Incidental Mutation 'R1676:Jmjd1c'
| ID |
188095 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Jmjd1c
|
| Ensembl Gene |
ENSMUSG00000037876 |
| Gene Name |
jumonji domain containing 1C |
| Synonyms |
D630035I23Rik, TRIP8, 5430433L24Rik |
| MMRRC Submission |
039712-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.662)
|
| Stock # |
R1676 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
66932189-67092105 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 67060588 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 693
(D693E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134246
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051446]
[ENSMUST00000173689]
[ENSMUST00000174317]
[ENSMUST00000174408]
|
| AlphaFold |
Q69ZK6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000051446
AA Change: D980E
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000056227
Gene: ENSMUSG00000037876
AA Change: D980E
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2236 |
N/A |
BLAST |
|
JmjC
|
2264 |
2488 |
3.29e-53 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173689
AA Change: D799E
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000133700
Gene: ENSMUSG00000037876
AA Change: D799E
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
2056 |
N/A |
BLAST |
|
JmjC
|
2084 |
2308 |
3.29e-53 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174317
AA Change: D693E
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000134246
Gene: ENSMUSG00000037876
AA Change: D693E
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
744 |
N/A |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174408
AA Change: D980E
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000134551
Gene: ENSMUSG00000037876
AA Change: D980E
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2237 |
N/A |
BLAST |
|
JmjC
|
2265 |
2489 |
3.29e-53 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
G |
T |
11: 58,771,819 (GRCm39) |
A434S |
possibly damaging |
Het |
| Abhd8 |
T |
A |
8: 71,914,517 (GRCm39) |
D37V |
probably damaging |
Het |
| Acvr2a |
G |
A |
2: 48,763,095 (GRCm39) |
S97N |
probably benign |
Het |
| Ampd3 |
T |
A |
7: 110,394,940 (GRCm39) |
H296Q |
probably damaging |
Het |
| Arid4a |
G |
A |
12: 71,122,112 (GRCm39) |
S509N |
probably benign |
Het |
| Cap2 |
T |
G |
13: 46,791,335 (GRCm39) |
H167Q |
probably damaging |
Het |
| Car8 |
A |
G |
4: 8,185,616 (GRCm39) |
L180S |
probably damaging |
Het |
| Casp8 |
T |
A |
1: 58,883,575 (GRCm39) |
I314N |
probably damaging |
Het |
| Cavin2 |
T |
A |
1: 51,340,330 (GRCm39) |
S336T |
probably benign |
Het |
| Cdc14b |
A |
T |
13: 64,373,416 (GRCm39) |
I119N |
possibly damaging |
Het |
| Cemip |
T |
A |
7: 83,613,246 (GRCm39) |
I651F |
possibly damaging |
Het |
| Cfap57 |
T |
A |
4: 118,453,137 (GRCm39) |
D522V |
probably damaging |
Het |
| Clrn3 |
A |
T |
7: 135,120,307 (GRCm39) |
V93D |
probably damaging |
Het |
| Crppa |
T |
C |
12: 36,526,720 (GRCm39) |
C170R |
probably benign |
Het |
| Cyp4f39 |
A |
G |
17: 32,701,176 (GRCm39) |
D222G |
probably benign |
Het |
| D5Ertd579e |
A |
G |
5: 36,773,453 (GRCm39) |
V314A |
probably benign |
Het |
| Dchs1 |
C |
T |
7: 105,404,128 (GRCm39) |
V2805I |
probably benign |
Het |
| Dsp |
A |
T |
13: 38,377,350 (GRCm39) |
K1712* |
probably null |
Het |
| Emilin2 |
T |
C |
17: 71,581,085 (GRCm39) |
D547G |
probably benign |
Het |
| Erbb3 |
T |
C |
10: 128,419,117 (GRCm39) |
H248R |
probably benign |
Het |
| Erich3 |
A |
G |
3: 154,468,260 (GRCm39) |
|
probably benign |
Het |
| Fbn1 |
T |
C |
2: 125,151,701 (GRCm39) |
T2518A |
