Mutagenetix > Incidental Mutation

Incidental Mutation 'R1671:Tg'

187641

Institutional Source

Beutler Lab

Gene Symbol

Ensembl Gene

ENSMUSG00000053469

Gene Name

thyroglobulin

Synonyms

Tgn

MMRRC Submission

039707-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.128) question?

Stock #

R1671 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

66670753-66850721 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 66692387 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 1146 (C1146S)

Ref Sequence

ENSEMBL: ENSMUSP00000070239 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065916]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000065916
AA Change: C1146S

PolyPhen 2 Score 0.892 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000070239
Gene: ENSMUSG00000053469
AA Change: C1146S

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
TY	50	97	5.9e-16	SMART
TY	118	165	5.59e-17	SMART
Pfam:Thyroglobulin_1	174	252	4e-9	PFAM
TY	317	363	4.36e-19	SMART
low complexity region	495	504	N/A	INTRINSIC
TY	617	662	3.58e-15	SMART
TY	684	730	1.47e-16	SMART
TY	880	926	1.51e-4	SMART
TY	1029	1078	1.21e-12	SMART
TY	1106	1150	7.56e-5	SMART
TY	1167	1215	7.26e-16	SMART
low complexity region	1244	1255	N/A	INTRINSIC
Pfam:GCC2_GCC3	1464	1509	2.7e-16	PFAM
TY	1519	1568	9.81e-13	SMART
Pfam:COesterase	2181	2717	8.4e-140	PFAM

