Incidental Mutation 'R1653:Adam34'
ID 188858
Institutional Source Beutler Lab
Gene Symbol Adam34
Ensembl Gene ENSMUSG00000079058
Gene Name a disintegrin and metallopeptidase domain 34
Synonyms testase 4
MMRRC Submission 039689-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1653 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 44103346-44118597 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 44103682 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 654 (C654*)
Ref Sequence ENSEMBL: ENSMUSP00000148332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110411] [ENSMUST00000212185]
AlphaFold A2RSG8
Predicted Effect probably null
Transcript: ENSMUST00000110411
AA Change: C654*
SMART Domains Protein: ENSMUSP00000106041
Gene: ENSMUSG00000079058
AA Change: C654*

DomainStartEndE-ValueType
transmembrane domain 13 32 N/A INTRINSIC
Pfam:Pep_M12B_propep 40 159 5.9e-20 PFAM
Pfam:Reprolysin_5 205 377 1.6e-16 PFAM
Pfam:Reprolysin_4 205 393 3e-12 PFAM
Pfam:Reprolysin 207 397 9.4e-49 PFAM
Pfam:Reprolysin_2 224 389 1e-14 PFAM
Pfam:Reprolysin_3 231 352 2.7e-14 PFAM
DISIN 416 491 3.38e-40 SMART
ACR 492 628 9.18e-62 SMART
transmembrane domain 685 707 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000212185
AA Change: C654*
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 T A 18: 59,023,365 (GRCm39) N253K probably benign Het
Adgrb3 A G 1: 25,140,584 (GRCm39) L1162S probably benign Het
Ap2b1 T A 11: 83,237,657 (GRCm39) Y574N probably damaging Het
Atrn A G 2: 130,777,544 (GRCm39) I198V probably benign Het
Bcan T A 3: 87,901,503 (GRCm39) I400F probably damaging Het
Capn10 A G 1: 92,874,620 (GRCm39) Y617C probably damaging Het
Capn8 A G 1: 182,451,516 (GRCm39) N578D probably benign Het
Casd1 T C 6: 4,624,134 (GRCm39) L309P probably benign Het
Ccser1 T A 6: 61,288,449 (GRCm39) I204K probably benign Het
Cd276 T C 9: 58,444,732 (GRCm39) T80A probably benign Het
Cdh3 T C 8: 107,265,700 (GRCm39) S248P probably damaging Het
Celsr2 T C 3: 108,320,836 (GRCm39) T659A possibly damaging Het
Col6a4 C T 9: 105,949,608 (GRCm39) V676I probably damaging Het
Crmp1 T A 5: 37,443,812 (GRCm39) V575D probably damaging Het
Ep400 G A 5: 110,841,040 (GRCm39) Q1795* probably null Het
Gcnt3 A G 9: 69,942,359 (GRCm39) C70R probably damaging Het
Gm12258 T C 11: 58,749,113 (GRCm39) I96T possibly damaging Het
Gpr183 A G 14: 122,191,675 (GRCm39) F282S probably damaging Het
Igfals T C 17: 25,100,052 (GRCm39) V381A probably benign Het
Irs3 C A 5: 137,642,783 (GRCm39) L218F probably damaging Het
Kdm5b T C 1: 134,530,219 (GRCm39) F410S probably damaging Het
Klc4 T C 17: 46,942,785 (GRCm39) Y593C possibly damaging Het
Lce1h T A 3: 92,670,750 (GRCm39) Q134L unknown Het
Lyst T C 13: 13,809,811 (GRCm39) S494P probably damaging Het
Marchf3 A G 18: 56,944,967 (GRCm39) M42T probably benign Het
Myh7 A G 14: 55,228,246 (GRCm39) I250T probably benign Het
N4bp1 G T 8: 87,571,576 (GRCm39) H807Q probably benign Het
Ndn C T 7: 61,998,256 (GRCm39) P34L probably benign Het
Nfs1 C T 2: 155,967,256 (GRCm39) G44D probably damaging Het
Nrg1 C T 8: 32,308,681 (GRCm39) R445H probably damaging Het
Or14c43 T C 7: 86,115,420 (GRCm39) V267A probably benign Het
Or4e5 A T 14: 52,728,229 (GRCm39) F64Y probably damaging Het
