Incidental Mutation 'R1665:Slit3'
| ID |
187126 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Slit3
|
| Ensembl Gene |
ENSMUSG00000056427 |
| Gene Name |
slit guidance ligand 3 |
| Synonyms |
Slit1, b2b2362.1Clo |
| MMRRC Submission |
039701-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.871)
|
| Stock # |
R1665 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
35012283-35599334 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 35125733 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 137
(R137S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000066857
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069837]
|
| AlphaFold |
Q9WVB4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000069837
AA Change: R137S
PolyPhen 2
Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000066857
Gene: ENSMUSG00000056427
AA Change: R137S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
23 |
N/A |
INTRINSIC |
|
LRRNT
|
33 |
65 |
2.12e-8 |
SMART |
|
LRR
|
59 |
83 |
1.37e2 |
SMART |
|
LRR_TYP
|
84 |
107 |
1.12e-3 |
SMART |
|
LRR_TYP
|
108 |
131 |
7.78e-3 |
SMART |
|
LRR_TYP
|
132 |
155 |
5.42e-2 |
SMART |
|
LRR
|
156 |
179 |
5.88e0 |
SMART |
|
LRR
|
180 |
203 |
7.55e-1 |
SMART |
|
LRRCT
|
215 |
264 |
1.33e-6 |
SMART |
|
LRRNT
|
279 |
311 |
6.79e-7 |
SMART |
|
LRR
|
305 |
329 |
1.16e2 |
SMART |
|
LRR
|
330 |
353 |
1.26e1 |
SMART |
|
LRR_TYP
|
354 |
377 |
2.79e-4 |
SMART |
|
LRR
|
378 |
401 |
4.05e-1 |
SMART |
|
LRR
|
402 |
425 |
4.05e-1 |
SMART |
|
LRRCT
|
437 |
486 |
7.75e-8 |
SMART |
|
LRRNT
|
504 |
536 |
1.95e-7 |
SMART |
|
LRR_TYP
|
556 |
579 |
7.49e-5 |
SMART |
|
LRR
|
581 |
603 |
6.41e1 |
SMART |
|
LRR_TYP
|
604 |
627 |
2.53e-2 |
SMART |
|
LRR
|
628 |
651 |
1.76e-1 |
SMART |
|
LRRCT
|
663 |
712 |
2.52e-7 |
SMART |
|
LRRNT
|
724 |
756 |
3e-8 |
SMART |
|
LRR
|
774 |
797 |
2.14e0 |
SMART |
|
LRR_TYP
|
798 |
821 |
2.95e-3 |
SMART |
|
LRR_TYP
|
822 |
845 |
2.43e-4 |
SMART |
|
LRRCT
|
857 |
906 |
1.12e-13 |
SMART |
|
EGF
|
919 |
953 |
6.86e-4 |
SMART |
|
EGF
|
958 |
994 |
8.84e-7 |
SMART |
|
EGF
|
999 |
1032 |
1.13e-4 |
SMART |
|
EGF
|
1037 |
1072 |
2.3e-5 |
SMART |
|
EGF_CA
|
1074 |
1110 |
5.92e-8 |
SMART |
|
EGF
|
1122 |
1155 |
3.79e-6 |
SMART |
|
LamG
|
1178 |
1314 |
3.16e-34 |
SMART |
|
EGF
|
1331 |
1365 |
2.19e-2 |
SMART |
|
EGF
|
1371 |
1403 |
1.13e-4 |
SMART |
|
EGF
|
1411 |
1444 |
5.57e-4 |
SMART |
|
CT
|
1455 |
1523 |
4.56e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153098
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156571
|
| Meta Mutation Damage Score |
0.1460 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
100% (87/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca3 |
G |
A |
17: 24,596,816 (GRCm39) |
G423E |
probably damaging |
Het |
| Acox3 |
A |
T |
5: 35,760,371 (GRCm39) |
H429L |
probably damaging |
Het |
| Afg1l |
T |
A |
10: 42,302,573 (GRCm39) |
K142N |
probably damaging |
Het |
| Aldh1a7 |
T |
C |
19: 20,704,825 (GRCm39) |
I18V |
probably benign |
Het |
| Angel2 |
T |
C |
1: 190,669,664 (GRCm39) |
Y115H |
probably damaging |
Het |
| Bsg |
T |
G |
10: 79,547,352 (GRCm39) |
N261K |
probably damaging |
Het |
| C2cd2l |
A |
T |
9: 44,228,072 (GRCm39) |
V83E |
probably benign |
Het |
| Caml |
C |
A |
13: 55,779,784 (GRCm39) |
L286I |
probably benign |
Het |
| Ccdc125 |
A |
G |
13: 100,830,081 (GRCm39) |
I284V |
probably benign |
Het |
| Ces2a |
G |
A |
8: 105,464,187 (GRCm39) |
|
probably benign |
Het |
| Cfap61 |
T |
C |
2: 145,877,239 (GRCm39) |
|
probably null |
Het |
| Creg2 |
C |
T |
1: 39,662,372 (GRCm39) |
W253* |
probably null |
Het |
| Csmd3 |
T |
C |
15: 47,560,185 (GRCm39) |
T2293A |
probably damaging |
Het |
| Cttnbp2 |
A |
T |
6: 18,434,982 (GRCm39) |
I292K |
probably benign |
Het |
| Dab2ip |
T |
A |
2: 35,610,290 (GRCm39) |
M770K |
probably damaging |
Het |
| Dct |
T |
A |
14: 118,271,663 (GRCm39) |
D389V |
probably damaging |
Het |
| Dnah17 |
A |
T |
11: 118,012,321 (GRCm39) |
|
probably benign |
Het |
| Dnah6 |
T |
