Incidental Mutation 'R1681:Idh2'
| ID |
188507 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Idh2
|
| Ensembl Gene |
ENSMUSG00000030541 |
| Gene Name |
isocitrate dehydrogenase 2 (NADP+), mitochondrial |
| Synonyms |
Idh-2, IDPm |
| MMRRC Submission |
039717-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1681 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
79744594-79765140 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 79748906 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Alanine
at position 125
(E125A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118184
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000107384]
[ENSMUST00000125542]
[ENSMUST00000134328]
[ENSMUST00000164056]
[ENSMUST00000206714]
|
| AlphaFold |
P54071 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107384
AA Change: E125A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000103007
Gene: ENSMUSG00000030541
AA Change: E125A
| Domain | Start | End | E-Value | Type |
|---|
|
Iso_dh
|
49 |
441 |
5.32e-135 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000125542
AA Change: E47A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134070
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000134328
AA Change: E125A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000118184
Gene: ENSMUSG00000030541
AA Change: E125A
| Domain | Start | End | E-Value | Type |
|---|
|
Iso_dh
|
49 |
284 |
1.59e-8 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139178
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156761
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164056
|
| SMART Domains |
Protein: ENSMUSP00000132361
Gene: ENSMUSG00000048897
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
88 |
N/A |
INTRINSIC |
|
low complexity region
|
106 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
169 |
181 |
N/A |
INTRINSIC |
|
low complexity region
|
187 |
201 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
297 |
319 |
2.71e-2 |
SMART |
|
ZnF_C2H2
|
325 |
347 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
353 |
375 |
2.71e-2 |
SMART |
|
ZnF_C2H2
|
381 |
403 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
409 |
431 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
437 |
459 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
465 |
487 |
3.83e-2 |
SMART |
|
ZnF_C2H2
|
493 |
515 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
521 |
543 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
549 |
571 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
577 |
600 |
3.69e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206714
|
| Meta Mutation Damage Score |
0.7794 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.6%
- 20x: 93.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit suppression of tumorigenesis from B16F10 melanoma cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaca |
T |
A |
11: 84,117,011 (GRCm39) |
I247N |
probably damaging |
Het |
| Ankle1 |
G |
T |
8: 71,860,262 (GRCm39) |
S260I |
probably benign |
Het |
| Aoc2 |
T |
C |
11: 101,216,018 (GRCm39) |
S34P |
probably benign |
Het |
| Ap1m1 |
A |
C |
8: 73,009,966 (GRCm39) |
I397L |
possibly damaging |
Het |
| Apba1 |
C |
A |
19: 23,913,925 (GRCm39) |
D649E |
probably damaging |
Het |
| Aptx |
C |
T |
4: 40,697,274 (GRCm39) |
V25M |
probably benign |
Het |
| Arhgef18 |
G |
A |
8: 3,489,645 (GRCm39) |
G326R |
probably damaging |
Het |
| Atm |
A |
C |
9: 53,433,455 (GRCm39) |
I265S |
possibly damaging |
Het |
| B3galt4 |
A |
T |
17: 34,170,187 (GRCm39) |
V17E |
probably benign |
Het |
| Bcl7a |
T |
A |
5: 123,494,086 (GRCm39) |
M86K |
possibly damaging |
Het |
| Calhm6 |
A |
G |
10: 34,003,896 (GRCm39) |
F4L |
probably benign |
Het |
| Cela3a |
T |
A |
4: 137,129,995 (GRCm39) |
|
probably null |
Het |
| Cep85 |
