Mutagenetix > Incidental Mutation

Incidental Mutation 'R1673:Tasor2'

187844

Institutional Source

Beutler Lab

Gene Symbol

Tasor2

Ensembl Gene

ENSMUSG00000033799

Gene Name

transcription activation suppressor family member 2

Synonyms

BC016423, Fam208b

MMRRC Submission

039709-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R1673 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

3566035-3611108 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 3584498 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000096069] [ENSMUST00000096069]

AlphaFold

Q5DTT3

Predicted Effect

probably null
Transcript: ENSMUST00000096069

SMART Domains

Protein: ENSMUSP00000093774
Gene: ENSMUSG00000033799

Domain	Start	End	E-Value	Type
Pfam:DUF3699	91	167	1.4e-24	PFAM
low complexity region	272	282	N/A	INTRINSIC
low complexity region	447	459	N/A	INTRINSIC
Pfam:DUF3715	533	695	2.3e-25	PFAM
low complexity region	1156	1168	N/A	INTRINSIC
low complexity region	1196	1207	N/A	INTRINSIC
low complexity region	1312	1330	N/A	INTRINSIC
low complexity region	2012	2021	N/A	INTRINSIC
low complexity region	2250	2263	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000096069

SMART Domains

Protein: ENSMUSP00000093774
Gene: ENSMUSG00000033799

Domain	Start	End	E-Value	Type
Pfam:DUF3699	91	167	1.4e-24	PFAM
low complexity region	272	282	N/A	INTRINSIC
low complexity region	447	459	N/A	INTRINSIC
Pfam:DUF3715	533	695	2.3e-25	PFAM
low complexity region	1156	1168	N/A	INTRINSIC
low complexity region	1196	1207	N/A	INTRINSIC
low complexity region	1312	1330	N/A	INTRINSIC
low complexity region	2012	2021	N/A	INTRINSIC
low complexity region	2250	2263	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000222909

