|Institutional Source||Beutler Lab|
|Gene Name||G protein-coupled receptor 183|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1653 (G1)|
|Chromosomal Location||121952551-121965195 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 121954263 bp (GRCm38)|
|Amino Acid Change||Phenylalanine to Serine at position 282 (F282S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000052404 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000039803] [ENSMUST00000049872] [ENSMUST00000226998] [ENSMUST00000227267]|
AA Change: F282S
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: F282S
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous inactivation of this gene leads to altered B cell migration during immune activation. Mice homozygous for a null allele exhibit decreased plasmacytoid and myeloid dendritic cell number, and increased type I interferon responses upon TLR ligand challenge or viral infection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gpr183||
(F):5'- ATTCTCTTCAGGGGCTGACCTCAC -3'
(R):5'- ACGTGCTGCCTATCACAGTCATTC -3'
(F):5'- ACTGCGCTGGAGATCGAC -3'
(R):5'- GCTGCAAACTCTTCAGGACTG -3'