C |
6: 73,101,761 (GRCm39) |
E1921G |
probably benign |
Het |
| Efcab3 |
A |
G |
11: 104,611,940 (GRCm39) |
K594R |
probably benign |
Het |
| Ehmt1 |
A |
G |
2: 24,767,476 (GRCm39) |
S272P |
probably damaging |
Het |
| Ero1b |
T |
C |
13: 12,594,142 (GRCm39) |
|
probably null |
Het |
| Fnip2 |
A |
G |
3: 79,422,456 (GRCm39) |
F108S |
probably benign |
Het |
| Foxb1 |
G |
A |
9: 69,667,104 (GRCm39) |
A142V |
probably damaging |
Het |
| Fras1 |
A |
T |
5: 96,746,768 (GRCm39) |
S613C |
probably damaging |
Het |
| Gm7276 |
C |
A |
18: 77,273,266 (GRCm39) |
|
probably benign |
Het |
| Gnb4 |
A |
C |
3: 32,644,188 (GRCm39) |
L152* |
probably null |
Het |
| H1f7 |
G |
T |
15: 98,154,796 (GRCm39) |
Q118K |
probably benign |
Het |
| Hdac7 |
A |
G |
15: 97,704,406 (GRCm39) |
L119P |
probably damaging |
Het |
| Hsd17b4 |
G |
A |
18: 50,293,282 (GRCm39) |
E274K |
probably benign |
Het |
| Htr4 |
T |
C |
18: 62,545,305 (GRCm39) |
I30T |
probably damaging |
Het |
| Ikzf2 |
T |
A |
1: 69,577,973 (GRCm39) |
Y512F |
probably damaging |
Het |
| Itga10 |
C |
T |
3: 96,559,054 (GRCm39) |
|
probably benign |
Het |
| Klhl22 |
C |
A |
16: 17,594,352 (GRCm39) |
D160E |
probably benign |
Het |
| Kpna6 |
T |
A |
4: 129,551,264 (GRCm39) |
R80S |
probably benign |
Het |
| Lclat1 |
A |
G |
17: 73,494,999 (GRCm39) |
E142G |
probably damaging |
Het |
| Lrig3 |
T |
C |
10: 125,833,570 (GRCm39) |
Y349H |
probably benign |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Map1b |
T |
A |
13: 99,568,437 (GRCm39) |
N1428I |
unknown |
Het |
| Map3k19 |
T |
A |
1: 127,745,393 (GRCm39) |
T1354S |
possibly damaging |
Het |
| Med13l |
T |
A |
5: 118,887,813 (GRCm39) |
W1696R |
probably damaging |
Het |
| Mfn1 |
T |
G |
3: 32,588,471 (GRCm39) |
V66G |
probably benign |
Het |
| Mllt10 |
A |
T |
2: 18,213,601 (GRCm39) |
Q459L |
possibly damaging |
Het |
| Morc2a |
G |
A |
11: 3,625,885 (GRCm39) |
V162M |
probably benign |
Het |
| Muc15 |
C |
T |
2: 110,564,243 (GRCm39) |
Q260* |
probably null |
Het |
| Nfkb1 |
T |
C |
3: 135,300,718 (GRCm39) |
H616R |
probably damaging |
Het |
| Nr2c1 |
T |
A |
10: 94,024,045 (GRCm39) |
W417R |
probably damaging |
Het |
| Or10a2 |
T |
C |
7: 106,673,481 (GRCm39) |
S149P |
probably damaging |
Het |
| Or13a26 |
G |
T |
7: 140,284,707 (GRCm39) |
C181F |
probably damaging |
Het |
| Or4g16 |
T |
C |
2: 111,137,116 (GRCm39) |
C189R |
probably damaging |
Het |
| Or4k39 |
T |
C |
2: 111,239,098 (GRCm39) |
Y113H |
probably damaging |
Het |
| Or5b121 |
A |
T |
19: 13,507,202 (GRCm39) |
H99L |
probably damaging |
Het |
| Or8c10 |
C |
T |
9: 38,278,862 (GRCm39) |
H7Y |
probably benign |
Het |
| Pde10a |
A |
G |
17: 9,117,702 (GRCm39) |
D26G |
probably damaging |
Het |
| Pi15 |
G |
T |
1: 17,691,726 (GRCm39) |
C176F |
probably damaging |
Het |
| Pou2f2 |
T |
A |
7: 24,792,149 (GRCm39) |
T569S |
possibly damaging |
Het |
| Prf1 |
A |
C |
10: 61,138,666 (GRCm39) |
E208A |
probably benign |
Het |
| Prkd1 |
G |
A |
12: 50,441,709 (GRCm39) |
H277Y |
probably damaging |
Het |
| Rc3h1 |
T |
A |
1: 160,786,993 (GRCm39) |
V796E |
probably benign |
Het |
| Rgl1 |
T |
C |
1: 152,409,326 (GRCm39) |
Y503C |
probably damaging |
Het |
| Ripk3 |
T |
A |
14: 56,023,808 (GRCm39) |
H1L |
probably benign |
Het |
| Ryr1 |
C |
T |
7: 28,735,503 (GRCm39) |
D4064N |
probably damaging |
Het |
| Sec63 |
T |
A |
10: 42,674,724 (GRCm39) |
|
probably null |
Het |
| Slco1a4 |
T |
G |
6: 141,785,303 (GRCm39) |
M96L |
possibly damaging |
Het |
| Smad1 |
T |
C |
8: 80,098,658 (GRCm39) |
E52G |
probably damaging |
Het |
| Srd5a2 |
A |
T |
17: 74,328,476 (GRCm39) |
W201R |
probably damaging |
Het |
| Steap1 |
A |
T |
5: 5,786,498 (GRCm39) |
L313Q |
probably damaging |
Het |
| Syt2 |
C |
A |
1: 134,675,358 (GRCm39) |
A403D |
probably damaging |
Het |
| Tax1bp1 |
T |
A |
6: 52,713,897 (GRCm39) |
S225R |
probably benign |
Het |
| Thap3 |
C |
T |
4: 152,070,161 (GRCm39) |
V78M |
probably damaging |
Het |
| Thoc5 |
A |
G |
11: 4,869,792 (GRCm39) |
K446R |