probably damaging |
Het |
| Fzd2 |
G |
A |
11: 102,496,707 (GRCm39) |
V384M |
probably damaging |
Het |
| Gpc5 |
T |
A |
14: 115,607,510 (GRCm39) |
S371T |
probably damaging |
Het |
| Hbb-bh2 |
T |
C |
7: 103,488,362 (GRCm39) |
K145R |
probably null |
Het |
| Hectd1 |
G |
T |
12: 51,791,571 (GRCm39) |
P2558Q |
probably damaging |
Het |
| Hgsnat |
C |
T |
8: 26,444,633 (GRCm39) |
|
probably null |
Het |
| Hirip3 |
T |
C |
7: 126,462,647 (GRCm39) |
|
probably null |
Het |
| Itpkc |
T |
C |
7: 26,907,706 (GRCm39) |
D666G |
probably damaging |
Het |
| Katnbl1 |
T |
C |
2: 112,236,454 (GRCm39) |
L60P |
probably damaging |
Het |
| Kcna1 |
T |
A |
6: 126,619,645 (GRCm39) |
E225V |
probably damaging |
Het |
| Kcnj6 |
T |
A |
16: 94,633,443 (GRCm39) |
M223L |
probably damaging |
Het |
| Kcnk7 |
G |
T |
19: 5,757,006 (GRCm39) |
V332F |
probably benign |
Het |
| Kmt5a |
GAA |
GA |
5: 124,597,948 (GRCm39) |
|
probably null |
Het |
| Mdga2 |
C |
A |
12: 66,615,546 (GRCm39) |
G618V |
probably damaging |
Het |
| Mdga2 |
C |
A |
12: 66,615,547 (GRCm39) |
G618* |
probably null |
Het |
| Morc2b |
T |
C |
17: 33,354,955 (GRCm39) |
E939G |
possibly damaging |
Het |
| Mstn |
T |
A |
1: 53,101,224 (GRCm39) |
D100E |
probably benign |
Het |
| Mthfd1l |
G |
A |
10: 4,033,877 (GRCm39) |
|
probably null |
Het |
| Muc20 |
T |
A |
16: 32,614,649 (GRCm39) |
T243S |
probably damaging |
Het |
| Myo1d |
A |
T |
11: 80,575,247 (GRCm39) |
N156K |
probably damaging |
Het |
| Myo7a |
A |
G |
7: 97,748,679 (GRCm39) |
|
probably null |
Het |
| Naa35 |
A |
T |
13: 59,760,490 (GRCm39) |
Q274L |
probably damaging |
Het |
| Ncam1 |
G |
A |
9: 49,468,472 (GRCm39) |
T329I |
probably damaging |
Het |
| Nisch |
T |
C |
14: 30,902,859 (GRCm39) |
|
probably benign |
Het |
| Nlrp1b |
A |
T |
11: 71,073,637 (GRCm39) |
W69R |
probably benign |
Het |
| Nrap |
T |
A |
19: 56,323,687 (GRCm39) |
H1294L |
probably damaging |
Het |
| Nsun6 |
T |
A |
2: 15,052,024 (GRCm39) |
R56* |
probably null |
Het |
| Nudt1 |
A |
G |
5: 140,320,378 (GRCm39) |
|
probably null |
Het |
| Nxph4 |
T |
G |
10: 127,362,077 (GRCm39) |
K271N |
probably damaging |
Het |
| Or1af1 |
A |
T |
2: 37,109,653 (GRCm39) |
R51* |
probably null |
Het |
| Or4a66 |
T |
G |
2: 88,531,661 (GRCm39) |
H4P |
probably benign |
Het |
| Or51e2 |
T |
A |
7: 102,391,605 (GRCm39) |
I202F |
probably damaging |
Het |
| Or52a20 |
T |
C |
7: 103,366,319 (GRCm39) |
W173R |
probably benign |
Het |
| Otud6b |
T |
A |
4: 14,825,617 (GRCm39) |
N71I |
probably damaging |
Het |
| Parp8 |
T |
A |
13: 117,014,064 (GRCm39) |
D623V |
probably damaging |
Het |
| Pcdhb5 |
T |
C |
18: 37,453,805 (GRCm39) |
S62P |
probably benign |
Het |
| Ppp1r12b |
A |
G |
1: 134,705,190 (GRCm39) |
S833P |
probably damaging |
Het |
| Ppp1r1a |
T |
G |
15: 103,441,915 (GRCm39) |
D51A |
probably damaging |
Het |
| Prag1 |
C |
A |
8: 36,570,052 (GRCm39) |
P212T |
probably damaging |
Het |
| Prxl2b |
C |
T |
4: 154,981,520 (GRCm39) |
V186I |
probably benign |
Het |
| Ptdss1 |
A |
G |
13: 67,081,701 (GRCm39) |
T44A |
probably damaging |
Het |
| Rab14 |
T |
C |
2: 35,076,735 (GRCm39) |
H83R |
possibly damaging |
Het |
| Rapgef3 |
C |
T |
15: 97,659,063 (GRCm39) |
G101E |
probably benign |
Het |
| Rimbp3 |
T |
A |
16: 17,028,977 (GRCm39) |
D800E |
probably benign |
Het |
| Rsf1 |
ATGGCG |
ATGGCGACGGTGGCG |
7: 97,229,111 (GRCm39) |
|
probably benign |
Het |
| Selenbp1 |
A |
G |
3: 94,851,854 (GRCm39) |
D465G |
probably damaging |
Het |
| Slc28a2b |
T |
C |
2: 122,352,340 (GRCm39) |
S366P |
probably damaging |
Het |
| Slc29a1 |
T |
C |
17: 45,899,936 (GRCm39) |
