Incidental Mutation 'R1403:Adam26a'
ID 188614
Institutional Source Beutler Lab
Gene Symbol Adam26a
Ensembl Gene ENSMUSG00000048516
Gene Name ADAM metallopeptidase domain 26A
Synonyms Dtgn4, Adam26
MMRRC Submission 039465-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1403 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 44021315-44029744 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 44022229 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 420 (C420*)
Ref Sequence ENSEMBL: ENSMUSP00000058256 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049577]
AlphaFold Q9R158
Predicted Effect probably null
Transcript: ENSMUST00000049577
AA Change: C420*
SMART Domains Protein: ENSMUSP00000058256
Gene: ENSMUSG00000048516
AA Change: C420*

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:Pep_M12B_propep 29 147 2.1e-18 PFAM
Pfam:Reprolysin_5 193 364 4.8e-15 PFAM
Pfam:Reprolysin_4 194 380 2.2e-9 PFAM
Pfam:Reprolysin 195 385 2.7e-48 PFAM
Pfam:Reprolysin_2 215 377 2.4e-16 PFAM
Pfam:Reprolysin_3 219 340 1.2e-15 PFAM
DISIN 401 476 2.98e-41 SMART
ACR 477 613 2.06e-64 SMART
transmembrane domain 671 693 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 94% (51/54)
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during the late stages of spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to two other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 G A 4: 53,059,253 (GRCm39) probably benign Het
AC238840.3 T G 7: 38,567,345 (GRCm39) I28L probably benign Het
Acsf2 G T 11: 94,453,700 (GRCm39) N420K probably benign Het
Afap1l1 T C 18: 61,874,909 (GRCm39) Y424C probably damaging Het
Agl A G 3: 116,576,246 (GRCm39) V553A probably benign Het
Akr7a5 T A 4: 139,045,434 (GRCm39) M325K probably damaging Het
Akt3 C T 1: 176,958,676 (GRCm39) probably benign Het
Aldh7a1 C A 18: 56,692,341 (GRCm39) E87* probably null Het
Arhgap29 A G 3: 121,767,578 (GRCm39) K7E probably damaging Het
Brca2 T A 5: 150,466,114 (GRCm39) D1959E probably benign Het
Cdc42se2 A G 11: 54,611,192 (GRCm39) probably benign Het
Cdh20 G A 1: 109,988,862 (GRCm39) V255I probably benign Het
Chil5 G T 3: 105,925,409 (GRCm39) Q171K probably benign Het
Cul9 C G 17: 46,833,101 (GRCm39) A1326P probably damaging Het
Dhrs7c A T 11: 67,702,476 (GRCm39) I155F probably damaging Het
Dip2c A G 13: 9,603,300 (GRCm39) probably null Het
Ell T A 8: 71,044,138 (GRCm39) probably benign Het
Fam124b T C 1: 80,191,056 (GRCm39) Y109C possibly damaging Het
Gak T A 5: 108,739,011 (GRCm39) K156M probably damaging Het
Gm9797 C A 10: 11,485,294 (GRCm39) noncoding transcript Het
Got1l1 C G 8: 27,690,745 (GRCm39) probably null Het
Grm1 T C 10: 10,955,879 (GRCm39) D135G probably benign Het
Hrh3 T G 2: 179,744,547 (GRCm39) D131A probably damaging Het
Itpr1 A T 6: 108,366,514 (GRCm39) Q979L probably null Het
Kdm7a C A 6: 39,128,187 (GRCm39) probably benign Het
