Incidental Mutation 'R1673:Hdac5'
| ID |
187839 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hdac5
|
| Ensembl Gene |
ENSMUSG00000008855 |
| Gene Name |
histone deacetylase 5 |
| Synonyms |
mHDA1 |
| MMRRC Submission |
039709-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1673 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
102085244-102120968 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 102089631 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 860
(V860M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102770
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000008999]
[ENSMUST00000070334]
[ENSMUST00000078975]
[ENSMUST00000107150]
[ENSMUST00000107151]
[ENSMUST00000107152]
[ENSMUST00000124077]
[ENSMUST00000140962]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000008999
AA Change: V878M
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000008999
Gene: ENSMUSG00000008855
AA Change: V878M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
75 |
N/A |
INTRINSIC |
|
Pfam:HDAC4_Gln
|
86 |
174 |
1e-30 |
PFAM |
|
low complexity region
|
233 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
322 |
337 |
N/A |
INTRINSIC |
|
low complexity region
|
502 |
541 |
N/A |
INTRINSIC |
|
low complexity region
|
560 |
577 |
N/A |
INTRINSIC |
|
coiled coil region
|
583 |
617 |
N/A |
INTRINSIC |
|
Pfam:Hist_deacetyl
|
704 |
1034 |
1.4e-81 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070334
|
| SMART Domains |
Protein: ENSMUSP00000064276
Gene: ENSMUSG00000034793
| Domain | Start | End | E-Value | Type |
|---|
|
acidPPc
|
53 |
187 |
2.53e-15 |
SMART |
|
transmembrane domain
|
196 |
218 |
N/A |
INTRINSIC |
|
transmembrane domain
|
284 |
302 |
N/A |
INTRINSIC |
|
transmembrane domain
|
317 |
336 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000078975
|
| SMART Domains |
Protein: ENSMUSP00000077995
Gene: ENSMUSG00000034793
| Domain | Start | End | E-Value | Type |
|---|
|
acidPPc
|
53 |
187 |
2.53e-15 |
SMART |
|
transmembrane domain
|
196 |
218 |
N/A |
INTRINSIC |
|
transmembrane domain
|
284 |
302 |
N/A |
INTRINSIC |
|
transmembrane domain
|
317 |
336 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107150
AA Change: V859M
PolyPhen 2
Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000102768
Gene: ENSMUSG00000008855
AA Change: V859M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
56 |
N/A |
INTRINSIC |
|
Pfam:HDAC4_Gln
|
66 |
155 |
5.1e-37 |
PFAM |
|
low complexity region
|
214 |
228 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
483 |
522 |
N/A |
INTRINSIC |
|
low complexity region
|
541 |
558 |
N/A |
INTRINSIC |
|
coiled coil region
|
564 |
598 |
N/A |
INTRINSIC |
|
Pfam:Hist_deacetyl
|
685 |
1015 |
9.4e-91 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107151
AA Change: V775M
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000102769
Gene: ENSMUSG00000008855
AA Change: V775M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
40 |
57 |
N/A |
INTRINSIC |
|
Pfam:HDAC4_Gln
|
67 |
156 |
1.1e-37 |
PFAM |
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
low complexity region
|
304 |
319 |
N/A |
INTRINSIC |
|
low complexity region
|
484 |
523 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
559 |
N/A |
INTRINSIC |
|
coiled coil region
|
565 |
599 |
N/A |
INTRINSIC |
|
Pfam:Hist_deacetyl
|
618 |
931 |
1.2e-82 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107152
AA Change: V860M
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000102770
Gene: ENSMUSG00000008855
AA Change: V860M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
40 |
57 |
N/A |
INTRINSIC |
|
Pfam:HDAC4_Gln
|
67 |
156 |
3.7e-37 |
PFAM |
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
low complexity region
|
304 |
319 |
N/A |
INTRINSIC |
|
low complexity region
|
484 |
523 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
559 |
N/A |
INTRINSIC |
|
coiled coil region
|
565 |
599 |
N/A |
INTRINSIC |
|
Pfam:Hist_deacetyl
|
686 |
1016 |
6.4e-91 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124077
|