Predicted Effect

probably null
Transcript: ENSMUST00000222909

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.1%
20x: 91.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	T	C	11: 110,212,339 (GRCm38)	S809G	probably benign	Het
Ap4b1	T	A	3: 103,817,845 (GRCm38)		probably null	Het
Aqp12	A	G	1: 93,006,884 (GRCm38)	Q161R	possibly damaging	Het
Atp8a2	A	G	14: 59,791,240 (GRCm38)	I926T	probably benign	Het
Cacna2d1	A	T	5: 16,299,990 (GRCm38)	N314I	probably damaging	Het
Cd209d	A	G	8: 3,877,113 (GRCm38)	S81P	probably damaging	Het
Cdcp1	T	A	9: 123,178,021 (GRCm38)	K554*	probably null	Het
Celsr1	A	G	15: 85,932,457 (GRCm38)	Y1762H	probably benign	Het
Cklf	A	G	8: 104,257,351 (GRCm38)	T49A	possibly damaging	Het
Col12a1	T	G	9: 79,693,538 (GRCm38)	I755L	probably benign	Het
Cts3	G	A	13: 61,567,554 (GRCm38)	Q140*	probably null	Het
Ddx1	A	T	12: 13,244,966 (GRCm38)		probably null	Het
Dnah3	C	A	7: 119,971,179 (GRCm38)	E2262*	probably null	Het
Dnah5	A	G	15: 28,290,148 (GRCm38)	N1228S	probably benign	Het
Dsg1a	G	A	18: 20,331,504 (GRCm38)	R352Q	probably damaging	Het
Efcab5	A	G	11: 77,151,853 (GRCm38)	F25L	probably damaging	Het
Efhd1	T	A	1: 87,264,682 (GRCm38)	V78D	probably damaging	Het
Eif5a2	T	C	3: 28,793,818 (GRCm38)		probably null	Het
Elp2	T	A	18: 24,611,926 (GRCm38)	V101D	possibly damaging	Het
Enpp2	A	T	15: 54,910,196 (GRCm38)		probably null	Het
F5	A	G	1: 164,179,520 (GRCm38)	T298A	probably damaging	Het
Fbxo21	G	T	5: 118,008,064 (GRCm38)	R584L	probably benign	Het
Fbxw22	G	T	9: 109,382,128 (GRCm38)	F368L	possibly damaging	Het
Gcn1	T	C	5: 115,582,297 (GRCm38)	I409T	probably benign	Het
Gm12887	T	C	4: 121,616,458 (GRCm38)	Y65C	probably damaging	Het
Gria4	G	A	9: 4,537,637 (GRCm38)	Q224*	probably null	Het
Hdac5	C	T	11: 102,198,805 (GRCm38)	V860M	probably damaging	Het
Ino80	G	A	2: 119,381,936 (GRCm38)	R1302C	probably damaging	Het
Kcns2	A	T	15: 34,838,820 (GRCm38)	I110F	probably damaging	Het
Lrig3	A	G	10: 126,010,167 (GRCm38)	T822A	probably damaging	Het
Mapk6	T	C	9: 75,395,569 (GRCm38)	D214G	probably damaging	Het
Mcm2	A	T	6: 88,892,078 (GRCm38)	L264Q	probably benign	Het
Mpnd	A	T	17: 56,010,455 (GRCm38)	Y64F	probably damaging	Het
Muc1	T	A	3: 89,231,772 (GRCm38)	M520K	possibly damaging	Het
Muc4	T	A	16: 32,756,902 (GRCm38)	S189T	probably benign	Het
Myh13	T	C	11: 67,352,119 (GRCm38)	S953P	possibly damaging	Het
Ncf2	A	T	1: 152,830,479 (GRCm38)	M281L	probably benign	Het
Nipal2	A	G	15: 34,648,695 (GRCm38)	I116T	probably damaging	Het
Nptn	T	C	9: 58,623,732 (GRCm38)	L46P	probably benign	Het