Meta Mutation Damage Score

0.3083

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.6%
20x: 93.3%

Validation Efficiency

100% (70/70)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930578I06Rik	A	C	14: 63,973,188 (GRCm38)	L197R	probably benign	Het
Arglu1	A	G	8: 8,683,896 (GRCm38)	V140A	possibly damaging	Het
Arhgef28	T	C	13: 97,931,034 (GRCm38)	E1461G	possibly damaging	Het
Best3	A	T	10: 117,024,668 (GRCm38)	D611V	possibly damaging	Het
C130026I21Rik	C	T	1: 85,257,385 (GRCm38)		probably null	Het
Cenpf	T	C	1: 189,679,144 (GRCm38)		probably null	Het
Cenpj	A	C	14: 56,565,045 (GRCm38)	M21R	probably damaging	Het
Cltc	A	T	11: 86,732,595 (GRCm38)	H201Q	possibly damaging	Het
Col28a1	A	T	6: 8,083,773 (GRCm38)	N561K	possibly damaging	Het
Cyp2c70	G	A	19: 40,153,637 (GRCm38)	P470L	probably damaging	Het
Cyp4f14	G	A	17: 32,916,909 (GRCm38)		probably benign	Het
Ddi1	A	T	9: 6,266,225 (GRCm38)	V48D	possibly damaging	Het
Dnah11	A	C	12: 117,916,788 (GRCm38)	Y3866D	probably damaging	Het
Dnah9	A	G	11: 65,927,963 (GRCm38)	V3183A	probably damaging	Het
Elmo1	T	A	13: 20,287,884 (GRCm38)		probably benign	Het
Fap	T	A	2: 62,553,835 (GRCm38)	Y9F	possibly damaging	Het
Fbxo15	T	A	18: 84,959,106 (GRCm38)	S93T	possibly damaging	Het
Gal3st2	C	T	1: 93,873,678 (GRCm38)	R19C	probably damaging	Het
Gm6970	C	A	19: 47,170,855 (GRCm38)	V94L	possibly damaging	Het
Gmnn	A	T	13: 24,752,071 (GRCm38)	*207R	probably null	Het
Gucy1a1	A	C	3: 82,106,222 (GRCm38)	I371S	probably damaging	Het
Igsf10	G	T	3: 59,328,500 (GRCm38)	S1420*	probably null	Het
Itih5	G	T	2: 10,186,971 (GRCm38)	V106L	probably benign	Het
Itsn1	T	A	16: 91,812,150 (GRCm38)	I201K	probably damaging	Het
Kirrel	C	T	3: 87,089,151 (GRCm38)	M380I	probably null	Het
Lars2	C	T	9: 123,418,279 (GRCm38)	T283I	probably benign	Het
Loxhd1	T	C	18: 77,404,802 (GRCm38)	I1313T	probably damaging	Het
Mamdc4	T	A	2: 25,568,223 (GRCm38)	R368*	probably null	Het
Mdga1	A	T	17: 29,850,629 (GRCm38)	Y422N	probably damaging	Het
Mro	A	T	18: 73,870,055 (GRCm38)		probably benign	Het
Mroh2b	T	C	15: 4,951,294 (GRCm38)		probably null	Het
Nlrp1b	C	A	11: 71,201,259 (GRCm38)	V14L	probably benign	Het
Nos3	A	G	5: 24,383,840 (GRCm38)	D1157G	probably damaging	Het
Nrxn2	C	A	19: 6,473,750 (GRCm38)	R598S	probably damaging	Het
Olfr332	A	T	11: 58,490,609 (GRCm38)	W49R	possibly damaging	Het
Olfr629	C	A	7: 103,740,410 (GRCm38)	A277S	possibly damaging	Het
Olfr728	T	C	14: 50,139,833 (GRCm38)	K269E	probably damaging	Het
Olfr888	A	G	9: 38,109,132 (GRCm38)	M144V	probably benign	Het
Otog	A	T	7: 46,261,786 (GRCm38)	D687V	probably damaging	Het
Pcsk5	C	T	19: 17,454,868 (GRCm38)	C1461Y	probably damaging	Het
Raet1d	A	G	10: 22,362,715 (GRCm38)	M1V	probably null	Het
Rnf6	A	T	5: 146,211,188 (GRCm38)	L340*	probably null	Het
Rsl1d1	T	C	16: 11,201,381 (GRCm38)	T99A	probably damaging	Het
Sbno1	A	T	5: 124,392,067 (GRCm38)		probably null	Het
Sipa1l1	A	G	12: 82,397,461 (GRCm38)	Y982C	probably damaging	Het
Sorbs3	G	T	14: 70,191,466 (GRCm38)	R417S	possibly damaging	Het
Sorl1	A	G	9: 41,974,000 (GRCm38)	C2102R	probably damaging	Het
Sptbn1	T	A	11: 30,142,245 (GRCm38)	I494F	possibly damaging	Het
Tank	T	A	2: 61,649,753 (GRCm38)	V211E	probably damaging	Het
Tbcd	T	A	11: 121,597,294 (GRCm38)	D840E	probably benign	Het
Tiam2	A	T	17: 3,506,834 (GRCm38)	E110V	probably damaging	Het
Tle4	A	T	19: 14,453,739 (GRCm38)	W560R	probably damaging	Het
Triml2	G	A	8: 43,183,743 (GRCm38)	R76H	possibly damaging	Het
Ttn	T	C	2: 76,711,620 (GRCm38)	E25347G	probably damaging	Het
Ube2e2	A	G	14: 18,586,889 (GRCm38)	L124P	probably damaging	Het
Vmn2r81	A	G	10: 79,267,431 (GRCm38)	K153E	probably benign	Het
Wnt16	A	T	6: 22,298,179 (GRCm38)	Y348F	probably damaging	Het
Xpo6	A	G	7: 126,108,543 (GRCm38)	V897A	possibly damaging	Het
Zbtb26	T	C	2: 37,436,365 (GRCm38)	T220A	probably benign	Het
Zik1	A	T	7: 10,490,748 (GRCm38)	S141T	probably damaging	Het
Zkscan3	A	G	13: 21,396,135 (GRCm38)	Y128H	possibly damaging	Het

