Incidental Mutation 'R1404:Fam151b'
ID 188669
Institutional Source Beutler Lab
Gene Symbol Fam151b
Ensembl Gene ENSMUSG00000034334
Gene Name family with sequence similarity 151, member B
Synonyms 4930405M20Rik
MMRRC Submission 039466-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1404 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 92586133-92620523 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 92610480 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 103 (D103G)
Ref Sequence ENSEMBL: ENSMUSP00000045024 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040106] [ENSMUST00000225299]
AlphaFold D3YUE4
Predicted Effect probably damaging
Transcript: ENSMUST00000040106
AA Change: D103G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000045024
Gene: ENSMUSG00000034334
AA Change: D103G

DomainStartEndE-ValueType
Pfam:DUF2181 29 263 2.3e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225299
Meta Mutation Damage Score 0.9185 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 92.0%
Validation Efficiency 100% (28/28)
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 G A 4: 53,059,253 (GRCm39) probably benign Het
Actl6a T C 3: 32,776,759 (GRCm39) probably benign Het
Aoc1l1 A T 6: 48,952,767 (GRCm39) T231S probably benign Het
Aox1 T C 1: 58,385,371 (GRCm39) probably benign Het
Arrdc3 A G 13: 81,031,973 (GRCm39) T69A probably damaging Het
Bbs2 T C 8: 94,808,627 (GRCm39) K360R probably null Het
Cdh8 A T 8: 100,006,250 (GRCm39) N112K probably damaging Het
Ces5a A T 8: 94,228,809 (GRCm39) F474I probably damaging Het
Dync1i1 G A 6: 5,915,876 (GRCm39) D253N probably damaging Het
Fam227b A G 2: 125,845,759 (GRCm39) L410P probably damaging Het
Ihh A T 1: 74,990,372 (GRCm39) M1K probably null Het
Itga6 A G 2: 71,669,060 (GRCm39) T617A probably benign Het
Itpr1 T A 6: 108,363,609 (GRCm39) C744S probably benign Het
Kif5a T C 10: 127,081,311 (GRCm39) I208V probably benign Het
Lama4 A G 10: 38,937,387 (GRCm39) K659R probably benign Het
Lpin3 T A 2: 160,734,310 (GRCm39) probably null Het
Macf1 T A 4: 123,270,309 (GRCm39) E6612V probably damaging Het
Naip2 T C 13: 100,298,362 (GRCm39) E558G probably benign Het
Ncdn T C 4: 126,643,833 (GRCm39) K330E probably benign Het
Neb C T 2: 52,073,287 (GRCm39) D1975N possibly damaging Het
Nell1 T A 7: 50,503,621 (GRCm39) N675K possibly damaging Het
Nlrp6 GAGAAGAAGAAGAAGAAGAAGA GAGAAGAAGAAGAAGAAGA 7: 140,504,026 (GRCm39) probably benign Het
Or4f47 G A 2: 111,972,968 (GRCm39) R226H probably benign Het
Rnf43 A G 11: 87,625,003 (GRCm39) E737G possibly damaging Het
Sardh C A 2: 27,129,473 (GRCm39) W275L probably damaging Het
Sel1l2 C T 2: 140,071,979 (GRCm39) probably benign Het
Sipa1l2 G A 8: 126,176,712 (GRCm39) H1185Y probably damaging Het
Skp2 G A 15: 9,117,012 (GRCm39) Q298* probably null Het
Spag16 G A 1: 69,934,439 (GRCm39) probably benign Het
Spink14 A G 18: 44,161,896 (GRCm39) probably benign Het
Stk4 C T 2: 163,942,448 (GRCm39) T360M probably benign Het
Stx12 T A 4: 132,598,960 (GRCm39) I43L probably benign Het
Tmc1 T A 19: 20,793,548 (GRCm39) I538F possibly damaging Het
Tollip T C 7: 141,438,292 (GRCm39) M209V probably benign Het
Ttn A T 2: 76,643,312 (GRCm39) S13202R probably damaging Het
Vmn2r60 T A 7: 41,786,211 (GRCm39) V338D probably damaging Het
Vwa8 T C 14: 79,263,471 (GRCm39) L767P probably damaging Het
Zfp202 C T 9: 40,122,792 (GRCm39) T518I probably damaging Het
Other mutations in Fam151b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00799:Fam151b APN 13 92,614,361 (GRCm39) missense probably damaging 1.00
IGL02253:Fam151b APN 13 92,614,435 (GRCm39) missense probably damaging 1.00
IGL03084:Fam151b APN 13 92,604,534 (GRCm39) missense probably damaging 0.97
IGL03130:Fam151b APN 13 92,586,701 (GRCm39) missense probably benign 0.01
P0015:Fam151b UTSW 13 92,604,452 (GRCm39) critical splice donor site probably null
R0067:Fam151b UTSW 13 92,610,504 (GRCm39) missense probably benign 0.08
R0067:Fam151b UTSW 13 92,610,504 (GRCm39) missense probably benign 0.08
R0348:Fam151b UTSW 13 92,586,689 (GRCm39) missense probably benign 0.00
R1404:Fam151b UTSW 13 92,610,480 (GRCm39) missense probably damaging 1.00
R1482:Fam151b UTSW 13 92,586,674 (GRCm39) missense probably benign 0.03
R1837:Fam151b UTSW 13 92,610,639 (GRCm39) intron probably benign
R1891:Fam151b UTSW 13 92,586,678 (GRCm39) missense probably benign 0.00
R1957:Fam151b UTSW 13 92,614,411 (GRCm39) missense probably damaging 1.00
R1957:Fam151b UTSW 13 92,614,410 (GRCm39) missense probably damaging 1.00
R2175:Fam151b UTSW 13 92,614,426 (GRCm39) missense probably damaging 0.99
R4583:Fam151b UTSW 13 92,604,617 (GRCm39) missense probably damaging 1.00
R6762:Fam151b UTSW 13 92,604,558 (GRCm39) missense possibly damaging 0.79
R8153:Fam151b UTSW 13 92,614,410 (GRCm39) missense probably damaging 1.00
R8881:Fam151b UTSW 13 92,604,630 (GRCm39) missense probably benign 0.00
R8950:Fam151b UTSW 13 92,610,567 (GRCm39) missense probably damaging 1.00
R9497:Fam151b UTSW 13 92,610,621 (GRCm39) missense probably damaging 0.99
X0021:Fam151b UTSW 13 92,586,734 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- AGTCCTCAAGGAGCAATCTTAGCCA -3'
(R):5'- GGTAGGTGCTGCCCACATGATAGA -3'

Sequencing Primer
(F):5'- agtctccttttgctgcctg -3'
(R):5'- CCACATGATAGAGGCTGATGTCC -3'
Posted On 2014-05-09