D251G |
probably damaging |
Het |
| Slc6a11 |
G |
T |
6: 114,224,627 (GRCm39) |
V604F |
probably benign |
Het |
| Sltm |
T |
A |
9: 70,480,929 (GRCm39) |
D260E |
probably damaging |
Het |
| Spta1 |
G |
A |
1: 174,007,405 (GRCm39) |
V212M |
probably damaging |
Het |
| St6gal2 |
T |
C |
17: 55,803,396 (GRCm39) |
|
probably null |
Het |
| Tc2n |
A |
G |
12: 101,655,251 (GRCm39) |
S235P |
probably damaging |
Het |
| Tenm3 |
T |
A |
8: 48,870,154 (GRCm39) |
N213I |
possibly damaging |
Het |
| Ticam2 |
T |
C |
18: 46,693,677 (GRCm39) |
T137A |
probably damaging |
Het |
| Ttn |
TCCC |
TCCCC |
2: 76,573,251 (GRCm39) |
|
probably null |
Het |
| Tyk2 |
G |
A |
9: 21,026,545 (GRCm39) |
Q684* |
probably null |
Het |
| Ubqln1 |
A |
G |
13: 58,327,205 (GRCm39) |
F478S |
possibly damaging |
Het |
| Uckl1 |
G |
A |
2: 181,216,711 (GRCm39) |
T78I |
probably damaging |
Het |
| Uhmk1 |
A |
G |
1: 170,027,581 (GRCm39) |
V372A |
probably damaging |
Het |
| Unc5c |
G |
A |
3: 141,463,598 (GRCm39) |
V240I |
possibly damaging |
Het |
| Ush2a |
T |
C |
1: 188,460,782 (GRCm39) |
L2681P |
probably damaging |
Het |
| Vmn2r1 |
C |
T |
3: 63,997,603 (GRCm39) |
Q420* |
probably null |
Het |
| Vmn2r101 |
A |
T |
17: 19,832,184 (GRCm39) |
T727S |
probably benign |
Het |
| Vmn2r79 |
A |
G |
7: 86,651,839 (GRCm39) |
T413A |
probably benign |
Het |
| Vps13c |
T |
C |
9: 67,834,244 (GRCm39) |
V1637A |
probably benign |
Het |
| Xpc |
A |
G |
6: 91,469,929 (GRCm39) |
V765A |
possibly damaging |
Het |
| Zbtb18 |
T |
G |
1: 177,274,913 (GRCm39) |
|
probably null |
Het |
| Zfp712 |
A |
T |
13: 67,200,400 (GRCm39) |
D28E |
probably benign |
Het |
| Zfp735 |
A |
G |
11: 73,602,301 (GRCm39) |
N415S |
possibly damaging |
Het |
|
| Other mutations in Jmjd1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01062:Jmjd1c
|
APN |
10 |
67,062,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01604:Jmjd1c
|
APN |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Jmjd1c
|
APN |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02081:Jmjd1c
|
APN |
10 |
67,055,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02128:Jmjd1c
|
APN |
10 |
67,079,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02134:Jmjd1c
|
APN |
10 |
67,056,171 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02215:Jmjd1c
|
APN |
10 |
67,056,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Jmjd1c
|
APN |
10 |
67,062,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02502:Jmjd1c
|
APN |
10 |
67,061,640 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02546:Jmjd1c
|
APN |
10 |
67,061,115 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02943:Jmjd1c
|
APN |
10 |
67,055,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03171:Jmjd1c
|
APN |
10 |
67,061,277 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03261:Jmjd1c
|
APN |
10 |
67,067,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Accordion
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Jmjd1c
|
UTSW |
10 |
67,065,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Jmjd1c
|
UTSW |
10 |
67,055,105 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0133:Jmjd1c
|
UTSW |
10 |
67,076,587 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0201:Jmjd1c
|
UTSW |
10 |
67,054,888 (GRCm39) |
missense |
unknown |
|
|
R0396:Jmjd1c
|
UTSW |
10 |
67,055,302 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0401:Jmjd1c
|
UTSW |
10 |
67,056,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Jmjd1c
|
UTSW |
10 |
67,091,261 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0488:Jmjd1c
|
UTSW |