Other mutations in Tg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Tg	APN	15	66,847,166 (GRCm38)	missense	probably damaging	1.00
IGL00230:Tg	APN	15	66,827,290 (GRCm38)	missense	probably benign	0.00
IGL00324:Tg	APN	15	66,693,424 (GRCm38)	missense	probably benign
IGL00428:Tg	APN	15	66,773,424 (GRCm38)	missense	probably benign	0.33
IGL00703:Tg	APN	15	66,696,489 (GRCm38)	missense	probably benign	0.34
IGL00808:Tg	APN	15	66,683,813 (GRCm38)	missense	probably damaging	1.00
IGL00833:Tg	APN	15	66,688,801 (GRCm38)	missense	probably benign	0.34
IGL00899:Tg	APN	15	66,674,073 (GRCm38)	critical splice donor site	probably null
IGL00921:Tg	APN	15	66,764,453 (GRCm38)	missense	probably benign	0.28
IGL00975:Tg	APN	15	66,681,882 (GRCm38)	missense	probably benign
IGL01288:Tg	APN	15	66,736,276 (GRCm38)	missense	possibly damaging	0.81
IGL01397:Tg	APN	15	66,696,092 (GRCm38)	splice site	probably benign
IGL01634:Tg	APN	15	66,729,566 (GRCm38)	missense	probably benign	0.34
IGL01646:Tg	APN	15	66,678,087 (GRCm38)	missense	probably damaging	1.00
IGL01704:Tg	APN	15	66,671,351 (GRCm38)	missense	probably damaging	0.98
IGL01958:Tg	APN	15	66,759,486 (GRCm38)	missense	probably benign	0.06
IGL02093:Tg	APN	15	66,692,374 (GRCm38)	missense	possibly damaging	0.83
IGL02113:Tg	APN	15	66,705,330 (GRCm38)	missense	probably benign	0.08
IGL02138:Tg	APN	15	66,717,233 (GRCm38)	missense	probably benign	0.01
IGL02156:Tg	APN	15	66,705,348 (GRCm38)	missense	probably benign	0.19
IGL02169:Tg	APN	15	66,757,943 (GRCm38)	missense	probably benign	0.04
IGL02342:Tg	APN	15	66,764,291 (GRCm38)	missense	probably benign
IGL02434:Tg	APN	15	66,764,342 (GRCm38)	missense	probably damaging	0.97
IGL02506:Tg	APN	15	66,741,594 (GRCm38)	missense	possibly damaging	0.71
IGL02513:Tg	APN	15	66,705,274 (GRCm38)	missense	probably benign
IGL02549:Tg	APN	15	66,839,361 (GRCm38)	missense	probably damaging	1.00
IGL02669:Tg	APN	15	66,748,726 (GRCm38)	splice site	probably benign
IGL02756:Tg	APN	15	66,734,586 (GRCm38)	missense	probably benign
IGL02800:Tg	APN	15	66,757,886 (GRCm38)	missense	probably damaging	1.00
IGL02828:Tg	APN	15	66,682,394 (GRCm38)	missense	probably damaging	1.00
IGL02927:Tg	APN	15	66,678,093 (GRCm38)	missense	probably damaging	1.00
IGL03061:Tg	APN	15	66,671,405 (GRCm38)	missense	probably damaging	1.00
IGL03105:Tg	APN	15	66,715,106 (GRCm38)	missense	probably benign	0.01
IGL03160:Tg	APN	15	66,839,303 (GRCm38)	nonsense	probably null
IGL03242:Tg	APN	15	66,683,798 (GRCm38)	missense	probably damaging	0.99
Also_ran	UTSW	15	66,678,839 (GRCm38)	missense	probably damaging	1.00
bedraggled	UTSW	15	66,740,714 (GRCm38)	missense	probably damaging	1.00
foster	UTSW	15	66,693,260 (GRCm38)	nonsense	probably null
