|Institutional Source||Beutler Lab|
|Gene Name||chemokine (C-C motif) ligand 11|
|Is this an essential gene?||Probably non essential (E-score: 0.080)|
|Stock #||R1678 (G1)|
|Chromosomal Location||82057823-82062955 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to T at 82058040 bp|
|Amino Acid Change||Proline to Leucine at position 25 (P25L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000000342 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000000342]|
|Predicted Effect||probably damaging
AA Change: P25L
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: P25L
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a disruption in this gene display decreased numbers of eosinophils and impaired eosinophil recruitment after antigen challenge. However, a different homozygous disruption does not result in eosinophil abnormalities. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ccl11||
(F):5'- AGAGTGTTCCACTGCTCAAGACCC -3'
(R):5'- TGTGTGGATGCACTTAGCACCTG -3'
(F):5'- TCAAGACCCCTCCTTCATGAC -3'
(R):5'- gagacagagacagacacagag -3'