| SMART Domains |
Protein: ENSMUSP00000116672
Gene: ENSMUSG00000008855
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
50 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133651
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140481
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149087
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126453
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155065
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150965
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136304
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137787
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145540
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140962
|
| SMART Domains |
Protein: ENSMUSP00000115435
Gene: ENSMUSG00000008855
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2VQQ|B
|
1 |
71 |
3e-21 |
PDB |
|
transmembrane domain
|
118 |
135 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.1%
- 20x: 91.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are viable and display cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca6 |
T |
C |
11: 110,103,165 (GRCm39) |
S809G |
probably benign |
Het |
| Ap4b1 |
T |
A |
3: 103,725,161 (GRCm39) |
|
probably null |
Het |
| Aqp12 |
A |
G |
1: 92,934,606 (GRCm39) |
Q161R |
possibly damaging |
Het |
| Atp8a2 |
A |
G |
14: 60,028,689 (GRCm39) |
I926T |
probably benign |
Het |
| Cacna2d1 |
A |
T |
5: 16,504,988 (GRCm39) |
N314I |
probably damaging |
Het |
| Cd209d |
A |
G |
8: 3,927,113 (GRCm39) |
S81P |
probably damaging |
Het |
| Cdcp1 |
T |
A |
9: 123,007,086 (GRCm39) |
K554* |
probably null |
Het |
| Celsr1 |
A |
G |
15: 85,816,658 (GRCm39) |
Y1762H |
probably benign |
Het |
| Cklf |
A |
G |
8: 104,983,983 (GRCm39) |
T49A |
possibly damaging |
Het |
| Col12a1 |
T |
G |
9: 79,600,820 (GRCm39) |
I755L |
probably benign |
Het |
| Cts3 |
G |
A |
13: 61,715,368 (GRCm39) |
Q140* |
probably null |
Het |
| Ddx1 |
A |
T |
12: 13,294,967 (GRCm39) |
|
probably null |
Het |
| Dnah3 |
C |
A |
7: 119,570,402 (GRCm39) |
E2262* |
probably null |
Het |
| Dnah5 |
A |
G |
15: 28,290,294 (GRCm39) |
N1228S |
probably benign |
Het |
| Dsg1a |
G |
A |
18: 20,464,561 (GRCm39) |
R352Q |
probably damaging |
Het |
| Efcab5 |
A |
G |
11: 77,042,679 (GRCm39) |
F25L |
probably damaging |
Het |
| Efhd1 |
T |
A |
1: 87,192,404 (GRCm39) |
V78D |
probably damaging |
Het |
| Eif5a2 |
T |
C |
3: 28,847,967 (GRCm39) |
|
probably null |
Het |
| Elp2 |
T |
A |
18: 24,744,983 (GRCm39) |
V101D |
possibly damaging |
Het |
| Enpp2 |
A |
T |
15: 54,773,592 (GRCm39) |
|
probably null |
Het |
| F5 |
A |
G |
1: 164,007,089 (GRCm39) |
T298A |
probably damaging |
Het |
| Fbxo21 |
G |
T |
5: 118,146,129 (GRCm39) |
R584L |
probably benign |
Het |
| Fbxw22 |
G |
T |
9: 109,211,196 (GRCm39) |
F368L |
possibly damaging |
Het |
| Gcn1 |
T |
C |
5: 115,720,356 (GRCm39) |
I409T |
probably benign |
Het |
| Gm12887 |
T |
C |
4: 121,473,655 (GRCm39) |
Y65C |
probably damaging |
Het |
| Gria4 |
G |
A |
9: 4,537,637 (GRCm39) |
Q224* |
probably null |
Het |
| Ino80 |
G |
A |
2: 119,212,417 (GRCm39) |
R1302C |
probably damaging |
Het |
| Kcns2 |
A |
T |
15: 34,838,966 (GRCm39) |
I110F |
probably damaging |
Het |
| Lrig3 |
A |
G |
10: 125,846,036 (GRCm39) |
T822A |
probably damaging |
Het |
| Mapk6 |
T |
C |
9: 75,302,851 (GRCm39) |
D214G |
probably damaging |
Het |
| Mcm2 |
A |
T |
6: 88,869,060 (GRCm39) |
L264Q |
probably benign |
Het |
| Mpnd |
A |
T |
17: 56,317,455 (GRCm39) |
Y64F |
probably damaging |
Het |
| Muc1 |
T |
A |
3: 89,139,079 (GRCm39) |
M520K |
possibly damaging |
Het |
| Muc4 |
T |
A |
16: 32,577,276 (GRCm39) |
S189T |
probably benign |
Het |
| Myh13 |
T |
C |
11: 67,242,945 (GRCm39) |
S953P |
possibly damaging |
Het |
| Ncf2 |
A |
T |
1: 152,706,230 (GRCm39) |
M281L |
probably benign |
Het |
| Nipal2 |
A |
G |
15: 34,648,841 (GRCm39) |
I116T |
probably damaging |
Het |
| Nptn |
T |
C |
9: 58,531,015 (GRCm39) |
L46P |
probably benign |
Het |
| Or2b6 |
A |
T |
13: 21,823,214 (GRCm39) |
S160T |
