Incidental Mutation 'R1667:Map3k2'
ID 187324
Institutional Source Beutler Lab
Gene Symbol Map3k2
Ensembl Gene ENSMUSG00000024383
Gene Name mitogen-activated protein kinase kinase kinase 2
Synonyms 9630061B06Rik, MEK kinase 2, Mekk2
MMRRC Submission 039703-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1667 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 32296142-32369804 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 32336845 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000094326 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096575]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000096575
SMART Domains Protein: ENSMUSP00000094326
Gene: ENSMUSG00000024383

DomainStartEndE-ValueType
PB1 43 122 6.96e-20 SMART
low complexity region 203 219 N/A INTRINSIC
low complexity region 300 315 N/A INTRINSIC
low complexity region 322 334 N/A INTRINSIC
S_TKc 356 616 2.86e-92 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.0%
Validation Efficiency 99% (76/77)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene are grossly normal and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra1 G A 7: 139,425,564 (GRCm39) A26T possibly damaging Het
Adgrg3 T A 8: 95,760,001 (GRCm39) Y73* probably null Het
Alk A T 17: 72,218,562 (GRCm39) V761E probably damaging Het
Ankrd13a T C 5: 114,924,794 (GRCm39) V93A possibly damaging Het
Anks1b T C 10: 90,347,046 (GRCm39) probably null Het
Arb2a T A 13: 77,907,635 (GRCm39) M1K probably null Het
Ascl1 T C 10: 87,328,655 (GRCm39) N99S probably benign Het
Atm A T 9: 53,412,232 (GRCm39) L972Q probably damaging Het
Atp2c1 A T 9: 105,309,996 (GRCm39) L566Q probably null Het
Bank1 T A 3: 135,799,057 (GRCm39) Y629F probably damaging Het
Bod1l G T 5: 41,974,118 (GRCm39) L2399I probably benign Het
Bub1b G A 2: 118,471,670 (GRCm39) G1010D probably benign Het
Ces1b G A 8: 93,783,532 (GRCm39) H563Y possibly damaging Het
Cfap70 T C 14: 20,454,225 (GRCm39) E853G probably benign Het
Cfh T C 1: 140,033,261 (GRCm39) E779G probably benign Het
Cox7c A G 13: 86,194,003 (GRCm39) S7P probably benign Het
Cyp2c67 A G 19: 39,632,034 (GRCm39) probably null Het
Dhx30 G T 9: 109,914,513 (GRCm39) L995I possibly damaging Het
Dhx30 G C 9: 109,914,514 (GRCm39) N957K possibly damaging Het
Dsc3 T C 18: 20,124,617 (GRCm39) T36A possibly damaging Het
Dstyk A G 1: 132,384,657 (GRCm39) D717G probably damaging Het
Dusp10 A G 1: 183,769,055 (GRCm39) D7G probably damaging Het
E230001N04Rik T G 17: 28,742,935 (GRCm39) noncoding transcript Het
Ece2 T C 16: 20,456,588 (GRCm39) S330P possibly damaging Het
Frmd5 ATAGTGGAATTGTTCAAACTC ATAGTGGAATTGTTCAAACTCTAGTGGAATTGTTCAAACTC 2: 121,379,211 (GRCm39) probably null Het
Gata3 T C 2: 9,882,360 (GRCm39) H14R possibly damaging Het
Ggta1 T A 2: 35,304,295 (GRCm39) I75F possibly damaging Het
Hcn1 A T 13: 117,739,609 (GRCm39) I124F unknown Het
Herpud1 A C 8: 95,115,994 (GRCm39) D53A probably damaging Het
Inhba T A 13: 16,201,209 (GRCm39) L257Q possibly damaging Het
Itga10 C T 3: 96,559,054 (GRCm39) probably benign Het
Jmy T A 13: 93,634,878 (GRCm39) S313C probably damaging Het
Lpo G A 11: 87,698,067 (GRCm39) probably benign Het
Lsg1 T C 16: 30,390,170 (GRCm39) E315G probably damaging Het
Lsm14a T A 7: 34,065,079 (GRCm39) T167S possibly damaging Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Mapk12 A T 15: 89,024,344 (GRCm39) M81K probably damaging Het
Matn2 T A 15: 34,378,878 (GRCm39) C305S probably damaging Het
Mgam T C 6: 40,653,978 (GRCm39) Y844H possibly damaging Het
Mgat5b A G 11: 116,838,203 (GRCm39) R281G probably benign Het
Mon1b T G 8: 114,368,589 (GRCm39) C497G probably damaging Het
Mybbp1a A T 11: 72,336,043 (GRCm39) H452L probably benign Het
Mybl2 A G 2: 162,917,616 (GRCm39) T41A probably damaging Het
Ncoa5 A G 2: 164,843,623 (GRCm39) V540A probably damaging Het
Nup93 T A 8: 95,019,315 (GRCm39) V47E possibly damaging Het
Or10a4 A T 7: 106,696,977 (GRCm39) M102L probably benign Het
Or5j3 A G 2: 86,129,080 (GRCm39) M307V probably null Het
Orc6 T A 8: 86,031,914 (GRCm39) C100S possibly damaging Het
Otogl G T 10: 107,649,826 (GRCm39) Y1176* probably null Het