hognose	UTSW	15	66,717,208 (GRCm38)	missense	probably damaging	0.99
ito	UTSW	15	66,766,162 (GRCm38)	nonsense	probably null
ito2	UTSW	15	66,671,396 (GRCm38)	missense	probably damaging	1.00
ito3	UTSW	15	66,773,474 (GRCm38)	missense	probably damaging	1.00
ito4	UTSW	15	66,696,520 (GRCm38)	missense	possibly damaging	0.47
Papua	UTSW	15	66,674,050 (GRCm38)	missense	probably damaging	1.00
Pipistrella	UTSW	15	66,696,135 (GRCm38)	missense	probably damaging	1.00
pluribus	UTSW	15	66,715,163 (GRCm38)	missense	probably damaging	0.98
samarai	UTSW	15	66,758,006 (GRCm38)	critical splice donor site	probably null
sariba	UTSW	15	66,694,870 (GRCm38)	missense	probably benign	0.01
ticker	UTSW	15	66,827,382 (GRCm38)	nonsense	probably null
Vampire	UTSW	15	66,682,827 (GRCm38)	missense	probably damaging	1.00
IGL03134:Tg	UTSW	15	66,740,718 (GRCm38)	missense	probably damaging	1.00
P0019:Tg	UTSW	15	66,688,863 (GRCm38)	missense	probably benign	0.01
R0121:Tg	UTSW	15	66,740,781 (GRCm38)	missense	probably benign	0.04
R0135:Tg	UTSW	15	66,694,870 (GRCm38)	missense	probably benign	0.01
R0227:Tg	UTSW	15	66,698,446 (GRCm38)	missense	possibly damaging	0.84
R0448:Tg	UTSW	15	66,764,442 (GRCm38)	missense	probably damaging	1.00
R0453:Tg	UTSW	15	66,828,533 (GRCm38)	missense	probably benign	0.09
R0504:Tg	UTSW	15	66,682,404 (GRCm38)	missense	probably damaging	0.97
R0543:Tg	UTSW	15	66,729,597 (GRCm38)	missense	probably benign	0.13
R0638:Tg	UTSW	15	66,717,208 (GRCm38)	missense	probably damaging	0.99
R0639:Tg	UTSW	15	66,741,484 (GRCm38)	critical splice acceptor site	probably null
R0646:Tg	UTSW	15	66,729,626 (GRCm38)	missense	probably damaging	0.99
R0666:Tg	UTSW	15	66,737,521 (GRCm38)	missense	probably benign
R0673:Tg	UTSW	15	66,741,484 (GRCm38)	critical splice acceptor site	probably null
R0689:Tg	UTSW	15	66,839,404 (GRCm38)	splice site	probably benign
R0704:Tg	UTSW	15	66,757,880 (GRCm38)	missense	probably benign	0.02
R0730:Tg	UTSW	15	66,678,789 (GRCm38)	missense	probably damaging	1.00
R0830:Tg	UTSW	15	66,725,144 (GRCm38)	missense	probably damaging	1.00
R0959:Tg	UTSW	15	66,708,010 (GRCm38)	missense	probably damaging	0.98
R1027:Tg	UTSW	15	66,672,409 (GRCm38)	missense	possibly damaging	0.65
R1061:Tg	UTSW	15	66,698,559 (GRCm38)	missense	probably benign	0.09
R1086:Tg	UTSW	15	66,684,062 (GRCm38)	missense	probably benign
R1103:Tg	UTSW	15	66,719,655 (GRCm38)	missense	probably benign	0.45
R1240:Tg	UTSW	15	66,828,548 (GRCm38)	missense	probably benign	0.16
R1281:Tg	UTSW	15	66,696,489 (GRCm38)	missense	probably benign	0.34
R1470:Tg	UTSW	15	66,849,463 (GRCm38)	missense	possibly damaging	0.95
R1470:Tg	UTSW	15	66,849,463 (GRCm38)	missense	possibly damaging	0.95
