Incidental Mutation 'R1653:Or4e5'
ID 188879
Institutional Source Beutler Lab
Gene Symbol Or4e5
Ensembl Gene ENSMUSG00000059887
Gene Name olfactory receptor family 4 subfamily E member 5
Synonyms MOR28, MOR244-1, GA_x6K02T2RJGY-491851-492792, Olfr1507
MMRRC Submission 039689-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R1653 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 52727392-52733152 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 52728229 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 64 (F64Y)
Ref Sequence ENSEMBL: ENSMUSP00000146152 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073571] [ENSMUST00000205963] [ENSMUST00000206062] [ENSMUST00000206069] [ENSMUST00000206931]
AlphaFold Q0VEP0
Predicted Effect probably damaging
Transcript: ENSMUST00000073571
AA Change: F64Y

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000073260
Gene: ENSMUSG00000059887
AA Change: F64Y

Pfam:7tm_4 34 308 1.1e-47 PFAM
Pfam:7TM_GPCR_Srsx 38 305 3.6e-9 PFAM
Pfam:7tm_1 44 290 9.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205963
AA Change: F37Y

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000206062
AA Change: F64Y

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000206069
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206087
AA Change: F64Y
Predicted Effect probably benign
Transcript: ENSMUST00000206931
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 A T 8: 44,103,682 (GRCm39) C654* probably null Het
Adamts19 T A 18: 59,023,365 (GRCm39) N253K probably benign Het
Adgrb3 A G 1: 25,140,584 (GRCm39) L1162S probably benign Het
Ap2b1 T A 11: 83,237,657 (GRCm39) Y574N probably damaging Het
Atrn A G 2: 130,777,544 (GRCm39) I198V probably benign Het
Bcan T A 3: 87,901,503 (GRCm39) I400F probably damaging Het
Capn10 A G 1: 92,874,620 (GRCm39) Y617C probably damaging Het
Capn8 A G 1: 182,451,516 (GRCm39) N578D probably benign Het
Casd1 T C 6: 4,624,134 (GRCm39) L309P probably benign Het
Ccser1 T A 6: 61,288,449 (GRCm39) I204K probably benign Het
Cd276 T C 9: 58,444,732 (GRCm39) T80A probably benign Het
Cdh3 T C 8: 107,265,700 (GRCm39) S248P probably damaging Het
Celsr2 T C 3: 108,320,836 (GRCm39) T659A possibly damaging Het
Col6a4 C T 9: 105,949,608 (GRCm39) V676I probably damaging Het
Crmp1 T A 5: 37,443,812 (GRCm39) V575D probably damaging Het
Ep400 G A 5: 110,841,040 (GRCm39) Q1795* probably null Het
Gcnt3 A G 9: 69,942,359 (GRCm39) C70R probably damaging Het
Gm12258 T C 11: 58,749,113 (GRCm39) I96T possibly damaging Het
Gpr183 A G 14: 122,191,675 (GRCm39) F282S probably damaging Het
Igfals T C 17: 25,100,052 (GRCm39) V381A probably benign Het
Irs3 C A 5: 137,642,783 (GRCm39) L218F probably damaging Het
Kdm5b T C 1: 134,530,219 (GRCm39) F410S probably damaging Het
Klc4 T C 17: 46,942,785 (GRCm39) Y593C possibly damaging Het
Lce1h T A 3: 92,670,750 (GRCm39) Q134L unknown Het
Lyst T C 13: 13,809,811 (GRCm39) S494P probably damaging Het
Marchf3 A G 18: 56,944,967 (GRCm39) M42T probably benign Het
Myh7 A G 14: 55,228,246 (GRCm39) I250T probably benign Het
N4bp1 G T 8: 87,571,576 (GRCm39) H807Q probably benign Het
Ndn C T 7: 61,998,256 (GRCm39) P34L probably benign Het
