Incidental Mutation 'R1681:Olfr917'
ID 188518
Institutional Source Beutler Lab
Gene Symbol Olfr917
Ensembl Gene ENSMUSG00000063225
Gene Name olfactory receptor 917
Synonyms GA_x6K02T2PVTD-32368166-32367237, MOR168-2P
MMRRC Submission 039717-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R1681 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38664913-38665842 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38665320 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 175 (Y175H)
Ref Sequence ENSEMBL: ENSMUSP00000075857 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076542] [ENSMUST00000215461]
AlphaFold Q7TRC3
Predicted Effect probably benign
Transcript: ENSMUST00000076542
AA Change: Y175H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000075857
Gene: ENSMUSG00000063225
AA Change: Y175H

Pfam:7tm_4 31 307 3.2e-42 PFAM
Pfam:7tm_1 41 289 3e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213750
Predicted Effect probably benign
Transcript: ENSMUST00000215461
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216579
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217596
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,226,185 (GRCm38) I247N probably damaging Het
Ankle1 G T 8: 71,407,618 (GRCm38) S260I probably benign Het
Aoc2 T C 11: 101,325,192 (GRCm38) S34P probably benign Het
Ap1m1 A C 8: 72,256,122 (GRCm38) I397L possibly damaging Het
Apba1 C A 19: 23,936,561 (GRCm38) D649E probably damaging Het
Aptx C T 4: 40,697,274 (GRCm38) V25M probably benign Het
Arhgef18 G A 8: 3,439,645 (GRCm38) G326R probably damaging Het
Atm A C 9: 53,522,155 (GRCm38) I265S possibly damaging Het
B3galt4 A T 17: 33,951,213 (GRCm38) V17E probably benign Het
Bcl7a T A 5: 123,356,023 (GRCm38) M86K possibly damaging Het
Cela3a T A 4: 137,402,684 (GRCm38) probably null Het
Cep85 T A 4: 134,148,728 (GRCm38) K456* probably null Het
Ces1f C A 8: 93,275,414 (GRCm38) A29S probably benign Het
Chd9 A T 8: 90,973,135 (GRCm38) I598F probably damaging Het
Cntln T C 4: 84,947,635 (GRCm38) L176S probably damaging Het
Cntn3 A T 6: 102,170,668 (GRCm38) N909K probably damaging Het
Cntnap5b T C 1: 100,076,107 (GRCm38) S271P probably damaging Het
Col6a3 T A 1: 90,773,502 (GRCm38) H2564L unknown Het
Cyp2b19 C A 7: 26,763,340 (GRCm38) probably null Het
Dapk1 G T 13: 60,718,464 (GRCm38) probably null Het
Dnah7b T A 1: 46,324,712 (GRCm38) Y3497* probably null Het
Duoxa2 T C 2: 122,299,162 (GRCm38) probably null Het
Eny2 T C 15: 44,432,478 (GRCm38) W42R probably damaging Het
Epha3 A G 16: 63,595,728 (GRCm38) V635A probably damaging Het
Fam167b G C 4: 129,578,276 (GRCm38) Q34E probably benign Het
Fam26f A G 10: 34,127,900 (GRCm38) F4L probably benign Het
Fancm T C 12: 65,105,656 (GRCm38) M962T probably benign Het
Gimap8 T A 6: 48,656,411 (GRCm38) I388N probably benign Het
Gpaa1 A G 15: 76,331,453 (GRCm38) T22A probably benign Het
Hoxc11 T C 15: 102,955,156 (GRCm38) S211P possibly damaging Het
Hsd17b12 T C 2: 94,033,561 (GRCm38) N312S unknown Het
Idh2 T G 7: 80,099,158 (GRCm38) E125A probably damaging Het
Igdcc4 A G 9: 65,128,795 (GRCm38) Y712C probably damaging Het
Kank1 T C 19: 25,410,304 (GRCm38) V447A possibly damaging Het
Kif1b T A 4: 149,195,501 (GRCm38) probably null Het
Klc4 A T 17: 46,636,770 (GRCm38) D335E probably damaging Het
Klhl33 T A 14: 50,893,077 (GRCm38) D320V probably benign Het
Krt73 A T 15: 101,802,047 (GRCm38) M84K possibly damaging Het
Kti12 T A 4: 108,848,858 (GRCm38) I323N probably damaging Het
Kynu T C 2: 43,679,825 (GRCm38) L373P probably damaging Het
Lats1 T C 10: 7,705,914 (GRCm38) M821T probably damaging Het
Lnx1 A T 5: 74,685,410 (GRCm38) H126Q probably benign Het
Lonrf2 G A 1: 38,813,276 (GRCm38) P165S probably benign Het
Lrrc4b T A 7: 44,461,177 (GRCm38) Y158N probably damaging Het
Lrrc74b C A 16: 17,559,753 (GRCm38) R87L probably damaging Het
Meig1 T C 2: 3,409,274 (GRCm38) D63G probably damaging Het
Mrpl38 G A 11: 116,138,429 (GRCm38) probably benign Het
Naip2 C T 13: 100,161,860 (GRCm38) G556D probably benign Het
Naip2 T C 13: 100,161,854 (GRCm38) E558G probably benign Het