Or2b6	A	T	13: 21,639,044 (GRCm38)	S160T	probably damaging	Het
Or4k77	A	G	2: 111,369,207 (GRCm38)	T192A	probably benign	Het
Or51ag1	C	A	7: 103,506,689 (GRCm38)	V86F	probably damaging	Het
Or5ae1	T	A	7: 84,916,117 (GRCm38)	F113I	probably damaging	Het
Pgr	A	T	9: 8,902,068 (GRCm38)	Y534F	possibly damaging	Het
Pip4k2a	A	T	2: 18,872,282 (GRCm38)		probably null	Het
Pkd1l2	C	G	8: 117,040,775 (GRCm38)	V1259L	probably benign	Het
Ppp1r12a	A	G	10: 108,249,565 (GRCm38)	E457G	probably damaging	Het
Rasa4	T	A	5: 136,104,637 (GRCm38)	V650D	probably benign	Het
Rem2	C	T	14: 54,476,309 (GRCm38)		probably benign	Het
Rps18-ps6	A	T	13: 97,760,360 (GRCm38)	Y77N	possibly damaging	Het
Sdc1	G	A	12: 8,790,409 (GRCm38)	R62Q	possibly damaging	Het
Sdk1	A	G	5: 141,948,506 (GRCm38)	E366G	possibly damaging	Het
Setd2	T	A	9: 110,604,180 (GRCm38)	H2406Q	probably damaging	Het
Slc30a5	A	G	13: 100,813,383 (GRCm38)	V397A	probably benign	Het
Slc36a2	A	T	11: 55,184,913 (GRCm38)	L16H	possibly damaging	Het
Slc44a1	T	C	4: 53,542,468 (GRCm38)	V334A	probably benign	Het
Sox8	A	T	17: 25,567,482 (GRCm38)	Y416N	possibly damaging	Het
Speg	T	C	1: 75,411,163 (GRCm38)	V1416A	possibly damaging	Het
Stimate	T	C	14: 30,864,434 (GRCm38)	L72S	possibly damaging	Het
Stk24	T	A	14: 121,337,571 (GRCm38)	I42F	probably damaging	Het
Tcerg1	T	A	18: 42,552,581 (GRCm38)	L661Q	possibly damaging	Het
Tpp1	G	A	7: 105,747,673 (GRCm38)	R417W	probably damaging	Het
Trim12a	T	A	7: 104,306,057 (GRCm38)	D153V	possibly damaging	Het
Trpm2	T	C	10: 77,942,944 (GRCm38)	N396S	probably benign	Het
Ttn	G	A	2: 76,810,287 (GRCm38)	R11960C	probably damaging	Het
Ttn	T	C	2: 76,807,083 (GRCm38)	K5695R	probably damaging	Het
Tulp3	A	C	6: 128,333,943 (GRCm38)		probably null	Het
Uaca	T	A	9: 60,872,156 (GRCm38)	L1273H	probably damaging	Het
Usp33	A	G	3: 152,368,282 (GRCm38)	E255G	probably damaging	Het
Vmn2r54	T	G	7: 12,616,211 (GRCm38)		probably null	Het
Vwa8	C	T	14: 78,908,230 (GRCm38)	R116C	probably damaging	Het
Wnt5b	A	T	6: 119,446,354 (GRCm38)	F116L	probably benign	Het
Zbtb12	CTTCAT	CTTCATTCAT	17: 34,896,308 (GRCm38)		probably null	Het
Zbtb12	TCATC	TCATCCATC	17: 34,896,310 (GRCm38)		probably null	Het
Zfp408	G	A	2: 91,646,008 (GRCm38)	T367I	probably damaging	Het
Zfp512b	G	A	2: 181,588,493 (GRCm38)	A480V	possibly damaging	Het
Zfp560	T	C	9: 20,347,653 (GRCm38)	T638A	probably benign	Het
Zfp932	G	T	5: 110,008,988 (GRCm38)	G151V	probably damaging	Het
Zpbp	T	C	11: 11,352,696 (GRCm38)	K320E	probably damaging	Het
Zranb2	C	T	3: 157,537,640 (GRCm38)	P91L	probably damaging	Het