Nfs1 C T 2: 155,967,256 (GRCm39) G44D probably damaging Het
Nrg1 C T 8: 32,308,681 (GRCm39) R445H probably damaging Het
Or14c43 T C 7: 86,115,420 (GRCm39) V267A probably benign Het
Or56a5 T A 7: 104,793,077 (GRCm39) D141V possibly damaging Het
Pak5 C T 2: 135,958,807 (GRCm39) V94M probably damaging Het
Pdk1 G A 2: 71,719,339 (GRCm39) probably null Het
Sin3b G T 8: 73,468,147 (GRCm39) V290L probably benign Het
Sirt1 T C 10: 63,157,588 (GRCm39) T609A probably benign Het
Skint5 A T 4: 113,347,875 (GRCm39) S1289T unknown Het
Slc32a1 A T 2: 158,456,809 (GRCm39) H488L probably benign Het
Slc35b3 A G 13: 39,139,774 (GRCm39) S18P probably benign Het
Spaca7 T A 8: 12,636,501 (GRCm39) I109K possibly damaging Het
Tmem204 A G 17: 25,299,501 (GRCm39) L6P possibly damaging Het
Tubgcp6 G A 15: 88,991,645 (GRCm39) R651C probably damaging Het
Vps13b T A 15: 35,607,418 (GRCm39) L1117* probably null Het
Wdcp T C 12: 4,901,815 (GRCm39) L557P probably damaging Het
Wwp2 T C 8: 108,210,042 (GRCm39) F140S possibly damaging Het
Zfp429 C T 13: 67,538,043 (GRCm39) R467H possibly damaging Het
Zfp747l1 G T 7: 126,983,652 (GRCm39) H483Q possibly damaging Het
Zfp839 T A 12: 110,821,684 (GRCm39) M166K probably benign Het
Zfyve9 G A 4: 108,517,774 (GRCm39) Q1106* probably null Het
Zrsr2-ps1 T A 11: 22,924,158 (GRCm39) C311S probably damaging Het
Other mutations in Or4e5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01336:Or4e5 APN 14 52,728,205 (GRCm39) missense probably damaging 1.00
IGL01367:Or4e5 APN 14 52,727,624 (GRCm39) missense probably benign 0.42
IGL01664:Or4e5 APN 14 52,728,002 (GRCm39) missense probably benign 0.01
IGL02890:Or4e5 APN 14 52,728,368 (GRCm39) missense probably benign
IGL03108:Or4e5 APN 14 52,727,533 (GRCm39) missense probably damaging 0.97
IGL03184:Or4e5 APN 14 52,728,380 (GRCm39) missense probably benign 0.20
R0563:Or4e5 UTSW 14 52,727,714 (GRCm39) nonsense probably null
R1080:Or4e5 UTSW 14 52,728,042 (GRCm39) nonsense probably null
R1558:Or4e5 UTSW 14 52,727,603 (GRCm39) missense probably benign 0.26
R1714:Or4e5 UTSW 14 52,727,871 (GRCm39) splice site probably null
R1720:Or4e5 UTSW 14 52,728,051 (GRCm39) nonsense probably null
R3430:Or4e5 UTSW 14 52,727,882 (GRCm39) missense possibly damaging 0.92
R4995:Or4e5 UTSW 14 52,727,988 (GRCm39) nonsense probably null
R5954:Or4e5 UTSW 14 52,727,624 (GRCm39) missense probably benign 0.42
R6183:Or4e5 UTSW 14 52,728,188 (GRCm39) missense probably benign 0.05
R6518:Or4e5 UTSW 14 52,728,077 (GRCm39) missense probably damaging 1.00
R6651:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R6652:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R6653:Or4e5 UTSW 14 52,728,250 (GRCm39) missense probably benign 0.07
R7385:Or4e5 UTSW 14 52,727,638 (GRCm39) missense probably damaging 1.00
R7524:Or4e5 UTSW 14 52,727,750 (GRCm39) missense probably damaging 1.00
R8902:Or4e5 UTSW 14 52,728,010 (GRCm39) missense probably benign 0.02
R9165:Or4e5 UTSW 14 52,727,830 (GRCm39) missense possibly damaging 0.71
R9763:Or4e5 UTSW 14 52,728,307 (GRCm39) missense probably damaging 1.00
X0025:Or4e5 UTSW 14 52,727,923 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-05-09