R1531:Tg	UTSW	15	66,850,502 (GRCm38)	missense	probably benign	0.02
R1544:Tg	UTSW	15	66,705,232 (GRCm38)	missense	probably benign	0.04
R1550:Tg	UTSW	15	66,693,430 (GRCm38)	missense	possibly damaging	0.52
R1575:Tg	UTSW	15	66,729,685 (GRCm38)	critical splice donor site	probably null
R1638:Tg	UTSW	15	66,696,166 (GRCm38)	nonsense	probably null
R1655:Tg	UTSW	15	66,828,568 (GRCm38)	critical splice donor site	probably null
R1789:Tg	UTSW	15	66,737,548 (GRCm38)	missense	probably benign	0.00
R1883:Tg	UTSW	15	66,671,309 (GRCm38)	missense	probably damaging	1.00
R1984:Tg	UTSW	15	66,682,842 (GRCm38)	missense	probably benign
R2063:Tg	UTSW	15	66,828,553 (GRCm38)	missense	probably damaging	1.00
R2092:Tg	UTSW	15	66,849,607 (GRCm38)	missense	probably null	0.26
R2109:Tg	UTSW	15	66,729,594 (GRCm38)	missense	probably benign	0.02
R2128:Tg	UTSW	15	66,694,894 (GRCm38)	missense	probably benign	0.10
R2129:Tg	UTSW	15	66,694,894 (GRCm38)	missense	probably benign	0.10
R2207:Tg	UTSW	15	66,681,939 (GRCm38)	missense	probably benign	0.15
R2219:Tg	UTSW	15	66,681,933 (GRCm38)	missense	probably benign	0.03
R2228:Tg	UTSW	15	66,674,011 (GRCm38)	missense	probably damaging	0.99
R2229:Tg	UTSW	15	66,674,011 (GRCm38)	missense	probably damaging	0.99
R2259:Tg	UTSW	15	66,683,898 (GRCm38)	missense	probably benign
R2994:Tg	UTSW	15	66,681,953 (GRCm38)	missense	probably benign
R3904:Tg	UTSW	15	66,766,162 (GRCm38)	nonsense	probably null
R3946:Tg	UTSW	15	66,674,023 (GRCm38)	missense	probably damaging	1.00
R3965:Tg	UTSW	15	66,684,190 (GRCm38)	missense	probably benign
R4245:Tg	UTSW	15	66,696,469 (GRCm38)	missense	possibly damaging	0.68
R4451:Tg	UTSW	15	66,766,147 (GRCm38)	missense	probably benign	0.01
R4487:Tg	UTSW	15	66,671,396 (GRCm38)	missense	probably damaging	1.00
R4489:Tg	UTSW	15	66,707,942 (GRCm38)	missense	probably damaging	1.00
R4623:Tg	UTSW	15	66,735,271 (GRCm38)	missense	probably benign	0.23
R4659:Tg	UTSW	15	66,673,920 (GRCm38)	missense	possibly damaging	0.67
R4728:Tg	UTSW	15	66,682,827 (GRCm38)	missense	probably damaging	1.00
R4760:Tg	UTSW	15	66,693,319 (GRCm38)	missense	probably damaging	1.00
R4797:Tg	UTSW	15	66,758,006 (GRCm38)	critical splice donor site	probably null
R4944:Tg	UTSW	15	66,764,337 (GRCm38)	missense	probably damaging	1.00
R4998:Tg	UTSW	15	66,674,050 (GRCm38)	missense	probably damaging	1.00
R5009:Tg	UTSW	15	66,696,586 (GRCm38)	missense	probably benign	0.01
R5025:Tg	UTSW	15	66,707,930 (GRCm38)	missense	probably damaging	1.00
R5035:Tg	UTSW	15	66,681,813 (GRCm38)	splice site	probably null
R5049:Tg	UTSW	15	66,827,382 (GRCm38)	nonsense	probably null
R5073:Tg	UTSW	15	66,735,252 (GRCm38)	missense	probably benign	0.05