Klb G C 5: 65,506,089 (GRCm39) R112P possibly damaging Het
Lingo2 A T 4: 35,709,420 (GRCm39) C187S possibly damaging Het
Lrp1 T A 10: 127,417,760 (GRCm39) probably null Het
Ltbp4 T C 7: 27,028,464 (GRCm39) N266S unknown Het
Mgam G A 6: 40,643,815 (GRCm39) S581N possibly damaging Het
Mrgpra9 T A 7: 46,885,386 (GRCm39) I94L probably benign Het
Msantd4 A T 9: 4,384,023 (GRCm39) I115F probably benign Het
Mterf3 A G 13: 67,077,944 (GRCm39) probably benign Het
Neurl1a C A 19: 47,242,150 (GRCm39) N414K probably damaging Het
Nfkbiz A G 16: 55,636,833 (GRCm39) probably benign Het
Nrxn1 A C 17: 90,950,481 (GRCm39) L566R probably benign Het
Nsmce1 A G 7: 125,067,027 (GRCm39) probably benign Het
Or5p59 T A 7: 107,702,822 (GRCm39) I102N probably benign Het
Prl7d1 A T 13: 27,893,180 (GRCm39) F243I possibly damaging Het
Rbm27 T C 18: 42,450,746 (GRCm39) S509P probably damaging Het
Rnf126 C T 10: 79,596,702 (GRCm39) A239T probably benign Het
Rnf44 C T 13: 54,829,821 (GRCm39) E306K probably damaging Het
Rp1 T C 1: 4,416,520 (GRCm39) R1531G possibly damaging Het
Sf3b4 A G 3: 96,080,953 (GRCm39) probably null Het
Stk4 C T 2: 163,942,448 (GRCm39) T360M probably benign Het
Syt15 C A 14: 33,943,159 (GRCm39) probably benign Het
Vcan T A 13: 89,836,603 (GRCm39) E2980D probably benign Het
Vps13b A G 15: 35,709,268 (GRCm39) probably benign Het
Vwa2 C T 19: 56,869,570 (GRCm39) P2S unknown Het
Wdr77 G A 3: 105,874,573 (GRCm39) V322I possibly damaging Het
Zfp12 C A 5: 143,230,535 (GRCm39) Y287* probably null Het
Zfp937 T A 2: 150,080,868 (GRCm39) Y299* probably null Het
Other mutations in Adam26a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00499:Adam26a APN 8 44,021,896 (GRCm39) missense possibly damaging 0.75
IGL00519:Adam26a APN 8 44,022,562 (GRCm39) missense probably damaging 1.00
IGL00658:Adam26a APN 8 44,021,940 (GRCm39) missense probably benign 0.00
IGL01514:Adam26a APN 8 44,021,485 (GRCm39) missense probably benign
IGL01988:Adam26a APN 8 44,022,207 (GRCm39) missense possibly damaging 0.68
IGL02030:Adam26a APN 8 44,021,894 (GRCm39) missense probably benign 0.00
IGL02081:Adam26a APN 8 44,023,233 (GRCm39) missense probably damaging 0.99
IGL02444:Adam26a APN 8 44,022,710 (GRCm39) missense possibly damaging 0.46
IGL02734:Adam26a APN 8 44,022,812 (GRCm39) missense probably benign 0.27
IGL03243:Adam26a APN 8 44,021,733 (GRCm39) missense probably benign 0.14
IGL03350:Adam26a APN 8 44,022,589 (GRCm39) nonsense probably null
R0206:Adam26a UTSW 8 44,023,455 (GRCm39) missense possibly damaging 0.81
R0206:Adam26a UTSW 8 44,023,455 (GRCm39) missense possibly damaging 0.81
R0324:Adam26a UTSW 8 44,021,490 (GRCm39) missense probably benign
R0830:Adam26a UTSW 8 44,021,439 (GRCm39) missense probably benign 0.23
R0960:Adam26a UTSW 8 44,021,800 (GRCm39) missense probably damaging 1.00
R1259:Adam26a UTSW 8 44,021,750 (GRCm39) missense possibly damaging 0.95