Other mutations in Tasor2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00330:Tasor2	APN	13	3,574,832 (GRCm38)	missense	probably benign
IGL00670:Tasor2	APN	13	3,585,241 (GRCm38)	missense	probably benign	0.14
IGL00957:Tasor2	APN	13	3,577,101 (GRCm38)	missense	possibly damaging	0.86
IGL01311:Tasor2	APN	13	3,575,885 (GRCm38)	missense	possibly damaging	0.85
IGL01318:Tasor2	APN	13	3,575,067 (GRCm38)	missense	possibly damaging	0.66
IGL01767:Tasor2	APN	13	3,576,633 (GRCm38)	missense	probably benign	0.00
IGL02073:Tasor2	APN	13	3,574,721 (GRCm38)	missense	probably benign	0.01
IGL02152:Tasor2	APN	13	3,585,371 (GRCm38)	missense	probably benign
IGL02431:Tasor2	APN	13	3,574,736 (GRCm38)	missense	possibly damaging	0.85
IGL02478:Tasor2	APN	13	3,574,661 (GRCm38)	missense	probably benign	0.12
IGL02732:Tasor2	APN	13	3,573,626 (GRCm38)	missense	probably benign	0.09
IGL02745:Tasor2	APN	13	3,585,140 (GRCm38)	missense	probably benign	0.23
IGL02800:Tasor2	APN	13	3,585,154 (GRCm38)	missense	probably benign
IGL02989:Tasor2	APN	13	3,584,820 (GRCm38)	missense	probably benign	0.01
IGL03124:Tasor2	APN	13	3,574,704 (GRCm38)	missense	probably benign	0.41
IGL03154:Tasor2	APN	13	3,575,255 (GRCm38)	missense	possibly damaging	0.56
IGL03216:Tasor2	APN	13	3,574,553 (GRCm38)	missense	probably damaging	0.98
BB001:Tasor2	UTSW	13	3,594,331 (GRCm38)	missense	possibly damaging	0.92
BB011:Tasor2	UTSW	13	3,594,331 (GRCm38)	missense	possibly damaging	0.92
H8562:Tasor2	UTSW	13	3,577,000 (GRCm38)	missense	probably damaging	0.98
PIT4585001:Tasor2	UTSW	13	3,574,979 (GRCm38)	missense	possibly damaging	0.55
R0016:Tasor2	UTSW	13	3,585,170 (GRCm38)	splice site	probably null
R0016:Tasor2	UTSW	13	3,585,170 (GRCm38)	splice site	probably null
R0157:Tasor2	UTSW	13	3,575,550 (GRCm38)	missense	probably benign	0.06
R0375:Tasor2	UTSW	13	3,596,842 (GRCm38)	missense	possibly damaging	0.85
R0403:Tasor2	UTSW	13	3,582,052 (GRCm38)	nonsense	probably null
R0472:Tasor2	UTSW	13	3,588,364 (GRCm38)	missense	possibly damaging	0.93
R0517:Tasor2	UTSW	13	3,566,964 (GRCm38)	missense	possibly damaging	0.94
R0586:Tasor2	UTSW	13	3,590,321 (GRCm38)	missense	probably damaging	0.99
R0600:Tasor2	UTSW	13	3,576,054 (GRCm38)	missense	probably benign
R0659:Tasor2	UTSW	13	3,574,448 (GRCm38)	missense	probably damaging	0.99
R1257:Tasor2	UTSW	13	3,575,049 (GRCm38)	missense	probably benign	0.25
R1375:Tasor2	UTSW	13	3,576,029 (GRCm38)	missense	probably benign	0.06
R1443:Tasor2	UTSW	13	3,575,543 (GRCm38)	missense	probably benign	0.00
R1497:Tasor2	UTSW	13	3,570,409 (GRCm38)	missense	probably damaging	0.96
R1544:Tasor2	UTSW	13	3,590,413 (GRCm38)	missense	possibly damaging	0.68
R1554:Tasor2	UTSW	13	3,576,374 (GRCm38)	missense	possibly damaging	0.85
R1629:Tasor2	UTSW	13	3,574,121 (GRCm38)	missense	possibly damaging	0.84
R1633:Tasor2	UTSW	13	3,581,771 (GRCm38)	missense	possibly damaging	0.53
R1661:Tasor2	UTSW	13	3,573,860 (GRCm38)	missense	possibly damaging	0.63
R1675:Tasor2	UTSW	13	3,569,507 (GRCm38)	missense	possibly damaging	0.65