Or56a5 T A 7: 104,793,077 (GRCm39) D141V possibly damaging Het
Pak5 C T 2: 135,958,807 (GRCm39) V94M probably damaging Het
Pdk1 G A 2: 71,719,339 (GRCm39) probably null Het
Sin3b G T 8: 73,468,147 (GRCm39) V290L probably benign Het
Sirt1 T C 10: 63,157,588 (GRCm39) T609A probably benign Het
Skint5 A T 4: 113,347,875 (GRCm39) S1289T unknown Het
Slc32a1 A T 2: 158,456,809 (GRCm39) H488L probably benign Het
Slc35b3 A G 13: 39,139,774 (GRCm39) S18P probably benign Het
Spaca7 T A 8: 12,636,501 (GRCm39) I109K possibly damaging Het
Tmem204 A G 17: 25,299,501 (GRCm39) L6P possibly damaging Het
Tubgcp6 G A 15: 88,991,645 (GRCm39) R651C probably damaging Het
Vps13b T A 15: 35,607,418 (GRCm39) L1117* probably null Het
Wdcp T C 12: 4,901,815 (GRCm39) L557P probably damaging Het
Wwp2 T C 8: 108,210,042 (GRCm39) F140S possibly damaging Het
Zfp429 C T 13: 67,538,043 (GRCm39) R467H possibly damaging Het
Zfp747l1 G T 7: 126,983,652 (GRCm39) H483Q possibly damaging Het
Zfp839 T A 12: 110,821,684 (GRCm39) M166K probably benign Het
Zfyve9 G A 4: 108,517,774 (GRCm39) Q1106* probably null Het
Zrsr2-ps1 T A 11: 22,924,158 (GRCm39) C311S probably damaging Het
Other mutations in Adam34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00545:Adam34 APN 8 44,105,227 (GRCm39) missense possibly damaging 0.91
IGL01296:Adam34 APN 8 44,104,178 (GRCm39) missense possibly damaging 0.90
IGL01369:Adam34 APN 8 44,104,094 (GRCm39) missense probably benign 0.00
IGL01933:Adam34 APN 8 44,104,569 (GRCm39) missense probably damaging 1.00
IGL01938:Adam34 APN 8 44,104,053 (GRCm39) missense probably damaging 1.00
IGL02112:Adam34 APN 8 44,104,175 (GRCm39) missense possibly damaging 0.46
IGL02182:Adam34 APN 8 44,104,790 (GRCm39) missense probably benign
IGL02306:Adam34 APN 8 44,103,522 (GRCm39) missense probably benign 0.44
IGL02661:Adam34 APN 8 44,104,572 (GRCm39) missense probably damaging 1.00
IGL02888:Adam34 APN 8 44,104,610 (GRCm39) missense probably damaging 1.00
IGL02979:Adam34 APN 8 44,104,408 (GRCm39) missense probably damaging 1.00
IGL03073:Adam34 APN 8 44,103,940 (GRCm39) missense probably damaging 0.99
BB010:Adam34 UTSW 8 44,103,911 (GRCm39) missense probably damaging 1.00
BB020:Adam34 UTSW 8 44,103,911 (GRCm39) missense probably damaging 1.00
PIT4453001:Adam34 UTSW 8 44,104,349 (GRCm39) missense probably damaging 1.00
R0060:Adam34 UTSW 8 44,128,920 (GRCm39) intron probably benign
R0317:Adam34 UTSW 8 44,105,288 (GRCm39) missense probably benign 0.14
R0322:Adam34 UTSW 8 44,104,958 (GRCm39) missense probably benign 0.00
R0427:Adam34 UTSW 8 44,105,493 (GRCm39) missense probably benign 0.15
R0593:Adam34 UTSW 8 44,104,724 (GRCm39) missense possibly damaging 0.87
R0837:Adam34 UTSW 8 44,104,537 (GRCm39) missense probably benign 0.00
R0927:Adam34 UTSW 8 44,104,621 (GRCm39) missense probably damaging 1.00
R1634:Adam34 UTSW 8 44,105,127 (GRCm39) missense possibly damaging 0.81
R1826:Adam34 UTSW 8 44,104,379 (GRCm39) missense probably damaging 1.00
R1873:Adam34 UTSW 8 44,104,843 (GRCm39) missense probably benign 0.02
R1943:Adam34 UTSW 8 44,104,852 (GRCm39) missense probably damaging 1.00
R1943:Adam34 UTSW 8 44,103,864 (GRCm39) missense possibly damaging 0.48
R2147:Adam34 UTSW 8 44,105,538 (GRCm39) missense probably benign 0.01