probably benign |
Het |
| Timmdc1 |
A |
C |
16: 38,331,079 (GRCm39) |
|
probably null |
Het |
| Tm6sf2 |
G |
T |
8: 70,531,580 (GRCm39) |
|
probably benign |
Het |
| Tmem126b |
G |
T |
7: 90,125,179 (GRCm39) |
A2E |
probably damaging |
Het |
| Trim9 |
T |
A |
12: 70,301,887 (GRCm39) |
R584W |
probably damaging |
Het |
| Ttn |
C |
A |
2: 76,661,200 (GRCm39) |
|
probably benign |
Het |
| Vmn1r25 |
A |
T |
6: 57,955,446 (GRCm39) |
I281N |
probably damaging |
Het |
| Wdr59 |
A |
G |
8: 112,205,994 (GRCm39) |
F553S |
probably damaging |
Het |
| Zc3h4 |
A |
G |
7: 16,163,505 (GRCm39) |
M575V |
unknown |
Het |
| Zfp53 |
A |
G |
17: 21,729,766 (GRCm39) |
T600A |
probably damaging |
Het |
| Zic5 |
A |
G |
14: 122,696,939 (GRCm39) |
S559P |
unknown |
Het |
|
| Other mutations in Slit3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00731:Slit3
|
APN |
11 |
35,512,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Slit3
|
APN |
11 |
35,501,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01612:Slit3
|
APN |
11 |
35,591,211 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02145:Slit3
|
APN |
11 |
35,520,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02146:Slit3
|
APN |
11 |
35,125,675 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02430:Slit3
|
APN |
11 |
35,068,601 (GRCm39) |
splice site |
probably null |
|
|
IGL02528:Slit3
|
APN |
11 |
35,469,801 (GRCm39) |
missense |
probably benign |
|
|
IGL02530:Slit3
|
APN |
11 |
35,598,969 (GRCm39) |
makesense |
probably null |
|
|
IGL02640:Slit3
|
APN |
11 |
35,591,172 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02819:Slit3
|
APN |
11 |
35,062,417 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02839:Slit3
|
APN |
11 |
35,539,874 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL03150:Slit3
|
APN |
11 |
35,399,084 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03161:Slit3
|
APN |
11 |
35,591,241 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03336:Slit3
|
APN |
11 |
35,560,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Bloated
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
Quellung
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02988:Slit3
|
UTSW |
11 |
35,598,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4791001:Slit3
|
UTSW |
11 |
35,552,072 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0334:Slit3
|
UTSW |
11 |
35,469,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0385:Slit3
|
UTSW |
11 |
35,591,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0840:Slit3
|
UTSW |
11 |
35,514,263 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Slit3
|
UTSW |
11 |
35,012,462 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1364:Slit3
|
UTSW |
11 |
35,560,934 (GRCm39) |
missense |
probably benign |
|
|
R1476:Slit3
|
UTSW |
11 |
35,577,126 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1508:Slit3
|
UTSW |
11 |
35,461,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1692:Slit3
|
UTSW |
11 |
35,550,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1696:Slit3
|
UTSW |
11 |
35,566,750 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1727:Slit3
|
UTSW |
11 |
35,520,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1752:Slit3
|
UTSW |
11 |
35,455,480 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1970:Slit3
|
UTSW |
11 |
35,521,668 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2077:Slit3
|
UTSW |
11 |
35,435,575 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2126:Slit3
|
UTSW |
11 |
35,579,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Slit3
|
UTSW |
11 |
35,503,088 (GRCm39) |
splice site |
probably null |
|
|
R2162:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R2873:Slit3
|
UTSW |
11 |
35,435,620 (GRCm39) |
nonsense |
probably null |
|
|
R3813:Slit3
|
UTSW |
11 |
35,566,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3831:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3832:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3833:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3839:Slit3
