Incidental Mutation 'R1680:Oasl1'
ID 188405
Institutional Source Beutler Lab
Gene Symbol Oasl1
Ensembl Gene ENSMUSG00000041827
Gene Name 2'-5' oligoadenylate synthetase-like 1
Synonyms
MMRRC Submission 039716-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # R1680 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 114923240-114937915 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 114935944 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 304 (D304G)
Ref Sequence ENSEMBL: ENSMUSP00000107771 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031540] [ENSMUST00000112143]
AlphaFold Q8VI94
Predicted Effect probably damaging
Transcript: ENSMUST00000031540
AA Change: D304G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000031540
Gene: ENSMUSG00000041827
AA Change: D304G

DomainStartEndE-ValueType
low complexity region 31 42 N/A INTRINSIC
Pfam:OAS1_C 162 348 8e-76 PFAM
UBQ 350 425 1.58e0 SMART
UBQ 430 501 2.22e-11 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112143
AA Change: D304G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000107771
Gene: ENSMUSG00000041827
AA Change: D304G

DomainStartEndE-ValueType
low complexity region 31 42 N/A INTRINSIC
Pfam:OAS1_C 163 346 1.9e-79 PFAM
UBQ 350 425 1.58e0 SMART
UBQ 430 501 2.22e-11 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140159
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152329
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155274
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155394
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice with a deletion of this gene have increased expression of type I interferon and show increased resistance to viral infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik C G 10: 100,603,528 P187R probably damaging Het
Ahnak T A 19: 9,009,963 H2870Q probably benign Het
Arhgef33 C T 17: 80,347,651 S95F probably damaging Het
Atp1a2 T A 1: 172,278,954 D827V probably damaging Het
Bcat1 T G 6: 145,039,628 D96A probably damaging Het
Birc6 A T 17: 74,548,746 I184L probably benign Het
Ccdc129 C T 6: 55,968,766 T824I probably damaging Het
Clca3b A T 3: 144,837,824 L415M probably damaging Het
Clstn1 T C 4: 149,643,726 V617A probably benign Het
Col22a1 G A 15: 71,799,361 A1050V unknown Het
Col5a3 C T 9: 20,784,668 probably null Het
Csmd3 G A 15: 47,741,170 T1059I probably damaging Het
Dclk2 C T 3: 86,805,639 R503Q possibly damaging Het
Dnm3 A G 1: 162,010,976 V272A probably benign Het
Dnmt3a A G 12: 3,873,361 Q187R probably damaging Het
Dpp9 A G 17: 56,190,103 Y710H probably benign Het
Eef1a2 A T 2: 181,152,941 M155K possibly damaging Het
Entpd8 G A 2: 25,084,024 C331Y probably damaging Het
Erc1 A C 6: 119,575,761 L1072R probably damaging Het
Fam160b2 T C 14: 70,586,851 Y482C probably damaging Het
Gtf3c2 A G 5: 31,173,868 S155P probably damaging Het
Gucy2c A G 6: 136,722,493 S617P probably damaging Het
Ice1 T C 13: 70,605,448 R840G probably benign Het
Il1rl2 T C 1: 40,351,793 Y299H possibly damaging Het
Ints7 T G 1: 191,621,162 probably null Het
Ireb2 C T 9: 54,881,518 T92I probably damaging Het
Kcnj8 A T 6: 142,570,189 L64* probably null Het
Mapk8ip3 A G 17: 24,901,011 V983A probably damaging Het
Mertk A G 2: 128,801,636 D985G probably benign Het
Mical3 A T 6: 120,959,643 S1307R probably benign Het
Ncaph2 A G 15: 89,364,622 D222G probably benign Het
Nf1 C A 11: 79,550,998 S295* probably null Het
Nlrp12 T A 7: 3,241,174 D236V probably damaging Het
Npnt A G 3: 132,906,802 V74A probably benign Het
Olfr1098 C T 2: 86,923,161 V124I probably benign Het
Olfr556 A G 7: 102,670,733 D271G possibly damaging Het
Olfr834 A G 9: 18,988,516 H176R possibly damaging Het
Olfr936 T C 9: 39,047,000 I140V probably benign Het