Patj A T 4: 98,301,264 (GRCm39) D183V probably damaging Het
Pik3r3 A G 4: 116,079,514 (GRCm39) T4A probably damaging Het
Pla2g4d G A 2: 120,100,631 (GRCm39) probably benign Het
Pla2r1 A G 2: 60,250,601 (GRCm39) I1407T probably benign Het
Pramel13 A T 4: 144,119,606 (GRCm39) C320* probably null Het
Prex2 A T 1: 11,256,981 (GRCm39) H1231L probably benign Het
Prkca A G 11: 107,874,772 (GRCm39) V390A probably damaging Het
Psmd13 T A 7: 140,470,522 (GRCm39) W255R probably damaging Het
Rec8 T A 14: 55,856,253 (GRCm39) N37K probably damaging Het
Rnf207 C T 4: 152,397,672 (GRCm39) E361K probably benign Het
Serpina3f T A 12: 104,183,699 (GRCm39) L187Q probably damaging Het
Skint11 A T 4: 114,051,978 (GRCm39) T109S probably damaging Het
Slc7a8 A G 14: 54,962,306 (GRCm39) S443P probably damaging Het
Slc8b1 T A 5: 120,659,147 (GRCm39) F197Y probably benign Het
Sox2 T C 3: 34,704,568 (GRCm39) Y2H probably damaging Het
Speg T A 1: 75,387,193 (GRCm39) probably benign Het
Tlr3 T C 8: 45,853,874 (GRCm39) N149D probably benign Het
Trim60 A C 8: 65,454,116 (GRCm39) D44E probably benign Het
Ugt1a7c A G 1: 88,023,657 (GRCm39) Y272C probably damaging Het
Vmn1r4 T A 6: 56,933,738 (GRCm39) Y81N probably damaging Het
Vmn2r73 A T 7: 85,506,889 (GRCm39) C808S probably benign Het
Ythdf3 T C 3: 16,259,056 (GRCm39) I412T possibly damaging Het
Zfp672 T C 11: 58,206,921 (GRCm39) T467A possibly damaging Het
Zfp985 A T 4: 147,668,407 (GRCm39) Q425L possibly damaging Het
Other mutations in Map3k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00770:Map3k2 APN 18 32,361,292 (GRCm39) missense probably benign 0.00
IGL00774:Map3k2 APN 18 32,361,292 (GRCm39) missense probably benign 0.00
IGL01993:Map3k2 APN 18 32,359,684 (GRCm39) nonsense probably null
IGL02043:Map3k2 APN 18 32,340,587 (GRCm39) missense probably damaging 1.00
IGL02314:Map3k2 APN 18 32,351,553 (GRCm39) splice site probably benign
IGL02441:Map3k2 APN 18 32,333,099 (GRCm39) splice site probably benign
IGL03350:Map3k2 APN 18 32,345,201 (GRCm39) missense probably damaging 0.98
IGL03097:Map3k2 UTSW 18 32,333,070 (GRCm39) missense probably benign 0.01
PIT4434001:Map3k2 UTSW 18 32,343,088 (GRCm39) missense possibly damaging 0.51
R0086:Map3k2 UTSW 18 32,351,521 (GRCm39) missense probably damaging 1.00
R0374:Map3k2 UTSW 18 32,345,226 (GRCm39) splice site probably null
R0445:Map3k2 UTSW 18 32,350,263 (GRCm39) missense probably damaging 0.96
R1158:Map3k2 UTSW 18 32,350,211 (GRCm39) missense probably benign 0.00
R1415:Map3k2 UTSW 18 32,361,330 (GRCm39) missense possibly damaging 0.82
R1926:Map3k2 UTSW 18 32,336,163 (GRCm39) missense probably damaging 0.99
R3795:Map3k2 UTSW 18 32,359,701 (GRCm39) missense probably benign 0.00
R4607:Map3k2 UTSW 18 32,333,030 (GRCm39) missense probably damaging 1.00
R4793:Map3k2 UTSW 18 32,361,203 (GRCm39) missense probably damaging 1.00
R5332:Map3k2 UTSW 18 32,340,509 (GRCm39) missense probably damaging 0.98
R5492:Map3k2 UTSW 18 32,361,189 (GRCm39) missense probably damaging 1.00
R6008:Map3k2 UTSW 18 32,336,104 (GRCm39) missense probably damaging 1.00
R6317:Map3k2 UTSW 18 32,336,086 (GRCm39) missense probably damaging 1.00
R6356:Map3k2 UTSW 18 32,345,023 (GRCm39) missense probably damaging 1.00
R6841:Map3k2 UTSW 18 32,359,682 (GRCm39) missense probably benign 0.12
R6928:Map3k2 UTSW 18 32,340,593 (GRCm39) critical splice donor site probably null
R7475:Map3k2 UTSW 18 32,333,015 (GRCm39) missense possibly damaging 0.61
R7696:Map3k2 UTSW 18 32,353,647 (GRCm39) missense probably benign 0.00
R8774:Map3k2 UTSW 18 32,345,117 (GRCm39) missense probably damaging 1.00
R8774-TAIL:Map3k2 UTSW 18 32,345,117 (GRCm39) missense probably damaging 1.00
R9103:Map3k2 UTSW 18 32,353,625 (GRCm39) missense possibly damaging 0.91
R9282:Map3k2 UTSW 18 32,342,805 (GRCm39) missense probably damaging 0.99
R9800:Map3k2 UTSW 18 32,333,069 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- CACCTGATGTGCTGCTGTCTTACTG -3'
(R):5'- CAGAAGCGTCTAGCCCACTCATTTC -3'

Sequencing Primer
(F):5'- agtcatcttcctgctctcatc -3'
(R):5'- CCAAGTGGCTAAAGCATATAACTG -3'
Posted On 2014-05-09