R5169:Tg	UTSW	15	66,678,780 (GRCm38)	nonsense	probably null
R5185:Tg	UTSW	15	66,773,474 (GRCm38)	missense	probably damaging	1.00
R5227:Tg	UTSW	15	66,759,567 (GRCm38)	missense	possibly damaging	0.87
R5300:Tg	UTSW	15	66,678,855 (GRCm38)	missense	probably damaging	1.00
R5334:Tg	UTSW	15	66,678,055 (GRCm38)	missense	probably damaging	1.00
R5339:Tg	UTSW	15	66,678,093 (GRCm38)	missense	probably damaging	1.00
R5402:Tg	UTSW	15	66,739,168 (GRCm38)	missense	probably damaging	0.98
R5441:Tg	UTSW	15	66,696,520 (GRCm38)	missense	possibly damaging	0.47
R5509:Tg	UTSW	15	66,827,293 (GRCm38)	missense	probably benign	0.45
R5580:Tg	UTSW	15	66,685,300 (GRCm38)	missense	possibly damaging	0.66
R5582:Tg	UTSW	15	66,693,435 (GRCm38)	missense	probably damaging	1.00
R5624:Tg	UTSW	15	66,838,057 (GRCm38)	missense	probably benign	0.11
R5686:Tg	UTSW	15	66,688,889 (GRCm38)	missense	probably benign	0.28
R6042:Tg	UTSW	15	66,683,993 (GRCm38)	missense	probably benign	0.01
R6122:Tg	UTSW	15	66,828,457 (GRCm38)	missense	probably damaging	1.00
R6146:Tg	UTSW	15	66,673,367 (GRCm38)	splice site	probably null
R6159:Tg	UTSW	15	66,735,247 (GRCm38)	missense	possibly damaging	0.71
R6223:Tg	UTSW	15	66,707,922 (GRCm38)	missense	probably benign	0.15
R6480:Tg	UTSW	15	66,671,311 (GRCm38)	missense	probably damaging	1.00
R6505:Tg	UTSW	15	66,759,558 (GRCm38)	missense	probably damaging	0.99
R6531:Tg	UTSW	15	66,839,362 (GRCm38)	missense	probably damaging	0.99
R6614:Tg	UTSW	15	66,735,259 (GRCm38)	missense	probably damaging	0.99
R6698:Tg	UTSW	15	66,839,362 (GRCm38)	missense	probably damaging	1.00
R6798:Tg	UTSW	15	66,678,839 (GRCm38)	missense	probably damaging	1.00
R6837:Tg	UTSW	15	66,696,135 (GRCm38)	missense	probably damaging	1.00
R6861:Tg	UTSW	15	66,688,891 (GRCm38)	missense	probably benign	0.00
R6888:Tg	UTSW	15	66,696,246 (GRCm38)	missense	probably damaging	0.99
R6933:Tg	UTSW	15	66,764,309 (GRCm38)	missense	possibly damaging	0.73
R6983:Tg	UTSW	15	66,693,358 (GRCm38)	missense	probably benign	0.01
R7078:Tg	UTSW	15	66,673,543 (GRCm38)	missense	probably damaging	1.00
R7244:Tg	UTSW	15	66,740,714 (GRCm38)	missense	probably damaging	1.00
R7320:Tg	UTSW	15	66,694,784 (GRCm38)	missense	possibly damaging	0.71
R7334:Tg	UTSW	15	66,725,272 (GRCm38)	missense	probably benign	0.01
R7418:Tg	UTSW	15	66,696,583 (GRCm38)	missense	probably damaging	0.99
R7485:Tg	UTSW	15	66,696,588 (GRCm38)	missense	probably benign	0.04
R7524:Tg	UTSW	15	66,696,161 (GRCm38)	missense	probably benign	0.01
R7529:Tg	UTSW	15	66,694,768 (GRCm38)	missense	probably damaging	0.99
R7540:Tg	UTSW	15	66,689,927 (GRCm38)	missense	probably benign	0.16
R7583:Tg	UTSW	15	66,764,418 (GRCm38)	missense	probably damaging	1.00