Patz1 A G 11: 3,307,812 K604E probably damaging Het
Pcsk6 T A 7: 66,035,250 V793E probably benign Het
Pla2g4d C T 2: 120,277,750 probably null Het
Plxnc1 A C 10: 94,841,551 L938R probably benign Het
Pou4f2 G T 8: 78,434,831 A381D probably damaging Het
Prdm4 A G 10: 85,899,223 L685P possibly damaging Het
Pxn T A 5: 115,552,147 V383E probably damaging Het
Rbl1 A G 2: 157,174,783 L632P probably damaging Het
Rnf135 T A 11: 80,196,881 S219T possibly damaging Het
Sdk2 T C 11: 113,791,436 D2039G possibly damaging Het
Sdk2 C T 11: 113,838,646 silent Het
Slc5a6 A G 5: 31,042,644 Y131H probably damaging Het
Slc9a1 T C 4: 133,418,080 I492T probably damaging Het
Soga3 A T 10: 29,196,839 Q709L probably damaging Het
Spag5 A G 11: 78,320,616 K993E probably damaging Het
Sptbn1 T G 11: 30,159,371 I75L possibly damaging Het
Syngap1 T C 17: 26,952,579 S46P possibly damaging Het
Tfcp2l1 T A 1: 118,675,605 F458I probably damaging Het
Tmem67 A G 4: 12,087,840 V102A probably benign Het
Tomm70a T C 16: 57,121,961 S34P unknown Het
Txlnb G T 10: 17,843,233 G604V probably benign Het
Ube2q1 A G 3: 89,776,176 T143A probably benign Het
Unc80 C T 1: 66,503,669 R361* probably null Het
Vcan T C 13: 89,703,547 D1098G probably benign Het
Vmn1r176 T A 7: 23,835,381 T116S probably damaging Het
Wdr81 C T 11: 75,454,423 R6K probably benign Het
Zan T A 5: 137,403,050 T4136S unknown Het
Zbtb14 C A 17: 69,388,502 F398L probably damaging Het
Zfp606 A T 7: 12,493,971 H615L probably damaging Het
Zp3r A T 1: 130,582,880 N433K probably benign Het
Other mutations in Oasl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Oasl1 APN 5 114937407 missense probably benign 0.01
IGL02061:Oasl1 APN 5 114923592 missense probably damaging 0.97
IGL02888:Oasl1 APN 5 114937182 missense probably damaging 1.00
IGL03230:Oasl1 APN 5 114937056 missense probably damaging 1.00
ammonite UTSW 5 114936937 missense probably damaging 1.00
dreadnaught UTSW 5 114936070 critical splice donor site probably null
nautilus UTSW 5 114937183 missense probably damaging 1.00
spirogyra UTSW 5 114937406 missense probably benign 0.00
IGL03048:Oasl1 UTSW 5 114937341 missense possibly damaging 0.56
R1510:Oasl1 UTSW 5 114928108 missense probably benign 0.00
R1918:Oasl1 UTSW 5 114923469 missense possibly damaging 0.84
R2090:Oasl1 UTSW 5 114935934 missense probably damaging 1.00
R3977:Oasl1 UTSW 5 114932898 missense probably damaging 1.00
R3978:Oasl1 UTSW 5 114932898 missense probably damaging 1.00
R3980:Oasl1 UTSW 5 114932898 missense probably damaging 1.00
R4158:Oasl1 UTSW 5 114937014 missense possibly damaging 0.77
R4159:Oasl1 UTSW 5 114937014 missense possibly damaging 0.77
R4160:Oasl1 UTSW 5 114937014 missense possibly damaging 0.77
R4161:Oasl1 UTSW 5 114937014 missense possibly damaging 0.77
R4797:Oasl1 UTSW 5 114928158 missense probably benign 0.00
R5354:Oasl1 UTSW 5 114936996 missense probably damaging 1.00
R5443:Oasl1 UTSW 5 114936070 critical splice donor site probably null
R5820:Oasl1 UTSW 5 114936978 missense possibly damaging 0.94
R5919:Oasl1 UTSW 5 114928270 missense probably damaging 1.00
R6746:Oasl1 UTSW 5 114937183 missense probably damaging 1.00
R7471:Oasl1 UTSW 5 114935926 missense probably damaging 1.00
R7720:Oasl1 UTSW 5 114929921 missense probably damaging 1.00
R7766:Oasl1 UTSW 5 114937110 missense probably damaging 1.00
R8115:Oasl1 UTSW 5 114936937 missense probably damaging 1.00
R8243:Oasl1 UTSW 5 114928161 missense probably benign 0.04
R8358:Oasl1 UTSW 5 114937406 missense probably benign 0.00
Z1177:Oasl1 UTSW 5 114932745 missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TTCCAGGACCCAGTTTACAGCCTC -3'
(R):5'- TGCCTCTGAAAAGCTGTTCCCC -3'

Sequencing Primer
(F):5'- TCTGCACTTCCCGGAATG -3'
(R):5'- GAAAAGCTGTTCCCCACTTTG -3'
Posted On 2014-05-09