T |
A |
4: 133,876,039 (GRCm39) |
K456* |
probably null |
Het |
| Ces1f |
C |
A |
8: 94,002,042 (GRCm39) |
A29S |
probably benign |
Het |
| Chd9 |
A |
T |
8: 91,699,763 (GRCm39) |
I598F |
probably damaging |
Het |
| Cntln |
T |
C |
4: 84,865,872 (GRCm39) |
L176S |
probably damaging |
Het |
| Cntn3 |
A |
T |
6: 102,147,629 (GRCm39) |
N909K |
probably damaging |
Het |
| Cntnap5b |
T |
C |
1: 100,003,832 (GRCm39) |
S271P |
probably damaging |
Het |
| Col6a3 |
T |
A |
1: 90,701,224 (GRCm39) |
H2564L |
unknown |
Het |
| Cyp2b19 |
C |
A |
7: 26,462,765 (GRCm39) |
|
probably null |
Het |
| Dapk1 |
G |
T |
13: 60,866,278 (GRCm39) |
|
probably null |
Het |
| Dnah7b |
T |
A |
1: 46,363,872 (GRCm39) |
Y3497* |
probably null |
Het |
| Duoxa2 |
T |
C |
2: 122,129,643 (GRCm39) |
|
probably null |
Het |
| Eny2 |
T |
C |
15: 44,295,874 (GRCm39) |
W42R |
probably damaging |
Het |
| Epha3 |
A |
G |
16: 63,416,091 (GRCm39) |
V635A |
probably damaging |
Het |
| Fam167b |
G |
C |
4: 129,472,069 (GRCm39) |
Q34E |
probably benign |
Het |
| Fancm |
T |
C |
12: 65,152,430 (GRCm39) |
M962T |
probably benign |
Het |
| Gimap8 |
T |
A |
6: 48,633,345 (GRCm39) |
I388N |
probably benign |
Het |
| Gpaa1 |
A |
G |
15: 76,215,653 (GRCm39) |
T22A |
probably benign |
Het |
| Hoxc11 |
T |
C |
15: 102,863,591 (GRCm39) |
S211P |
possibly damaging |
Het |
| Hsd17b12 |
T |
C |
2: 93,863,906 (GRCm39) |
N312S |
unknown |
Het |
| Igdcc4 |
A |
G |
9: 65,036,077 (GRCm39) |
Y712C |
probably damaging |
Het |
| Kank1 |
T |
C |
19: 25,387,668 (GRCm39) |
V447A |
possibly damaging |
Het |
| Kif1b |
T |
A |
4: 149,279,958 (GRCm39) |
|
probably null |
Het |
| Klc4 |
A |
T |
17: 46,947,696 (GRCm39) |
D335E |
probably damaging |
Het |
| Klhl33 |
T |
A |
14: 51,130,534 (GRCm39) |
D320V |
probably benign |
Het |
| Krt73 |
A |
T |
15: 101,710,482 (GRCm39) |
M84K |
possibly damaging |
Het |
| Kti12 |
T |
A |
4: 108,706,055 (GRCm39) |
I323N |
probably damaging |
Het |
| Kynu |
T |
C |
2: 43,569,837 (GRCm39) |
L373P |
probably damaging |
Het |
| Lats1 |
T |
C |
10: 7,581,678 (GRCm39) |
M821T |
probably damaging |
Het |
| Lnx1 |
A |
T |
5: 74,846,071 (GRCm39) |
H126Q |
probably benign |
Het |
| Lonrf2 |
G |
A |
1: 38,852,357 (GRCm39) |
P165S |
probably benign |
Het |
| Lrrc4b |
T |
A |
7: 44,110,601 (GRCm39) |
Y158N |
probably damaging |
Het |
| Lrrc74b |
C |
A |
16: 17,377,617 (GRCm39) |
R87L |
probably damaging |
Het |
| Meig1 |
T |
C |
2: 3,410,311 (GRCm39) |
D63G |
probably damaging |
Het |
| Mrpl38 |
G |
A |
11: 116,029,255 (GRCm39) |
|
probably benign |
Het |
| Mtcl2 |
T |
C |
2: 156,872,450 (GRCm39) |
T966A |
possibly damaging |
Het |
| Naip2 |
C |
T |
13: 100,298,368 (GRCm39) |
G556D |
probably benign |
Het |
| Naip2 |
T |
C |
13: 100,298,362 (GRCm39) |
E558G |
probably benign |
Het |
| Nlrp1a |
T |
A |
11: 71,033,184 (GRCm39) |
E3D |
unknown |
Het |
| Nphs2 |
T |
A |
1: 156,148,468 (GRCm39) |
D110E |
probably damaging |
Het |
| Nxn |
T |
A |
11: 76,163,290 (GRCm39) |
K244N |
probably benign |
Het |
| Oas3 |
A |
T |
5: 120,907,973 (GRCm39) |
F322L |
probably benign |
Het |
| Obscn |
T |
A |
11: 58,994,151 (GRCm39) |
Y1577F |
probably damaging |
Het |
| Or10ag57 |
G |
A |
2: 87,218,964 (GRCm39) |
R305K |
possibly damaging |
Het |
| Or8b47 |
T |
A |
9: 38,435,413 (GRCm39) |
N128K |
probably benign |
Het |
| Or8b50 |
G |
A |
9: 38,518,244 (GRCm39) |
G161D |
probably damaging |
Het |
| Or8b52 |
A |
G |
9: 38,576,616 (GRCm39) |
Y175H |
probably benign |
Het |
| Or8d2 |
T |
C |
9: 38,759,809 (GRCm39) |
M133T |
probably damaging |
Het |
| Panx1 |
T |
C |
9: 14,919,079 (GRCm39) |
D260G |
probably benign |
Het |
| Pcdhb15 |
T |
C |
18: 37,606,866 (GRCm39) |
Y33H |
probably damaging |
Het |
| Pik3ap1 |
C |
A |
19: 41,296,968 (GRCm39) |
V461F |
probably damaging |
Het |
| Plpp3 |
G |
A |