R1781:Tasor2	UTSW	13	3,584,759 (GRCm38)	missense	possibly damaging	0.95
R1792:Tasor2	UTSW	13	3,590,559 (GRCm38)	missense	possibly damaging	0.91
R1826:Tasor2	UTSW	13	3,581,759 (GRCm38)	missense	probably damaging	0.98
R1920:Tasor2	UTSW	13	3,576,612 (GRCm38)	missense	possibly damaging	0.63
R1983:Tasor2	UTSW	13	3,574,853 (GRCm38)	missense	possibly damaging	0.92
R2016:Tasor2	UTSW	13	3,576,770 (GRCm38)	missense	probably benign	0.41
R2017:Tasor2	UTSW	13	3,576,770 (GRCm38)	missense	probably benign	0.41
R2220:Tasor2	UTSW	13	3,581,872 (GRCm38)	missense	probably benign	0.00
R2513:Tasor2	UTSW	13	3,582,150 (GRCm38)	missense	possibly damaging	0.53
R2898:Tasor2	UTSW	13	3,585,122 (GRCm38)	missense	possibly damaging	0.82
R2904:Tasor2	UTSW	13	3,582,185 (GRCm38)	missense	possibly damaging	0.53
R3149:Tasor2	UTSW	13	3,574,359 (GRCm38)	missense	probably damaging	0.98
R3623:Tasor2	UTSW	13	3,595,556 (GRCm38)	missense	probably benign
R3624:Tasor2	UTSW	13	3,595,556 (GRCm38)	missense	probably benign
R3725:Tasor2	UTSW	13	3,590,538 (GRCm38)	missense	probably benign	0.33
R3835:Tasor2	UTSW	13	3,575,292 (GRCm38)	missense	probably benign	0.01
R3890:Tasor2	UTSW	13	3,596,785 (GRCm38)	missense	probably damaging	0.96
R4023:Tasor2	UTSW	13	3,584,554 (GRCm38)	missense	probably damaging	0.99
R4024:Tasor2	UTSW	13	3,584,554 (GRCm38)	missense	probably damaging	0.99
R4025:Tasor2	UTSW	13	3,584,554 (GRCm38)	missense	probably damaging	0.99
R4050:Tasor2	UTSW	13	3,573,507 (GRCm38)	missense	probably benign	0.09
R4308:Tasor2	UTSW	13	3,569,498 (GRCm38)	missense	probably damaging	0.97
R4484:Tasor2	UTSW	13	3,581,831 (GRCm38)	missense	probably benign	0.12
R4674:Tasor2	UTSW	13	3,573,686 (GRCm38)	missense	possibly damaging	0.69
R4718:Tasor2	UTSW	13	3,574,495 (GRCm38)	missense	probably benign	0.00
R4745:Tasor2	UTSW	13	3,590,069 (GRCm38)	missense	probably benign	0.26
R4776:Tasor2	UTSW	13	3,570,391 (GRCm38)	missense	probably damaging	1.00
R4839:Tasor2	UTSW	13	3,584,807 (GRCm38)	missense	probably damaging	0.96
R4855:Tasor2	UTSW	13	3,566,680 (GRCm38)	splice site	probably null
R5049:Tasor2	UTSW	13	3,574,000 (GRCm38)	missense	probably benign	0.00
R5076:Tasor2	UTSW	13	3,576,357 (GRCm38)	missense	probably benign	0.41
R5287:Tasor2	UTSW	13	3,575,744 (GRCm38)	missense	probably benign	0.41
R5298:Tasor2	UTSW	13	3,595,613 (GRCm38)	splice site	probably null
R5379:Tasor2	UTSW	13	3,588,496 (GRCm38)	missense	probably benign	0.41
R5512:Tasor2	UTSW	13	3,595,517 (GRCm38)	missense	probably damaging	0.99
R5624:Tasor2	UTSW	13	3,584,996 (GRCm38)	missense	possibly damaging	0.66
R5750:Tasor2	UTSW	13	3,573,642 (GRCm38)	nonsense	probably null
R6114:Tasor2	UTSW	13	3,590,081 (GRCm38)	missense	probably damaging	1.00
R6118:Tasor2	UTSW	13	3,581,891 (GRCm38)	missense	possibly damaging	0.76
R6119:Tasor2	UTSW	13	3,581,891 (GRCm38)	missense	possibly damaging	0.76
R6269:Tasor2	UTSW	13	3,581,891 (GRCm38)	missense	possibly damaging	0.76
R6270:Tasor2	UTSW	13	3,581,891 (GRCm38)	missense	possibly damaging	0.76