10 |
67,076,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0504:Jmjd1c
|
UTSW |
10 |
67,061,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Jmjd1c
|
UTSW |
10 |
67,061,568 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0673:Jmjd1c
|
UTSW |
10 |
67,062,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Jmjd1c
|
UTSW |
10 |
67,054,725 (GRCm39) |
splice site |
probably null |
|
|
R0755:Jmjd1c
|
UTSW |
10 |
66,932,378 (GRCm39) |
intron |
probably benign |
|
|
R1142:Jmjd1c
|
UTSW |
10 |
67,061,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Jmjd1c
|
UTSW |
10 |
67,075,015 (GRCm39) |
splice site |
probably benign |
|
|
R1413:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1619:Jmjd1c
|
UTSW |
10 |
67,055,654 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1751:Jmjd1c
|
UTSW |
10 |
67,061,469 (GRCm39) |
missense |
probably benign |
|
|
R1950:Jmjd1c
|
UTSW |
10 |
67,075,701 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1968:Jmjd1c
|
UTSW |
10 |
67,061,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2049:Jmjd1c
|
UTSW |
10 |
66,993,777 (GRCm39) |
nonsense |
probably null |
|
|
R2061:Jmjd1c
|
UTSW |
10 |
67,054,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2203:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2256:Jmjd1c
|
UTSW |
10 |
67,061,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Jmjd1c
|
UTSW |
10 |
67,074,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2349:Jmjd1c
|
UTSW |
10 |
67,091,279 (GRCm39) |
missense |
probably benign |
|
|
R2392:Jmjd1c
|
UTSW |
10 |
67,065,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3015:Jmjd1c
|
UTSW |
10 |
66,993,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Jmjd1c
|
UTSW |
10 |
67,075,863 (GRCm39) |
splice site |
probably benign |
|
|
R4043:Jmjd1c
|
UTSW |
10 |
67,055,245 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4097:Jmjd1c
|
UTSW |
10 |
67,054,787 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4118:Jmjd1c
|
UTSW |
10 |
67,055,532 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4193:Jmjd1c
|
UTSW |
10 |
66,932,460 (GRCm39) |
intron |
probably benign |
|
|
R4352:Jmjd1c
|
UTSW |
10 |
67,080,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4577:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Jmjd1c
|
UTSW |
10 |
66,993,753 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Jmjd1c
|
UTSW |
10 |
66,993,830 (GRCm39) |
nonsense |
probably null |
|
|
R4741:Jmjd1c
|
UTSW |
10 |
67,060,718 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4774:Jmjd1c
|
UTSW |
10 |
67,060,571 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R4836:Jmjd1c
|
UTSW |
10 |
67,069,225 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4914:Jmjd1c
|
UTSW |
10 |
67,054,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Jmjd1c
|
UTSW |
10 |
67,081,916 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5211:Jmjd1c
|
UTSW |
10 |
67,067,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Jmjd1c
|
UTSW |
10 |
67,076,480 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5514:Jmjd1c
|
UTSW |
10 |
67,053,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5530:Jmjd1c
|
UTSW |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Jmjd1c
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5640:Jmjd1c
|
UTSW |
10 |
67,061,857 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5654:Jmjd1c
|
UTSW |
10 |
67,065,785 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5742:Jmjd1c
|
UTSW |
10 |
67,056,112 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5764:Jmjd1c
|
UTSW |
10 |