|
UTSW |
11 |
35,399,064 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4152:Slit3
|
UTSW |
11 |
35,589,147 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4387:Slit3
|
UTSW |
11 |
35,574,875 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4795:Slit3
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4910:Slit3
|
UTSW |
11 |
35,523,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4933:Slit3
|
UTSW |
11 |
35,579,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5106:Slit3
|
UTSW |
11 |
35,503,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5218:Slit3
|
UTSW |
11 |
35,575,002 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5338:Slit3
|
UTSW |
11 |
35,512,975 (GRCm39) |
missense |
probably benign |
|
|
R5354:Slit3
|
UTSW |
11 |
35,566,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5436:Slit3
|
UTSW |
11 |
35,598,738 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5896:Slit3
|
UTSW |
11 |
35,598,932 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5933:Slit3
|
UTSW |
11 |
35,520,578 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5963:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5964:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6125:Slit3
|
UTSW |
11 |
35,461,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6153:Slit3
|
UTSW |
11 |
35,591,310 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6484:Slit3
|
UTSW |
11 |
35,552,125 (GRCm39) |
missense |
probably benign |
|
|
R6526:Slit3
|
UTSW |
11 |
35,552,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6797:Slit3
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6887:Slit3
|
UTSW |
11 |
35,435,633 (GRCm39) |
splice site |
probably null |
|
|
R7067:Slit3
|
UTSW |
11 |
35,399,057 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7150:Slit3
|
UTSW |
11 |
35,461,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7228:Slit3
|
UTSW |
11 |
35,490,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7232:Slit3
|
UTSW |
11 |
35,501,516 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7418:Slit3
|
UTSW |
11 |
35,577,255 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7545:Slit3
|
UTSW |
11 |
35,591,139 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7727:Slit3
|
UTSW |
11 |
35,574,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Slit3
|
UTSW |
11 |
35,591,235 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8177:Slit3
|
UTSW |
11 |
35,469,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8179:Slit3
|
UTSW |
11 |
35,554,903 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8416:Slit3
|
UTSW |
11 |
35,399,062 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8417:Slit3
|
UTSW |
11 |
35,501,438 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8476:Slit3
|
UTSW |
11 |
35,520,596 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8785:Slit3
|
UTSW |
11 |
35,560,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8955:Slit3
|
UTSW |
11 |
35,589,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9040:Slit3
|
UTSW |
11 |
35,594,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9068:Slit3
|
UTSW |
11 |
35,574,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Slit3
|
UTSW |
11 |
35,012,463 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9266:Slit3
|
UTSW |
11 |
35,598,808 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9539:Slit3
|
UTSW |
11 |
35,589,155 (GRCm39) |
nonsense |
probably null |
|
|
R9636:Slit3
|
UTSW |
11 |
35,594,088 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0028:Slit3
|
UTSW |
11 |
35,455,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Slit3
|
UTSW |
11 |
35,598,751 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCCCAGACTTGTGACCAAGGAGAG -3'
(R):5'- TCATGTAGTAAGTCCAGGCCGGAG -3'
Sequencing Primer
(F):5'- CCATGCTAGAAGATCTAGAATGTCTC -3'
(R):5'- TTTCTAAGGGGAAAAGCCATCC -3'
|
| Posted On |
2014-05-09 |
Incidental Mutation