Nlrp1a T A 11: 71,142,358 (GRCm38) E3D unknown Het
Nphs2 T A 1: 156,320,898 (GRCm38) D110E probably damaging Het
Nxn T A 11: 76,272,464 (GRCm38) K244N probably benign Het
Oas3 A T 5: 120,769,908 (GRCm38) F322L probably benign Het
Obscn T A 11: 59,103,325 (GRCm38) Y1577F probably damaging Het
Olfr1122 G A 2: 87,388,620 (GRCm38) R305K possibly damaging Het
Olfr911-ps1 T A 9: 38,524,117 (GRCm38) N128K probably benign Het
Olfr914 G A 9: 38,606,948 (GRCm38) G161D probably damaging Het
Olfr924 T C 9: 38,848,513 (GRCm38) M133T probably damaging Het
Panx1 T C 9: 15,007,783 (GRCm38) D260G probably benign Het
Pcdhb15 T C 18: 37,473,813 (GRCm38) Y33H probably damaging Het
Pik3ap1 C A 19: 41,308,529 (GRCm38) V461F probably damaging Het
Plpp3 G A 4: 105,208,805 (GRCm38) probably null Het
Prtn3 A T 10: 79,880,541 (GRCm38) T61S probably benign Het
Psen1 T A 12: 83,724,620 (GRCm38) Y225N probably damaging Het
Rab44 T A 17: 29,140,124 (GRCm38) S429T possibly damaging Het
Ralgapa1 T C 12: 55,762,603 (GRCm38) I462M probably benign Het
Rbfox3 T C 11: 118,505,669 (GRCm38) N105S probably damaging Het
Rbm7 A C 9: 48,489,721 (GRCm38) Y236D possibly damaging Het
Samhd1 T C 2: 157,101,732 (GRCm38) T621A probably benign Het
Samt3 C A X: 86,046,650 (GRCm38) D49E probably benign Het
Sass6 T C 3: 116,603,473 (GRCm38) V26A possibly damaging Het
Scn11a C T 9: 119,804,412 (GRCm38) M418I possibly damaging Het
Scrib T C 15: 76,064,567 (GRCm38) E480G probably damaging Het
Sec24a T G 11: 51,695,189 (GRCm38) T1071P probably damaging Het
Siglecg A C 7: 43,408,941 (GRCm38) E84A probably benign Het
Slc6a17 C T 3: 107,474,386 (GRCm38) V419I probably damaging Het
Soga1 T C 2: 157,030,530 (GRCm38) T966A possibly damaging Het
Ssr2 T C 3: 88,581,042 (GRCm38) M75T possibly damaging Het
Tbc1d22b A G 17: 29,575,177 (GRCm38) T275A possibly damaging Het
Tbx15 T A 3: 99,351,824 (GRCm38) probably null Het
Tll1 A C 8: 64,085,551 (GRCm38) L353R possibly damaging Het
Tlr4 C T 4: 66,841,105 (GRCm38) P712S probably damaging Het
Tmem145 T A 7: 25,314,734 (GRCm38) F424L possibly damaging Het
Tnrc18 T C 5: 142,773,817 (GRCm38) K755E unknown Het
Trmt44 A G 5: 35,569,977 (GRCm38) I298T probably benign Het
Vmn1r69 A G 7: 10,580,252 (GRCm38) V184A probably benign Het
Zfp84 T C 7: 29,777,400 (GRCm38) C506R probably damaging Het
Other mutations in Olfr917
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01309:Olfr917 APN 9 38,664,993 (GRCm38) missense probably benign
IGL02704:Olfr917 APN 9 38,665,767 (GRCm38) missense possibly damaging 0.84
R0529:Olfr917 UTSW 9 38,665,512 (GRCm38) missense probably benign 0.11
R1575:Olfr917 UTSW 9 38,665,277 (GRCm38) missense probably damaging 1.00
R2941:Olfr917 UTSW 9 38,665,026 (GRCm38) missense probably damaging 0.98
R3083:Olfr917 UTSW 9 38,665,616 (GRCm38) missense probably damaging 0.99
R4450:Olfr917 UTSW 9 38,665,754 (GRCm38) missense probably benign 0.17
R4755:Olfr917 UTSW 9 38,665,832 (GRCm38) missense probably benign
R4774:Olfr917 UTSW 9 38,665,223 (GRCm38) missense probably benign 0.21
R5322:Olfr917 UTSW 9 38,665,206 (GRCm38) missense probably benign 0.24
R5577:Olfr917 UTSW 9 38,665,001 (GRCm38) missense possibly damaging 0.49
R6101:Olfr917 UTSW 9 38,665,620 (GRCm38) missense probably damaging 0.99
R6105:Olfr917 UTSW 9 38,665,620 (GRCm38) missense probably damaging 0.99
R7084:Olfr917 UTSW 9 38,665,269 (GRCm38) missense probably benign 0.04
R8048:Olfr917 UTSW 9 38,665,812 (GRCm38) missense probably benign 0.03
R8280:Olfr917 UTSW 9 38,665,487 (GRCm38) missense probably damaging 1.00
R8676:Olfr917 UTSW 9 38,665,768 (GRCm38) missense probably benign 0.02
R8924:Olfr917 UTSW 9 38,665,484 (GRCm38) missense probably damaging 1.00
R9087:Olfr917 UTSW 9 38,665,415 (GRCm38) missense probably damaging 1.00
R9117:Olfr917 UTSW 9 38,665,810 (GRCm38) missense probably benign 0.03
R9220:Olfr917 UTSW 9 38,665,507 (GRCm38) nonsense probably null
R9317:Olfr917 UTSW 9 38,665,359 (GRCm38) missense probably benign 0.00
R9318:Olfr917 UTSW 9 38,665,284 (GRCm38) missense possibly damaging 0.78
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-05-09