67,062,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6118:Jmjd1c
|
UTSW |
10 |
67,075,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Jmjd1c
|
UTSW |
10 |
67,083,827 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6256:Jmjd1c
|
UTSW |
10 |
67,056,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Jmjd1c
|
UTSW |
10 |
67,085,439 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6358:Jmjd1c
|
UTSW |
10 |
67,061,718 (GRCm39) |
missense |
probably benign |
|
|
R6430:Jmjd1c
|
UTSW |
10 |
67,059,939 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6455:Jmjd1c
|
UTSW |
10 |
67,061,795 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6887:Jmjd1c
|
UTSW |
10 |
67,025,599 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6895:Jmjd1c
|
UTSW |
10 |
67,052,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Jmjd1c
|
UTSW |
10 |
67,056,388 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7095:Jmjd1c
|
UTSW |
10 |
67,055,411 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7113:Jmjd1c
|
UTSW |
10 |
66,993,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7225:Jmjd1c
|
UTSW |
10 |
67,061,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Jmjd1c
|
UTSW |
10 |
67,025,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7361:Jmjd1c
|
UTSW |
10 |
67,054,143 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7383:Jmjd1c
|
UTSW |
10 |
67,025,537 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7460:Jmjd1c
|
UTSW |
10 |
67,052,815 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7475:Jmjd1c
|
UTSW |
10 |
67,061,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7502:Jmjd1c
|
UTSW |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7699:Jmjd1c
|
UTSW |
10 |
67,054,195 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7745:Jmjd1c
|
UTSW |
10 |
67,052,824 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7897:Jmjd1c
|
UTSW |
10 |
67,075,644 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Jmjd1c
|
UTSW |
10 |
67,061,621 (GRCm39) |
missense |
probably benign |
|
|
R7911:Jmjd1c
|
UTSW |
10 |
67,067,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Jmjd1c
|
UTSW |
10 |
67,085,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Jmjd1c
|
UTSW |
10 |
67,090,274 (GRCm39) |
missense |
not run |
|
|
R8224:Jmjd1c
|
UTSW |
10 |
67,080,628 (GRCm39) |
missense |
noncoding transcript |
|
|
R8251:Jmjd1c
|
UTSW |
10 |
67,075,068 (GRCm39) |
missense |
noncoding transcript |
|
|
R8797:Jmjd1c
|
UTSW |
10 |
67,060,616 (GRCm39) |
missense |
probably benign |
|
|
R8833:Jmjd1c
|
UTSW |
10 |
67,054,162 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9262:Jmjd1c
|
UTSW |
10 |
67,083,793 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9354:Jmjd1c
|
UTSW |
10 |
67,059,875 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9373:Jmjd1c
|
UTSW |
10 |
66,932,495 (GRCm39) |
intron |
probably benign |
|
|
R9477:Jmjd1c
|
UTSW |
10 |
66,993,734 (GRCm39) |
nonsense |
probably null |
|
|
R9519:Jmjd1c
|
UTSW |
10 |
66,993,798 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9701:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9802:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
RF011:Jmjd1c
|
UTSW |
10 |
67,055,978 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1088:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,081,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACCAGTGTTTAACACTTAACACATGCCT -3'
(R):5'- CCTTGATTTTGGTTGTAAATGGAGCCAC -3'
Sequencing Primer
(F):5'- ctcaaactcagaaatccgcc -3'
(R):5'- GGTTGTAAATGGAGCCACATCAATAC -3'
|
| Posted On |
2014-05-09 |
Incidental Mutation