probably damaging |
Het |
| Or4k77 |
A |
G |
2: 111,199,552 (GRCm39) |
T192A |
probably benign |
Het |
| Or51ag1 |
C |
A |
7: 103,155,896 (GRCm39) |
V86F |
probably damaging |
Het |
| Or5ae1 |
T |
A |
7: 84,565,325 (GRCm39) |
F113I |
probably damaging |
Het |
| Pgr |
A |
T |
9: 8,902,069 (GRCm39) |
Y534F |
possibly damaging |
Het |
| Pip4k2a |
A |
T |
2: 18,877,093 (GRCm39) |
|
probably null |
Het |
| Pkd1l2 |
C |
G |
8: 117,767,514 (GRCm39) |
V1259L |
probably benign |
Het |
| Ppp1r12a |
A |
G |
10: 108,085,426 (GRCm39) |
E457G |
probably damaging |
Het |
| Rasa4 |
T |
A |
5: 136,133,491 (GRCm39) |
V650D |
probably benign |
Het |
| Rem2 |
C |
T |
14: 54,713,766 (GRCm39) |
|
probably benign |
Het |
| Rps18-ps6 |
A |
T |
13: 97,896,868 (GRCm39) |
Y77N |
possibly damaging |
Het |
| Sdc1 |
G |
A |
12: 8,840,409 (GRCm39) |
R62Q |
possibly damaging |
Het |
| Sdk1 |
A |
G |
5: 141,934,261 (GRCm39) |
E366G |
possibly damaging |
Het |
| Setd2 |
T |
A |
9: 110,433,248 (GRCm39) |
H2406Q |
probably damaging |
Het |
| Slc30a5 |
A |
G |
13: 100,949,891 (GRCm39) |
V397A |
probably benign |
Het |
| Slc36a2 |
A |
T |
11: 55,075,739 (GRCm39) |
L16H |
possibly damaging |
Het |
| Slc44a1 |
T |
C |
4: 53,542,468 (GRCm39) |
V334A |
probably benign |
Het |
| Sox8 |
A |
T |
17: 25,786,456 (GRCm39) |
Y416N |
possibly damaging |
Het |
| Speg |
T |
C |
1: 75,387,807 (GRCm39) |
V1416A |
possibly damaging |
Het |
| Stimate |
T |
C |
14: 30,586,391 (GRCm39) |
L72S |
possibly damaging |
Het |
| Stk24 |
T |
A |
14: 121,574,983 (GRCm39) |
I42F |
probably damaging |
Het |
| Tasor2 |
A |
G |
13: 3,634,498 (GRCm39) |
|
probably null |
Het |
| Tcerg1 |
T |
A |
18: 42,685,646 (GRCm39) |
L661Q |
possibly damaging |
Het |
| Tpp1 |
G |
A |
7: 105,396,880 (GRCm39) |
R417W |
probably damaging |
Het |
| Trim12a |
T |
A |
7: 103,955,264 (GRCm39) |
D153V |
possibly damaging |
Het |
| Trpm2 |
T |
C |
10: 77,778,778 (GRCm39) |
N396S |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,637,427 (GRCm39) |
K5695R |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,640,631 (GRCm39) |
R11960C |
probably damaging |
Het |
| Tulp3 |
A |
C |
6: 128,310,906 (GRCm39) |
|
probably null |
Het |
| Uaca |
T |
A |
9: 60,779,438 (GRCm39) |
L1273H |
probably damaging |
Het |
| Usp33 |
A |
G |
3: 152,073,919 (GRCm39) |
E255G |
probably damaging |
Het |
| Vmn2r54 |
T |
G |
7: 12,350,138 (GRCm39) |
|
probably null |
Het |
| Vwa8 |
C |
T |
14: 79,145,670 (GRCm39) |
R116C |
probably damaging |
Het |
| Wnt5b |
A |
T |
6: 119,423,315 (GRCm39) |
F116L |
probably benign |
Het |
| Zbtb12 |
CTTCAT |
CTTCATTCAT |
17: 35,115,284 (GRCm39) |
|
probably null |
Het |
| Zbtb12 |
TCATC |
TCATCCATC |
17: 35,115,286 (GRCm39) |
|
probably null |
Het |
| Zfp408 |
G |
A |
2: 91,476,353 (GRCm39) |
T367I |
probably damaging |
Het |
| Zfp512b |
G |
A |
2: 181,230,286 (GRCm39) |
A480V |
possibly damaging |
Het |
| Zfp560 |
T |
C |
9: 20,258,949 (GRCm39) |
T638A |
probably benign |
Het |
| Zfp932 |
G |
T |
5: 110,156,854 (GRCm39) |
G151V |
probably damaging |
Het |
| Zpbp |
T |
C |
11: 11,302,696 (GRCm39) |
K320E |
probably damaging |
Het |
| Zranb2 |
C |
T |
3: 157,243,277 (GRCm39) |
P91L |
probably damaging |
Het |
|
| Other mutations in Hdac5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00815:Hdac5
|
APN |
11 |
102,088,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01614:Hdac5
|
APN |
11 |
102,090,854 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL01799:Hdac5
|
APN |
11 |
102,090,911 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02839:Hdac5
|
APN |
11 |
102,095,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
E0354:Hdac5
|
UTSW |
11 |
102,092,972 (GRCm39) |
unclassified |
probably benign |
|
|
R0544:Hdac5
|
UTSW |
11 |
102,086,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0612:Hdac5
|
UTSW |
11 |
102,087,078 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0632:Hdac5
|
UTSW |
11 |
102,096,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0659:Hdac5
|
UTSW |
11 |
102,086,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Hdac5
