Incidental Mutation 'R1403:Syt15'
ID 188627
Institutional Source Beutler Lab
Gene Symbol Syt15
Ensembl Gene ENSMUSG00000041479
Gene Name synaptotagmin XV
Synonyms sytXV, CHR10SYT, E230025K04Rik
MMRRC Submission 039465-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R1403 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 33941915-33952378 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to A at 33943159 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113725 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035351] [ENSMUST00000119693]
AlphaFold Q8C6N3
Predicted Effect probably benign
Transcript: ENSMUST00000035351
SMART Domains Protein: ENSMUSP00000036755
Gene: ENSMUSG00000041479

DomainStartEndE-ValueType
transmembrane domain 5 27 N/A INTRINSIC
C2 160 262 2.44e-10 SMART
C2 291 397 6.01e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119693
SMART Domains Protein: ENSMUSP00000113725
Gene: ENSMUSG00000041479

DomainStartEndE-ValueType
transmembrane domain 5 27 N/A INTRINSIC
C2 160 262 2.44e-10 SMART
C2 291 389 7.53e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147298
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227397
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 94% (51/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Synaptotagmin (Syt) family of membrane trafficking proteins. Members of this family contain a transmembrane region and a C-terminal-type tandem C2 domain. Unlike related family members, the encoded protein may be involved in membrane trafficking in non-neuronal tissues. Two trancript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 G A 4: 53,059,253 (GRCm39) probably benign Het
AC238840.3 T G 7: 38,567,345 (GRCm39) I28L probably benign Het
Acsf2 G T 11: 94,453,700 (GRCm39) N420K probably benign Het
Adam26a A T 8: 44,022,229 (GRCm39) C420* probably null Het
Afap1l1 T C 18: 61,874,909 (GRCm39) Y424C probably damaging Het
Agl A G 3: 116,576,246 (GRCm39) V553A probably benign Het
Akr7a5 T A 4: 139,045,434 (GRCm39) M325K probably damaging Het
Akt3 C T 1: 176,958,676 (GRCm39) probably benign Het
Aldh7a1 C A 18: 56,692,341 (GRCm39) E87* probably null Het
Arhgap29 A G 3: 121,767,578 (GRCm39) K7E probably damaging Het
Brca2 T A 5: 150,466,114 (GRCm39) D1959E probably benign Het
Cdc42se2 A G 11: 54,611,192 (GRCm39) probably benign Het
Cdh20 G A 1: 109,988,862 (GRCm39) V255I probably benign Het
Chil5 G T 3: 105,925,409 (GRCm39) Q171K probably benign Het
Cul9 C G 17: 46,833,101 (GRCm39) A1326P probably damaging Het
Dhrs7c A T 11: 67,702,476 (GRCm39) I155F probably damaging Het
Dip2c A G 13: 9,603,300 (GRCm39) probably null Het
Ell T A 8: 71,044,138 (GRCm39) probably benign Het
Fam124b T C 1: 80,191,056 (GRCm39) Y109C possibly damaging Het
Gak T A 5: 108,739,011 (GRCm39) K156M probably damaging Het
Gm9797 C A 10: 11,485,294 (GRCm39) noncoding transcript Het
Got1l1 C G 8: 27,690,745 (GRCm39) probably null Het
Grm1 T C 10: 10,955,879 (GRCm39) D135G probably benign Het
Hrh3 T G 2: 179,744,547 (GRCm39) D131A probably damaging Het
Itpr1 A T 6: 108,366,514 (GRCm39) Q979L probably null Het
Kdm7a C A 6: 39,128,187 (GRCm39) probably benign Het
Klb G C 5: 65,506,089 (GRCm39) R112P possibly damaging Het
Lingo2 A T 4: 35,709,420 (GRCm39) C187S possibly damaging Het
Lrp1 T A 10: 127,417,760 (GRCm39) probably null Het
Ltbp4 T C 7: 27,028,464 (GRCm39) N266S unknown Het
Mgam G A 6: 40,643,815 (GRCm39) S581N possibly damaging Het
Mrgpra9 T A 7: 46,885,386 (GRCm39) I94L probably benign Het
Msantd4 A T 9: 4,384,023 (GRCm39) I115F probably benign Het
Mterf3 A G 13: 67,077,944 (GRCm39) probably benign Het
Neurl1a C A 19: 47,242,150 (GRCm39) N414K probably damaging Het
Nfkbiz A G 16: 55,636,833 (GRCm39) probably benign Het
Nrxn1 A C 17: 90,950,481 (GRCm39) L566R probably benign Het
Nsmce1 A G 7: 125,067,027 (GRCm39) probably benign Het
Or5p59 T A 7: 107,702,822 (GRCm39) I102N probably benign Het
Prl7d1 A T 13: 27,893,180 (GRCm39) F243I possibly damaging Het
Rbm27 T C 18: 42,450,746 (GRCm39) S509P probably damaging Het
Rnf126 C T 10: 79,596,702 (GRCm39) A239T probably benign Het
Rnf44 C T 13: 54,829,821 (GRCm39) E306K probably damaging Het
Rp1 T C 1: 4,416,520 (GRCm39) R1531G possibly damaging Het
Sf3b4 A G 3: 96,080,953 (GRCm39) probably null Het
Stk4 C T 2: 163,942,448 (GRCm39) T360M probably benign Het
Vcan T A 13: 89,836,603 (GRCm39) E2980D probably benign Het
Vps13b A G 15: 35,709,268 (GRCm39) probably benign Het
Vwa2 C T 19: 56,869,570 (GRCm39) P2S unknown Het
Wdr77 G A 3: 105,874,573 (GRCm39) V322I possibly damaging Het
Zfp12 C A 5: 143,230,535 (GRCm39) Y287* probably null Het
Zfp937 T A 2: 150,080,868 (GRCm39) Y299* probably null Het
Other mutations in Syt15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Syt15 APN 14 33,946,881 (GRCm39) missense possibly damaging 0.91
IGL02486:Syt15 APN 14 33,944,933 (GRCm39) missense probably damaging 0.96
IGL02559:Syt15 APN 14 33,943,760 (GRCm39) missense probably benign
IGL02807:Syt15 APN 14 33,944,870 (GRCm39) missense probably benign
R1695:Syt15 UTSW 14 33,944,858 (GRCm39) missense probably benign 0.37
R1993:Syt15 UTSW 14 33,944,969 (GRCm39) missense probably benign 0.06
R2163:Syt15 UTSW 14 33,948,073 (GRCm39) missense probably benign 0.00
R2214:Syt15 UTSW 14 33,944,989 (GRCm39) missense probably damaging 1.00
R3120:Syt15 UTSW 14 33,944,950 (GRCm39) missense probably benign 0.19
R3978:Syt15 UTSW 14 33,945,061 (GRCm39) missense probably benign 0.00
R4688:Syt15 UTSW 14 33,950,011 (GRCm39) missense probably damaging 1.00
R5214:Syt15 UTSW 14 33,943,703 (GRCm39) missense possibly damaging 0.89
R6715:Syt15 UTSW 14 33,944,819 (GRCm39) missense probably damaging 1.00
R7731:Syt15 UTSW 14 33,945,024 (GRCm39) missense possibly damaging 0.94
R8901:Syt15 UTSW 14 33,948,028 (GRCm39) missense probably damaging 1.00
R9466:Syt15 UTSW 14 33,942,991 (GRCm39) missense probably damaging 1.00
X0026:Syt15 UTSW 14 33,947,006 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-05-09