4: 105,066,002 (GRCm39) |
|
probably null |
Het |
| Prtn3 |
A |
T |
10: 79,716,375 (GRCm39) |
T61S |
probably benign |
Het |
| Psen1 |
T |
A |
12: 83,771,394 (GRCm39) |
Y225N |
probably damaging |
Het |
| Rab44 |
T |
A |
17: 29,359,098 (GRCm39) |
S429T |
possibly damaging |
Het |
| Ralgapa1 |
T |
C |
12: 55,809,388 (GRCm39) |
I462M |
probably benign |
Het |
| Rbfox3 |
T |
C |
11: 118,396,495 (GRCm39) |
N105S |
probably damaging |
Het |
| Rbm7 |
A |
C |
9: 48,401,021 (GRCm39) |
Y236D |
possibly damaging |
Het |
| Samhd1 |
T |
C |
2: 156,943,652 (GRCm39) |
T621A |
probably benign |
Het |
| Samt3 |
C |
A |
X: 85,090,256 (GRCm39) |
D49E |
probably benign |
Het |
| Sass6 |
T |
C |
3: 116,397,122 (GRCm39) |
V26A |
possibly damaging |
Het |
| Scn11a |
C |
T |
9: 119,633,478 (GRCm39) |
M418I |
possibly damaging |
Het |
| Scrib |
T |
C |
15: 75,936,416 (GRCm39) |
E480G |
probably damaging |
Het |
| Sec24a |
T |
G |
11: 51,586,016 (GRCm39) |
T1071P |
probably damaging |
Het |
| Siglecg |
A |
C |
7: 43,058,365 (GRCm39) |
E84A |
probably benign |
Het |
| Slc6a17 |
C |
T |
3: 107,381,702 (GRCm39) |
V419I |
probably damaging |
Het |
| Ssr2 |
T |
C |
3: 88,488,349 (GRCm39) |
M75T |
possibly damaging |
Het |
| Tbc1d22b |
A |
G |
17: 29,794,151 (GRCm39) |
T275A |
possibly damaging |
Het |
| Tbx15 |
T |
A |
3: 99,259,140 (GRCm39) |
|
probably null |
Het |
| Tll1 |
A |
C |
8: 64,538,585 (GRCm39) |
L353R |
possibly damaging |
Het |
| Tlr4 |
C |
T |
4: 66,759,342 (GRCm39) |
P712S |
probably damaging |
Het |
| Tmem145 |
T |
A |
7: 25,014,159 (GRCm39) |
F424L |
possibly damaging |
Het |
| Tnrc18 |
T |
C |
5: 142,759,572 (GRCm39) |
K755E |
unknown |
Het |
| Trmt44 |
A |
G |
5: 35,727,321 (GRCm39) |
I298T |
probably benign |
Het |
| Vmn1r69 |
A |
G |
7: 10,314,179 (GRCm39) |
V184A |
probably benign |
Het |
| Zfp84 |
T |
C |
7: 29,476,825 (GRCm39) |
C506R |
probably damaging |
Het |
|
| Other mutations in Idh2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01529:Idh2
|
APN |
7 |
79,747,693 (GRCm39) |
missense |
probably benign |
|
|
IGL02281:Idh2
|
APN |
7 |
79,745,550 (GRCm39) |
splice site |
probably null |
|
|
IGL02874:Idh2
|
APN |
7 |
79,747,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02892:Idh2
|
APN |
7 |
79,745,418 (GRCm39) |
missense |
probably benign |
|
|
IGL02937:Idh2
|
APN |
7 |
79,748,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02989:Idh2
|
APN |
7 |
79,748,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0040:Idh2
|
UTSW |
7 |
79,747,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0040:Idh2
|
UTSW |
7 |
79,747,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0090:Idh2
|
UTSW |
7 |
79,747,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0322:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0385:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0386:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0387:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0494:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1603:Idh2
|
UTSW |
7 |
79,748,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1711:Idh2
|
UTSW |
7 |
79,748,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1844:Idh2
|
UTSW |
7 |
79,748,625 (GRCm39) |
missense |
probably benign |
0.31 |
|
R3700:Idh2
|
UTSW |
7 |
79,748,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4941:Idh2
|
UTSW |
7 |
79,745,847 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5234:Idh2
|
UTSW |
7 |
79,745,853 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5387:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R5582:Idh2
|
UTSW |
7 |
79,748,087 (GRCm39) |
frame shift |
probably null |
|
|
R5655:Idh2
|
UTSW |
7 |