R7594:Tg	UTSW	15	66,729,583 (GRCm38)	missense	probably benign	0.20
R7667:Tg	UTSW	15	66,715,163 (GRCm38)	missense	probably damaging	0.98
R7722:Tg	UTSW	15	66,764,309 (GRCm38)	missense	possibly damaging	0.73
R7790:Tg	UTSW	15	66,849,604 (GRCm38)	missense	probably damaging	0.99
R7838:Tg	UTSW	15	66,693,263 (GRCm38)	missense	probably benign	0.00
R7890:Tg	UTSW	15	66,683,814 (GRCm38)	missense	probably damaging	1.00
R7904:Tg	UTSW	15	66,705,279 (GRCm38)	missense	probably benign	0.08
R7919:Tg	UTSW	15	66,684,074 (GRCm38)	missense	possibly damaging	0.73
R7921:Tg	UTSW	15	66,683,793 (GRCm38)	missense	probably benign	0.08
R8037:Tg	UTSW	15	66,688,875 (GRCm38)	missense	probably benign	0.00
R8038:Tg	UTSW	15	66,688,875 (GRCm38)	missense	probably benign	0.00
R8214:Tg	UTSW	15	66,773,398 (GRCm38)	missense	probably damaging	1.00
R8304:Tg	UTSW	15	66,693,260 (GRCm38)	nonsense	probably null
R8688:Tg	UTSW	15	66,694,953 (GRCm38)	critical splice donor site	probably benign
R8709:Tg	UTSW	15	66,681,937 (GRCm38)	missense	probably benign	0.08
R8714:Tg	UTSW	15	66,684,042 (GRCm38)	missense	probably damaging	0.97
R8901:Tg	UTSW	15	66,685,335 (GRCm38)	missense	probably damaging	1.00
R8917:Tg	UTSW	15	66,773,483 (GRCm38)	critical splice donor site	probably null
R9023:Tg	UTSW	15	66,683,673 (GRCm38)	missense	probably damaging	1.00
R9232:Tg	UTSW	15	66,698,461 (GRCm38)	missense	probably benign	0.01
R9310:Tg	UTSW	15	66,827,269 (GRCm38)	missense	possibly damaging	0.69
R9361:Tg	UTSW	15	66,685,397 (GRCm38)	missense	possibly damaging	0.50
R9389:Tg	UTSW	15	66,689,324 (GRCm38)	missense	probably benign	0.04
R9501:Tg	UTSW	15	66,847,074 (GRCm38)	missense	possibly damaging	0.52
R9510:Tg	UTSW	15	66,674,064 (GRCm38)	missense	probably damaging	1.00
R9594:Tg	UTSW	15	66,735,260 (GRCm38)	nonsense	probably null
R9629:Tg	UTSW	15	66,683,738 (GRCm38)	missense	possibly damaging	0.95
R9701:Tg	UTSW	15	66,766,142 (GRCm38)	missense	probably benign	0.03
R9743:Tg	UTSW	15	66,689,990 (GRCm38)	missense	probably benign	0.18
R9748:Tg	UTSW	15	66,847,159 (GRCm38)	missense	possibly damaging	0.91
T0975:Tg	UTSW	15	66,688,863 (GRCm38)	missense	probably benign	0.01
X0005:Tg	UTSW	15	66,688,863 (GRCm38)	missense	probably benign	0.01
X0065:Tg	UTSW	15	66,682,454 (GRCm38)	missense	probably damaging	1.00
X0067:Tg	UTSW	15	66,748,743 (GRCm38)	missense	probably benign	0.10
Z1177:Tg	UTSW	15	66,849,547 (GRCm38)	missense	probably benign	0.02
Z1177:Tg	UTSW	15	66,685,310 (GRCm38)	missense	possibly damaging	0.49

Predicted Primers

PCR Primer
(F):5'- GCCAACATTCCAGAGAGTGAGACAG -3'
(R):5'- TGGCTATAGAGCACAGCAGACTCC -3'

Sequencing Primer
(F):5'- GAGTGAGACAGTGACCTCTTC -3'
(R):5'- GGCCATACTGATTATTCTGAGATGC -3'

Posted On

2014-05-09