R1259:Adam26a UTSW 8 44,021,684 (GRCm39) missense probably benign 0.20
R1403:Adam26a UTSW 8 44,022,229 (GRCm39) nonsense probably null
R1719:Adam26a UTSW 8 44,023,073 (GRCm39) missense possibly damaging 0.93
R1750:Adam26a UTSW 8 44,023,226 (GRCm39) missense possibly damaging 0.90
R1860:Adam26a UTSW 8 44,022,578 (GRCm39) missense possibly damaging 0.66
R1861:Adam26a UTSW 8 44,022,578 (GRCm39) missense possibly damaging 0.66
R1875:Adam26a UTSW 8 44,022,888 (GRCm39) missense probably benign 0.37
R3959:Adam26a UTSW 8 44,022,908 (GRCm39) missense probably benign 0.00
R4355:Adam26a UTSW 8 44,023,222 (GRCm39) missense probably benign 0.35
R4604:Adam26a UTSW 8 44,023,088 (GRCm39) missense probably benign 0.02
R4612:Adam26a UTSW 8 44,021,830 (GRCm39) missense probably damaging 0.99
R4909:Adam26a UTSW 8 44,023,475 (GRCm39) missense probably benign 0.08
R4937:Adam26a UTSW 8 44,021,918 (GRCm39) missense probably damaging 1.00
R5112:Adam26a UTSW 8 44,021,893 (GRCm39) missense probably benign 0.04
R5276:Adam26a UTSW 8 44,023,457 (GRCm39) missense probably benign 0.30
R5406:Adam26a UTSW 8 44,022,141 (GRCm39) missense probably damaging 1.00
R5501:Adam26a UTSW 8 44,022,941 (GRCm39) nonsense probably null
R5955:Adam26a UTSW 8 44,022,889 (GRCm39) missense probably benign 0.11
R6262:Adam26a UTSW 8 44,022,125 (GRCm39) missense possibly damaging 0.91
R6847:Adam26a UTSW 8 44,021,465 (GRCm39) missense probably benign 0.23
R6957:Adam26a UTSW 8 44,021,940 (GRCm39) missense probably benign 0.00
R7053:Adam26a UTSW 8 44,021,836 (GRCm39) nonsense probably null
R7287:Adam26a UTSW 8 44,023,380 (GRCm39) missense possibly damaging 0.95
R7393:Adam26a UTSW 8 44,022,725 (GRCm39) missense probably benign 0.01
R7477:Adam26a UTSW 8 44,022,107 (GRCm39) missense probably damaging 1.00
R7552:Adam26a UTSW 8 44,023,007 (GRCm39) missense possibly damaging 0.77
R7670:Adam26a UTSW 8 44,023,190 (GRCm39) missense probably benign 0.13
R7918:Adam26a UTSW 8 44,022,566 (GRCm39) missense probably damaging 0.98
R8193:Adam26a UTSW 8 44,022,273 (GRCm39) missense probably damaging 1.00
R8262:Adam26a UTSW 8 44,022,178 (GRCm39) nonsense probably null
R8987:Adam26a UTSW 8 44,022,358 (GRCm39) missense probably benign 0.02
R9104:Adam26a UTSW 8 44,023,108 (GRCm39) missense probably damaging 0.99
R9350:Adam26a UTSW 8 44,022,669 (GRCm39) missense probably benign 0.00
R9487:Adam26a UTSW 8 44,022,456 (GRCm39) missense possibly damaging 0.49
R9550:Adam26a UTSW 8 44,022,120 (GRCm39) missense probably damaging 1.00
R9762:Adam26a UTSW 8 44,021,635 (GRCm39) missense probably benign 0.00
Z1088:Adam26a UTSW 8 44,022,735 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATCTTCCGACACTGCTCATCACG -3'
(R):5'- TGGCACACATTGTAGCACACGAG -3'

Sequencing Primer
(F):5'- ACTGCTCATCACGTTGATGAC -3'
(R):5'- GGTTAAAAGACTGTCTAATGGCCC -3'
Posted On 2014-05-09