79,747,996 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6191:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6261:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R6311:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6351:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6413:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6561:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6709:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6772:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6781:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6848:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6861:Idh2
|
UTSW |
7 |
79,747,966 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6899:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7063:Idh2
|
UTSW |
7 |
79,745,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7076:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7081:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R7090:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7254:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
frame shift |
probably null |
|
|
R7298:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7401:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R7560:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
frame shift |
probably null |
|
|
R7561:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7694:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7816:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7884:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R7919:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7961:Idh2
|
UTSW |
7 |
79,748,001 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8009:Idh2
|
UTSW |
7 |
79,748,001 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8036:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8162:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R8321:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8451:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8488:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R8501:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8671:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8673:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8707:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R8725:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
frame shift |
probably null |
|
|
R8863:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8872:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8892:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8915:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8935:Idh2
|
UTSW |
7 |
79,764,946 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8951:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8954:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8985:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9101:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9111:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9138:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
frame shift |
probably null |
|
|
R9138:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R9140:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9555:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9580:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9614:Idh2
|
UTSW |
7 |
79,747,925 (GRCm39) |
nonsense |
probably null |
|
|
R9619:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9697:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9756:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9790:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
RF030:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCAGTTCAAGCCAAGGCTTC -3'
(R):5'- CACAGTCAGAGATGCAAGGTTCCAG -3'
Sequencing Primer
(F):5'- TCAAGCCAAGGCTTCCTGTG -3'
(R):5'- tcctactgccgagaccc -3'
|
| Posted On |
2014-05-09 |
Incidental Mutation