R2150:Adam34 UTSW 8 44,105,538 (GRCm39) missense probably benign 0.01
R2206:Adam34 UTSW 8 44,105,274 (GRCm39) missense probably benign 0.02
R2207:Adam34 UTSW 8 44,105,274 (GRCm39) missense probably benign 0.02
R2268:Adam34 UTSW 8 44,103,647 (GRCm39) missense probably benign 0.00
R2349:Adam34 UTSW 8 44,105,415 (GRCm39) missense probably damaging 0.99
R3983:Adam34 UTSW 8 44,103,806 (GRCm39) missense probably benign
R4158:Adam34 UTSW 8 44,103,854 (GRCm39) missense probably damaging 1.00
R4179:Adam34 UTSW 8 44,104,128 (GRCm39) missense probably benign 0.18
R5219:Adam34 UTSW 8 44,104,461 (GRCm39) missense probably benign
R5398:Adam34 UTSW 8 44,104,278 (GRCm39) missense probably damaging 1.00
R5611:Adam34 UTSW 8 44,104,749 (GRCm39) missense probably benign 0.43
R5928:Adam34 UTSW 8 44,105,067 (GRCm39) missense probably benign 0.08
R6115:Adam34 UTSW 8 44,105,098 (GRCm39) missense probably benign
R6319:Adam34 UTSW 8 44,104,952 (GRCm39) missense probably benign 0.01
R6384:Adam34 UTSW 8 44,103,836 (GRCm39) missense probably benign 0.00
R6706:Adam34 UTSW 8 44,104,479 (GRCm39) nonsense probably null
R6992:Adam34 UTSW 8 44,105,642 (GRCm39) start codon destroyed probably null 1.00
R7032:Adam34 UTSW 8 44,105,303 (GRCm39) missense probably damaging 1.00
R7151:Adam34 UTSW 8 44,104,499 (GRCm39) missense probably benign 0.19
R7187:Adam34 UTSW 8 44,105,565 (GRCm39) missense probably benign 0.02
R7223:Adam34 UTSW 8 44,105,041 (GRCm39) missense probably benign 0.02
R7487:Adam34 UTSW 8 44,104,191 (GRCm39) missense probably damaging 1.00
R7726:Adam34 UTSW 8 44,104,208 (GRCm39) missense probably damaging 0.99
R7789:Adam34 UTSW 8 44,105,488 (GRCm39) missense probably benign 0.00
R7810:Adam34 UTSW 8 44,105,045 (GRCm39) missense probably benign 0.01
R7933:Adam34 UTSW 8 44,103,911 (GRCm39) missense probably damaging 1.00
R8192:Adam34 UTSW 8 44,103,970 (GRCm39) missense probably damaging 1.00
R8231:Adam34 UTSW 8 44,104,659 (GRCm39) missense probably benign
R8238:Adam34 UTSW 8 44,103,993 (GRCm39) missense probably damaging 1.00
R8259:Adam34 UTSW 8 44,104,646 (GRCm39) missense probably benign 0.03
R8339:Adam34 UTSW 8 44,103,640 (GRCm39) missense probably benign 0.20
R8381:Adam34 UTSW 8 44,104,847 (GRCm39) missense possibly damaging 0.70
R8670:Adam34 UTSW 8 44,105,126 (GRCm39) missense possibly damaging 0.91
R8693:Adam34 UTSW 8 44,104,641 (GRCm39) missense probably benign
R8932:Adam34 UTSW 8 44,105,192 (GRCm39) missense probably benign 0.19
R8936:Adam34 UTSW 8 44,104,439 (GRCm39) missense probably benign 0.00
R8981:Adam34 UTSW 8 44,103,840 (GRCm39) missense probably benign 0.05
R9040:Adam34 UTSW 8 44,103,363 (GRCm39) unclassified probably benign
R9105:Adam34 UTSW 8 44,103,785 (GRCm39) missense probably damaging 1.00
R9305:Adam34 UTSW 8 44,104,416 (GRCm39) missense probably damaging 1.00
R9321:Adam34 UTSW 8 44,105,243 (GRCm39) missense probably damaging 1.00
R9641:Adam34 UTSW 8 44,104,076 (GRCm39) missense probably damaging 0.97
R9644:Adam34 UTSW 8 44,104,766 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GCGTGGCATCTTCTTCAGATTTTGC -3'
(R):5'- TCACCTGCTGGACTACGGACTATC -3'

Sequencing Primer
(F):5'- TGCAAGTCTGAAAATCAGAGATCC -3'
(R):5'- ACGGACTATCATTTTGGGATCACC -3'
Posted On 2014-05-09