417T probably damaging Het
Spink6 T G 18: 44,204,588 (GRCm39) F18C unknown Het
Sptbn1 T C 11: 30,070,783 (GRCm39) Q1538R possibly damaging Het
Strn3 A G 12: 51,699,609 (GRCm39) Y188H probably damaging Het
Tecpr1 C A 5: 144,134,762 (GRCm39) K1040N probably benign Het
Tll1 T A 8: 64,470,720 (GRCm39) Y901F probably benign Het
Tmem81 C T 1: 132,435,635 (GRCm39) A147V probably benign Het
Tnpo3 T C 6: 29,565,758 (GRCm39) D532G probably benign Het
Vmn2r19 T A 6: 123,313,411 (GRCm39) I827N probably benign Het
Wdr35 A G 12: 9,070,000 (GRCm39) K857R probably benign Het
Zfp110 A G 7: 12,582,569 (GRCm39) T406A probably benign Het
Zfp52 T C 17: 21,782,084 (GRCm39) L644P possibly damaging Het
Zfp964 A G 8: 70,116,733 (GRCm39) probably null Het
Zmynd8 A G 2: 165,649,805 (GRCm39) S779P probably benign Het
Zswim5 T A 4: 116,844,092 (GRCm39) N1043K probably damaging Het
Other mutations in Zfp605
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02388:Zfp605 APN 5 110,275,506 (GRCm39) missense possibly damaging 0.95
R0010:Zfp605 UTSW 5 110,275,400 (GRCm39) missense probably benign 0.03
R0357:Zfp605 UTSW 5 110,272,245 (GRCm39) missense probably benign
R0383:Zfp605 UTSW 5 110,276,720 (GRCm39) missense probably damaging 1.00
R1017:Zfp605 UTSW 5 110,275,860 (GRCm39) missense probably benign 0.42
R1688:Zfp605 UTSW 5 110,276,907 (GRCm39) missense possibly damaging 0.83
R1752:Zfp605 UTSW 5 110,271,639 (GRCm39) missense probably damaging 1.00
R1994:Zfp605 UTSW 5 110,275,418 (GRCm39) missense probably damaging 1.00
R2173:Zfp605 UTSW 5 110,275,323 (GRCm39) missense probably benign 0.00
R3740:Zfp605 UTSW 5 110,276,564 (GRCm39) missense probably damaging 1.00
R3742:Zfp605 UTSW 5 110,276,564 (GRCm39) missense probably damaging 1.00
R3981:Zfp605 UTSW 5 110,275,604 (GRCm39) missense probably damaging 1.00
R4095:Zfp605 UTSW 5 110,275,602 (GRCm39) missense probably damaging 1.00
R4349:Zfp605 UTSW 5 110,276,552 (GRCm39) missense probably damaging 1.00
R4669:Zfp605 UTSW 5 110,275,227 (GRCm39) missense possibly damaging 0.94
R4914:Zfp605 UTSW 5 110,275,567 (GRCm39) nonsense probably null
R4994:Zfp605 UTSW 5 110,275,352 (GRCm39) missense probably damaging 1.00
R6672:Zfp605 UTSW 5 110,275,863 (GRCm39) missense probably damaging 1.00
R6814:Zfp605 UTSW 5 110,275,311 (GRCm39) missense probably benign 0.00
R6872:Zfp605 UTSW 5 110,275,311 (GRCm39) missense probably benign 0.00
R7251:Zfp605 UTSW 5 110,275,826 (GRCm39) missense probably damaging 1.00
R7395:Zfp605 UTSW 5 110,259,885 (GRCm39) start gained probably benign
R7560:Zfp605 UTSW 5 110,275,157 (GRCm39) nonsense probably null
R7623:Zfp605 UTSW 5 110,275,386 (GRCm39) missense probably benign 0.03
R7965:Zfp605 UTSW 5 110,275,316 (GRCm39) missense probably benign 0.00
R7999:Zfp605 UTSW 5 110,276,300 (GRCm39) missense probably damaging 1.00
R8307:Zfp605 UTSW 5 110,276,063 (GRCm39) missense probably damaging 1.00
R8355:Zfp605 UTSW 5 110,259,848 (GRCm39) start gained probably benign
R8455:Zfp605 UTSW 5 110,259,848 (GRCm39) start gained probably benign
X0063:Zfp605 UTSW 5 110,271,714 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGCTTCAAGATGAACAAGACAAGCCTA -3'
(R):5'- ACGTTCTGGTTCTTCTCCTGAGTGA -3'

Sequencing Primer
(F):5'- TGTCACTCAAGCATGAACTCTG -3'
(R):5'- AGTCTTTTGGTGGATAGCAAGC -3'
Posted On 2014-05-09