R6271:Tasor2	UTSW	13	3,581,891 (GRCm38)	missense	possibly damaging	0.76
R6272:Tasor2	UTSW	13	3,581,891 (GRCm38)	missense	possibly damaging	0.76
R6525:Tasor2	UTSW	13	3,576,540 (GRCm38)	nonsense	probably null
R6550:Tasor2	UTSW	13	3,590,519 (GRCm38)	missense	possibly damaging	0.85
R6714:Tasor2	UTSW	13	3,594,189 (GRCm38)	missense	probably benign	0.00
R6797:Tasor2	UTSW	13	3,576,769 (GRCm38)	missense	probably benign	0.26
R6967:Tasor2	UTSW	13	3,574,819 (GRCm38)	missense	probably benign	0.22
R7016:Tasor2	UTSW	13	3,576,857 (GRCm38)	missense	possibly damaging	0.92
R7219:Tasor2	UTSW	13	3,590,521 (GRCm38)	missense	probably damaging	0.99
R7454:Tasor2	UTSW	13	3,585,332 (GRCm38)	missense	probably benign	0.21
R7570:Tasor2	UTSW	13	3,573,621 (GRCm38)	missense	probably damaging	0.99
R7571:Tasor2	UTSW	13	3,575,292 (GRCm38)	missense	probably benign	0.01
R7580:Tasor2	UTSW	13	3,574,752 (GRCm38)	missense	probably damaging	0.99
R7587:Tasor2	UTSW	13	3,568,849 (GRCm38)	missense	possibly damaging	0.83
R7657:Tasor2	UTSW	13	3,573,777 (GRCm38)	missense	probably damaging	0.98
R7810:Tasor2	UTSW	13	3,575,714 (GRCm38)	missense	possibly damaging	0.61
R7909:Tasor2	UTSW	13	3,573,765 (GRCm38)	missense	possibly damaging	0.93
R7924:Tasor2	UTSW	13	3,594,331 (GRCm38)	missense	possibly damaging	0.92
R7945:Tasor2	UTSW	13	3,576,085 (GRCm38)	missense	probably benign
R8005:Tasor2	UTSW	13	3,575,681 (GRCm38)	missense	probably benign
R8067:Tasor2	UTSW	13	3,569,602 (GRCm38)	missense	probably benign
R8112:Tasor2	UTSW	13	3,569,516 (GRCm38)	missense	probably damaging	1.00
R8162:Tasor2	UTSW	13	3,599,691 (GRCm38)	missense	probably damaging	0.96
R8170:Tasor2	UTSW	13	3,574,881 (GRCm38)	nonsense	probably null
R8240:Tasor2	UTSW	13	3,574,388 (GRCm38)	missense	probably benign
R8263:Tasor2	UTSW	13	3,590,016 (GRCm38)	missense	probably benign	0.03
R8263:Tasor2	UTSW	13	3,575,286 (GRCm38)	missense	possibly damaging	0.70
R8477:Tasor2	UTSW	13	3,575,079 (GRCm38)	missense	probably benign	0.18
R9022:Tasor2	UTSW	13	3,576,659 (GRCm38)	missense	probably benign
R9140:Tasor2	UTSW	13	3,588,441 (GRCm38)	missense	probably benign	0.04
R9167:Tasor2	UTSW	13	3,574,724 (GRCm38)	missense	probably benign
R9527:Tasor2	UTSW	13	3,585,191 (GRCm38)	missense	possibly damaging	0.61
R9535:Tasor2	UTSW	13	3,573,559 (GRCm38)	missense	possibly damaging	0.69
R9711:Tasor2	UTSW	13	3,599,667 (GRCm38)	missense	probably benign
X0024:Tasor2	UTSW	13	3,599,837 (GRCm38)	missense	probably null	0.99
X0025:Tasor2	UTSW	13	3,576,827 (GRCm38)	missense	probably benign	0.15
X0066:Tasor2	UTSW	13	3,588,441 (GRCm38)	missense	probably benign	0.04
Z1176:Tasor2	UTSW	13	3,588,429 (GRCm38)	missense	probably damaging	0.98
Z1176:Tasor2	UTSW	13	3,576,636 (GRCm38)	missense	probably benign	0.01
Z1177:Tasor2	UTSW	13	3,574,234 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- GTGGTCATCAACAGTGGCAAAACC -3'
(R):5'- TCCTTGCTGAGCAGTCACAGAAAC -3'

Sequencing Primer
(F):5'- GTGGCAAAACCTGAAATTGTCAAC -3'
(R):5'- TAGGAAAGGTCATGCCATTTCG -3'

Posted On

2014-05-09