|
UTSW |
11 |
102,095,472 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1195:Hdac5
|
UTSW |
11 |
102,096,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1195:Hdac5
|
UTSW |
11 |
102,096,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1195:Hdac5
|
UTSW |
11 |
102,096,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1475:Hdac5
|
UTSW |
11 |
102,093,012 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1491:Hdac5
|
UTSW |
11 |
102,092,079 (GRCm39) |
missense |
probably benign |
|
|
R1596:Hdac5
|
UTSW |
11 |
102,095,482 (GRCm39) |
splice site |
probably null |
|
|
R1783:Hdac5
|
UTSW |
11 |
102,091,342 (GRCm39) |
missense |
probably benign |
|
|
R1932:Hdac5
|
UTSW |
11 |
102,086,698 (GRCm39) |
splice site |
probably benign |
|
|
R2197:Hdac5
|
UTSW |
11 |
102,095,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Hdac5
|
UTSW |
11 |
102,090,840 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2518:Hdac5
|
UTSW |
11 |
102,087,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3081:Hdac5
|
UTSW |
11 |
102,096,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3622:Hdac5
|
UTSW |
11 |
102,086,644 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4543:Hdac5
|
UTSW |
11 |
102,104,770 (GRCm39) |
intron |
probably benign |
|
|
R4559:Hdac5
|
UTSW |
11 |
102,089,928 (GRCm39) |
unclassified |
probably benign |
|
|
R4661:Hdac5
|
UTSW |
11 |
102,096,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4682:Hdac5
|
UTSW |
11 |
102,097,456 (GRCm39) |
missense |
probably null |
0.99 |
|
R4708:Hdac5
|
UTSW |
11 |
102,093,019 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4933:Hdac5
|
UTSW |
11 |
102,091,389 (GRCm39) |
unclassified |
probably benign |
|
|
R4957:Hdac5
|
UTSW |
11 |
102,096,082 (GRCm39) |
unclassified |
probably benign |
|
|
R4991:Hdac5
|
UTSW |
11 |
102,096,450 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5090:Hdac5
|
UTSW |
11 |
102,088,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5103:Hdac5
|
UTSW |
11 |
102,087,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5330:Hdac5
|
UTSW |
11 |
102,088,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Hdac5
|
UTSW |
11 |
102,088,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5386:Hdac5
|
UTSW |
11 |
102,092,967 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5449:Hdac5
|
UTSW |
11 |
102,086,923 (GRCm39) |
nonsense |
probably null |
|
|
R5682:Hdac5
|
UTSW |
11 |
102,104,749 (GRCm39) |
intron |
probably benign |
|
|
R6615:Hdac5
|
UTSW |
11 |
102,087,882 (GRCm39) |
splice site |
probably null |
|
|
R6705:Hdac5
|
UTSW |
11 |
102,092,062 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6875:Hdac5
|
UTSW |
11 |
102,093,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6952:Hdac5
|
UTSW |
11 |
102,095,786 (GRCm39) |
missense |
probably benign |
|
|
R7179:Hdac5
|
UTSW |
11 |
102,095,385 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7368:Hdac5
|
UTSW |
11 |
102,088,207 (GRCm39) |
missense |
probably null |
1.00 |
|
R8140:Hdac5
|
UTSW |
11 |
102,088,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8151:Hdac5
|
UTSW |
11 |
102,097,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8684:Hdac5
|
UTSW |
11 |
102,096,147 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8719:Hdac5
|
UTSW |
11 |
102,097,963 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8751:Hdac5
|
UTSW |
11 |
102,109,280 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8893:Hdac5
|
UTSW |
11 |
102,097,512 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9337:Hdac5
|
UTSW |
11 |
102,096,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Hdac5
|
UTSW |
11 |
102,093,522 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9595:Hdac5
|
UTSW |
11 |
102,096,129 (GRCm39) |
missense |
probably benign |
0.06 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACTGCTCAAGGTAAGACATCTGGC -3'
(R):5'- ATGTGAGTACCCCTCTGACCTGAC -3'
Sequencing Primer
(F):5'- CAAGGTAAGACATCTGGCTGTTG -3'
(R):5'- GACCTGACATCCTTCTGCCATC -3'
|
| Posted On |
2014-05-09 |
Incidental Mutation